REFERENCES (part 3/3)

Nabti, I., Marangos, P., Bormann, J., Kudo, N. R. and Carroll, J. (2014). Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity. J Cell Biol 204: 891-900. PubMed ID: 24637322

Nagel, A. C. and Preiss, A. (2014). Mutation of potential MAPK phosphorylation sites in the Notch antagonist Hairless. Hereditas 151: 102-108. PubMed ID: 25363277

Nakamura, K., et al. (2005). Wnt signaling drives WRM-1/ß-catenin asymmetries in early C. elegans embryos. Genes Dev. 19: 1749-1754. 16077004

Nakano, H., et al. (1998). Differential regulation of IkappaB kinase and by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. 95(7): 3537-3542. PubMed Citation: 9520401

Naska, S., et al. (2004). ERK signaling is required for eye-specific retino-geniculate segregation. Development 131: 3559-3570. 15215205

Nichols, J., Silva, J., Roode, M. and Smith, A. (2009). Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development 136(19): 3215-22. PubMed Citation: 19710168

Nie, L., Xu, M., Vladimirova, A., and Sun, X.-H. (2003). Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J. 22: 5780-5792. 14592976

Nie, S. and Chang, C. (2007). PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation. Mech. Dev. 124(9-10): 657-67. PubMed citation: 17716876

Nir, R., Grossman, R., Paroush, Z. and Volk, T. (2012). Phosphorylation of the Drosophila melanogaster RNA-binding protein HOW by MAPK/ERK enhances its dimerization and activity. PLoS Genet. 8(3): e1002632. PubMed Citation: 22479211

Niu, H., Ye, B. H. and Dalla-Favera, R. (1998). Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 12(13): 1953-1961. PubMed Citation: 9649500

O'Brien, L. E., et al. (2004). ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev. Cell 7: 21-32. 15239951

Obrietan, K., Impey, S. and Storm, D. R. (1999). Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei. Nature Neurosci. 1(8): 693-700. PubMed Citation: 10196585

Oishi, K., et al. (2006). Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. Hum. Mol. Genet. 15(4): 543-53. 16399795

O'Reilly, A. M., et al. (2000). Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Mol. Cell. Biol. 20(1): 299-311. 10594032

Ormond, J., et al. (2004). ApTrkl, a Trk-like receptor, mediates serotonin- dependent ERK activation and long-term facilitation in Aplysia sensory neurons. Neuron 44: 715-728. 15541318

Ouwens, D. M., et al. (2002). Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. EMBO J. 21: 3782-3793. 12110590

Pace, A. M., Faure, M. and Bourne, H. R. (1995). Gi2-mediated activation of the MAP kinase cascade. Mol. Biol. Cell 6: 1685-1695. PubMed Citation: 8590798

Page, B. D., et al. (2001). The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling. Molec. Cell 7: 451-460. PubMed Citation: 11463371

Pages, G., et al. (1999). Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286: 1374-1377. PubMed Citation: 10558995

Pagani, M. R., Oishi, K., Gelb, B. D. and Zhong, Y. (2009). The phosphatase SHP2 regulates the spacing effect for long-term memory induction. Cell 139: 186-198. PubMed Citation: 19804763

Panitz, F., et al. (1998). The Spemann organizer-expressed zinc finger gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction pathway. EMBO J. 17: 4414-4425. PubMed Citation: 9687509

Parra-Palau, J. L., Scheper, G. C., Harper, D. E. and Proud, C. G. (2005). The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo. Biochem. J. 385(Pt 3): 695-702. PubMed citation: 15487973

Paroush, Z., Wainwright, S. M. and Ish-Horowicz, D. (1997). Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression. Development 124(19): 3827-3834. PubMed Citation: 9367438

Patterson, S. L., Pittenger, C., Morozov, A., Martin, K. C., Scanlin, H., Drake, C. and Kandel, E. R. (2001). Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase. Neuron 32: 123-140. 11604144

