basket/JNK


REFERENCES (part 2/2)

Nagata, K.-i., et al. (1998). The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J. 17: 149-158. PubMed Citation: 9427749

Nakata, K., et al. (2005). Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell 120: 407-420. 15707898

Natoli, G., Costanzo, A., Ianni, A., Templeton, D.J., Woodgett, J.R., Balsano, C. and Levrero, M. (1997). Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science 275(5297): 200-203. PubMed Citation: 8985011

Nihalani, D., et al. (2001). Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components EMBO J. 20: 3447-3458. 11432832

Nishitoh, H., et al. (1998). ASK1 is essential for JNK/SAPK activation by TRAF2. Mol. Cell 2(3): 389-95. PubMed Citation: 9774977

Rudrapatna, V. A., Bangi, E. and Cagan, R. L. (2013). Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion. EMBO Rep 14: 172-177. PubMed ID: 23306653

Nüsslein-Volhard, C., Wieschaus, E. and Kluding, H. (1984). Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193: 267-282

Oktay, M., et al. (1999). Integrin-mediated activation of focal adhesion kinase Is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J. Cell Biol. 145: 1461-1469. PubMed Citation: 10385525

Olson, M. F., Ashworth, A. and Hall, A. (1995). An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269: 1270-1272. PubMed Citation: 7652575

Orsborn, A. M., et al. (2007). GLH-1, the C. elegans P granule protein, is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5. Development 134: 3383-3392. Medline abstract: 17699606

Ortega-Arellano, H. F., Jimenez-Del-Rio, M. and Velez-Pardo, C. (2013). Dmp53, basket and drICE gene knockdown and polyphenol gallic acid increase life span and locomotor activity in a Drosophila Parkinson's disease model. Genet Mol Biol 36: 608-615. PubMed ID: 24385865

Otto, I. M., et al. (2000). The p150Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization. Curr. Biol. 10: 345-348. PubMed Citation: 10744979

Owusu-Ansah, E. and Banerjee, U. (2009). Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature 461(7263): 537-41. PubMed Citation: 19727075

Pagliarini, R. A. and Xu. T. (2003), A genetic screen in Drosophila for metastatic behavior. Science 302: 1227-1231. 14551319

Palacios, C., Collins, M. K. L. and Perkins, G. R. (2001). The JNK phosphatase M3/6 is inhibited by protein-damaging stress. Curr. Biol. 11: 1439-1443. 11566103

Pallavi, S. K., Ho, D. M., Hicks, C., Miele, L. and Artavanis-Tsakonas, S. (2012). Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. EMBO J. 31(13): 2895-907. PubMed Citation: 22580825

Paricio, N., et al. (1999). The Drosophila STE20-like kinase Misshapen is required downstream of the Frizzled receptor in planar polarity signaling. EMBO J. 18: 4669-4678. PubMed Citation: 10469646

Park, H.-S., et al. (2001). Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO J. 20: 446-456. 11157751

Park, J., et al. (1997). Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of bcl-2. J. Biol. Chem. 272(27): 16725-16728. PubMed Citation: 9201973

Park, J. M., et al. (2004). Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Dev. 18(5): 584-94. 15037551

Pastor-Pareja, J. C., Grawe, F., Martín-Blanco, E. and García-Bellido, A. (2004). Invasive cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade. Dev. Cell 7: 387-399. 15363413

Patel, P. H., Dutta, D. and Edgar, B. A. (2015). Niche appropriation by Drosophila intestinal stem cell tumours. Nat Cell Biol 17: 1182-1192. PubMed ID: 26237646

Patel, R., Bartosch, B. and Blank, J. L. (1998). p21WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression. J. Cell Sci. 111(Pt 15): 2247-2255. PubMed Citation: 9664046

Pattingre, S., Bauvy, C., Carpentier, S., Levade, T., Levine, B. and Codogno, P. (2008). Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J. Biol. Chem. 284(5): 2719-28. PubMed Citation: 19029119

Peineau, S., et al. (2007). LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53: 703-717. PubMed Citation: 17329210

