Retinoblastoma-family protein
Acharya, P., et al. (2010). Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins. Mol. Biol. Cell 21(22): 3890-901. PubMed Citation: 20861300
Adams, P. D., et al. (1999). Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Mol. Cell. Biol. 19(2): 1068-80. PubMed Citation: 9891042
Alevizopoulos, K, et al. (1997). Cyclin E and c-Myc promote cell proliferation in the presence of p16(INK4a) and of hypophosphorylated retinoblastoma family proteins. EMBO J. 16(17): 5322-5333. PubMed Citation: 9311992
Andersen, E. C., Lu. X. and Horvitz, H. R. (2006). C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. Development 133(14): 2695-704. 16774993
Ariss, M. M., Islam, A., Critcher, M., Zappia, M. P. and Frolov, M. V. (2018). Single cell RNA-sequencing identifies a metabolic aspect of apoptosis in Rbf mutant. Nat Commun 9(1): 5024. PubMed ID: 30479347
Astigarraga, S., (2007). A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J. 26(3): 668-77. PubMed ID: 17255944
Avni, D., et al. (2003). Active localization of the Retinoblastoma protein in chromatin and its response to S phase DNA damage. Molec. Cell 12: 735-746. 14527418
Baldi, A., et al. (1996). Genomic structure of the human retinoblastoma-related Rb2/p130 gene. Proc. Natl. Acad. Sci. 93: 4629-4632. PubMed Citation: 8643454
Bang, O. S., et al. (1996). Transforming growth factor-beta1 modulates p107 function in myeloid cells: correlation with cell cycle progression. J. Biol. Chem. 271: 7811-7819. PubMed Citation: 8631825
Batsche E., et al. (1998). RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol. Cell. Biol. 18(7): 3647-3658. PubMed Citation: 9632747
Bender, A. M., Wells, O. and Fay, D. S. (2004). lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans. Dev. Biol. 273: 335-349. 15328017
Bosco, G., Du, W. and Orr-Weaver, T. L. (2001). DNA replication control through interaction of E2F-RB and the origin recognition complex. Nature Cell Biol. 3: 289-295. 11231579
Bourachot, B., Yaniv, M. and Muchardt, C. (1999). The activity of mammalian brm/SNF2alpha is dependent on a high-mobility-group protein I/Y-like DNA binding domain. Mol. Cell. Biol. 19: 3931-3939. PubMed Citation: 10330133
Boxem, M. and van den Heuvel, S. (2001). lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans. Development 128: 4349-4359. 11684669
Brehm, A., et al. (1998). Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391(6667): 597-601. PubMed Citation: 9468139
Brumby, A. M., et al. (2002). Drosophila cyclin E interacts with components of the Brahma complex. EMBO J. 21: 3377-3389. 12093739
Callaghan, D. A., et al. (1999), Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity. Dev. Biol. 207(2): 257-70. PubMed Citation: 10068462
Cam, H., et al. (2003). A common set of gene regulatory networks links metabolism and growth inhibition. Mol. Cell 16(3): 399-411. 15525513
Cardoso, C., et al. (2005). XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans. Dev. Biol. 278(1): 49-59. 15649460
Carnac, et al. (2000). The retinoblastoma-like protein p130 is involved in the determination of reserve cells in differentiating myoblasts. Curr. Biol. 10: 543-546. PubMed ID: 10801445
Castano, E., Kleyner, Y. and Dynlacht, B. D. (1998). Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor. Mol. Cell. Biol. 18(9): 5380-91. PubMed Citation: 9710622
Chang, K. H., et al. (1997). A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. 94(17): 9040-9045. PubMed Citation: 9256431
Chen, P.-L., et al. (1996). Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10: 2794-2804. PubMed Citation: 8946919
Chen, X., Lu, C., Prado, J. R., Eun, S. H. and Fuller, M. T. (2011). Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. Development 138(12): 2441-50. PubMed Citation: 21610025
Chen, Z. and Han, M. (2001). C. elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification. Curr. Biol. 11: 1874-1879. 11728311
Chien, Y., et al. (2011). Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity. Genes Dev. 25(20): 2125-36. PubMed Citation: 21979375
Chu, W. M., et al. (1997). RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2. J. Biol. Chem. 272(23): 14755-14761. PubMed Citation: 9169441
Clavier, A., Baillet, A., Rincheval-Arnold, A., Coleno-Costes, A., Lasbleiz, C., Mignotte, B. and Guenal, I. (2014). The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA. Cell Death Dis 5: e1405. PubMed ID: 25188515
Clavier, A., Rincheval-Arnold, A., Baillet, A., Mignotte, B. and Guenal, I. (2016). Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila. Cell Cycle 15: 283-294. PubMed ID: 26825229
Coats, S., et al. (1999). A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells. Curr. Biol. 9(4): 163-73. PubMed Citation: 10074425
Conkrite, K., et al. (2011). miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. Genes Dev. 25(16): 1734-45. PubMed Citation: 21816922
Coschi, C. H., et al. (2009). Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev. 24(13): 1351-63. PubMed Citation: 20551166
