The Interactive Fly

Evolutionarily conserved developmental pathways



Subdivision of anterior-posterior axis by Homeobox cluster

In Drosophila, the eight Hox (Homeobox) cluster genes are arranged in two linkage groups, the Antennapedia complex and the bithorax complex. This contrasts with 38 genesin 4 linkage groups in humans. In both Drosophila and humans, homeoboxclusters control the identity of cells along the anterior-posterior axis,including cells of ectodermal, mesodermal, endodermal and neural fates.Both Extradenticle and PBX proteins interact with Hox proteinsto form heterotypic complexes that act to regulate expression of specificsubordinate genes.

Drosophila(proximal to distal)        Homologs in other species --------------------        -------------------------Labial                      Xenopus: HoxA1, HoxD1                            Mammalian: HoxD1, HoxB1, HoxA1  Proboscipedia               Mammalian: HoxB2, HoxA2, HoxB3, HoxA3, HoxD3 Deformed                    Mammalian: HoxB4, HoxA4, HoxD4, HoxC4Sex combs reduced           Mammalian: HoxC5, HoxB5, HoxA5Antennapedia                Mammalian: HoxC8, HoxB8                            Mammalian: HoxC6, HoxB6, HoxA6, HoxA7, HoxB7, Ultrabithorax               Mammalian: Same as Antennapediaabdominal-A                 Mammalian: Same as Antennapedia Abdominal-B                 Mammalian: HoxC11, HoxA11, HoxD11                            Mammalian: HoxA10, HoxC10, HoxD10                            Mammalian: BoxB9, HoxA9, HoxD9, HoxC9                             Mammalian: HoxD13, HoxA13, HoxD12, HoxC12Extradenticle               Human: PBX1, PBX2 and PBX3


REFERENCE

Duboule, D. (1994). Guidebook to Homeobox Genes. Oxford U. Press,New York. pp. 33-37



date revised: 13 Oct 96

Developmental Pathways conserved in Evolution

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