Philipova, R., Kisielewska, J., Lu, P., Larman, M., Huang, J. Y. and Whitaker, M. (2005). ERK1 activation is required for S-phase onset and cell cycle progression after fertilization in sea urchin embryos. Development 132(3): 579-89. 15634691

Picco, V., Hudson, C. and Yasuo, H. (2007). Ephrin-Eph signalling drives the asymmetric division of notochord/neural precursors in Ciona embryos. Development 134(8): 1491-7. Medline abstract: 17344225

Poeck, B., Triphan, T., Neuser, K. and Strauss, R. (2008). Locomotor control by the central complex in Drosophila -- An analysis of the tay bridge mutant. Dev Neurobiol 68: 1046-1058. PubMed ID: 18446784

Purcell, A. L., et al. (2003). Activation of a tyrosine kinase-MAPK cascade enhances the induction of long-term synaptic facilitation and long-term memory in Aplysia. Neuron 37: 473-484. 12575954

Peri, F., Bokel, C. and Roth, S. (1999). Local gurken signaling and dynamic MAPK activation during Drosophila oogenesis. Mech. Dev. 81(1-2): 75-88. PubMed Citation: 10330486

Perkinton, M. S., Sihra, T. S. and Williams, R. J. (1999). Ca2+-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a Phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons. J. Neurosci. 19(14): 5861-5874. PubMed Citation: 10407026

Peverali, F. A., et al. (1996). Phosphorylation of Drosophila Jun by the MAP kinase Rolled regulates photoreceptor differentiation. EMBO J. 15: 3943-50. PubMed Citation: 8670899

Philipova, R. and Whitaker, M. (1998). MAP kinase activity increases during mitosis in early sea urchin embryos. J. Cell Sci. 111( Pt 17): 2497-2505. PubMed Citation: 9701549

Phillips, K. P., et al. (2002). Inhibition of MEK or cdc2 kinase parthenogenetically activates mouse eggs and yields the same phenotypes as Mos-/- parthenogenotes. Dev. Biol. 247: 210-223. 12074563

Picco, V., Hudson, C. and Yasuo, H. (2007). Ephrin-Eph signalling drives the asymmetric division of notochord/neural precursors in Ciona embryos. Development 134(8): 1491-7. PubMed Citation: 17344225

Potempa, S. and Ridley, A. J. (1998). Activation of both MAP kinase and Phosphatidylinositide 3-kinase by Ras Is required for Hepatocyte growth factor/Scatter factor-induced adherens junction disassembly. Mol. Biol. Cell 9(8): 2185-2200. PubMed Citation: 9693375

Proft, M. and Struhl, K. (2004). MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction. Cell 118(3): 351-61. 15294160

Purcell, A. L., et al. (2003). Activation of a tyrosine kinase-MAPK cascade enhances the induction of long-term synaptic facilitation and long-term memory in Aplysia. Neuron 37: 473-484. 12575954

Qiao, F., et al. (2005), Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site. EMBO J. 25(1): 70-9. 16362034

Rebay, I. and Rubin, G. M. (1995). Yan functions as a general inhibitor of differentiation and is negatively regulated by acivation of the Ras1/MAPK pathway. Cell 80: 857-866. 7781063

Reddy, B. V. and Irvine, K. D. (2013). Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins. Dev Cell 24: 459-471. PubMed ID: 23484853

Renshaw, M. W., Ren, X. D. and Schwartz, M. A. (1997). Growth factor activation of MAP kinase requires cell adhesion. EMBO J. 16(18): 5592-5599. PubMed Citation: 9312018

Ribeiro, C., Ebner, A. and Affolter, M. (2002). In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev. Cell 2: 677-683. 12015974

Rintelen, F., Hafen, E. and Nairz, K. (2003). The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER. Development 130: 3479-3490. 12810595

Roberson, E. D., et al. (1999). The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus. J. Neurosci. 19(11): 4337-48

Robinson, M. J., et al. (1998). A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Curr. Biol. 8(21): 1141-50