Corbeil, H. B. and Branton, P. E. (1997). Characterization of an E2F-p130 complex formed during growth arrest. Oncogene 15(6): 657-668. PubMed Citation: 9264406
Cui, M., Fay, D. S. and Han, M. (2004), lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development. Genetics 167(3): 1177-85. 15280233
Dahiya, A., et al. (2001). Linking the Rb and Polycomb pathways. Mol. Cell 8: 557-568. 11583618
Davidson, J. M. and Duronio, R. J. (2012). S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues. PLoS Genet. 8(8): e1002831. PubMed Citation: 22916021
Dominado, N., La Marca, J.E., Siddall, N.A., Heaney, J., Tran, M., Cai, Y., Yu, F., Wang, H., Somers, W.G., Quinn, L.M. and Hime, G.R. (2016). Rbf regulates Drosophila spermatogenesis via control of somatic stem and progenitor cell fate in the larval testis. Stem Cell-Reports 7: 1152-1163. PubMed ID: 27974223
Duman-Scheel, M., et al. (2002). Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417: 299-304. 12015606
Dannenberg, J.-H., et al. (2000). Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 14: 3051-3064. 11114893
Dannenberg, J.-H., et al. (2004). Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev. 18: 2952-2962. 15574596
Dasgupta, B. and Milbrandt, J. (2009). AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev. Cell 16(2): 256-70. PubMed Citation: 19217427
Datar, S. A., et al. (2000) The Drosophila Cyclin D-Cdk4 complex promotes cellular growth. EMBO J. 19: 4543-4554. PubMed Citation: 10970848
de Nooij, J. C., Letendre, M. A. and Hariharan, I. K. (1996). A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell 87: 1237-47. PubMed Citation: 8980230
Deverman, B. E., et al. (2002). Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 111: 51-62. 12372300
Dick, F. A. and Dyson, N. (2003). pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Molec. Cell 12: 639-649. 14527410
Dimova, D. K., Stevaux, O., Frolov, M. V. and Dyson, N. J. (2003). Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev. 17: 2308-2320. 12975318
Dimri, G. P., et al. (1997). Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol. Cell. Biol. 16: 2987-2997. PubMed Citation: 8649410
Divecha, N., et al. (2002). Type I PIPkinases interact with and are regulated by the retinoblastoma susceptibility gene product -- pRB. Curr. Biol. 12: 582-587. 11937028
Du, W., et al. (1996a). RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10: 1206-1218. PubMed Citation: 8675008
Du, W., Xie, J.-E., and Dyson, N. (1996b). Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15: 3684-92. PubMed Citation: 8670872
Du, W. (2000). Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development 127: 367-379. PubMed Citation: 10603353
Duman-Scheel, M., Johnston, L. A. and Du, W. (2004). Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc. Natl. Acad. Sci. 101(11): 3857-62. 15001704
Dunaief, J. L.,et al. (1994). The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79: 119-130
Eberhard, D. and Busslinger, M. (1999). The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins. Cancer Res. 59: S1716-S1725. 10197586
Edgar, K. A., et al. (2005). Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene. Genetics 170: 161-171. 15744054
Ezhevsky, S. A., et al. (1997). Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc. Natl. Acad. Sci. 94(20): 10699-10704
Fajas, L., et al. (2002a). E2Fs regulate adipocyte differentiation. Dev. Cell 3: 39-49. 12110166
Fajas, L., et al. (2002b). The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev. Cell 3: 903-910. 12479814
Fay, D. S., Keenan, S. and Han, M. (2002). fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev. 16: 503-517. 11850412
Fay, D. S., Large, E., Han, M. and Darland, M. (2003). lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans. Development 130: 3319-3330. 12783801
Ferguson, K. L., et al. (2002). Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J. 21: 3337-3346. 12093735
Ferres-Marco, D., et al. (2006). Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature 439(7075): 430-6. 16437107
Firth, L. C. and Baker, N. E. (2005). Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8(4): 541-51. 15809036
Gagrica, S., Hauser, S., Kolfschoten, I., Osterloh, L., Agami, R. and Gaubatz, S. (2004). Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. EMBO J. 23: 4627-4638. Medline abstract: 15538385
Garbe, D., Doto, J. B. and Sundaram, M. V. (2004). Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8. Genetics 167(2): 663-72. 15238519
Geng, Y., et al. (1996). Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 12: 1173-1180
Gilde, J. J., Lopez, R. and Shearn, A. (2000). A screen for new Trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics 156: 645-663
Grinstein, E., et al. (2006). Cell cycle-controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation. J. Biol. Chem. 281(31): 22223-35. Medline abstract: 16698799
Gu, W., Schneider, J. W., Condorelli, G., Kaushal, S., Mahdavi, V. and Nadal-Ginard, B. (1993). Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72: 309-324. 8381715