Perez-Garijo, A., Fuchs, Y. and Steller, H. (2013). Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway. Elife 2: e01004. PubMed ID: 24066226

Wu, M., Pastor-Pareja, J. C. and Xu, T. (2010). Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature 463: 545-548. PubMed ID: 20072127

Peterson, U.-M., et al. (1995). The dorsal-related immunity, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression. EMBO J. 14: 3146-58. PubMed Citation: 7621828

Pham, C. G., et al. (2004). Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 119(4): 529-42. 15537542

Pickup, A. T., et al. (2002). Control of photoreceptor cell morphology, planar polarity and epithelial integrity during Drosophila eye development. Development 129: 2247-2258. 11959832

Poitras, L., et al. (2003). A tissue restricted role for the Xenopus Jun N-terminal kinase kinase kinase MLK2 in cement gland and pronephric tubule differentiation. Dev. Biol. 254: 200-214. 12591241

Polverino, A., et al. (1995). Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes. J. Biol. Chem. 270: 26067-26070. PubMed Citation: 7592806

Raingeaud, J. A., et al. (1995). MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16: 1247-1255. PubMed Citation: 8622669

Rallis, A., Lu, B. and Ng, J. (2013). Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila. J Cell Sci 126: 838-849. PubMed ID: 23264732

Ramet, M., et al. (2002). JNK signaling pathway is required for efficient wound healing in Drosophila. Dev. Bio. 241: 145-156. 11784101

Read, R. D., Bach, E. A. and Cagan, R. L. (2004). Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol. Cell. Biol. 24: 6676-6689. 15254235

Reed, B. H., Wilk, R. and Lipshitz, H. B. (2001). Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo. Cur. Bio. 11: 1098-1108. 11269501

Reed, B. H., Wilk, R., Schöck, F. and and Lipshitz, H. D. (2004), Integrin-dependent apposition of Drosophila extraembryonic membranes promotes morphogenesis and prevents anoikis. Curr. Biol. 14: 372-380. 15028211

Reinhard, C., et al. (1997). Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J. 16: 1080-92. PubMed Citation: 9118946

Resnik-Docampo, M. and de Celis, J. F. (2011). MAP4K3 is a component of the TORC1 signalling complex that modulates cell growth and viability in Drosophila melanogaster. PLoS One. 6(1): e14528. PubMed Citation: 21267071

Rewitz, K. F., Yamanaka, N., Gilbert, L. I. and O'Connor, M. B. (2009). The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis. Science 326(5958): 1403-5. PubMed Citation: 19965758

Rhee, D. Y., Cho, D. Y., Zhai, B., Slattery, M., Ma, L., Mintseris, J., Wong, C. Y., White, K. P., Celniker, S. E., Przytycka, T. M., Gygi, S. P., Obar, R. A. and Artavanis-Tsakonas, S. (2014). Transcription factor networks in Drosophila melanogaster. Cell Rep 8: 2031-2043. PubMed ID: 25242320

Riesgo-Escovar, J. R., et al. (1996). The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 10: 2759-68. PubMed Citation: 8946916

Riesgo-Escovar, J. R. and Hafen, E. (1997). Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev. 11: 1717-1727. PubMed Citation: 9224720

Rogatsky, I. Logan, S. K. and Garabedian, M. J. (1998). Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase. Proc. Natl. Acad. Sci. 95: 2050-2055. PubMed Citation: 9482836

Rousset, R., et al. (2010). The Drosophila serine protease homologue Scarface regulates JNK signalling in a negative-feedback loop during epithelial morphogenesis. Development 137(13): 2177-86. PubMed Citation: 20530545

Rui, Y., et al. (2007). A β-Catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by Aida. Dev. Cell 13: 268-282. PubMed citation: 17681137

Ryoo, H. D., Gorenc, T. and Steller, H. (2004). Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev. Cell 7: 491-501. 15469838

Sabapathy, K., et al. (1999a). JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr. Biol. 9(3): 116-25. PubMed Citation: 10021384

Sabapathy, K., et al. (1999b). Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech. Dev. 89: 115-124. PubMed Citation: 10559486

