Retinoblastoma-family protein


REFERENCES

Acharya, P., et al. (2010). Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins. Mol. Biol. Cell 21(22): 3890-901. PubMed Citation: 20861300

Adams, P. D., et al. (1999). Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Mol. Cell. Biol. 19(2): 1068-80. PubMed Citation: 9891042

Alevizopoulos, K, et al. (1997). Cyclin E and c-Myc promote cell proliferation in the presence of p16(INK4a) and of hypophosphorylated retinoblastoma family proteins. EMBO J. 16(17): 5322-5333. PubMed Citation: 9311992

Andersen, E. C., Lu. X. and Horvitz, H. R. (2006). C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. Development 133(14): 2695-704. 16774993

Astigarraga, S., (2007). A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J. 26(3): 668-77. PubMed ID: 17255944

Avni, D., et al. (2003). Active localization of the Retinoblastoma protein in chromatin and its response to S phase DNA damage. Molec. Cell 12: 735-746. 14527418

Baldi, A., et al. (1996). Genomic structure of the human retinoblastoma-related Rb2/p130 gene. Proc. Natl. Acad. Sci. 93: 4629-4632. PubMed Citation: 8643454

Bang, O. S., et al. (1996). Transforming growth factor-beta1 modulates p107 function in myeloid cells: correlation with cell cycle progression. J. Biol. Chem. 271: 7811-7819. PubMed Citation: 8631825

Batsche E., et al. (1998). RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol. Cell. Biol. 18(7): 3647-3658. PubMed Citation: 9632747

Bender, A. M., Wells, O. and Fay, D. S. (2004). lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans. Dev. Biol. 273: 335-349. 15328017

Bosco, G., Du, W. and Orr-Weaver, T. L. (2001). DNA replication control through interaction of E2F-RB and the origin recognition complex. Nature Cell Biol. 3: 289-295. 11231579

Bourachot, B., Yaniv, M. and Muchardt, C. (1999). The activity of mammalian brm/SNF2alpha is dependent on a high-mobility-group protein I/Y-like DNA binding domain. Mol. Cell. Biol. 19: 3931-3939. PubMed Citation: 10330133

Boxem, M. and van den Heuvel, S. (2001). lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans. Development 128: 4349-4359. 11684669

Brehm, A., et al. (1998). Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391(6667): 597-601. PubMed Citation: 9468139

Brumby, A. M., et al. (2002). Drosophila cyclin E interacts with components of the Brahma complex. EMBO J. 21: 3377-3389. 12093739

Callaghan, D. A., et al. (1999), Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity. Dev. Biol. 207(2): 257-70. PubMed Citation: 10068462

Cam, H., et al. (2003). A common set of gene regulatory networks links metabolism and growth inhibition. Mol. Cell 16(3): 399-411. 15525513

Cardoso, C., et al. (2005). XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans. Dev. Biol. 278(1): 49-59. 15649460

Carnac, et al. (2000). The retinoblastoma-like protein p130 is involved in the determination of reserve cells in differentiating myoblasts. Curr. Biol. 10: 543-546. PubMed ID: 10801445

Castano, E., Kleyner, Y. and Dynlacht, B. D. (1998). Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor. Mol. Cell. Biol. 18(9): 5380-91. PubMed Citation: 9710622

Chang, K. H., et al. (1997). A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. 94(17): 9040-9045. PubMed Citation: 9256431

Chen, P.-L., et al. (1996). Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10: 2794-2804. PubMed Citation: 8946919

Chen, X., Lu, C., Prado, J. R., Eun, S. H. and Fuller, M. T. (2011). Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. Development 138(12): 2441-50. PubMed Citation: 21610025

Chen, Z. and Han, M. (2001). C. elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification. Curr. Biol. 11: 1874-1879. 11728311

Chien, Y., et al. (2011). Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity. Genes Dev. 25(20): 2125-36. PubMed Citation: 21979375

Chu, W. M., et al. (1997). RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2. J. Biol. Chem. 272(23): 14755-14761. PubMed Citation: 9169441

