cubitus interruptus


REFERENCES

Abzhanov, A. and Tabin, C. J. (2004). Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development. Dev. Biol. 273: 134-148. 15302603

Akimaru, H., et al. (1997). Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 386: 735-738. PubMed Citation: 9109493

Akiyama, T. and Gibson, M. C. (2015). Decapentaplegic and growth control in the developing Drosophila wing. Nature 527(7578):375-8. PubMed ID: 26550824

Alexandre, C., Jacinto, A., and Ingham, P. W. (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10: 2003-13. PubMed Citation: 8769644

Angelats, C., et al. (2001). Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos. Dev. Biol. 241(1): 132-144. 11784100

Aoto, K., et al. (2002). Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev. Bio. 251: 320-332. 12435361

Apidianakis, Y., et al. (2001). Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch. Development 128: 4361-4370. 11684670

Aruga, J., et al. (1999). Zic1 regulates the patterning of vertebral arches in cooperation with Gli3. Mech. Dev. 89: 141-150. PubMed Citation: 10559489

Aza-Blanc, P., et al. (1997). Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89(7): 1043-1053. PubMed Citation: 9215627

Aza-Blanc, P., et al. (2000). Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 127: 4293-4301. PubMed Citation: 10976059

Bai, C. B. and Joyner, A. L. (2001). Gli1 can rescue the in vivo function of Gli2. Development 128: 5161-5172. 11748151

Bai, C. B., et al. (2002). Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 129: 4753-4761. 12361967

Bai, C. B., Stephen, D. and Joyner, A. L. (2004). All mouse ventral spinal cord patterning by Hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6: 103-115. 14723851

Bai, J. and Montell, D. (2002). Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis. Development 129: 5377-5388. 12403709

Baker, N. E., Bhattacharya, A. and Firth, L. C. (2009). Regulation of Hh signal transduction as Drosophila eye differentiation progresses. Dev. Biol. 335(2): 356-66. PubMed Citation: 19761763

Barresi, M. J. F., et al. (2005). Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain. Development 132: 3643-3656. 16033800

Besse, L., et al. (2011). Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing. Development 138: 2079-2088. PubMed Citation: 21490064

Bielinski, V. A. and Mumby, M. C. (2007). Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Exp Cell Res 313: 3117-3126. PubMed ID: 17570358

Bok, J., et al. (2007). Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134(9): 1713-22. Medline abstract: 17395647

Borycki, A.-G., Mendham, L. and Emerson, C. P. (1998). Control of somite patterning by Sonic hedgehog and its downstream signal response genes. Development 125(4): 777-790. PubMed Citation: 9435297

Borycki, A.-G., Brown, A. M. C. and Emerson, C. P. (2000). Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites. Development 127: 2075-2087. PubMed Citation: 10769232

Brewster, R., Lee, J. and Ruiz i Altaba, A. (1998). Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. Nature 393: 579-583. PubMed Citation: 9634234

Brewster, R, Mullor, J. L. and Ruiz I Altaba, A. (2000). Gli2 functions in FGF signaling during antero-posterior patterning. Development 127: 4395-4405. PubMed Citation: 11003839

Brunner, E., et al. (1997). pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature 385: 829-833. PubMed Citation: 9039917

Bulgakov, O. V., et al. (2004). FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development 131: 2149-2159. 1510537

Buscher, D., et al. (1997). Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev. 62 (2): 175-182. PubMed Citation: 9152009

Buscher, D. and Ruther, U. (1998). Expression profile of Gli family members and Shh in normal and mutant mouse limb development. Dev. Dyn. 211(1):88-96. PubMed Citation: 9438426

Callahan, C. A., et al. (2004). MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev. 18(22): 2724-9. 15545630

Campbell, G. L. and Tomlinson, A. (2000). Transcriptional regulation of the Hedgehog effector Ci by the zinc-finger gene combgap. Development 127: 4095-4103. PubMed Citation: 10976042

Caspary, T., Larkins, C. E. and Anderson, K. V. (2007). The graded response to Sonic Hedgehog depends on cilia architecture. Dev. Cell 12(5): 767-78. PubMed citation: 17488627

Chen, E. H. and Baker. B. S. (1997). Compartmental organization of the Drosophila genital imaginal discs. Development 124: 205-218. PubMed ID: 9006081

Chen, C., et al. (1998). Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc. Natl. Acad. Sci. 95: 2349-2354. PubMed ID: 9482888