Sabio, G., et al. (2010). Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 24(3): 256-64. PubMed Citation: 20080940

Sanna, M. G., et al. (1998). Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP. Proc. Natl. Acad. Sci. 95(11): 6015-6020. PubMed Citation: 9600909

Sato, M., et al. (2005). DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. Nat. Neurosci. 9: 67-75. 16369482

Sawamoto, K., et al. (1999a). The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway. J. Cell Biol. 146(2): 361-372. PubMed Citation: 10427090

She, Q., et al. (2002). Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 62: 1343-1348. PubMed citation: 11888903

See, R. H. and Shi, Y. (1998). Adenovirus E1B 19,000-molecular-weight protein activates c-Jun N-terminal kinase and c-Jun-mediated transcription. Mol. Cell. Biol. 18(7): 4012-4022. PubMed Citation: 9632786

Seong, K. H., Matsuo, T., Fuyama, Y. and Aigaki, T. (2001).Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies. Biogerontology 2(4): 271-81. 11868902

Skov, S., Klausen, P. and Claesson, M. H. (1997). Ligation of major histocompatability complex (MHC) class I molecules on human T cells induces cell death through PI-3 kinase-induced c-Jun NH2-terminal kinase activity: A novel apoptotic pathway distinct from fas-induced apoptosis. J. Cell Biol. 139(6): 1523-1531. PubMed Citation: 9396757

Shi, C. S. and Kehrl, J. H. (1997). Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-kappaB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway. J. Biol. Chem. 272(51): 32102-7. PubMed Citation: 9405407

Shukla, A. K., Pragya, P., Chaouhan, H. S., Tiwari, A. K., Patel, D. K., Abdin, M. Z. and Chowdhuri, D. K. (2014). Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and Caspase-3 activation in Drosophila model of Parkinson's disease. PLoS One 9: e98886. PubMed ID: 24887138

Silverman, N., et al. (2003). Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J. Biol. Chem. 278: 48928-48934. 14519762

Simonsen, A., et al. (2008). Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4: 176-184. PubMed Citation: 18059160

Singh, J., Aaronson, S. A. and Mlodzik, M. (2010). Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways. Oncogene 29(28): 4033-45. PubMed Citation: 20453880

Sluss, H. K., et al. (1994). Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol. Cell. Biol. 14: 8376-8384. PubMed Citation: 7969172

Sluss, H. K., et al. (1996). A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 10: 2745-2758. PubMed Citation: 8946915

Smith, A., et al. (1997). A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells. Curr. Biol. 7(11): 893-896. PubMed Citation: 9382802

Sorrosal, G., Pérez, L., Herranz, H., and Milán, M. (2010). Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo. EMBO Rep. 11(5): 373-9. PubMed Citation: 20379222

Srahna, M., Leyssen, M., Choi, C. M., Fradkin, L. G., Noordermeer, J. N. and Hassan, B. A. (2006). A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 4(11): e348. Medline abstract: 17032066

Stappenbeck, T. S. and Gordon, J. I. (2001). Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice. Development 128: 2603-2614. 11493576

Stowers, L., et al. (1995). Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. 9295: 5027-5031

Stronach, B., Lennox, A. L. and Garlena, R. A. (2014). Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila. Genetics [Epub ahead of print]. PubMed ID: 24429281

Strutt, D. I., Weber. U., and Mlodzik, M. (1997). The role of RhoA in tissue polarity and Frizzled signalling. Nature 387 (6630): 292-295

Strutt, D., Johnson, R., Cooper, K. and Bray, S. (2002). Asymmetric localization of Frizzled and the determination of Notch-dependent cell fate in the Drosophila eye. Curr. Biol. 12: 813-824. 12015117

Su, B. E., et al. (1994). JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77: 727-735

Su, Y., Ospina, J. K., Zhang, J., Michelson, A. P., Schoen, A. M. and Zhu, A. J. (2011). Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal 4: ra43. PubMed ID: 21730325