Clavier, A., Baillet, A., Rincheval-Arnold, A., Coleno-Costes, A., Lasbleiz, C., Mignotte, B. and Guenal, I. (2014). The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA. Cell Death Dis 5: e1405. PubMed ID: 25188515

Coats, S., et al. (1999). A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells. Curr. Biol. 9(4): 163-73. PubMed Citation: 10074425

Conkrite, K., et al. (2011). miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. Genes Dev. 25(16): 1734-45. PubMed Citation: 21816922

Coschi, C. H., et al. (2009). Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev. 24(13): 1351-63. PubMed Citation: 20551166

Corbeil, H. B. and Branton, P. E. (1997). Characterization of an E2F-p130 complex formed during growth arrest. Oncogene 15(6): 657-668. PubMed Citation: 9264406

Cui, M., Fay, D. S. and Han, M. (2004), lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development. Genetics 167(3): 1177-85. 15280233

Dahiya, A., et al. (2001). Linking the Rb and Polycomb pathways. Mol. Cell 8: 557-568. 11583618

Davidson, J. M. and Duronio, R. J. (2012). S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues. PLoS Genet. 8(8): e1002831. PubMed Citation: 22916021

Duman-Scheel, M., et al. (2002). Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417: 299-304. 12015606

Dannenberg, J.-H., et al. (2000). Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 14: 3051-3064. 11114893

Dannenberg, J.-H., et al. (2004). Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev. 18: 2952-2962. 15574596

Dasgupta, B. and Milbrandt, J. (2009). AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev. Cell 16(2): 256-70. PubMed Citation: 19217427

Datar, S. A., et al. (2000) The Drosophila Cyclin D-Cdk4 complex promotes cellular growth. EMBO J. 19: 4543-4554. PubMed Citation: 10970848

de Nooij, J. C., Letendre, M. A. and Hariharan, I. K. (1996). A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell 87: 1237-47. PubMed Citation: 8980230

Deverman, B. E., et al. (2002). Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 111: 51-62. 12372300

Dick, F. A. and Dyson, N. (2003). pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Molec. Cell 12: 639-649. 14527410

Dimova, D. K., Stevaux, O., Frolov, M. V. and Dyson, N. J. (2003). Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev. 17: 2308-2320. 12975318

Dimri, G. P., et al. (1997). Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol. Cell. Biol. 16: 2987-2997. PubMed Citation: 8649410

Divecha, N., et al. (2002). Type I PIPkinases interact with and are regulated by the retinoblastoma susceptibility gene product -- pRB. Curr. Biol. 12: 582-587. 11937028

Du, W., et al. (1996a). RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10: 1206-1218. PubMed Citation: 8675008

Du, W., Xie, J.-E., and Dyson, N. (1996b). Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15: 3684-92. PubMed Citation: 8670872

Du, W. (2000). Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development 127: 367-379. PubMed Citation: 10603353

Duman-Scheel, M., Johnston, L. A. and Du, W. (2004). Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc. Natl. Acad. Sci. 101(11): 3857-62. 15001704

Dunaief, J. L.,et al. (1994). The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79: 119-130

Eberhard, D. and Busslinger, M. (1999). The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins. Cancer Res. 59: S1716-S1725. 10197586

Edgar, K. A., et al. (2005). Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene. Genetics 170: 161-171. 15744054

Ezhevsky, S. A., et al. (1997). Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc. Natl. Acad. Sci. 94(20): 10699-10704

Fajas, L., et al. (2002a). E2Fs regulate adipocyte differentiation. Dev. Cell 3: 39-49. 12110166

Fajas, L., et al. (2002b). The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev. Cell 3: 903-910. 12479814

Fay, D. S., Keenan, S. and Han, M. (2002). fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev. 16: 503-517. 11850412

Fay, D. S., Large, E., Han, M. and Darland, M. (2003). lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans. Development 130: 3319-3330. 12783801

Ferguson, K. L., et al. (2002). Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J. 21: 3337-3346. 12093735

Ferres-Marco, D., et al. (2006). Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature 439(7075): 430-6. 16437107

Firth, L. C. and Baker, N. E. (2005). Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8(4): 541-51. 15809036

