decapentaplegic


REFERENCES: A-G | H- M | N-S | T-Z

Nakagoshi, H., et al. (1998). A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells. Genes Dev. 12: 2724-2734. PubMed Citation: 9732270

Nakajima, Y., et al. (2002). Significance of Bone morphogenetic protein-4 function in the initial myofibrillogenesis of chick cardiogenesis. Dev. Biol. 245: 291-303. 11977982

Nakayama, T., et al. (1998a). Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning. Development 125(5): 857-867. PubMed Citation: 9449668

Nakayama, T., et al. (1998b). Smad6 functions as an intracellular antagonist of some TGF-beta family members during Xenopus embryogenesis. Genes Cells 3(6): 387-94. PubMed Citation: 9734784

Narbonne-Reveau, K., Besse, F., Lamour-Isnard, C., Busson, D. and Pret, A. M. (2006). fused regulates germline cyst mitosis and differentiation during Drosophila oogenesis. Mech. Dev. 23(3): 197-209. 16516445

Narita, T., et al. (2000). BMPs are necessary for stomach gland formation in the chicken embryo: a study using virally induced BMP-2 and Noggin expression. Development 127: 981-988. PubMed Citation: 10662637

Naski, M. C., et al. (1998). Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 125(24): 4977-88. PubMed Citation: 9811582

Nasonkin, I., Alikasifoglu, A., Ambrose, C., Cahill, P., Cheng, M., Sarniak, A., Egan, M. and Thomas, P. (1999). A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system. J. Biol. Chem. 274: 29420-24925. 10506204

Neave, B., Holder, N. and Patient, R. (1997). A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish. Mech. Dev. 62 (2): 183-195. PubMed Citation: 9152010

Nederbragt, A. J., van Loon, A. E. and Dictus, W. J. A. G. (2002). Expression of Patella vulgata orthologs of engrailed and dpp-BMP2/4 in adjacent domains during molluscan shell development suggests a conserved compartment boundary mechanism. Dev. Biol. 246: 341-355. 12051820

Nellen, D., et al. (1996). Direct and long-range action of a DPP morphogen gradient. Cell 85: 357-368. PubMed Citation: 8616891

Neto, M., Aguilar-Hidalgo, D. and Casares, F. (2016). Increased avidity for Dpp/BMP2 maintains the proliferation of progenitors-like cells in the Drosophila eye. Dev Biol 418(1):98-107 . PubMed ID: 27502436

Neubuser, A., et al. (1997). Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90(2): 247-255. PubMed Citation: 9244299

Neul, J. L. and Ferguson, E. L. (1998). Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning. Cell 95(4):483-94. PubMed Citation: 9827801

Newfeld, S. J., et al. (1997a). Molecular evolution at the decapentaplegic locus in Drosophila. Genetics 145: 297-309. PubMed Citation: 9071585

Newfeld, S. J., et al. (1997b). Mothers against dpp participates in a DPP/TGF-beta responsive serine-threonine kinase signal transduction cascade. Development 124(16): 3167-3176. PubMed Citation: 9272957

Newfeld, S. J. and Takaesu, N. T. (2002). An analysis using the hobo genetic system reveals that combinatorial signaling by the Dpp and Wg pathways regulates dpp expression in leading edge cells of the dorsal ectoderm in Drosophila melanogaster. Genetics 161: 685-692. 12072465

Ng, E. S., Azzola, L., Sourris, K., Robb, L., Stanley, E. G., and Elefanty, A. G. (2005). The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Development. 132(5): 873-84. 15673572

Nguyen, M., et al. (1998). Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV. Cell 95(4):495-506. PubMed Citation: 9827802

Nguyen, V. H., et al. (1998). Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes. Dev. Biol. 199(1): 93-110. PubMed Citation: 9676195

Nguyen, V. H. et al. (2000). Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Development 127: 1209-1220. PubMed Citation: 10683174

Nicholls, R. E. and Gelbart, W. M. (1998). Identification of chromosomal regions Involved in decapentaplegic function in Drosophila. Genetics 149(1): 203-215. PubMed Citation: 9584097

Niepielko, M. G., Hernáiz-Hernández, Y. and Yakoby, N. (2011). BMP signaling dynamics in the follicle cells of multiple Drosophila species. Dev. Biol. 354(1): 151-9. PubMed Citation: 21402065