Su, Y.-C. Treisman, J. E. and Skolnik, E. Y. (1998). The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway. Genes Dev. 12: 2371-2380

Sun, G. and Irvine, K. D. (2011). Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev. Biol. 350(1): 139-51. PubMed Citation: 21145886

Sun, L., et al. (2008). Molecular identification and functional characterization of a Drosophila dual-specificity phosphatase DMKP-4 which is involved in PGN-induced activation of the JNK pathway. Cell Signal 20: 1329-1337. PubMed Citation: 18456458

Sun, T. Q., et al. (2001). PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nature Cell Bio. 3: 628-636. 11433294

Suzanne, M., Perrimon, N. and Noselli, S. (2001). The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Dev. Bio. 237: 282-294. 11543614

Suzanne M., et al. (2010). Coupling of apoptosis and L/R patterning controls stepwise organ looping. Curr. Biol. 20: 1773-1778. PubMed Citation: 20832313

Swantek, J. L., Cobb, M. H. and Geppert, T. D. (1997). Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK. Mol. Cell. Biol. 17(11): 6274-6282.

Takahama, K., et al. (2011). Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila. Biochem. Biophys. Res. Comm. 417(2): 807-11. PubMed Citation: 22197814

Takeuchi, M., et al. (2003). The prickle-related gene in vertebrates is essential for gastrulation cell movements. Curr. Biol. 13: 674-679. 12699625

Tang, H. W., Liao, H. M., Peng, W. H., Lin, H. R., Chen, C. H., Chen, G. C. (2013). Atg9 Interacts with dTRAF2/TRAF6 to Regulate Oxidative Stress-Induced JNK Activation and Autophagy Induction. Dev Cell 27(5):489-503. PubMed ID: 24268699

Tapon, N., Nagata, K., Lamarche, N. and Hall, A. (1998). A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J. 17(5): 1395-404. 9482736

Taniguchi, K., et al. (2007). D-JNK signaling in visceral muscle cells controls the laterality of the Drosophila gut. Dev. Biol. 311(1): 251-63. PubMed Citation: 17915206

Tare, M., et al. (2011). Activation of JNK signaling mediates amyloid-β-dependent cell death. PLoS One 6(9): e24361. PubMed Citation: 21949710

Tateno, M., Nishida, Y. and Adachi-Yamada, T. (2000). Regulation of JNK by Src during Drosophila development. Science 287(5451): 324-7. PubMed ID: 10634792

Temkin, V., Huang, Q., Liu, H., Osada, H. and Pope, R. M. (2006). Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol. Cell Biol. 26: 2215–2225. PubMed Citation: 16507998

Thomas, C. and Strutt, D. (2014). Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster. Dev Biol. 385(1): 107-21 PubMed ID: 24104056

Thompson, B. J. et al. (2005). Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev. Cell 9: 711-720. PubMed Citation: 16256745

Tibbles, L. A., et al. (1996). MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J 15 (24): 7026-7035

Tournier, C., et al. (1999). The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases. Mol. Cell. Biol. 19(2): 1569-81

Tsuda, M., et al. (2005). The RING-finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila. EMBO Rep. 6(11): 1082-7. 16179944

Tsuda, M., Seong, K. H. and Aigaki, T. (2006). POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila. FEBS Lett. 580(13): 3296-300. 16698022

Urano, F., et al. (2000). Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287(5453): 664-6.

Vaccari, T. and Bilder, D. (2005). The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking, Dev. Cell 9: 687-698. PubMed Citation: 16256743

Vadász, I., et al. (2012). Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction. PLoS One. 2012;7(10):e46696. PubMed Citation: 23056407

Vadasz, I., Dada, L. A., Briva, A., Helenius, I. T., Sharabi, K., Welch, L. C., Kelly, A. M., Grzesik, B. A., Budinger, G. R., Liu, J., Seeger, W., Beitel, G. J., Gruenbaum, Y. and Sznajder, J. I. (2012). Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction. PLoS One 7: e46696. PubMed ID: 23056407

Ventura, J. J. et al. (2004). JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev. 18: 2905-2915. 15545623