Roignant, J. Y. and Treisman, J. E. (2010). Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene. Cell 143: 238-250. PubMed ID: 20946982

Rommel, C., et al. (1999). Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 286: 1738-1741

Roovers, K. and Assoian, R. K. (2003). Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases. Mol Cell Biol. 23(12): 4283-94. 12773570

Rosen, L. B., et al. (1994). Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron 12: 1207-21

Röttinger, E., Besnardeau, L. and Lepage, T. (2004). A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets. Development 131: 1075-1087. 14973284

Runden, E., et al. (1998). Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. J. Neurosci. 18(18): 7296-305

Rusch, J. and Levine, M. (1994). Regulation of the dorsal morphogen by the Toll and torso signaling pathways: a receptor tyrosine kinase selectively masks transcriptional repression. Genes Dev. 8: 1247-1257

Sakakura, C., et al. (1996). Plasmalopsychosine of human brain mimics the effect of nerve growth factor by activating its receptor kinase and mitogen-activated protein kinase in PC12 cells. Induction of neurite outgrowth and prevention of apoptosis. J. Biol. Chem. 271: 946-52

Sasaki, K. and Chiba, K. (2001). Fertilization blocks apoptosis of starfish eggs by inactivation of the MAP kinase pathway. Dev. Bio. 237: 18-28. 11518502

Sastry, S. K., et al. (1999). Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal. J. Cell Biol. 144(6): 1295-1309

Sato, M. and Kornberg, T. B. (2002). FGF is an essential mitogen and chemoattractant for the air sacs of the Drosophila tracheal system. Dev. Cell 3: 195-207. 12194851

Sato, N., et al. (1997). Elevated amyloid beta protein(1-40) level induces CREB phosphorylation at serine-133 via p44/42 MAP kinase (Erk1/2)-dependent pathway in rat pheochromocytoma PC12 cells. Biochem. Biophys. Res. Commun. 232(3): 637-642

Sawada, A., et al. (2001). Fgf/MAPK signaling is a crucial positional cue in somite boundary formation. Development 128: 4873-4880. 11731466

Schaeffer, H. J., et al. (1998). MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 281(5383): 1668-1671

Scheid, M. P. and Duronio, V. (1998). Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation. Proc. Natl. Acad. Sci. 95(13): 7439-7444

Schlaepfer, D. D. and Hunter, T. (1997). Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J. Biol. Chem. 272(20): 13189-13195

Schlaepfer, D. D., Jones, K. C. and Hunter, T. (1998). Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol. Cell. Biol. 18(5): 2571-2585

Schmidt, M., Goebeler, M., Posern, G., Feller, S. M., Seitz, C. S., Brocker, E. B., Rapp, U. R. and Ludwig, S. (2000). Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes. J. Biol. Chem. 275: 41011-41017. 11018025

Schnepp, B., et al. (1996). Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 10: 2302-13

Schohl, S. and Fagotto, F. (2002). ß-catenin, MAPK and Smad signaling during early Xenopus development. Development 129: 37-52. 11782399

Scholl, F. A., et al. (2007). Mek1/2 MAPK kinases are essential for mammalian development, homeostasis, and Raf-induced hyperplasia. Dev. Cell 12(4): 615-29. Medline abstract: 17419998

Schonwasser, D. C., et al. (1998). Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18(2): 790-798

Schrick, C., et al. (2007). N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation. Neuron 55(5): 786-98. Medline abstract: 17785185

Schweitzer, R., et al. (1995). Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9: 1518-1529

Seidel, J. J. and Graves, B. J. (2002). An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors. Genes Dev. 16: 127-137. 11782450

Selcher, J. C., Atkins, C. M., Trzaskos, J. M., Paylor, R. and Sweatt, J. D. (1999). A necessity for MAP kinase activation in mammalian spatial learning. Learn. Mem. 6: 478-490. 10541468