Nikaido, M., et al. (1997). Conservation of BMP signaling in zebrafish mesoderm patterning, Mech. Dev. 61 (1-2): 75-88. PubMed Citation: 9076679

Nikaido, M., et al. (1999). In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning. Development 126(1): 181-190. PubMed Citation: 9834197

Ninov N., Menezes-Cabral S., Prat-Rojo C., Manjon C., Weiss A., Pyrowolakis G., Affolter M. and Martin-Blanco E. (2010). Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis. Curr. Biol. 20: 513-520. PubMed Citation: 20226662

Nishimatsu, S. and Thomsen G. H. (1998). Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryos. Mech. Dev. 74(1-2): 75-88. PubMed Citation: 9651485

Nishimura, R., et al. (1998). Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J. Biol. Chem. 273(4): 1872-9. PubMed Citation: 9442019

Niwa, N., et al. (2000). Correlation of diversity of leg morphology in Gryllus bimaculatus (cricket) with divergence in dpp expression pattern during leg development. Development 127: 4373-4381. PubMed Citation: 11003837

Nonaka, S., et al. (1998). Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95(6): 829-37. PubMed Citation: 9865700

Noramly, S. and Morgan, B. A. (1998). BMPs mediate lateral inhibition at successive stages in feather tract development. Development 125(19): 3775-3787. PubMed Citation: 9729486

Northrop, J., et al. (1995). BMP-4 regulates the dorsal-ventral differences in FGF/MAPKK-mediated mesoderm induction in Xenopus. Dev. Biol. 172(1): 242-252. PubMed Citation: 7589804

Nosaka, T., et al. (2003). Mammalian twisted gastrulation is essential for skeleto-lymphogenesis. Mol. Cell. Biol. 23(8): 2969-80. 12665593

Oelgeschlager, M., et al. (2000). The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signaling. Nature 405: 757-763. PubMed Citation: 10866189

Ogasawara, T., Kawaguchi, H., Jinno, S., Hoshi, K., Itaka, K., Takato, T., Nakamura, K. and Okayama, H. (2004). Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. Mol. Cell Biol. 24(15): 6560-8. 15254224

Ohkawara, B., et al. (2002). Action range of BMP is defined by its N-terminal basic amino acid core. Curr. Biol. 12: 205-209. 11839272

Ohta, K., et al. (2004). Tsukushi functions as an organizer inducer by inhibition of BMP activity in cooperation with chordin. Dev. Cell 7: 347-358. 15363410

Ohyama, K., Das, R. and Placzek, M. (2008). Temporal progression of hypothalamic patterning by a dual action of BMP. Development 135(20): 3325-31. PubMed Citation: 18787065

Oka, C., et al. (2004). HtrA1 serine protease inhibits signaling mediated by Tgfß family proteins. Development 131: 1041-1053. 14973287

O'Keefe, D. D., Thomas, S., Edgar, B. A. and Buttitta, L. (2014). Temporal regulation of Dpp signaling output in the Drosophila wing. Dev Dyn. [Epub ahead of print]. PubMed ID: 24591046

Ozuak, O., Buchta, T., Roth, S. and Lynch, J. A. (2014). Dorsoventral polarity of the Nasonia embryo primarily relies on a BMP gradient formed without input from Toll. Curr Biol [Epub ahead of print]. PubMed ID: 25308075

Padgett, R.W., St. Johnston, R.D. and Gelbart, R.W. (1987). A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family. Nature 355: 81-84

Paine-Saunders, S., et al. (2000). glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev. Biol. 225: 179-187. PubMed ID: 10964473

Pallavi, S. K. and Shashidhara, L. S. (2003). Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs. Development 130: 4931-4941. 12930782

Pan, D. and Rubin, G. M. (1995). cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80: 543-552

Pankratz, M. J. and Hoch, M. (1995). Control of epithelial morphogenesis by cell signaling and integrin molecules in the Drosophila foregut. Development 121: 1885-1898

Panopoulou, G. D., et al. (1998). AmphiBMP2/4, an amphioxus bone morphogenetic protein closely related to Drosophila decapentaplegic and vertebrate BMP2 and BMP4: insights into evolution of dorsoventral axis specification. Dev. Dyn. 213(1): 130-9

Pappu, K. S., et al. (2003). Mechanism of hedgehog signaling during Drosophila eye development. Development 130: 3053-3062. 12756186

