smoothened


REFERENCES

Aanstad P., et al. (2009). The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Curr. Biol. 19: 1034-1039. PubMed Citation: 19464178

Akiyama-Oda, Y. and Oda, H. (2010). Cell migration that orients the dorsoventral axis is coordinated with anteroposterior patterning mediated by Hedgehog signaling in the early spider embryo. Development 137(8): 1263-73. PubMed Citation: 20332148

Alcedo, J., et al. (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell 86:221-232. PubMed Citation: 8706127

Alcedo, J., Zou, Y. and Noll, M. (2000). Posttranscriptional regulation of Smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Molec. Cell 6: 457-465. 10983991

Balla, A., Tuymetova, G., Tsiomenko, A., Varnai, P., and Balla, T. (2005). A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1. Mol. Biol. Cell 16: 1282-1295. PubMed Citation: 15635101

Bielinski, V. A. and Mumby, M. C. (2007). Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Exp Cell Res 313: 3117-3126. PubMed ID: 17570358

Blair, S. S., Ralston A (1997). Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila. Development 124(20): 4053-4063. PubMed Citation: 9374402

Brown, A. S. and Epstein, D. J. (2011). Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. Development 138(18): 3967-76. PubMed Citation: 21831920

Cai, J., et al. (2005). Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron 45: 41-53. 15629701

Carroll, C. E., et al. (2012). The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation. Development 139: 612-621. PubMed Citation: 22223683

Casso, D. J., et al. (2008). A screen for modifiers of Hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics 178: 1399-1413. PubMed Citation: 18245841

Casso, D. J. Biehs, B. and Kornberg, T. B. (2011). A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing. Genetics 187(2): 485-99. PubMed Citation: 21098717

Charron, F., et al. (2003). The morphogen Sonic hedgehog is an axonal chemoattractant that collaborates with Netrin-1 in midline axon guidance. Cell 113: 11-23. 12679031

Chen, J. K., et al. (2002). Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 16: 2743-2748. 12414725

Chen, W., Burgess, S. and Hopkins, N. (2001). Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity Development 128: 2385-2396. 11493557

Chen, W., et al. (2004). Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 306: 2257-2260. PubMed Citation: 15618519

Chen, Y. and Struhl, G. (1996). Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87: 553-663. PubMed Citation: 8898207

Chen, Y. and Struhl, G. (1998). In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 125: 4943-4948. 9811578

Chen, Y., et al. (2010). G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev. 24(18): 2054-2067. PubMed Citation: 20844016

Claret, S., Sanial, M. and Plessis, A. (2007). Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused. Curr. Biol. 17(15): 1326-33. Medline abstract: 17658259

Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. and Reiter, J. F. (2005). Vertebrate Smoothened functions at the primary cilium. Nature 437(7061): 1018-21. 16136078

Cygnar, K. D., Gao, X., Pan, D. and Neufeld, T. P. (2005). The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila. Genetics 170: 733-740. PubMed ID: 15802506

Denef, N., Neubuser, D., Perez, L. and Cohen, S. M. (2000). Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102(4): 521-31. 10966113

De Rivoyre, M., et al. (2006). Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells. J. Biol. Chem. 281(39): 28584-95. 16867986

Deshpande, G., et al. (2001). Hedgehog signaling in germ cell migration. Cell 106: 759-769. 11572781

Fan, J., Jiang, K., Liu, Y. and Jia, J. (2013). Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling. PLoS One 8: e79021. PubMed ID: 24244405

Friggi-Grelin, F., Lavenant-Staccini, L. and Therond, P. (2009). Control of antagonistic components of the Hedgehog signaling pathway by microRNAs in Drosophila. Genetics 179: 429-439. PubMed Citation: 18493062

Fuccillo, M., Rallu, M., McMahon, A. P. and Fishell, G. (2004). Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development 131: 5031-5040. 15371303

Gorfinkiel, N., Sanchez, L. and Guerrero, I. (1999). Drosophila terminalia as an appendage-like structure. Mech. Dev. 86(1-2): 113-23. 10446270

Greenwood, S. and Struhl, G. (1999). Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway. Development 126: 5795-5808. 10572054

Gritli-Linde, A., et al. (2002). Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129: 5323-5337. 12403705

Hillman, R. T., et al. (2011). Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev. 25(22): 2333-46. PubMed Citation: 22051878

Hooper, J. E. (1994). Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. Nature 372: 461-464. PubMed Citation: 7984239