Sha, Q. Q., Dai, X. X., Dang, Y., Tang, F., Liu, J., Zhang, Y. L. and Fan, H. Y. (2016). MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocyte. Development. PubMed ID: 27993988

Shapiro, P. S., et al. (1998). Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen. J. Cell Biol. 142(6): 1533-45

Sharma, P., Veeranna, S. P., Sharma, M., Amin, N. D., Sihag, R. K., Grant, P., Ahn, N., Kulkarni, A. B. and Pant, H. C. (2002). Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J Biol. Chem. 277: 528-534. 11684694

Shenoy, S. K., et al. (2006). ß-Arrestin-dependent, G protein-independent ERK1/2 activation by the ß2 adrenergic receptor. J. Biol. Chem. 281(2): 1261-73. 16280323

Shimamura, A., et al. (2000). Rsk1 mediates a MEK-MAP kinase cell survival signal. Curr. Biol. 10: 127-135

Shimizu, K., Phan, T., Mansuy, I. M. and Storm, D. R. (2007). Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory. Cell 128(6): 1219-29. Medline abstract: 17382888

Shamloula, H. K., et al. (2002). rugose (rg), a Drosophila A kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways. Genetics 161(2): 693-710. 12072466

Shi, W. and Levine, M. (2008). Ephrin signaling establishes asymmetric cell fates in an endomesoderm lineage of the Ciona embryo. Development 135(5): 931-40. PubMed Citation: 18234724

Sif, S., et al. (1998). Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes Dev. 12(8): 2842-2851

Sindreu, C. B., Scheiner, Z. S. and Storm, D. R. (2007). Ca2+-stimulated adenylyl cyclases regulate ERK-dependent activation of MSK1 during fear conditioning. Neuron 53(1): 79-89. Medline abstract: 17196532

Singh, J., Aaronson, S. A. and Mlodzik, M. (2010). Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways. Oncogene 29(28): 4033-45. PubMed Citation: 20453880

Smith, E. R., Smedberg, J. L., Rula, M. E. and Xu, X. X. (2004). Regulation of Ras-MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells. J. Cell Biol. 164: 689-699. 14981092

Skeath, J. B. (1998). The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo. Development 125(17): 3301-3312

Smit, L., Baas, A., Kuipers, J., Korswagen, H., van de Wetering, M. and Clevers, H. (2004). Wnt activates the Tak1/Nemo-like kinase pathway. J. Biol. Chem. 279: 17232-17240. Medline abstract: 14960582

Smith, J. A., et al. (1999). Identification of an extracellular signal-regulated kinase (ERK) docking Site in ribosomal S6 Kinase, a sequence critical for activation by ERK in vivo. J. Biol. Chem. 274: 2893-2898

Smith, J. E., Cummings, C. A. and Cronmiller, C. (2002). daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila. Development 129: 3255-3267. 12070099

Smith, T. G., et al. (2005). Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite. Development 132: 1305-1314. 15716340

Stathopoulos, A., Tam, B., Ronshaugen, M., Frasch, M. and Levine, M. (2004). pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos. Genes Dev. 18: 687-699. 15075295

Stewart, S., et al. (1999). Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol. Cell. Biol. 19(8): 5523-34

Strahl, T., Gille, H. and Shaw, P. E. (1996). Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase subgroups. Proc. Natl. Acad. Sci. 93(21): 11563-11568

Su, Y.-C., et al. (2000). The Ste20 kinase Misshapen regulates both photoreceptor axon targeting and dorsal closure, acting downstream of distinct signals. Mol. Cell. Biol. 20: 4736-4744.