Park, K. S. and Gumbiner, B. M. (2010). Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest. Development 137(16): 2691-701. PubMed Citation: 20610481

Parker, D. S., Jemison, J. and Cadigan, K. M. (2002). Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila. Development 129: 2565-2576. 12015286

Parker, D. S., White, M. A., Ramos, A. I., Cohen, B. A. and Barolo, S. (2011). The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity. Sci. Signal 4(176): ra38. PubMed Citation: 21653228

Patel, K., Makarenkova, H. and Jung, H.-S. (1999). The role of long range, local and direct signalling molecules during chick feather bud development involving the BMPs, Follistatin and the Eph receptor tyrosine kinase Eph-A4. Mech. Dev. 86(1-2): 51-62

Patthey, C., Edlund, T. and Gunhaga, L. (2009). Wnt-regulated temporal control of BMP exposure directs the choice between neural plate border and epidermal fate. Development 136(1): 73-83. PubMed Citation: 19060333

Patzke, H., et al. (2001). BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development Mech. Dev. 108: 149-159. 11578868

Paul, L., Wang, S. H., Manivannan, S. N., Bonanno, L., Lewis, S., Austin, C. L. and Simcox, A. (2013). Dpp-induced Egfr signaling triggers postembryonic wing development in Drosophila. Proc Natl Acad Sci U S A 110: 5058-5063. PubMed ID: 23479629

Pearce, J. J., Penny, G. and Rossant, J. (1999). A mouse Cerberus/Dan-related gene family. Dev. Biol. 209(1): 98-110. PubMed Citation: 10208746

Peluso, C. E., Umulis, D., Kim, Y. J., O'Connor, M. B. and Serpe, M. (2011). Shaping BMP Morphogen Gradients through Enzyme-Substrate Interactions. Dev. Cell 21(2): 375-83. PubMed Citation: 21839924

Penton, A., et al. (1994). Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell 78: 239-250.

Penton, A., Selleck, S. B. and Hoffmann, F. M. (1997). Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development. Science 275(5297): 203-206

Pera, E. M. and Kessel, M. (1997). Patterning of the chick forebrain anlage by the prechordal plate. Development 124(20): 4153-4162

Pérez-Garijo, A., MartÍn, F. A. and Morata, G. (2004). Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila. Development 131: 5591-5598. 15496444

Perez-Garijo, A., Martin, F. A., Struhl, G. and Morata, G. (2005). Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila. Proc. Natl. Acad. Sci. 102(49): 17664-9. 16314564

Pérez-Garijo, A., Shlevkov, E. and Morata, G. (2009). The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc. Development 136(7): 1169-77. PubMed Citation: 19244279

Peri, F. and Roth, S. (2000). Combined activities of Gurken and Decapentaplegic specify dorsal chorion structures of the Drosophila egg. Development 127: 841-850

Phillips, R. G., Warner, N. L. and Whittle, J. R. (1999). Wingless signaling leads to an asymmetric response to Decapentaplegic-dependent signaling during sense organ patterning on the notum of Drosophila melanogaster. Dev. Biol. 207(1): 150-162

Piccolo, S., et al. (1996). Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of Chordin to BMP-4. Cell 86: 589-598

Piccolo, S., et al. (1997). Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. Cell 91(3): 407-416

Piccolo S., et al. (1999). The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397(6721): 707-10

Piedra, M. E. and Ros, M. A. (2002). BMP signaling positively regulates Nodal expression during left right specification in the chick embryo. Development 129: 3431-3440. 12091313

Pignoni, F. and Zipursky, S. L. (1997). Induction of Drosophila eye development by Decapentaplegic. Development 124: 271-278

Pizette, S. and Niswander, L. (2000). BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes. Dev. Biol. 219: 237-249.

Pizette, S., Abate-Shen, C. and Niswander, L. (2001). BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development 128: 4463-4474. 11714672

Podos, S. D., Hanson, K. K., Wang, Y.-C. and Ferguson, E. L. (2001). The Smurf1 ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis. Dev. Cell 1: 567-578. 11703946

Prall, O. W. J. et al. (2007). An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128: 947-959. Medline abstract: 17350578

Prpic, N. M. (2004). Homologs of wingless and decapentaplegic display a complex and dynamic expression profile during appendage development in the millipede Glomeris marginata (Myriapoda: Diplopoda). Front. Zool. 1(1): 6. 15679927

Pummila, M., et al. (2007). Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression. Development 134(1): 117-25. Medline abstract: 17164417