Chen, C.-H., et al. (1999). Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 98: 305-316. PubMed ID: 10458606

Chen, M. H., et al. (2009). Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23(16): 1910-28. PubMed Citation: 19684112

Chen, Y., et al. (1999). Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. Development 126: 3607-3616. PubMed ID: 10409506

Chen, Y., et al. (2004). Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh. Development 131: 2339-2347. 15102708

Cheng, S. Y. and Bishop, J. M. (2002). Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc. Natl. Acad. Sci. 99: 5442-5447. 11960000

Chotard, C., Leung, W. and Salecker, I. (2005). glial cells missing and gcm2 cell autonomously regulate both glial and neuronal development in the visual system of Drosophila. Neuron 48(2): 237-51. 16242405

Clement, V., et al. (2007). HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol. 17: 165-172. Medline abstract: 17196391

Corrales, J., et al. (2004). Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development 131: 5581-5590. 15496441

Croker, J. A., Ziegenhorn, S. L. and Holmgren, R. A. (2006). Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains. Dev. Biol. 291(2): 368-81. 16413529

Cygnar, K. D., Gao, X., Pan, D. and Neufeld, T. P. (2005). The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila. Genetics 170: 733-740. PubMed ID: 15802506

Dahmane, N., et al. (1997). Activation of the transcription factor Gli1 and the Sonic hedgehog signaling pathway in skin tumors. Nature 389(6653): 876-881

Dahmann, C., and Basler, K. (2000). Opposing transcriptional outputs of Hedgehog signaling and engrailed control compartmental cell sorting at the Drosophila A/P boundary. Cell 100(4): 411-22. 10693758

Dahmane, N., et al. (2001). The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 128: 5201-5212. 11748155

Dai, P., et al. (1999). Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274(12): 8143-52

Dai, P., Akimaru, H. and Ishii, S. (2003). A Hedgehog-responsive region in the Drosophila wing disc is defined by Debra-mediated ubiquitination and lysosomal degradation of Ci. Dev. Cell 4: 917-928. 12791275

Delattre, M., et al. (1999). The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals Dev. Genes Evol. 209: 294-300

Ding Q., et al. (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in gli2 mutant mice. Development 125(14): 2533-2543

Domínguez, M., et al. (1996). Sending and receiving the Hedgehog signal: Control by the Drosophila Gli protein Cubitus interruptus. Science 272: 1621-1625

Dominguez, M. (1999). Dual role for Hedgehog in the regulation of the proneural gene atonal during ommatidia development. Development 126: 2345-2353

Duman-Scheel, M., et al. (2002). Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417: 299-304. 12015606

Dunn, N. R., et al. (1997). Haploinsufficient phenotypes in bmp4 heterozygous null mice and modification by mutations in gli3 and alx4. Dev. Biol. 188(2): 235-247

Dussillol-Godar, F., et al. (2005). Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs. Dev. Biol. 129: 53-66. 16413525

Eaton, S. and Kornberg, T. (1990). Repression of ci-D in posterior compartments of Drosophila by engrailed. Genes Dev 4: 1068-77

Endoh-Yamagami, S., et al. (2009). The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr. Biol. 19: 1320-1326. PubMed Citation: 19592253

Fang, M., Ren, H., Liu, J., Cadigan, K. M., Patel, S. R. and Dressler, G. R. (2009). Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways. Development 136(11): 1929-38. PubMed Citation: 19429789

Franco, P. G., et al. (1999). Functional association of retinoic acid and hedgehog signaling in Xenopus primary neurogenesis. Development 126: 4257-4265

Fu, W. and Baker, N. E. (2003). Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development. Development 130: 5229-5239. 12954721

Gallet, A., et al. (2000). Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila. Development 127: 5509-5522

Gómez-Skarmeta, J. L. and Modolell, J. (1996). araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing. Genes Dev. 10: 2935-45

Gómez-Skarmeta, J. L., et al. (1998). Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate. EMBO J. 17: 181-190

Goodrich, L. V., et al. (1996). Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by hedgehog. Genes Dev. 10: 301-312.