Gagrica, S., Hauser, S., Kolfschoten, I., Osterloh, L., Agami, R. and Gaubatz, S. (2004). Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. EMBO J. 23: 4627-4638. Medline abstract: 15538385

Garbe, D., Doto, J. B. and Sundaram, M. V. (2004). Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8. Genetics 167(2): 663-72. 15238519

Geng, Y., et al. (1996). Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 12: 1173-1180

Gilde, J. J., Lopez, R. and Shearn, A. (2000). A screen for new Trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics 156: 645-663

Grinstein, E., et al. (2006). Cell cycle-controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation. J. Biol. Chem. 281(31): 22223-35. Medline abstract: 16698799

Gu, W., Schneider, J. W., Condorelli, G., Kaushal, S., Mahdavi, V. and Nadal-Ginard, B. (1993). Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72: 309-324. 8381715

Gupta, S., et al. (2003). Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription. J. Cell Physiol. 196(3): 541-56. 12891711

Harbour, J. W., et al. (1999). Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98(6): 859-69

Harrington, E. A., et al. (1998). pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc. Natl. Acad. Sci. 95(20): 11945-50

Harrison, M. M., Ceol, C. J., Lu, X. and Horvitz, H. R. (2006). Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. 103(45): 16782-7. Medline abstract: 17075059

Hateboer, G., et al. (1996). Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev. 10: 2960-2970

Hateboer G., et al., (1998). Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol. Cell. Biol. 18(11): 6679-97

Hauser, P. J., et al. (1997). p107 and p130 associated cyclin A has altered substrate specificity. J. Biol. Chem. 272(36): 22954-22959

Hériché, J. K., et al. (2003). Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 4 (1): 9. 12787468

Herz, H. M., et al. (2010). The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol. Cell. Biol. 30(10): 2485-97. PubMed Citation: 20212086

Hirano, T. (2005). Condensins: organizing and segregating the genome. Curr. Biol. 15: R265-R275. PubMed ID: 15823530

Hiromura, M., et al. (2003). YY1 is regulated by O-linked N-acetylglucosaminylation (O-glcNAcylation). J. Biol. Chem. 278(16): 14046-52. 12588874

Hofmann, F., et al. (1996). The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev. 10: 2949-2959

Hsieh, J. K., et al. (1997). E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11(14): 1840-1852

Humbert, P. O., et al. (2000). E2F4 is essential for normal erythrocyte maturation and neonatal viability. Molec. Cell 6: 281-291

Hurford, R. K. et al. (1997). pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11(11): 1447-1463

Iakova, P., Awad, S. S., and Timchenko, N. A. (2003). Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Cell 113: 495-506. 12757710

Jiang, Z., et al. (2000). E2F1 and p53 are dispensable, whereas p21 Waf1/Cip1 cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis. Dev. Bio. 227: 28-41.

Kato, J-y., et al. (1993). Direct binding of cyclin D to the tetinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7: 331-342

Kim, H.-Y., Ahn, B.-Y. and Cho, Y. (2001). Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen. EMBO J. 20: 295-304. 11226179

Kim, T. A., et al. (1998). NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. J. Cell Biol. 141(3): 553-566

Kim, T. H., Goodman, J., Anderson, K. V., Niswander, L. (2007). Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev. Cell 13(1): 87-102. PubMed citation: 17609112

Klose, R, J,, et al. (2007). The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 128(5): 889-900. PubMed citation: 17320163

Knudsen, E. S. and Wang, J. Y. (1996). Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J. Biol. Chem. 271: 8313-8320. PubMed ID: 8626527

Knudsen, E. S. and Wang, J. Y. (1997). Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol.17(10): 5771-5783. PubMed ID: 9315635

Knudsen, E. S., et al. (1998). Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev. 12(15): 2278-2292. PubMed ID: 9694794

Kobayashi, M., Yamauchi, Y. and Tanaka, A. (1998). Stable expression of antisense Rb-1 RNA inhibits terminal differentiation of mouse myoblast C2 cells. Exp. Cell Res. 239(1): 40-49. PubMed ID: 9511723

Korenjak, M., et al. (2004). Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell 119(2): 181-93. Medline abstract: 15479636