Pyati, U. J., Webb, A. E. and Kimelman, D. (2005). Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development. Development 132(10): 2333-43. 15829520

Quillien, A., et al. (2011). BMP signaling orchestrates photoreceptor specification in the zebrafish pineal gland in collaboration with Notch. Development 138(11): 2293-302. PubMed Citation: 21558377

Raft, S., et al. (2004). Suppression of neural fate and control of inner ear morphogenesis by Tbx1. Development 131: 1801-1812. 15084464

Raftery, L.A. and Sutherland, D. J. (1999). TGF-beta family signal transduction in Drosophila development: from Mad to Smads. Dev. Biol. 210(2): 251-68

Ramel, M. C., et al. (2006). Drosophila SnoN modulates growth and patterning by antagonizing TGF-β signalling. Mech. Dev. 124(4): 304-17. Medline abstract: 17289352

Ramos, A. I. and Barolo, S. (2013). Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution. Philos Trans R Soc Lond B Biol Sci 368: 20130018. PubMed ID: 24218631

Rangarajan, R., Courvoisier, H. and Gaul, U. (2001). Dpp and Hedgehog mediate neuron-glia interactions in Drosophila eye development by promoting the proliferation and motility of subretinal glia. Mech. Dev. 108: 93-103. 11578864

Rauskolb, C. and Wieschaus, E. (1994). Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins. EMBO J. 13: 3561-3569

Ray, T. P. and Wharton, K. A. (2001). Context-dependent relationships between the BMPs gbb and dpp during development of the Drosophila wing imaginal disk. Development 128: 3913-3925. 11641216

Recasens-Alvarez, C., Ferreira, A. and Milán, M. (2017). JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling. Nat Commun 8: 13815. PubMed ID: 28045022

Re'em-Kalma, Y., Lamb, T. and Frank, D. (1995). Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development. Proc. Natl. Acad. Sci. 92: 12141-12145

Rebagliati, M. R., et al. (1998). Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Dev. Biol. 199(2): 261-272

Reddien, P. W., Bermange, A. L., Kicza, A. M. and Sánchez Alvarado, A. (2007). BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development 134(22): 4043-51. Medline abstract: 17942485

Reed, H. C., et al. (2010). Alternative splicing modulates Ubx protein function in Drosophila melanogaster. Genetics. 2010 Mar;184(3):745-58. PubMed Citation: 20038634

Reichert, S., Randall, R. A. and Hill, C. S. (2013). A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border. Development 140: 4435-4444. PubMed ID: 24089471

Reim, I., Lee, H.-H. and Frasch, M. (2003). The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp. Development 130: 3187-3204. 12783790

Reim, I., Mohler, J. and Frasch, M. (2005a). Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila. Mech. Dev. 122: 1056-1069. 15922573

Reim, I. and Frasch, M. (2005b). The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila. Development 132: 4911-4925. 16221729

Reiter, J. F., Verkade, H. and Stainier, D. Y. R. (2001). Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5. Dev. Bio. 234: 330-338. 11397003

Rentzsch, F., Zhang, J., Kramer, C., Sebald, W. and Hammerschmidt, M. (2006a). Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation. Development 133: 801-811. PubMed Citation: 16439480

Rentzsch, F., Anton, R., Saina, M., Hammerschmidt, M., Holstein, T. W. and Technau, U. (2006b). Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: implications for the evolution of axial patterning. Dev. Biol. 296(2): 375-87. 16828077

Reshef, R., Maroto, M. and Lassar, A. B. (1998), Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression. Genes Dev. 12(3): 290-303

Reversade, B., Kuroda, H., Lee, H., Mays, A. and De Robertis, E. M. (2005). Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos. Development 132(15): 3381-92. 15975940

Ribeiro, C., Ebner, A. and Affolter, M. (2002). In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev. Cell 2: 677-683. 12015974

Rieckhof, G. E., et al. (1997). Nuclear translocation of Extradenticle requires homothorax, which encodes an Extradenticle-related homeodomain protein. Cell 91: 171-183

Riem, K. F., Jessell, T. M. and Briscoe, J. (2000). Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. Development 127: 4855-4866. 11044400

Riese, J., Tremml, G. and Bienz, M. (1997). D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction. Development 124: 3353-3361. 9310330