Sugiura, R., et al. (1999). The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch. Nature 398(6735): 479-83

Sun, F.-L., Cuaycong, M. H. and Elgin, S. C. R. (2001). Long-range nucleosome ordering is associated with gene silencing in Drosophila melanogaster pericentric heterochromatin. Mol. Cell. Bio. 21: 2867-2879. 11283265

Sun, X., Wheeler, C. T., Yolitz, J., Laslo, M., Alberico, T., Sun, Y., Song, Q. and Zou, S. (2014). A mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in Drosophila. Cell Rep 8: 1781-1792. PubMed ID: 25220459

Suzuki, T., et al. (2002). Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Genes Dev. 16: 1356-1370. 12050114

Tachibana, K., et al. (1997). MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs. EMBO J. 16(14): 4333-4339

Takeda, H., et al. (1999). PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor. EMBO J. 18(2): 386-395

Takenaka, K., Gotoh, Y. and Nishida, E. (1997). MAP kinase is required for the spindle assembly checkpoint but is dispensable for the normal M phase entry and exit in Xenopus egg cell cycle extracts. J. Cell Biol. 136(5): 1091-1097

Takeshita, H. and Sawa, H. (2005). Asymmetric cortical and nuclear localizations of WRM-1/ß-catenin during asymmetric cell division in C. elegans. Genes Dev. 19: 1743-1748. 16077003

Talarmin, H., et al. (1997). The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Mol. Cell. Biol. 19(9): 6003-11

Tamir, A., Granot, Y. and Isakov, N. (1996). Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two parallel mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-Jun N-terminal kinase. J. Immunol. 157: 1514-1522

Tan, P. B., Lackner, M. R. and Kim, S. K. (1998). MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. Cell 93(4): 569-580

Tang, T. L., et al. (1995). The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80: 473-483

Tangredi, M. M., Ng, F. S. and Jackson, F. R. (2012). The C-terminal kinase and ERK-binding domains of Drosophila S6KII (RSK) are required for phosphorylation of the protein and modulation of circadian behavior. J Biol Chem 287: 16748-16758. PubMed ID: 22447936

Tanoue, T., et al. (2000). A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell Biol. 2: 110-116.

Tanoue, T., et al. (2001). Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions. EMBO J. 20: 466-479. 11157753

Tansey, M. G., Chu, G. C. and Merlie, J. P. (1996). ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway. J. Cell Biol. 134: 465-476

Tasaki, J., et al. (2011). ERK signaling controls blastema cell differentiation during planarian regeneration. Development 138: 2417-2427. PubMed Citation: 21610023

Tee, W. W., Shen, S. S., Oksuz, O., Narendra, V. and Reinberg, D. (2014). Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs. Cell 156: 678-690. PubMed ID: 24529373

Tentler, J. J., Hadcock, J. R. and Gutierrez-Hartmann, A. (1997). Somatostatin acts by inhibiting the cyclic 3',5'-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency. Mol. Endocrinol. 11(7): 859-866

Thackeray, J. R., et al. (1998). small wing encodes a phospholipase C-gamma that acts as a negative regulator of R7 development in Drosophila. Development 125: 5033-5042

Thomas, S. M., et al. (1992). Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68: 1031-40

Thomson, S., et al. (1999). The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J. 18(17): 4779-93

Tipping, M., et al. (2010). beta-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development. EMBO J. 29: 3222-3235. PubMed Citation: 20802461

Torii, S., et al. (2004). Sef is a spatial regulator for Ras/MAP kinase signaling. Dev. Cell 7: 33-44. 15239952

Torres, M. and Ye, R. D. (1996). Activation of the mitogen-activated protein kinase pathway by fMet-leu-Phe in the absence of Lyn and tyrosine phosphorylation of SHC in transfected cells. J. Biol. Chem. 271: 13244-13249

Treier, M., Bohmann, D. and Mlodzik, M. (1995). JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell 83: 753-760

Tsai, P. S. Werner, S. and Weiner, R. I. (1995). Basic fibroblast growth factor is a neurotropic factor in GT1 gonadotropin-releasing hormone neuronal cell lines. Endocrinology 136: 3831-3838

Tsuda, L., et al. (1993). A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell 72: 407-14

Umbhauer, M., et al (1995). Mesoderm induction in Xenopus caused by activation of MAP kinase. Nature 376(6535): 58-62