Grindley, J. C., et al. (1997). Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev. Biol. 188(2):337-348

Grove, E. A., et al. (1998). The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development 125(12): 2315-25

Gustafsson, M. K., et al. (2002). Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification. Genes Dev. 16: 114-126. 11782449

Hardcastle, Z., et al. (1998). The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125(15): 2803-2811

Hays, R., et al. (1999). Patterning of Drosophila leg sensory organs through combinatorial signaling by Hedgehog, Decapentaplegic and Wingless. Development 126: 2891-2899

Hepker, J., et al. (1997). Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124 (2): 549-558

Hepker, J., Blackman, R. K. and Holmgren, R. (1999). Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer. Development 126: 3669-3677

Hersh, B. M. and Carroll, S. B. (2005). Direct regulation of knot gene expression by Ultrabithorax and the evolution of cis-regulatory elements in Drosophila. Development 132(7): 1567-77. 15753212

Hidalgo, A. and Ingham, P. (1990). Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched. Development 110: 291-301

Hilton, M. J., et al. (2005). Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. Development 132(19): 4339-51. 16141219

Ho, K. S., Suyama, K., Fish, M. and Scott, M. P. (2005), Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development 132: 1401-1412. 15750186

Hooper, J. E. (1994). Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. Nature 372: 461-464.

Hooper, J. E. (2003). Smoothened translates Hedgehog levels into distinct responses. Development 130: 3951-3963. 12874118

Horabin, J. I., Walthall, S., Vied, C. and Moses, M. (2003). A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch. Development 130: 6101-6109. 14597576

Horabin, J. I. (2005). Splitting the Hedgehog signal: sex and patterning in Drosophila. Development 132(21): 4801-10. 16207758

Hsu, S. H., (2011). Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu. Development 138(17): 3791-801. PubMed Citation: 21795282

Huang, B. L., Trofka, A., Furusawa, A., Norrie, J. L., Rabinowitz, A. H., Vokes, S. A., Mark Taketo, M., Zakany, J. and Mackem, S. (2016). An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5'Hoxd-Gli3 antagonism. Nat Commun 7: 12903. PubMed ID: 27713395

Huang, P. and Schier, A. F. (2009). Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development 136(18): 3089-98. PubMed Citation: 19700616

Huang, Z. and Kunes, S. (1998). Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly. Development 125: 3753-3764. PubMed Citation: 9729484

Hui, C. C., et al. (1994). Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol. 162: 402-413. PubMed Citation: 8150204

Humke, E. W., et al. (2010). The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 24(7): 670-82. PubMed Citation: 20360384

Hynes, M., et al. (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19(1): 15-26. PubMed Citation: 9247260

Janody, F., Martirosyan, Z., Benlali, A. and Treisman, J. E. (2003). Two subunits of the Drosophila mediator complex act together to control cell affinity. Development 130: 3691-3701. PubMed Citation: 12835386

Jia, H., Liu, Y., Yan, W. and Jia, J. (2009). PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 136: 307-316. PubMed ID: 19088085

Jia, J., et al. (2002). Shaggy/GSK3 antagonizes Hedgehog signaling by regulating Cubitus interruptus. Nature 416: 548-551. 11912487

Jia, J., Zhang, L., Zhang, Q., Tong, C., Wang, B., Hou, F., Amanai, K. and Jiang, J. (2005). Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev. Cell 9(6): 819-30. 16326393

Jiang, J. and Struhl, G. (1998). Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391(6666): 493-496

Jiang, K., Liu, Y., Fan, J., Epperly, G., Gao, T., Jiang, J. and Jia, J. (2014). Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila. Proc Natl Acad Sci U S A 111(45):E4842-50. PubMed ID: 25349414

Jimenez-Sanchez, M., Menzies, F. M., Chang, Y. Y., Simecek, N., Neufeld, T. P. and Rubinsztein, D. C. (2012). The Hedgehog signalling pathway regulates autophagy. Nat Commun 3: 1200. PubMed ID: 23149744

Joulia, L., Bourbon, H. M. and Cribbs, D. L. (2005). Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts. Dev. Biol. 278(2): 496-510. 15680366

Karandikar, U. C., Jin, M., Jusiak, B., Kwak, S., Chen, R. and Mardon, G. (2014). Drosophila eyes absent is required for normal cone and pigment cell development. PLoS One 9: e102143. PubMed ID: 25057928

Karlstrom, R. O., Talbot, W. S. and Schier, A. F. (1999). Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Genes Dev. 13(4): 388-93

Karlstrom, R. O., et al. (2003). Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development 130: 1549-1564. 12620981

Kent, D., Bush, E. W. and Hooper, J. E. (2006). Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development 133(10): 2001-10. 16651542

Keys, D. N., et al. (1999). Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution. Science 283(5401): 532-4