Richter, B., et al. (1997). Nucleotide variation and conservation at the dpp locus, a gene controlling early development in Drosophila. Genetics 145: 311-323

Ricos, M. G., et al. (1999). Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation. J. Cell Sci. 112(Pt 8): 1225-1235

Riesgo-Escovar, J. R. and Hafen, E. (1997). Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev. 11:1717-1727

Rios, I., et al. (2004). Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling. Development 131: 3159-3168. 15197161

Roch, F., Jiménez, G. and Casanova, J. (2002). EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins. Development 129: 993-1002. 11861482

Rodríguez, I. (2004). The dachsous gene, a member of the cadherin family, is required for Wg-dependent pattern formation in the Drosophila wing disc. Development 131: 3195-3206. 15175250

Rogulja, D. and Irvine, K. D. (2005). Regulation of cell proliferation by a morphogen gradient. Cell 123: 449-461. PubMed Citation: 16269336

Rogulja, D., Rauskolb, C. and Irvine, K. D. (2008). Morphogen control of wing growth through the fat signaling pathway. Dev. Cell 15: 309-321. PubMed Citation: 18694569

Rojas-Ríos, P., Guerrero, I. and González-Reyes, A. (2012). Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila. PLoS Biol 10(4): e1001298. PubMed Citation: 22509132

Ross, J. J., et al. (2001). Twisted gastrulation is a conserved extracellular BMP antagonist. Nature 410: 479-483. 11260716

Rossi, J. M., et al. (2001). Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev. 15: 1998-2009. 11485993

Rowan, S., Siggers, T., Lachke, S. A., Yue, Y., Bulyk, M. L. and Maas, R. L. (2010). Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes Dev 24: 980-985. PubMed ID: 20413611

Roy, S., Hsiung, F. and Kornberg, T. B. (2011). Specificity of Drosophila cytonemes for distinct signaling pathways. Science 332(6027): 354-8. PubMed Citation: 21493861

Roy, S., Huang, H., Liu, S. and Kornberg, T. B. (2014). Cytoneme-mediated contact-dependent transport of the Drosophila Decapentaplegic signaling protein. Science [Epub ahead of print]. PubMed ID: 24385607

Royet, J. and Finkelstein, R. (1997). Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog. Development 124(23): 4793-4800

Rusch, J. and Levine, M. (1994). Regulation of the dorsal morphogen by the Toll and torso signaling pathways: a receptor tyrosine kinase selectively masks transcriptional repression. Genes Dev 8: 1247-1257

Rusch, J. and Levine, M. (1997). Regulation of a dpp target gene in the Drosophila embryo. Development 124: 303-311

Rusten, T. E., et al. (2002). The role of TGFß signaling in the formation of the dorsal nervous system is conserved between Drosophila and chordates. Development 129: 3575-3584. 12117808

Samanta, J. and Kessler, J. A. (2004). Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Development 131: 4131-4142. 15280210

Sánchez, L., et al. (1997). The genital disc of Drosophila melanogaster II. Role of the genes hedgehog, decapentaplegic and wingless. Dev. Genes Evol. 207: 229-241

Sánchez-Herrero, E., et al. (1996). The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs. Mech. Dev. 55: 159-170

Sanchez-Salazar, J., et al. (1996). The Tribolium decapentaplegic gene is similar in sequence, structure, and expression to the Drosophila dpp gene. Dev. Genes Evol. 206: 237-246

Sanchez-Soriano, N. and Russell, S. (2000). Regulatory mutations of the Drosophila Sox gene Dichaete reveal new functions in embryonic brain and hindgut development. Dev. Biol. 220: 307-321

Sanicola, M., et al. (1995). Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed. Genetics 139: 745-756

Sapir, A., Schweitzer, R. and Shilo, B. Z. (1998). Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis. Development 125(2): 191-200

Sato, M, et al. (1999). Bar homeobox genes are latitudinal prepattern genes in the developing Drosophila notum whose expression is regulated by the concerted functions of decapentaplegic and wingless. Development 126: 1457-1466

Sato, M. and Saigo, K., et al. (2000). Involvement of pannier and u-shaped in regulation of Decapentaplegic-dependent wingless expression in developing Drosophila notum. Mech. Dev. 93: 127-138.

