The Interactive Fly
Evolutionarily conserved developmental pathways
Dorsal, the fly NF-kappaB (cRel) homolog is activated in a signal transductioncascade carried out by Dorsal groupproteins. The pathway for Dorsal activation is highly conserved, from thereceptor Toll to the I kappa B homolog Cactus. The activation of Dorsalis the major maternal pathway for Dorsal-ventral patterning and takes placeimmediately after fertilization. The Xenopus homolog of Dorsal (XrelA)is similarly involved in dorsal-ventral patterning in the frog. This conservedpathway is also involved in induction of the immune response in both fliesand vertebrates.
Drosophila Homologs in other species ---------- ----------------------------Toll Mammalian: Interleukin-1 receptorPelle Mammalian: Interleukin-1 receptor associated kinaseTube Mammalian: ?Cactus Mammalian: I kappa B familyDorsal Xenopus: XrelA Mammalian: NF-kappaB
date revised: 14 Oct 96
Developmental Pathways conserved in Evolution
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