Kiger, J. A., et al. (1999). Transgenic inhibitors identify two roles for Protein Kinase A in Drosophila development. Genetics 152(1): 281-290

Kiger, J. A. and O'Shea, C. (2001). Genetic evidence for a protein kinase A/Cubitus interruptus complex that facilitates processing of Cubitus interruptus in Drosophila. Genetics 158: 1157-1166. 11454764

Kim, J., Kato, M. and Beachy, P. A. (2009). Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc. Natl. Acad. Sci. 106: 21666-71. PubMed Citation: 19996169

Kim, S. H., Kim, H. J., Kim, S. and Yim, J. (2010). Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein. Dev. Biol. 346(2): 247-57. PubMed Citation: 20691177

Ko, H. W., et al. (2010). Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev. Cell 18(2): 237-47. PubMed Citation: 20159594

Kogerman, P., et al. (1999). Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of GLI-1. Nat. Cell Biol. 1: 312-319. PubMed Citation: 10559945

Kong, M., Fox, C. J., Mu, J., Solt, L., Xu, A., Cinalli, R. M., Birnbaum, M. J., Lindsten, T. and Thompson, C. B. (2004). The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science 306: 695-698. PubMed ID: 15499020

Koyabu, Y., et al. (2001). Physical and functional interactions between Zic and Gli proteins. J. Biol. Chem. 276(10): 6889-92. 11238441

Koziel, L., Wuelling, M., Schneider, S. and Vortkamp, A. (2005). Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132(23): 5249-60. 16284117

Kuschel, S., Rüther, U. and Theil, T. (2003). A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon. Dev. Bio. 260: 484-495. 12921747

Kwon, C., et al. (2004). Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc. Development 131: 2681-2692. 15128656

Lamm, M. L. G., et al. (2002). Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev. Bio. 249: 349-366. 12221011

Larsen, C. W., Hirst, E., Alexandre, C. and Vincent, J.-P. (2003). Segment boundary formation in Drosophila embryos. Development 130: 5625-5635. 14522878

Lee, J., et al. (1997). Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124(13): 2537-2552. PubMed Citation: 9216996

Lee, J. D. and Treisman, J. E. (2001). Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Cur. Bio. 11: 1147-1152. 11509241

Lee, J. D., Amanai, K., Shearn, A. and Treisman, J. E. (2002). The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms. Development 129: 5697-5706. 12421709

Lefers, M. A., Wang, Q. T. and Holmgren, R. A. (2001). Genetic dissection of the Drosophila Cubitus interruptus signaling complex. Dev. Bio. 236: 411-420. 11476581

Lei, Q., Zelman, A. K., Kuang, E., Li, S. and Matise, M. P. (2004). Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131: 3593-3604. 15215207

Lessing, D, and Nusse, R. (1998). Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Development 125(8): 1469-1476

Lewis, K. E., et al. (1999a). Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. Development 126(11): 2397-2407

Lewis, K. E., et al. (1999b). Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling. Dev. Bio. 216: 469-480

Lewis, K. E. and Eisen, J. S. (2001). Hedgehog signaling is required for primary motoneuron induction in zebrafish. Development 128: 3485-3495. 11566854

Lewis, M. T., et al. (2001). The Gli2 transcription factor is required for normal mouse mammary gland development. Dev. Biol. 238: 133-144. PubMed Citation: 11783999

Li, Q., Lewandowski, J. P., Powell, M. B., Norrie, J. L., Cho, S. H. and Vokes, S. A. (2014). A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud. Development 141: 1906-1914. PubMed ID: 24700818

Litingtung, Y., et al. (2002). Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418: 979-983. 12198547

Lobbardi, R., et al. (2011). Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development. Development 138(9): 1783-94. PubMed Citation: 21447554

Mao, F., Yang, X., Fu, L., Lv, X., Zhang, Z., Wu, W., Yang, S., Zhou, Z., Zhang, L. and Zhao, Y. (2014). Kto-Skd complex can regulate ptc expression by interacting with Ci in Hedgehog signaling pathway. J Biol Chem [Epub ahead of print]. PubMed ID: 24962581

Marigo, V., et al. (1996). Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol. 180: 273-283. PubMed Citation: 8948590

Marine, J. C., et al. (1997). A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm. Mech. Dev. 63(2): 211-225. PubMed Citation: 9203143

Marks, S. A. and Kalderon, D. (2011). Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation. Development 138(12): 2533-42. PubMed Citation: 21610030