Sauka-Spengler, T., Meulemans, D., Jones, M. and Bronner-Fraser, M. (2007). Ancient evolutionary origin of the neural crest gene regulatory network. Dev. Cell 13(3): 405-20. PubMed citation: 17765683

Sawala, A., Sutcliffe, C. and Ashe, H. L. (2012). Multistep molecular mechanism for bone morphogenetic protein extracellular transport in the Drosophila embryo. Proc. Natl. Acad. Sci. 109(28): 11222-7. PubMed Citation: 22733779

Scaal, M., et al. (2002). BMPs induce dermal markers and ectopic feather tracts. Mech. Dev. 110(1-2): 51-60. 11744368

Schaub, C. and Frasch, M. (2013). Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgutmorphogenesis. Dev Biol. 376(2): 245-59. Org-1 is required for the diversificationPubMed ID: 23380635

Schlange, T., Arnold, H.-H. and Brand, T. (2002). BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo. Development 129: 3421-3429. 12091312

Schleede, J. and Blair, S. S. (2015). The Gyc76C receptor Guanylyl cyclase and the Foraging cGMP-dependent kinase regulate extracellular matrix organization and BMP signaling in the developing wing of Drosophila melanogaster. PLoS Genet 11: e1005576. PubMed ID: 26440503

Schlichting, K. and Dahmann, C. (2008). Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development. Mech. Dev. 125: 712-728. PubMed Citation: 18539010

Schmid, B., et al. (2000). Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development 127: 957-967

Schmidl, M., et al. (2006). Twisted gastrulation modulates bone morphogenetic protein-induced Collagen II and X expression in chondrocytes in vitro and in vivo. J. Biol. Chem. 281: 31790-31800. Medline abstract: 16905550

Schwank, G., Restrepo, S. and Basler, K. (2008). Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels. Development 135(24): 4003-13. PubMed Citation: 19029041

Schwank, G., et al. (2011). Formation of the long range Dpp morphogen gradient. PLoS Biol. 9(7): e1001111. PubMed Citation: 21814489

Schultheiss, T. M., Burch, J. B. E. and Lassar, A. B. (1997). A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev. 11: 451-462

Schwyter, D. H., et al. (1995). The decapentaplegic core promoter region plays an integral role in the spatial control of transcription. Mol Cell Biol 15: 3960-3968

Scuderi, A., Simin, K., Kazuko, S. G., Metherall, J. E. and Letsou, A. (2006). scylla and charybde, homologues of the human apoptotic gene RTP801, are required for head involution in Drosophila. Dev. Biol. 291(1): 110-22. 1642334

Seitz, M. C., Wickenheisser, J. K. and Siegfried, E. (1998). Overexpression of Zeste white 3 blocks Wingless signaling in the Drosophila embryonic midgut. Dev. Biol. 197(2): 218-233

Sekelsky, J. J., et al. (1995). Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139: 1347-1358

Sela-Donenfeld, D. and Kalcheim, C. (1999). Regulation of the onset of neural crest migration by coordinated activity of BMP4 and Noggin in the dorsal neural tube. Development 126: 4749-4762

Sela-Donenfeld, D. and Kalcheim, C. (2002). Localized BMP4-Noggin interactions generate the dynamic patterning of noggin expression in somites. Dev. Biol. 246: 311-328. 12051818

Selleck, M. A., et al. (1998). Effects of Shh and Noggin on neural crest formation demonstrate that BMP is required in the neural tube but not ectoderm. Development 125(24): 4919-30

Sellin, J., Drechsler M., Nguyen H. T. and Paululat, A. (2009). Antagonistic function of Lmd and Zfh1 fine tunes cell fate decisions in the Twi and Tin positive mesoderm of Drosophila melanogaster. Dev. Biol. 326: 444-455. PubMed Citation: 19028484

Seppa, M. J., Johnson, R. I., Bao, S. and Cagan, R. L. (2008). Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retina. Dev. Biol. 318(1): 1-16. PubMed Citation: 18423436

Serpe, M., et al. (2008). The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. Dev. Cell 14: 940-953. PubMed Citation: 18539121

Shah, N. M., Groves, A. K. and Anderson, D. J. (1996). Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85 (3): 331-343

Shah, S. B., et al. (1997). Misexpression of chick Vg1 in the marginal zone induces primitive streak formation. Development 124(24): 5127-5138

Shapira, E., et al. (1999). A role for the homeobox gene Xvex-1 as part of the BMP-4 ventral signaling pathway. Mech. Dev. 86(1-2): 99-111

Shen, J. and Dahmann, C. (2005). The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev. Biol. 279(1): 31-43. 15708556

Shi, Y., et al. (2000). BMP signaling is required for heart formation in vertebrates. Dev. Bio. 224: 226-237.