Hooper, J. E. (2003). Smoothened translates Hedgehog levels into distinct responses. Development 130: 3951-3963. 12874118

Huang, Z. and Kunes, S. (1998). Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly. Development 125: 3753-3764. 9729484

Humke E. W., et al. (2010). The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 24: 670-682. PubMed Citation: 20360384

Incardona, J. P., Gruenberg, J. and Roelink, H. (2002). Sonic hedgehog induces the segregation of Patched and Smoothened in endosomes. Curr. Biol. 12: 983-995. 12123571

Ingham, P. W., et al. (2000). Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. Curr. Biol. 10: 1315-1318. 11069117

Jékely, G. and Rørth, P. (2003). Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO reports 4: 1163-1168. 14608370

Jia, J., Tong, C. and Jiang, J. (2003). Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev. 17: 2709-2720. 14597665

Jia, H., Liu, Y., Yan, W. and Jia, J. (2009). PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 136(2): 307-16. PubMed Citation: 19088085

Jiang, J. and Struhl, G. (1998). Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496. PubMed Citation: 9461217

Khaliullina, H., et al. (2009). Patched regulates Smoothened trafficking using lipoprotein-derived lipids. Development 136(24): 4111-21. PubMed Citation: 19906846

Kong, M., Fox, C. J., Mu, J., Solt, L., Xu, A., Cinalli, R. M., Birnbaum, M. J., Lindsten, T. and Thompson, C. B. (2004). The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science 306: 695-698. PubMed ID: 15499020

Lawrence, P. A., Casal, J. and Struhl, G. (1999). The Hedgehog morphogen and gradients of cell affinity in the abdomen of Drosophila. Development 126: 2441-2449. PubMed Citation: 10226003

Lawrence, P. A., Casal, J. and Struhl, G. (2002). Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen. Development 129: 2749-2760. 12015301

Lim, J. and Choi, K.-W. (2004). Induction and autoregulation of the anti-proneural gene Bar during retinal neurogenesis in Drosophila. Development 131: 5573-5580. 15496446

Lloyd, T. E., Atkinson, R., Wu, M. N., Zhou, Y., Pennetta, G. and Bellen, H. J. (2002). Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108: 261-269. 11832215

Long, F., et al. (2004). Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131(6): 1309-18. 14973297

Lum, L., et al. (2003). Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Molec. Cell 12: 1261-1274. 14636583

Lannutti, B. J. and Schneider, L. E. (2001). Gprk2 controls cAMP levels in Drosophila development. Dev. Biol. 233(1): 174-85. PubMed Citation: 11319866

Lefkowitz, R. J. and Shenoy, S. K. (2005). Transduction of receptor signals by beta-arrestins. Science 308: 512-517. PubMed Citation: 15845844

Li, S., Chen, Y., Shi, Q., Yue, T., Wang, B. and Jiang, J. (2012). Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS Biol 10: e1001239. PubMed ID: 22253574

Machold, R., et al. (2003). Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 39: 937-950. 12971894

Maloverjan A., et al. (2010). Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. Exp. Cell Res. 316: 627-637. PubMed Citation: 19878745

Marigo, V., et al. (1996). Biochemical evidence that Patched is the Hedgehog receptor. Nature 384: 176-179. PubMed Citation: 8906794

Martín, V., et al. (2001). The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking. Curr. Biol. 11: 601-607. 11369205

Massotte, D. and Kieffer, B. L. (2005). The second extracellular loop: a damper for G protein-coupled receptors? Nat. Struct. Mol. Biol. 12: 287-288. PubMed Citation: 15809647

May, S. R., et al. (2005). Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287(2): 378-89. 16229832

Meloni, A. R., et al. (2006). Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol. Cell Biol. 26: 7550-60. PubMed Citation: 16908539

Mich, J. K. and Chen, J. K. (2011). Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish. Development 138(23): 5113-9. PubMed Citation: 22069185

Michel, M., Kupinski, A. P., Raabe, I. and Bõkel, C. (2012). Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche. Development 139(15): 2663-9. PubMed Citation: 22745310

Molnar, C., et al. (2007). The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc. Natl. Acad. Sci. 104(19): 7963-8. PubMed Citation: 17483466

Molnar, C., Ruiz-Gómez, A., Martín, M., Rojo-Berciano, S., Mayor, F. and de Celis, J. F. (2011). Role of the Drosophila non-visual β-arrestin kurtz in hedgehog signalling. PLoS Genet. 7(3): e1001335. PubMed Citation: 21437272