Korenjak, M., Anderssen, E., Ramaswamy, S., Whetstine, J. R. and Dyson, N. J. (2012). RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Mol Cell Biol 32: 4375-4387. PubMed ID: 22927638

Kotake, Y., et al. (2007). pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene. Genes Dev. 21: 49-54. Medline abstract: 17210787

Krivy, K., Bradley-Gill, M. R. and Moon, N. S. (2013). Capicua regulates proliferation and survival of RB-deficient cells in Drosophila. Biol Open 2: 183-190. PubMed ID: 23429853

Kuzin, B., et al. (2000). Nitric oxide interacts with the retinoblastoma pathway to control eye development in Drosophila. Curr. Biol 10: 459-462. PubMed ID: 10801421

Lee, H., Ragusano, L., Martinez, A., Gill, J. and Dimova, D. K. (2012). A dual role for the dREAM/MMB complex in the regulation of differentiation-specific E2F/RB target genes. Mol. Cell Biol. 32(11): 2110-20. PubMed Citation: 22451490

Lee, K. Y., et al. (1997). Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein. J. Biol. Chem. 272(9): 5622-6

Lemercier, C., et al. (2000). Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression. Mol. Cell Biol. 20(18): 6627-37.

Leng, X., et al. (1997). S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation. Curr. Biol. 7(9): 709-712

Leopold, P. and O'Farrell, P. H. (1991). An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell 66: 1207-1216. 1833067

Lew, D. J., Dulic, V. and Reed, S. I. (1991). Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66: 1197-1206. 1833066

Lewis, P. W., et al. (2004). Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev. 18: 2929-2940. 15545624

Lewis, P. W., Sahoo, D., Geng, C., Bell, M., Lipsick, J. S. and Botchan, M. R. (2012). Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex. Mol Cell Biol 32: 3218-3227. PubMed ID: 22688510

Linke, S. P., et al. (1997). p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression. Oncogene 15(3): 337-345

Lipinski, M. M., et al. (2001). Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system. EMBO J. 20: 3402-3413. 11432828

Liu, D. X., et al. (2005). Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev. 19: 719-732. 15769944

Liu, X. and Marmorstein, R. (2007). Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. Genes Dev. 21(21): 2711-6. PubMed citation: 17974914

Longworth, M. S., Herr, A., Ji, J. Y. and Dyson, N. J. (2008). RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev 22: 1011-1024. PubMed ID: 18367646

Longworth, M. S. and Dyson, N. J. (2010). pRb, a local chromatin organizer with global possibilities. Chromosoma 119: 1-11. PubMed ID: 19714354

Longworth, M. S., Walker, J. A., Anderssen, E., Moon, N. S., Gladden, A., Heck, M. M., Ramaswamy, S. and Dyson, N. J. (2012). A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity. PLoS Genet 8: e1002618. PubMed ID: 22496667

Lu, X. and Horvitz, R. (1998). lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell 95: 981-991

Lukas, J., et al. (1997). Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev. 11(11): 1479-1492

Luo, R. X., Postigo, A. A. and Dean, D. C. (1998). Rb interacts with histone deacetylase to repress transcription. Cell 92: 463-473

Lundberg, A. S. and Weinberg, R. A. (1998). Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18(2): 753-761

MacPherson, D., et al. (2004). Cell type-specific effects of Rb deletion in the murine retina. Genes Dev. 18: 1681-1694. 15231717

Magnaghi-Jaulin, L., et al. (1998). Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391(6667): 601-605

Manning, A. L., Longworth, M. S. and Dyson, N. J. (2010). Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev. 24(13): 1364-76. PubMed Citation: 20551165

Mantela, J., et al. (2005). The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development 132: 2377-2388. 15843406

Marino, S., et al. (2003). Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence. Development 130: 3359-3368. 12810584

Martelli, F. and Livingston, D. M. (1999). Regulation of endogenous E2F1 stability by the retinoblastoma family proteins. Proc. Natl. Acad. Sci. 96(6): 2858-63