Shibuya, H., et al. (1998). Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J. 17: 1019-1028

Shimmi, O. and O'Connor, M. B. (2003). Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo. Development 130: 4673-4682. 12925593

Shimmi, O., Umulis, D., Othmer, H. and O'Connor, M. B. (2005a). Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. Cell 120(6): 873-86. PubMed Citation: 15797386

Shimmi, O., Ralston, A., Blair, S. S. and O'Connor, M. B. (2005b). The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing. Dev. Biol. 282(1): 70-83. PubMed Citation: 15936330

Shin, M., Nagai, H. and Sheng, G. (2009). Notch mediates Wnt and BMP signals in the early separation of smooth muscle progenitors and blood/endothelial common progenitors. Development 136(4): 595-603. PubMed Citation: 19168675

Shou, J., et al. (2000). Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage. Development 127: 5403-5413

Shoval, I., Ludwig, A. and Kalcheim, C. (2007). Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination. Development 134(3): 491-501. Medline abstract: 17185320

Singer, M. A., et al. (1997). Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing. Development 124: 79-89

Smith, D. M., et al. (2000). Roles of BMP signaling and Nkx2.5 in patterning at the chick midgut-foregut boundary. Development 127: 3671-3681. 10934012

Shimogori, T., et al. (2004). Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex, Development 131: 5639-5647. 15509764

Shravage, B. V., Altmann, G., Technau, M. and Roth, S. (2007). The role of Dpp and its inhibitors during eggshell patterning in Drosophila. Development 134(12): 2261-71. Medline abstract: 17507396

Sjödal, M., Edlund, T. and Gunhaga, L. (2007). Time of exposure to BMP signals plays a key role in the specification of the olfactory and lens placodes ex vivo. Dev. Cell 13: 141-149. Medline abstract: 17609116

Song, Q., Mehler, M. F. and Kessler, J. A. (1998). Bone morphogenetic proteins induce apoptosis and growth factor dependence of cultured sympathoadrenal progenitor cells. Dev. Biol. 196(1): 119-127. PubMed Citation: 9527885

Song, X., et al. (2004). Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development 131(6): 1353-64. 14973291

Song, X., Call, G. B., Kirilly, D. and Xie, T. (2007). Notch signaling controls germline stem cell niche formation in the Drosophila ovary. Development 134(6): 1071-80. Medline abstract: 17287246

Song, Y., Chung, S. and Kunes, S. (2000). Combgap relays Wingless signal reception to the determination of cortical cell fate in the Drosophila visual system. Mol. Cell 6: 1143-1154. PubMed Citation: 11106753

Sopory, S., Kwon, S., Wehrli, M. and Christian, J. L. (2010). Regulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain. Dev. Biol. 346(1): 102-12. PubMed Citation: 20659445

Sotillos, S. and de Celis, J. F. (2006). Regulation of decapentaplegic expression during Drosophila wing veins pupal development. Mech. Dev. 123(3): 241-51. 16423512

Staehling-Hampton, K., et al. (1994). dpp induces mesodermal gene expression in Drosophila. Nature 372: 783-6. PubMed Citation: 7997266

Staehling-Hampton, K., Laughon, A. S. and Hoffmann, F. M. (1995). A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling. Development 121: 3393-3403. PubMed Citation: 7588072

St. Amand, T. R., et al. (2000). Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. Dev. Biol. 217: 323-332

Stanley, E., et al. (1998). DAN is a secreted glycoprotein related to Xenopus cerberus. Mech. Dev. 77(2): 173-84

Steneberg, P., Hemphala, J. and Samakovlis, C. (1999). Dpp and Notch specify the fusion cell fate in the dorsal branches of the Drosophila trachea. Mech. Dev. 87: 153-163

St. Johnston, R.D., et al. (1990). Molecular organization of the decapentaplegic gene in Drosophila melanogaster. Genes Dev 4: 1114-1127

Steinfeld, J., Steinfeld, I., Coronato, N., Hampel, M. L., Layer, P. G., Araki, M. and Vogel-Hopker, A. (2013). RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling. Development 140: 4959-4969. PubMed ID: 24227655

Steventon, B., et al. (2009) Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction. Development 136(5): 771-9. PubMed Citation: 19176585

Storm, E. E., and Kingsley, D. M. (1996). Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 122: 3969-3979

Stottmann, R. W., Anderson, R. M. and Klingensmith, J. (2001). The BMP antagonists chordin and noggin have essential but redundant roles in mouse mandibular outgrowth. Dev. Biol. 240(2): 457-473. 11784076

Streit, A., et al. (1998). Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. Development 125(3): 507-519

Streit, A. and Stern, C. D. (1999). Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity. Mech. Dev. 82(1-2): 51-66

Strigini, M. and Cohen, S. M. (1997). A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124(22): 4697-4705.