Matise, M. P., et al. (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125(15): 2759-2770. PubMed Citation: 9655799

Matise, M. P., et al. (1999). Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord. Development 126: 3649-3659. PubMed Citation: 10409510

Maurya, A. K., Ben, J., Zhao, Z., Lee, R. T., Niah, W., Ng, A. S., Iyu, A., Yu, W., Elworthy, S., van Eeden, F. J. and Ingham, P. W. (2013). Positive and negative regulation of gli activity by kif7 in the zebrafish embryo. PLoS Genet 9: e1003955. PubMed ID: 24339784

May, S. R., et al. (2005). Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287(2): 378-89. 16229832

Methot, N. and Basler, K. (1999). Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96(6): 819-31. PubMed ID: 10102270

Methot, N. and Basler, K. (2000). Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 127(18): 4001-4010. PubMed ID: 10952898

Methot, N. and Basler, K. (2001). An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development 128: 733-742. 11171398

Meyer, N. é. P. and Roelink, H. (2003). The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord. Dev. Biol. 257: 343-355. 12729563

Mistry, H., Wilson, B. A., Roberts, I. J., O'Kane, C. J. and Skeath, J. B. (2004). Cullin-3 regulates pattern formation, external sensory organ development and cell survival during Drosophila development. Mech. Dev. 121(12): 1495-507. 15511641

Mizugishi, K., et al. (2001). Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J. Biol. Chem. 276(3): 2180-8. 11053430

Mo, R., et al. (1997). Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124: 113-123

Mondal, B. C., et al. (2011). Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell 147(7): 1589-600. PubMed Citation: 22196733

Monnier, V., et al. (1998). Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway. Curr. Biol. 8(10): 583-6

Mosimann, C., Hausmann, G. and Basler, K. (2009). The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control. Mech. Dev. 126(5-6): 394-405. PubMed Citation: 19368795

Motoyama, J., et al. (2003). Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev. Biol. 259: 150-161. 12812795

Motzny, C. K. and Holmgren, R. (1995). The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech Dev 52: 137-150

Muller, B. and Basler, K. (2000). The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic Gli-binding sites. Development 127: 2999-3007

Mullor, J. L., et al. (2001). Wnt signals are targets and mediators of Gli function. Curr. Biol. 11: 769-773. 11378387

Murone, M., et al. (2000). Gli regulation by the opposing activities of Fused and Suppressor of Fused. Nat. Cell Biol. 2: 310-312. PubMed Citation: 10806483

Nguyen, D., Fayol, O., Buisine, N., Lecorre, P. and Uguen, P. (2016). Functional interaction between HEXIM and Hedgehog signaling during Drosophila wing development. PLoS One 11: e0155438. PubMed ID: 27176767

Niewiadomski, P., Kong, J. H., Ahrends, R., Ma, Y., Humke, E. W., Khan, S., Teruel, M. N., Novitch, B. G. and Rohatgi, R. (2014). Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Rep 6: 168-181. PubMed ID: 24373970

Nolan-Stevaux, O., et al. (2009). GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 23(1): 24-36. PubMed Citation: 19136624

Noureddine, M. A., et al. (2002). Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase. Dev. Cell 2: 757-770. 12062088

Ogden, S. K., et al. (2006). Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. J. Biol. Chem. 281(11): 7237-43. 16423832

Ogden, S. K., et al. (2008). G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature 456(7224): 967-970. PubMed Citation: 18987629

Ohba, S., et al. (2008). Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev. Cell 14(5): 689-99. PubMed Citation: 18477452

Ohlmeyer, J. T. and Kalderon, D. (1997). Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 11(17): 2250-2258. PubMed Citation: 9303540

Ohlmeyer, J. T. and Kalderon, D. (1998). Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 397(6713): 749-53. PubMed Citation: 9874371

Oro, A. E. and Higgins, K. (2003). Hair cycle regulation of Hedgehog signal reception. Dev. Bio. 255: 238-248. 12648487

Orenic, T. V., et al. (1990). Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev 4: 1053-67. PubMed Citation: 2166702

O’Rourke, M. P., et al. (2002). Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev. Bio. 248: 143-156. 12142027

Ou, C.-Y., Lin, Y.-F. Chen, Y.-J. and Chien, C.-T. (2002). Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 16: 2403-2414. 12231629

Palma, V., and Altaba, A. R. i. (2004). Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex. Development 131: 337-345. 14681189

Pan, H., et al. (2011). A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis. Dev. Biol. 351(1): 120-7. PubMed Citation: 21211521