Matsui, T., Nieto-Estevez, V., Kyrychenko, S., Schneider, J. W. and Hsieh, J. (2017). RB controls growth, survival, and neuronal migration in human cerebral organoids. Development 144(6):1025-1034. PubMed ID: 28087635

McCaffery, P., et al. (1999). Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. Mech. Dev. 82(1-2): 119-130

Meloni, A. R., Smith, E. J. and Nevins, J. R. (1999). A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc. Natl. Acad. Sci. 96: 9574-9579

Meyer, C. A., et al. (2000). Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 19: 4533-4542

Milet, C., Rincheval-Arnold, A., Morieras, A., Clavier, A., Garrigue, A., Mignotte, B. and Guenal, I. (2014). Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis. PLoS One 9: e102902. PubMed ID: 25089524

Moberg, K., Starz, M. A. and Lees, J. A. (1996). E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol. 16: 1436-1449

Moon, N. S., Di Stefano, L. and Dyson, N. (2006). A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol. Cell Biol. 26(20): 7601-15. Medline abstract: 16954388

Murphy, D. J. Hardy, S. and Engel, D. A. (1999). Human SWI-SNF component BRG1 represses transcription of the c-fos gene. Mol. Cell. Biol. 19: 2724-2733

Narita, M., et al. (2003). Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113: 703-716. 12809602

Nasmyth, K. and Haering, C. H. (2005). The structure and function of SMC and kleisin complexes. Annu Rev Biochem 74: 595-648. PubMed ID: 15952899

Nead, N. A., et al. (1998). Rb binds c-Jun and activates transcription. EMBO J. 17: 2342-2352

Nicolay, B. N., et al. (2011). Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. Genes Dev. 25(4): 323-35. PubMed Citation: 21325133

Niculescu, A. B., et al. (1998). Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol. 18(1): 629-643.

Nielsen, S. J., et al. (2001). Rb targets histone H3 methylation and HP1 to promoters. Nature 412: 561-565. 11484059

Ono, T., Fang, Y., Spector, D. L. and Hirano, T. (2004). Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. Mol Biol Cell 15: 3296-3308. PubMed ID: 15146063

Otterson, G. A., et al. (1997). Incomplete penetrance of familial retinoblastoma linked to germ-line mutations that result in partial loss of RB function. Proc. Natl. Acad. Sci. 94(22): 12036-12040

Papadimou, E., et al. (2005). Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage. EMBO J. 24: 1750-1761. 15861132

Park, M. S., et al. (1999). p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice. Proc. Natl. Acad. Sci. 96(11):6382-7

Pasder, O., et al. (2006). Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene 25(30): 4194-206. 16732323

Peeper, D. S., et al. (1997). Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 386: 177-181

Pelletier, G., et al. (2000). Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. Mol. Cell 6: 1059-1066.

Porrello, A., et al. (2000). p53 regulates myogenesis by triggering the differentiation activity of pRb. J. Cell Biol. 151(6): 1295-304. 11121443

Pradhan, S., and Kim, G.-D. (2002). The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity. EMBO J. 21: 779-788. 11847125

Raj, N., Zhang, L., Wei, Y., Arnosti, D. N. and Henry, R. W. (2012). Rbf1 degron dysfunction enhances cellular DNA replication. Cell Cycle 11: 3731-3738. PubMed ID: 22895052

Reddien, P. W., Andersen, E. C., Huang, M. C. and Horvitz, H. R. (2007). DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics 175(4): 1719-33. PubMed citation: 17237514

Ren, S. and Rollins, B. J. (2004). Cyclin C/Cdk3 promotes Rb-dependent G0 exit. Cell 117: 239-251. 15084261

Reyes, J. C., et al. (1998). Altered control of cellular proliferation in the absence of mammalian brahma (SNF2). EMBO J. 17: 6979-6991

Ribeiro, P. S., et al. (2010). Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Mol. Cell 39: 521-534. PubMed Citation: 20797625

Riley, D. J., Liu, C. Y. and Lee, W. H. (1997). Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression. Mol. Cell. Biol. 17(12): 7342-7352

Robanus-Maandag, E., et al. (1998). p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 12(11): 1599-1609

