The Interactive Fly

Evolutionarily conserved developmental pathways



Axon guidance 1: The role of Netrins and the netrin receptor Frazzled

Netrins are related to the N terminal arm of Laminins, a large protein constituent of the extracellular matrix. The involvement of Netrins and a highly conserved netrin receptor in axon guidance is conserved from worms to mammals.


Drosophila                     Homologs in other species ----------                     ----------------------------Netrin A and Netrin B          C. elegans: Unc6                               Mammals: NetrinsFrazzled                       C. elegans: Unc 40 and Unc5                               Mammals: Deleted in Colorectal Cancer




date revised: 13 Oct 96

Developmental Pathways conserved in Evolution

Home page: The InteractiveFly © 1995, 1996 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.