Verheij, M., et al. (1996). Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380: 75-79. PubMed Citation: 8598911

Villanueva, A., et al. (2001). jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. EMBO J. 20: 5114-5128. 11566876

Wang, L., Du, F. and Wang, X. (2008). TNF-alpha induces two distinct caspase-8 activation pathways. Cell 133: 693–703. PubMed Citation: 18485876

Wang, L., Zeng, X., Ryoo, H. D. and Jasper, H. (2014). Integration of UPRER and oxidative stress signaling in the control of intestinal stem cell proliferation. PLoS Genet 10: e1004568. PubMed ID: 25166757

Wang, M., Bohmann, D. and Jasper, H. (2005). JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121: 115-125. PubMed citation: 15820683

Wang, M. C., Bohmann, D. and Jasper, H. (2003). JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev. Cell 5: 811-816. PubMed Citation: 14602080

Wang, M. C., Bohmann, D. and Jasper, H. (2005). JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121: 115-125. PubMed Citation: 15820683

Wang, N., Leung, H. T., Mazalouskas, M. D., Watkins, G. R., Gomez, R. J. and Wadzinski, B. E. (2012). Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster. PLoS One 7: e38569. PubMed ID: 22701670

Wang, S., et al. (1999). Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. EMBO J. 18(6): 1559-1570. PubMed Citation: 10075927

Wang, W., Bohmann, D. and Jasper, H. (2003). JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila, Dev. Cell 5: 811-816. PubMed citation: 14602080

Weber, U., Paricio, N. and Mlodzik, M. (2000). Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development 127: 3619-3629. PubMed Citation: 10903185

Wei, Y., et al. (2008). JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 30: 678-688. PubMed Citation: 18570871

Wessells, R. J., Fitzgerald, E., Cypser, J. R., Tatar, M. and Bodmer, R. (2004). Insulin regulation of heart function in aging fruit flies. Nat. Genet. 36(12): 1275-81. PubMed citation: 15565107

Weston, C., et al. (2000). Agrin-induced Acetylcholine receptor clustering is mediated by the small guanosine triphosphatases Rac and Cdc42. J. Cell Bio. 150: 205-212. 10893268

Weston, C. R., et al. (2003). JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. Genes Dev. 17: 1271-1280. 12756228

Westwick, J. K., et al. (1994). Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. J. Biol. Chem. 269: 26396-401

Westwick, J. K., et al. (1995). Ceramide activates the stress-activated protein kinases. J. Biol. Chem. 270: 22689-22692

Whitmarsh, A. J., et al. (1998). A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281(5383): 1671-1674

Wilhelm, D., et al. (1997). The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol. Cell. Biol. 17(8): 4792-4800

Willsey, H. R., Zheng, X., Carlos Pastor-Pareja, J., Willsey, A. J., Beachy, P. A. and Xu, T. (2016). Localized JNK signaling regulates organ size during development. Elife 5: e11491. PubMed ID: 26974344

Wong, B. R., et al. (1997). TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272(40): 25190-25194

Wong, C. O., Palmieri, M., Li, J., Akhmedov, D., Chao, Y., Broadhead, G. T., Zhu, M. X., Berdeaux, R., Collins, C. A., Sardiello, M. and Venkatachalam, K. (2015). Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction. Cell Rep 12: 2009-2020. PubMed ID: 26387958

Woodfield, S. E., Graves, H. K., Hernandez, J. A. and Bergmann, A. (2013). De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis. PLoS One 8: e56021. PubMed ID: 23418496

Wu, H., Meng C. Wang, M. C. and Bohmann, D. (2009). JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech. Dev. 126: 624-637. PubMed Citation: 19540338

Wu, M., Pastor-Pareja, J. C. and Xu, T. (2010). Interaction between RasV12 and scribbled clones induces tumour growth and invasion. Nature 463(7280): 545-8. PubMed Citation: 20072127

Xia, Z., et al. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331

Xing, H., et al. (2000). 14-3-3 proteins block apoptosis and differentially regulate MAPK cascades. EMBO J. 19: 349-358.