Rohde, M., et al. (1996). The retinoblastoma protein modulates expression of genes coding for diverse classes of proteins including components of the extracellular matrix. Oncogene 12: 2393-2401

Rossi, F., et al. (2002). p107 and p130 coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development. Dev. Bio. 247: 271-285. 12086466

Ruiz, S., et al. (2004). Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development 131: 2737-2748. 15148303

Sage, J., et al. (2000). Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization. Genes Dev. 14: 3037-3050. 11114892

Sage, J., et al. (2003). Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424(6945): 223-8. 12853964

Sala, A., et al. (1997). B-myb promotes S phase and is a downstream target of the negative regulator p107 in human cells. J. Biol. Chem. 271: 9363-9367

Savvidou, E., Cobbe, N., Steffensen, S., Cotterill, S. and Heck, M. M. (2005). Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids. J Cell Sci 118: 2529-2543. PubMed ID: 15923665

Sawado, T., et al. (1998). dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 251(2): 409-15

Schertel, C. and Conradt, B. (2007). C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development 134(20): 3691-701. PubMed citation: 17881492

Schulze, A., et al. (1994). Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1. Oncogene 9: 3475-82

Shao, Z., et al. (1997). Rb interacts with TAF(II)250/TFIID through multiple domains. Oncogene 15(4): 385-392

Sherr, C. J. (1993). Mammalian G1 cyclins. Cell 73: 1059-1065

Shih, H. H., Tevosian, S. G. and Yee, A. S. (1998). Regulation of differentiation by HBP1, a target of the retinoblastoma protein. Mol. Cell. Biol. 18: 4732-4743. 9671483

Siegert, J. L. and Robbins, P. D. (1999). Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250. Mol. Cell. Biol. 19(1): 846-54

Singh, P., Coe, J. and Hong, W. (1995). A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. Nature 374: 562-565. 7700385

Sowa, Y., et al. (1997). Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. Cancer Res. 57(15): 3145-3148

Starostik, P., Chow, K. N. and Dean, D. C. (1996). Transcriptional repression and growth suppression by the p107 pocket protein. Mol. Cell. Biol. 16: 3606-3614.

Stevaux, O., et al. (2002). Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. EMBO J. 21: 4927-4937. 12234932

Stevaux, O., Dimova, D., Ji, J.-Y., Moon, N. S., Frolov, M. and Dyson, N. (2005). Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Cell Cycle 4: 1272-1280. Medline abstract: 16082225

Strober, B. E., et al. (1996). Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins. Mol. Cell. Biol. 16: 1576-1583

Svoboda, D. S., Paquin, A., Park, D. S. and Slack, R. S. (2013). Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis. Dev Biol 384: 101-113. PubMed ID: 24056077

Tevosian, S. G., et al. (1997). HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev. 11: 383-396

Thomas, D. M., et al. (2001). The Retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Molec. Cell 8: 303-316. 11545733

Thomas, J. H., et al. (2003). New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans. Genetics 164: 135-151. 12750327

Truscott, M., Islam, A. B., Lightfoot, J., Lopez-Bigas, N. and Frolov, M. V. (2014). An intronic microRNA links Rb/E2F and EGFR signaling. PLoS Genet 10: e1004493. PubMed ID: 25058496

Tsai, K. Y., et al. (1998). Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2(3): 293-304. PubMed Citation: 9774968

Tsai, K. Y., et al. (1999). Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2(3): 293-304. PubMed Citation: 9774968

Tschöp, K., et al. (2011). A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev. 25(8): 814-30. PubMed Citation: 21498571

Uchida, C., et al. (2005). Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J. 24(1): 160-9. 15577944

Ullah, Z., Buckley, M. S., Arnosti, D. N. and Henry, R. W. (2007). Retinoblastoma protein regulation by the COP9 signalosome. Mol. Biol. Cell 18(4): 1179-86. PubMed Citation: 17251548

Umen, J. G. and Goodenough, U. W. (2001). Control of cell division by a retinoblastoma protein homolog in Chlamydomonas. Genes Dev. 15: 1652-1661. 11445540