Upadhyai, P. and Campbell, G. (2013). Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types. Development 140: 4256-4265. PubMed ID: 24086079

Uzgare, A. R., et al. (1998). Mitogen-activated protein kinase and neural specification in Xenopus. Proc. Natl. Acad. Sci. 95(25): 14833-8

Vaillancourt, R. R., et al. (1995). Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Mol. Cell. Biol. 15: 3644-3653

Vanderheyden, W. M., Gerstner, J. R., Tanenhaus, A., Yin, J. C. and Shaw, P. J. (2013). ERK phosphorylation regulates sleep and plasticity in Drosophila. PLoS One 8: e81554. PubMed ID: 24244744

Vanhoutte, P., et al. (1999). Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices. Mol. Cell. Biol. 19(1): 136-46

Venetianer, A., et al. (1995). Phosphorylation state of the RNA polymerase II C-terminal domain (CTD) in heat-shocked cells. Possible involvement of the stress-activated mitogen-activated protein (MAP) kinases. Eur. J. Biochem. 233: 83-92

Verlhac, M. H., et al. (2000). Mos activates MAP kinase in mouse oocytes through two opposite pathways. EMBO J. 19(22): 6065-74. 11080153

Vincent, S., et al. (1998). The Drosophila protein Dof is specifically required for FGF signaling. Molec. Cell 2: 515-525

Volente, C., Angelastro, J. M. and Greene, L. A. (1993). Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors. J. Biol. Chem. 268: 21410-5

Vossler, M. R., et al. (1997). cAMP activates MAP kinase and Elk-1 through a B-Raf-and Rap1-dependent pathway. Cell 89(1): 73-82

Volker, J. L., et al. (1997). Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity. Genes Dev. 11(11): 1435-46

Vrailas, A. D., et al. (2006). smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye. Development 133(8): 1485-94. 16540506

Wairkar, Y. P., et al. (2009). Unc-51 controls active zone density and protein composition by downregulating ERK signaling. J. Neurosci. 29(2): 517-28. PubMed Citation: 19144852

Walter, S. A., Guadagno, S. N., Ferrell, J. E. (2000). Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts. Mol. Biol. Cell 11(3): 887-96. 10712507

Wang, R., et al. (2007). Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell 128: 1119-1132. Medline abstract: 17382881

Wang, S., et al. (2009). The tyrosine kinase Stitcher activates Grainy head and epidermal wound healing in Drosophila. Nat. Cell Biol. 11: 890-895. PubMed Citation: 19525935

Wang, X., Weng, L. P., Yu, Q. (2000). Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR. Oncogene 19(19): 2346-53. 10822386

Wang, X. M., Zhai, Y. and Ferrell, J. E. (1997). A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells. J. Cell Biol. 137(2): 433-443. PubMed Citation: 9128253

Wappner, P., Gabay, L. and Shilo, B. Z. (1997). Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes. Development 124(22): 4707-4716

Waskiewicz, et al. (1997). Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16(8): 1909-20. PubMed Citation: 9155017

Watt, W. C., et al. (2004). Odorant stimulation enhances survival of olfactory sensory neurons via MAPK and CREB. Neuron 41: 955-967. 15046727

Weg-Remers, S., et al. (2001). Regulation of alternative pre-mRNA splicing by the ERK MAP-kinase pathway. EMBO J. 20: 4194-4203. 11483522

Whitlock, B. B., et al. (2000). Differential roles for alphaMß2 integrin clustering or activation in the control of apoptosis via regulation of Akt and ERK survival mechanisms. J. Cell Bio. 151: 1305-1320. 11121444

Winder, D. G., Martin, K. C., Muzzio, I. A., Rohrer, D., Chruscinski, A., Kobilka, B. and Kandel, E. R. (1999). ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors. Neuron 24: 715-726. 10595521

Williams, J. A., Su, H. S., Bernards, A., Field, J. and Sehgal, A. (2001). A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK. Science 293: 2251-2256. 11567138