Moraes, R. C., et al. (2007). Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia. Development 134(6): 1231-42. Medline abstract: 17287253

Murone, M., Rosenthal, A. and de Sauvage, F. J. (1999). Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr. Biol. 9(2): 76-84. PubMed Citation: 10021362

Nachtergaele, S., Whalen, D. M., Mydock, L. K., Zhao, Z., Malinauskas, T., Krishnan, K., Ingham, P. W., Covey, D. F., Siebold, C. and Rohatgi, R. (2013). Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife 2: e01340. PubMed ID: 24171105

Nakano, Y., Nystedt, S., Shivdasani, A. A., Strutt, H., Thomas, C. and Ingham, P. W. (2004). Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila. Mech. Dev. 121(6) :507-18. 15172682

Nybakken, K., et al. (2005). A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat. Genet. 37: 1323-1332. PubMed Citation: 16311596

Ogden, S. K., et al. (2003). Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr. Biol. 13: 1998-2003. 14614827

Ogden, S. K., et al. (2006). Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. J. Biol. Chem. 281(11): 7237-43. 16423832

Ogden, S. K., et al. (2008). G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature 456(7224): 967-970. PubMed Citation: 18987629

Ohlmeyer, J. T. and Kalderon, D. (1997). Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 11(17): 2250-2258. PubMed Citation: 9303540

Peppel, K., Boekhoff, I., McDonald, P., Breer, H., Caron, M. G., and Lefkowitz, R. J. (1997). G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J. Biol. Chem. 272: 25425-25428. PubMed Citation: 9325250

Perron, M., et al. (2003). A novel function for Hedgehog signalling in retinal pigment epithelium differentiation. Development 130: 1565-1577. 12620982

Raisin, S., et al. (2010). Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling. Dev. Biol. 344: 119-128. PubMed Citation: 20435030

Rana, R., Carroll, C. E., Lee, H. J., Bao, J., Marada, S., Grace, C. R., Guibao, C. D., Ogden, S. K. and Zheng, J. J. (2013). Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. Nat Commun 4: 2965. PubMed ID: 24351982

Reifenberger, J., et al. (1998). Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res, 58(9): 1798-803. PubMed Citation: 9581815

Rodriguez, I. and Basler, K. (1997). Control of compartmental affinity boundaries by Hedgehog. Nature 389(6651): 614-618. PubMed Citation: 9335503

Rohatgi, R., Milenkovic, L. and Scott, M. P. (2007). Patched1 regulates hedgehog signaling at the primary cilium. Science 317(5836): 372-6. Medline abstract: 17641202

Ruel, L., et al. (2007). Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling. Development 134(20): 3677-89. Medline abstract: 17881487

Shi, Q., Li, S., Jia, J. and Jiang, J. (2011). The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. Development 138(19): 4219-31. PubMed Citation: 21852395

Shyamala, B. V. and Bhat, K. M. (2002). A positive role for Patched-Smoothened signaling in promoting cell proliferation during normal head development in Drosophila. Development 129: 1839-1847. 11934850

Schneider, L. E. and Spradling, A. C. (1997). The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis. Development 124(13): 2591-602. PubMed Citation: 9217001

Skwarek, L. C. and Boulianne, G. L. (2009). Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease. Dev. Cell 16(1): 12-20. PubMed Citation: 19154715

Stenkamp, D. L. and Frey, R. A. (2003). Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafish. Dev. Biol. 258: 349-363. 12798293

Stone, D. M., et al. (1996). The tumor-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-34. PubMed Citation: 8906787

Struhl, G., Barbash, D. A. and Lawrence, P. A. (1997a). Hedgehog organizes the pattern and polarity of epidermal cells in the Drosophila abdomen. Development 124 (11): 2143-2154. PubMed Citation: 9187141

Struhl, G., Barbash, D. A. and Lawrence, P. A. (1997b). Hedgehog acts by distinct gradient and signal relay mechanisms to organize cell type and cell polarity in the Drosophila abdomen. Development 124 (11): 2155-2165. PubMed Citation: 9187142

Strutt, D. I. and Mlodzik, M. (1997). Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc. Development 124(17): 3233-3240. PubMed Citation: 9310318

Strutt, H., et al. (2001). Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Curr. Biol. Vol 11: 608-613. 11369206

Su, Y., Ospina, J. K., Zhang, J., Michelson, A. P., Schoen, A. M. and Zhu, A. J. (2011). Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal 4: ra43. PubMed ID: 21730325