Pappu, K. S., et al. (2003). Mechanism of hedgehog signaling during Drosophila eye development. Development 130: 3053-3062. 12756186

Park, H. L., et al. (2000). Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127: 1593-1605. PubMed Citation: 10725236

Parker, D. S., White, M. A., Ramos, A. I., Cohen, B. A. and Barolo, S. (2011). The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity. Sci. Signal 4(176): ra38. PubMed Citation: 21653228

Patel, S. R., Kim, D., Levitan, I. and Dressler, G. R. (2007). The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev. Cell 13: 580-592. PubMed Citation: 17925232

Pearse, R. V., et al. (1999). Vertebrate homologs of Drosophila Suppressor of fused interact with the gli family of transcriptional regulators. Dev. Biol. 212(2): 323-36

Perron, M., et al. (2003). A novel function for Hedgehog signalling in retinal pigment epithelium differentiation. Development 130: 1565-1577. 12620982

Persson, M., et al. (2002). Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 16: 2865-2878. 12435629

Piepenburg, O., Vorbruggen, G., Jackle, H. (2000). Drosophila segment borders result from unilateral repression of hedgehog activity by wingless signaling. Mol. Cell 6(1): 203-9. 10949042

Platt, K. A., Michaud, J. and Joyner, A. L. (1997). Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech. Dev. 62 (2): 121-135

Price, M. A. and Kalderon, D. (1999). Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by Protein Kinase A. Development 126: 4331-4339

Price, M. A. and Kalderon, D. (2002). Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 108(6): 823-35. 11955435

Pu, Y., Huang, L. and Prins, G. S. (2004), Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching. Dev. Biol. 273: 257-275. 15328011

Purandare, S. M., et al. (2002). A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice. Development 129: 2293-2302. 11959836

Rallu, M., et al. (2002). Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling Development 129: 4963-4974. 12397105

Ramos, A. I. and Barolo, S. (2013). Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution. Philos Trans R Soc Lond B Biol Sci 368: 20130018. PubMed ID: 24218631

Ranieri, N., Therond, P. P. and Ruel, L. (2014). Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex. Nat Commun 5: 5034. PubMed ID: 25289679

Robbins, D. J., et al. (1997). Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 90(2): 225-234. PubMed ID: 9244297

Rowan, S., Siggers, T., Lachke, S. A., Yue, Y., Bulyk, M. L. and Maas, R. L. (2010). Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes Dev 24: 980-985. PubMed ID: 20413611

Ruel, L., et al. (2007). Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling. Development 134(20): 3677-89. Medline abstract: 17881487

Ruiz i Altaba, A. (1998). Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 125(12): 2203-2212. PubMed Citation: 9584120

Saenz-Robles, M. T., et al. (1995). Selection and characterization of sequences with high affinity for engrailed proteins of Drosophila. Mech. Dev. 53: 185-195

Sasaki, H., et al. (1997). A binding site for Gli proteins is essential for HNF-3ß floor plate enhancer activity in transgenics and can respond to Shh in vitro Development 124, 1313-1322

Sasaki, H., et al. (1999). Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126: 3915-3924

Schlichting, K., Demontis, F. and Dahmann, C. (2005). Cadherin Cad99C is regulated by Hedgehog signaling in Drosophila. Dev. Biol. 279: 142-154. 15708564

Schwartz, C., Locke, J., Nishida, C. and Kornberg, T. B. (1995). Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks. Development 121: 1625-1635

Schweizer, L. and Basler, K. (1998). Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway. Mech. Dev. 78(1-2): 141-151.

Sheng, T., Chi, S., Zhang, X. and Xie, J. (2006). Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal. J. Biol. Chem. 281(1): 9-12. 16293631

Shi, Q., Han, Y. and Jiang, J. (2014). Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapbeta2 in Hedgehog signaling. J Cell Sci 127: 1092-1103. PubMed ID: 24413177

Sisson, B. E., Ziegenhorn, S. L. and Holmgren, R. A. (2006). Regulation of Ci and Su(fu) nuclear import in Drosophila. Dev. Biol. 294(1): 258-70. 16595130

Sisson, J. C., Ho, K. S., Suyama, K. and Scott, M. P. (1997). Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 90(2): 235-245.