Strutt, D. I. and Mlodzik, M. (1996). The regulation of hedgehog and decapentaplegic during Drosophila eye imaginal disc development. Mech. Dev. 58: 39-50

Stronach, B. E. and Perrimon, N. (2001). Investigation of leading edge formation at the interface of amnioserosa and dorsal ectoderm in the Drosophila embryo. Development 128: 2905-2913. 11532914

Stronach, B. and Perrimon, N. (2002). Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev. 16: 377-387. 11825878

Stultz, B. G., Ray, R. P. and Hursh, D. A. (2005). Analysis of the shortvein cis-regulatory region of the decapentaplegic gene of Drosophila melanogaster. Genesis 42(3): 181-92. 15986479

Stultz, B. G., Lee, H., Ramon, K. and Hursh, D. A. (2006a). Decapentaplegic head capsule mutations disrupt novel peripodial expression controlling the morphogenesis of the Drosophila ventral head. Dev. Biol. 296(2): 329-39. 16814276

Stultz, B. G., Jackson, D. G., Mortin, M. A., Yang, X., Beachy, P. A. and Hursh, D. A. (2006b). Transcriptional activation by Extradenticle in the Drosophila visceral mesoderm. Dev. Biol. 290(2): 482-94. 16403493

Stultz, B. G., Park, S. Y., Mortin, M. A., Kennison, J. A. and Hursh D. A. (2012). Hox proteins coordinate peripodial decapentaplegic expression to direct adult head morphogenesis in Drosophila. Dev. Biol. 369(2): 362-76. PubMed Citation: 22824425

Su, M. A., Wisotzkey, R. G. and Newfeld, S. J. (2001). A screen for modifiers of decapentaplegic mutant phenotypes identifies lilliputian, the only member of the Fragile-X/Burkitt's lymphoma family of transcription factors in Drosophila melanogaster. Genetics 157(2): 717-725. 11156991

Sun, B., Hursh, D. A., Jackson, D. and Beachy, P. A. (1995). Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. EMBO J. 14: 520-535. 7859741

Sun, B. I., et al. (1999). derriere: a TGF-beta family member required for posterior development in Xenopus. Development 126(7): 1467-1482. PubMed Citation: 10068640

Sun, P., Quan, Z., Zhang, B., Wu, T. and Xi, R. (2010). TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation. Development 137(15): 2461-9. PubMed Citation: 20573703

Sutherland, D. J., et al. (2003). Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo. Development 130: 5705-5716. 14534137

Suzuki, A., et al. (1997a). Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. Development 124(16): 3037-3044

Suzuki, A., et al. (1997b). Regulation of epidermal induction by BMP2 and BMP7 signaling. Dev. Biol. 189(1): 112-122

Suzuki, K., et al. (2003). Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia: development by concerted actions of BMP signaling. Development 130: 6209-6220. 14602679

Suzuki, T., et al. (2004). Tbx genes specify posterior digit identity through Shh and BMP signaling. Dev. Cell 6: 43-53. 14723846

Suzuki, Y., et al. (1999). A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans. Development 126(2): 241-250

Sun, B., Hursh, D. A. Jackson, A., Beachy, P. A. (1995). Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. EMBO J. 14: 520-535. PubMed Citation: 7859741

Szeto, D. P. and Kimelman, D. (2004). Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation. Development 131: 3751-3760. 15240553

Szuts, D., Eresh, S. and Bienz, M. (1998). Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction. Genes Dev. 12(13): 2022-2035. PubMed Citation: 9649506

REFERENCES: A-G | H- M | N-S | T-Z


decapentaplegic: Biological Overview | Evolutionary Homologs | Transcriptional regulation | Targets of activity | Protein Interactions | Post-transcriptional Regulation | Developmental Biology | Effect of mutation

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.