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Evolutionarily conserved developmental pathways
The cyclic AMP second messenger system is a signal transduction cascade tying neurotransmitter signals totranscription factors, bringing about the cellular changes that take placeduring learning. For more information, see the cAMP or LearningPathway site. This pathway is highly conserved in evolution. For example,cellular slime molds use it to transduce cAMP signals to the nucleus resultingin the induction of cell aggregation. Fos and Jun (targets of cAMP signals)and important in growth factor responses, are also activated through theRas pathway.
Drosophila Homologs in other species ---------- ----------------------------Rutabaga Mammalian: Type I adenyl cyclaseCa2+-calmodulin Vertebrates: Ca2+-calmodulincAMP-dependent Mammalian: cAMP-dependent protein kinase Aprotein kinase 1Dunce Vertebrates: cAMP-specific phosphodiesteraseRutabaga Mammalian: Type I adenyl cyclaseDCREB2 Mammalian: CREB, CREM and ATF-1DFos Mammalian: cFosDJun Mammalian: cJun
Developmental Pathways conserved in Evolution
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