Slusarski, D. C., Motzny, C. K. and Holmgren R. (1995). Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster. Genetics 139: 229-240

Smelkinson, M. G. and Kalderon, D. (2006). Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb. Curr. Biol. 16(1): 110-6. 16386907

Smelkinson, M. G., Zhou, Q. and Kalderon. D. (2007). Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation. Dev. Cell 13(4): 481-95. PubMed citation: 17925225

Stamataki, D., et al. (2005). A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev. 19(5): 626-41. 15741323

Starostina, N. G., et al. (2007). A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Dev. Cell 13: 127-139. PubMed citation: 17609115

Stegman, M. A. et al. (2000). Identification of a tetrameric hedgehog signaling complex. J. Biol. Chem. 275: 21809-12

Stone, D. M., et al. (1999). Characterization of the human Suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J. Cell Sci. 112: 4437-4448

Struhl, G., Barbash, D. A. and Lawrence, P. A. (1997). Hedgehog organizes the pattern and polarity of epidermal cells in the Drosophila abdomen. Development 124 (11): 2143-2154

Su, Y., Ospina, J. K., Zhang, J., Michelson, A. P., Schoen, A. M. and Zhu, A. J. (2011). Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal 4: ra43. PubMed ID: 21730325

Sun, J. and Deng, W.-M. (2007). Hindsight mediates the role of Notch in suppressing Hedgehog signaling and cell proliferation. Dev. Cell 12: 431-442. Medline abstract: 17336908

Sun, Y., Jan, L. Y. and Jan, Y. N. (1998). Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system. Development 125: 3731-3740

Svendsen, P. C., et al. (2000). The combgap locus encodes a zinc-finger protein that regulates cubitus interruptusduring limb development in Drosophila melanogaster. Development 127: 4083-4093

Tanimoto, H., et al. (2000). Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Molec. Cell 5: 59-71.

te Welscher, P., et al. (2002). Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. Genes Dev. 16: 421-426. 11850405

Theodosiou, N.A., et al. (1998). slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development. Development 125(17): 3411-3416

Theil, T., et al. (1999). Gli3 is required for Emx gene expression during dorsal telencephalon development. Development 126: 3561-3571.

Tian, L., Holmgren, R. A. and Matouschek, A. (2005). A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-kappaB. Nat. Struct. Mol. Biol. 12(12): 1045-53. 16299518

Tole, S., Ragsdale, C. W. and Grove, E. A. (2000). Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toesJ. Dev. Biol. 217: 254-265. PubMed Citation: 10625551

Tuson, M., He, M. and Anderson, K. V. (2011). Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development 138(22): 4921-30. PubMed Citation: 22007132

Tyurina, O. V., et al. (2005). Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Dev. Biol. 277(2): 537-56. 15617692

Ulloa, F., Itasaki, N. and Briscoe, J. (2007). Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. Curr. Biol. 17(6): 545-50. Medline abstract: 17331723

Usha, N. and Shashidhara, L. S. (2010). Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila. Dev. Biol. 341(2): 389-99. PubMed Citation: 20226779

Van Ohlen, T., et al. (1997a). Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc. Natl. Acad. Sci. 94: 2404-09. PubMed Citation: 9122207

Vervoort, M., Crozatier, M., Valle, D. and Vincent, A. (1999). The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. Curr. Biol. 9(12): 632-9. PubMed Citation: 10375526

Vied, C. and Horabin, J. I. (2001). The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline. Development 128: 2649-2660. 11526072

Vokes, S. A., et al. (2007). Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 134(10): 1977-89. Medline abstract: 17442700

Vokes, S. A., Ji, H., Wong, W. H. and McMahon, A. P. (2008). A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev. 22(19): 2651-63. PubMed Citation: 18832070

von Mering, C. and Basler, K. (1999). Distinct and regulated activities of human Gli proteins in Drosophila. Curr. Biol. 9: 1319-1322

Von Ohlen, T. and Hooper, J. E. (1997b). Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer. Mech. Dev. 68(1-2): 149-156

Von Ohlen, T. and Hooper, J. E. (1999). The ciD mutation encodes a chimeric protein whose activity is regulated by Wingless signaling. Dev. Biol. 208(1): 147-56

Vortkamp, A., Gessler, M. and Grzeschik, K. H. (1995). Identification of optimized target sequences for the GLI3 zinc finger protein. DNA Cell Biol 14: 629-634

Walterhouse, D., et al. (1993). gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development. Dev Dyn 196: 91-102

Wang, B., Fallon, J. F. and Beachy, P. A. (2000) Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100: 423-434