Taipale, J., et al. (2000). Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406: 1005-1009. PubMed Citation: 10984056

Taipale, J., Cooper, M. K., Maiti, T., and Beachy, P. A. (2002). Patched acts catalytically to suppress the activity of Smoothened. Nature 418: 892-896. 12192414

Tanoue, S., Krishnan, P., Chatterjee, A. and Hardin, P. E. (2008). G protein-coupled receptor kinase 2 is required for rhythmic olfactory responses in Drosophila. Curr. Biol. 18(11): 787-94. PubMed Citation: 18499458

Theodosiou, N.A., et al. (1998). slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development. Development 125(17): 3411-3416. PubMed Citation: 9693144

Tukachinsky, H., Lopez L. V. and Salic, A. (2010). A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J. Cell Biol. 191: 415-428. PubMed Citation: 20956384

van den Heuvel, M. and Ingham, P. W. (1996). smoothened encodes a receptor-like serpentine protein reuired for hedgehog signalling. Nature 382: 547-551. PubMed Citation: 8700230

Varga, Z. M., et al. (2001). Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development 128: 3497-3509. 11566855

Varjosalo, M., Li, S. P. and Taipale, J. (2006). Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev. Cell. 10(2): 177-86. 16459297

Végh, M. and Basler, K. (2003). A genetic screen for hedgehog targets involved in the maintenance of the Drosophila anteroposterior compartment boundary. Genetics 163: 1427-1438. 12702686

Vrailas, A. D. and Moses, K. (2006a). smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye. Mech. Dev. 123(2): 151-65. 16412615

Vrailas, A. D., et al. (2006b). smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye. Development 133(8): 1485-94. 16540506

Wang, N., Leung, H. T., Mazalouskas, M. D., Watkins, G. R., Gomez, R. J. and Wadzinski, B. E. (2012). Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster. PLoS One 7: e38569. PubMed ID: 22701670

Wijgerde, M., et al. (2002). A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 16: 2849-2864. 12435628

Wong, K., Meyers, R., and Cantley, L.C. (1997). Subcellular locations of phosphatidylinositol 4-kinase isoforms. J. Biol. Chem. 272: 13236-13241. PubMed Citation: 9148941

Xie, J., et al. (1998). Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391(6662): 90-92. PubMed Citation: 9422511

Yamashita, T., Inui, S., Maeda, K., Hua, D. R., Takagi, K., Fukunaga, K. and Sakaguchi, N. (2006). Regulation of CaMKII by alpha4/PP2Ac contributes to learning and memory. Brain Res 1082: 1-10. PubMed ID: 16516168

Yang, C., Chen, W., Chen, Y. and Jiang, J. (2012). Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Res. [Epub ahead of print]. PubMed Citation: 22986504

Yang, X., Mao, F., Lv, X., Zhang, Z., Fu, L., Lu, Y., Wu, W., Zhou, Z., Zhang, L. and Zhao, Y. (2013). Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. J Cell Sci 126: 4230-4238. PubMed ID: 23843610

Yavari, A., et al. (2010). Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev. Cell 19(1): 54-65. PubMed Citation: 20643350

Zhang, J., et al. (2001). Downregulation of hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev. Biol. 229: 188-202. 11133163

Zhang, X. M., et al. (2001). Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell 105: 781-792. 11440720

Zhang, Y. and Kalderon, D. (2000). Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling. Development 127: 2165-2176. 10769240

Zhang, Y. and Kalderon, D. (2001). Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature 410: 599-604. 11279500

Zhao, L., Saitsu, H., Sun, X., Shiota, K. and Ishibashi, M. (2010). Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain. Mech. Dev. 127(1-2): 62-72. PubMed Citation: 19854269

Zhou, Q. and Kalderon, D. (2011). Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev. Cell 20: 802-814. PubMed Citation: 21664578

Zhao, Y., Tong, C. and Jiang, J. (2007). Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 450(7167): 252-8. PubMed citation: 17960137

Zhou, Q., Apionishev, S. and Kalderon, D. (2006). The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. Genetics 173(4): 2049-62. 16783001

Zhou, Q. and Kalderon, D. (2011). Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev. Cell 20(6): 802-14. PubMed Citation: 21664578

Zhu, A. J., Zheng, L., Suyama, K. and Scott, M. P. (2003). Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev. 17: 1240-1252. 12730121


smoothened: Biological Overview |Evolutionary homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 10 February 2014

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