Vale-Cruz, D. S., et al. (2008). Activating transcription factor-2 affects skeletal growth by modulating pRb gene expression. Mech. Dev. 125: 843-856. PubMed Citation: 18638549

van Gurp, M. F., et al. (1999). The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A. Cancer Res. 59(23): 5980-8. 10606245

van Harn, T., et al. (2010). Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling. Genes Dev. 24(13): 1377-88. PubMed Citation: 20551164

Veal E., et al. (1998). A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. Mol. Cell. Biol. 18(9): 5032-41

Vernier M, et al. (2011). Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev. 25(1): 41-50. PubMed Citation: 21205865

Verona, R., et al. (1997). E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol. Cell. Biol. 17(12): 7268-7282

Versteege, I., Medjkane, S., Rouillard, D. and Delattre O. (2002). A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle. Oncogene 21: 6403-6412. 12226744

Voit, R., Schafer, K. and Grummt, I. (1997). Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein. Mol. Cell. Biol. 17(8): 4230-4237

Voit, R., Schafer, K. and Grummt, I. (1997). Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein. Mol. Cell. Biol. 17(8): 4230-7

Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E. and Orkin, S. H. (2007). Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 129(6): 1081-95. PubMed citation: 17574022

Wang, S., et al. (1999). Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. EMBO J. 18(6): 1559-1570

Wartiovaara, K., et al. (2002). N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J. Neurosci. 22(3): 815-824. 11826111

Weng, Li., Zhu, C., Xu, J. and Du, W. (2003). Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J. 22: 3865-3875. 12881421

Wenzel, P. L., et al. (2007). Rb is critical in a mammalian tissue stem cell population. Genes Dev. 21: 85-97. Medline abstract: 17210791

Whitaker, L. L., et al. (1998). Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket. Mol. Cell. Biol. 18(7): 4032-4042

White, R. J., et al. (1996). Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature 382: 88-90

White, J., Stead, E., Faast, R., Conn, S., Cartwright, P. and Dalton, S. (2005). Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol. Biol. Cell 16: 2018-2027. Medline abstract: 15703208

Wiggan, O., Taniguchi-Sidle, A. and Hamel, P. A. (1998). Interaction of the pRB-family proteins with factors containing paired-like homeodomains. Oncogene 16(2): 227-36

Wikenheiser-Brokamp, K. A. (2004). Rb family proteins differentially regulate distinct cell lineages during epithelial development. Development 131: 4299-4310. 15294860

Woo, M. S., Sanchez, I. and Dynlacht, B. D. (1997). p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity. Mol. Cell. Biol. (7): 3566-3579

Wu, L., de Bruin, A., Saavedra, H. I., Starovic, M., Trimboli, A., Yang, Y., Opavska, J., Wilson, P., Thompson, J. C., Ostrowski, M. C. et al. (2003). Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421: 942-947. Medline abstract: 12607001

Xiao, Z. X., et al. (1996). Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. 93: 4633-4637

Xin, S., Weng, L., Xu, J. and Du, W. (2002). The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development 129: 1345-1356. 11880344

Yang, H.-S. and Hinds, P. W. (2003). Increased Ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. Molec. Cell 11: 1163-1176. 12769842

Yuan, S. S., et al. (1999). Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev. Biol. 207(1): 62-75

Zacksenhaus, E., et al. (1996). pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 10: 3051-3064

Zarkowska, T. and Mittnacht, S. (1997). Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272(19): 12738-12746

Zerfass-Thome, K., et al. (1997). p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell. Biol. 17: 407-415

Zhang, H. S., Postigo, A. A. and Dean, D. C. (1999). Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition. Cell 97(1): 53-61. PubMed ID: 10199402

Zhang, H. S., et al. (2000). Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101: 79-89. PubMed ID: 10778858

Zhang, L., Wei, Y., Pushel, I., Heinze, K., Elenbaas, J., Henry, R. W. and Arnosti, D. N. (2014). Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein. J Biol Chem [Epub ahead of print]. PubMed ID: 25049232

Zhu, L., Harlow, E. and Dynlacht, B. D. (1995a). p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9: 1740-52

Zhu, L., et al. (1995b). The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J. 14: 1904-13


Retinoblastoma-family protein: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 25 November 2014
 

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.