Wang, B. and Li, Y. (2006). Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc. Natl. Acad. Sci. 103(1): 33-8. 16371461

Wang, C., Pan, Y. and Wang, B. (2010). Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development 137(12): 2001-9. PubMed Citation: 20463034

Wang, G., Wang, B. and Jiang, J. (1999). Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev. 13: 2828-2837. PubMed Citation: 10557210

Wang, G., et al. (2000). Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus. Genes Dev. 14: 2893-2905. 11090136

Wang, N., Leung, H. T., Mazalouskas, M. D., Watkins, G. R., Gomez, R. J. and Wadzinski, B. E. (2012). Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster. PLoS One 7: e38569. PubMed ID: 22701670

Wang, Q. T. and Holmgren, R. A. (1999). The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels. Development 126: 5097-5106. PubMed Citation: 10529426

Wang, Q. T. and Holmgren, R. A. (2000). Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development 127: 3131-3139. PubMed Citation: 10862750

Wang, Y. and Price, M. A. (2008). A unique protection signal in Cubitus interruptus prevents its complete proteasomal degradation. Mol. Cell. Biol. 28: 5555-5568. PubMed Citation: 18625727

Wijgerde, M., et al. (2002). A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 16: 2849-2864. 12435628

Willsey, H. R., Zheng, X., Carlos Pastor-Pareja, J., Willsey, A. J., Beachy, P. A. and Xu, T. (2016). Localized JNK signaling regulates organ size during development. Elife 5: e11491. PubMed ID: 26974344

Wolff, C., et al. (2004). iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev. 18: 1565-1576. 15198976

Yamashita, T., Inui, S., Maeda, K., Hua, D. R., Takagi, K., Fukunaga, K. and Sakaguchi, N. (2006). Regulation of CaMKII by alpha4/PP2Ac contributes to learning and memory. Brain Res 1082: 1-10. PubMed ID: 16516168

Yang, C., Chen, W., Chen, Y. and Jiang, J. (2012). Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Res. [Epub ahead of print]. PubMed Citation: 22986504

Yoon, J. W., et al. (1998). GLI activates transcription through a herpes simplex viral protein 16-like activation domain. J. Biol. Chem. 273(6): 3496-3501. PubMed Citation: 9452474

Zhang, Q., et al. (2006). A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev. Cell 10: 719-729. PubMed Citation: 16740475

Zhang, Y. and Kalderon, D. (2001). Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature 410: 599-604. 11279500

Zhang, Y., Fu, L., Qi, X., Zhang, Z., Xia, Y., Jia, J., Jiang, J., Zhao, Y. and Wu, G. (2013). Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 4: 2608. PubMed ID: 24217340

Zhang, Z., Feng, J., Pan, C., Lv, X., Wu, W., Zhou, Z., Liu, F., Zhang, L. and Zhao, Y. (2013). Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. J Cell Biol 203: 575-583. PubMed ID: 24385484

Zhang, Z., Lv, X., Yin, W. C., Zhang, X., Feng, J., Wu, W., Hui, C. C., Zhang, L. and Zhao, Y. (2013). Ter94 ATPase complex targets k11-linked ubiquitinated Ci to proteasomes for partial degradation. Dev Cell 25: 636-644. PubMed ID: 23747190

Zhao, M., et al. (2006). The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol. 26(16): 6197-208. Medline abstract: 16880529

Zhou, Q., Apionishev, S. and Kalderon, D. (2006). The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. Genetics 173(4): 2049-62. 16783001

Zhou, Q. and Kalderon, D. (2010). Costal 2 interactions with Cubitus interruptus (Ci) underlying Hedgehog-regulated Ci processing. Dev. Biol. 348(1): 47-57. PubMed Citation: 20850429

Zhou, Q. and Kalderon, D. (2011). Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev. Cell 20(6): 802-14. PubMed Citation: 21664578

Zhulyn, O., Li, D., Deimling, S., Vakili, N. A., Mo, R., Puviindran, V., Chen, M. H., Chuang, P. T., Hopyan, S. and Hui, C. C. (2014). A switch from low to high shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell 29: 241-249. PubMed ID: 24726283

Zuniga, A, and Zeller, R. (1999). Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity. Development 126(1): 13-21. PubMed Citation: 9834182


cubitus interruptus continued:

Biological Overview | Evolutionary Homologs | Regulation | Targets of Activity | Protein Interactions | Developmental Biology | Effects of Mutation

date revised:  21 November 2016

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.