Xu, P., Das, M., Reilly, J. and Davis, R. J. (2011). JNK regulates FoxO-dependent autophagy in neurons. Genes Dev. 25(4): 310-22. PubMed Citation: 21325132

Xu, X., et al. (1997). Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli. Proc. Natl. Acad. Sci. 94(23): 12655-12660

Xu, Z., Kukekov, N. V. and Greene, L. A. (2003). POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J. 22(2): 252-61. 12514131

Xue, L., et al. (2007). Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev. Cell 13: 446-454. PubMed citation: 17765686

Xu, Z., Kukekov, N. V. and Greene, L. A. (2003). POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J. 22(2): 252-61. 12514131

Yamaguchi, K., et al. (1995). Identification of a member of the MAPKKK family as a potential mediator of TGF-ß signal transduction. Science 270: 2008-11

Yamanaka, H., et al. (2002). JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Reports 3: 69-75. 11751577

Yamashita, T., Inui, S., Maeda, K., Hua, D. R., Takagi, K., Fukunaga, K. and Sakaguchi, N. (2006). Regulation of CaMKII by alpha4/PP2Ac contributes to learning and memory. Brain Res 1082: 1-10. PubMed ID: 16516168

Yan, D., et al. (2001). Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc. Natl. Acad. Sci. 98: 3802-3807. 11274398

Yan, H., Jahanshahi, M., Horvath, E. A., Liu, H. Y. and Pfleger, C. M. (2010). Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila. Curr Biol 20: 1378-1382. PubMed ID: 20655224

Yang, X., et al. (1997). Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89(7): 1067-1076. PubMed Citation: 9215629

Yano, H., et al. (2002). Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35: 697-709. 12194869

Yao, R., Yoshihara, M. and Osada, H. (1997). Specific activation of a c-Jun NH2-terminal kinase isoform and induction of neurite outgrowth in PC-12 cells by staurosporine. J. Biol. Chem. 272(29): 18261-18266. PubMed Citation: 9218464

Yoshioka, Y., et al. (2012). Drosophila DREF acting via the JNK pathway is required for thorax development. Genesis [Epub ahead of print]. PubMed Citation: 22307950

Yuasa, T., et al. (1998). Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J Biol Chem 273(35): 22681-92. PubMed Citation: 9712898

Zhai, R. G., Zhang, F., Hiesinger, P. R., Cao, Y., Haueter, C. M. and Bellen, H. J. (2008). NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature 452: 887-891. PubMed ID: 18344983

Zhang, D. W., et al. (2009). RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325: 332–336. PubMed Citation: 19498109

Zhang, J., Kalkum, M., Chait, B. T. and Roeder, R. G. (2002). The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol. Cell 9(3): 611-623. 11931768

Zhang, L., et al. (2003). A role for MEK kinase 1 in TGF-ß/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 22: 4443-4454. 12941696

Zhang, J. Y., et al. (2004). NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes Dev. 18: 17-22. 14724177

Zhang, Y., et al. (1998). A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system. Proc. Natl. Acad. Sci. 95: 2586-2591. PubMed Citation: 9482930

Zhang, Y., et al. (1999). Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. J. Biol. Chem. 274(49): 35247-54. 10575011

Zhao, J., Zheng, C. and Guan, J. (2000). Pyk2 and FAK differentially regulate progression of the cell cycle. J. Cell Sci. 113: 3063-3072. 10934044

Zhu, L. Q., et al. (2007). Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J. Neurosci. 27: 12211-12220. PubMed Citation: 17989287

Zhu, M., et al. (2010). Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs. Cell Res. 20: 242-245. PubMed Citation: 20066009

Zhu, Y., et al. (2005). Rap2-JNK removes synaptic AMPA receptors during depotentiation. Neuron 46(6): 905-16. 15953419

Zhuang, Z.-H., et al. (2006). Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB. Cell. Signalling 18(7): 964-70. 16311020

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basket/JNK: Biological Overview | Evolutionary Homolog | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

date revised:  30 October 2015
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