Wilson, R., Vogelsang, E. and Leptin M. (2005). FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos. Development 132(3): 491-501. 15634694

Wright, J. H., et al. (1999). Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. Proc. Natl. Acad. Sci. 96(20): 11335-40

Xia, Z., et al. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331

Xie H., et al. (1998). EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLC(gamma) signaling pathway. J. Cell Sci. 111(5): 615-624

Xing, J., Ginty, D. D. and Greenberg, M. E. (1996). Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273(5277): 959-63

Yabe, S.-I., et al. (2003). FRL-1, a member of the EGF-CFC family, is essential for neural differentiation in Xenopus early development. Development 130: 2071-2081. 12668622

Yagi, Y., Suzuki, T. and Hayashi, S. (1998). Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neuroectoderm. Development 125(18): 3625-3633

Yamamoto, D. (1994). Signaling mechanisms in induction of the R7 photoreceptor in the developing Drosophila retina. Bioessays 16: 237-244

Yamamoto, N., et al. (1999). Activation and degradation of the transcription factor C/EBP during long-term facilitation in Aplysia. J. Neurochem. 73(6): 2415-23.

Yamamoto, T., Cui, X.-M. and Shuler, C. F. (2003). Role of ERK1/2 signaling during EGF-induced inhibition of palatal fusion. Dev. Bio. 260: 512-521. 12921749

Yang, S.-H., et al. (1998a). The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif. Mol. Cell. Biol. 18: 710-720. PubMed Citation: 9447967

Yang, S.-H., et al. (1998b). Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J. 17: 1740-1749. PubMed Citation: 9501095

Yang, S.-H., et al. (2003). Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Molec. Cell 12: 63-74. 12887893

York, R. D., Yao, H., Dillon, T., Ellig, C. L., Eckert, S. P., McCleskey, E. W. and Stork, P. J. (1998). Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392: 622-626. 9560161

Yu, W., et al. (1998). Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. Curr. Biol. 8(1): 56-64

Yu, Y., et al. (2012). Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster. Mol. Cell Biol. 32(18): 3610-23. PubMed Citation: 22778134

Yue, J. and Ferrell, J. E. (2004). Mos mediates the mitotic activation of p42 MAPK in Xenopus egg extracts, Curr. Biol. 14: 1581-1586. 15341746

Zaheer, A. and Lim, R. (1996). In vitro inhibition of MAP kinase (ERK1/ERK2) activity by phosphorylated glia maturation factor (GMF). Biochemistry 35: 6283-6288

Zecevic, M., et al. (1998). Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E. J. Cell Biol. 142(6): 1547-58

Zeitlinger, J., et al. (2003). Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. Cell 113: 395-404. 12732146

Zetser, A., Frank, D. and Bengal, E. (2001). MAP kinase converts MyoD into an instructive muscle differentiation factor in Xenopus. Dev. Biol. 240(1): 168-81. 11784054

Zhang, Q., Zheng, Q. and Lu, X. (1999). A genetic screen for modifiers of Drosophila Src42A identifies mutations in Egfr, rolled and a novel signaling gene. Genetics 151: 697-711

Zhao, J., Zheng, C. and Guan, J. (2000). Pyk2 and FAK differentially regulate progression of the cell cycle. J. Cell Sci. 113: 3063-3072. 10934044

Zhang, W., Thompson, B. J., Hietakangas, V. and Cohen S. M. (2011). MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 7(12): e1002429. PubMed Citation: 22242005

Zhao, J. Z., et al. (2003). ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol. Cell 11: 405-413. 12620228

Zhu, A. J., Haase, I. and Watt, F. M. (1999). Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro. Proc. Natl. Acad. Sci. 96: 6728-6733

Zimmermann, S., et al. (1997). MEK1 mediates a positive feedback on Raf-1 activity independently of Ras and Src. Oncogene 15(13): 1503-1511

back to rolled References part 1/3 | part 2/3

rolled/MAPK: Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

date revised: 15 March 2017
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