Gupta, S., et al. (2003). Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription. J. Cell Physiol. 196(3): 541-56. 12891711
Harbour, J. W., et al. (1999). Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98(6): 859-69
Harrington, E. A., et al. (1998). pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc. Natl. Acad. Sci. 95(20): 11945-50
Harrison, M. M., Ceol, C. J., Lu, X. and Horvitz, H. R. (2006). Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. 103(45): 16782-7. Medline abstract: 17075059
Hateboer, G., et al. (1996). Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev. 10: 2960-2970
Hateboer G., et al., (1998). Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol. Cell. Biol. 18(11): 6679-97
Hauser, P. J., et al. (1997). p107 and p130 associated cyclin A has altered substrate specificity. J. Biol. Chem. 272(36): 22954-22959
Hériché, J. K., et al. (2003). Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 4 (1): 9. 12787468
Herz, H. M., et al. (2010). The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol. Cell. Biol. 30(10): 2485-97. PubMed Citation: 20212086
Hirano, T. (2005). Condensins: organizing and segregating the genome. Curr. Biol. 15: R265-R275. PubMed ID: 15823530
Hiromura, M., et al. (2003). YY1 is regulated by O-linked N-acetylglucosaminylation (O-glcNAcylation). J. Biol. Chem. 278(16): 14046-52. 12588874
Hofmann, F., et al. (1996). The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev. 10: 2949-2959
Hsieh, J. K., et al. (1997). E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11(14): 1840-1852
Humbert, P. O., et al. (2000). E2F4 is essential for normal erythrocyte maturation and neonatal viability. Molec. Cell 6: 281-291
Hurford, R. K. et al. (1997). pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11(11): 1447-1463
Iakova, P., Awad, S. S., and Timchenko, N. A. (2003). Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Cell 113: 495-506. 12757710
Jiang, Z., et al. (2000). E2F1 and p53 are dispensable, whereas p21 Waf1/Cip1 cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis. Dev. Bio. 227: 28-41.
Kato, J-y., et al. (1993). Direct binding of cyclin D to the tetinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7: 331-342
Kim, H.-Y., Ahn, B.-Y. and Cho, Y. (2001). Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen. EMBO J. 20: 295-304. 11226179
Kim, T. A., et al. (1998). NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. J. Cell Biol. 141(3): 553-566
Kim, T. H., Goodman, J., Anderson, K. V., Niswander, L. (2007). Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev. Cell 13(1): 87-102. PubMed citation: 17609112
Klose, R, J,, et al. (2007). The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 128(5): 889-900. PubMed citation: 17320163
Knudsen, E. S. and Wang, J. Y. (1996). Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J. Biol. Chem. 271: 8313-8320. PubMed ID: 8626527
Knudsen, E. S. and Wang, J. Y. (1997). Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol.17(10): 5771-5783. PubMed ID: 9315635
Knudsen, E. S., et al. (1998). Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev. 12(15): 2278-2292. PubMed ID: 9694794
Kobayashi, M., Yamauchi, Y. and Tanaka, A. (1998). Stable expression of antisense Rb-1 RNA inhibits terminal differentiation of mouse myoblast C2 cells. Exp. Cell Res. 239(1): 40-49. PubMed ID: 9511723
Korenjak, M., et al. (2004). Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell 119(2): 181-93. Medline abstract: 15479636
Korenjak, M., Anderssen, E., Ramaswamy, S., Whetstine, J. R. and Dyson, N. J. (2012). RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Mol Cell Biol 32: 4375-4387. PubMed ID: 22927638
Kotake, Y., et al. (2007). pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene. Genes Dev. 21: 49-54. Medline abstract: 17210787
Krivy, K., Bradley-Gill, M. R. and Moon, N. S. (2013). Capicua regulates proliferation and survival of RB-deficient cells in Drosophila. Biol Open 2: 183-190. PubMed ID: 23429853
Kuzin, B., et al. (2000). Nitric oxide interacts with the retinoblastoma pathway to control eye development in Drosophila. Curr. Biol 10: 459-462. PubMed ID: 10801421
Lee, H., Ragusano, L., Martinez, A., Gill, J. and Dimova, D. K. (2012). A dual role for the dREAM/MMB complex in the regulation of differentiation-specific E2F/RB target genes. Mol. Cell Biol. 32(11): 2110-20. PubMed Citation: 22451490
Lee, K. Y., et al. (1997). Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein. J. Biol. Chem. 272(9): 5622-6
Lemercier, C., et al. (2000). Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression. Mol. Cell Biol. 20(18): 6627-37.
Leng, X., et al. (1997). S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation. Curr. Biol. 7(9): 709-712
Leopold, P. and O'Farrell, P. H. (1991). An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell 66: 1207-1216. 1833067
Lew, D. J., Dulic, V. and Reed, S. I. (1991). Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66: 1197-1206. 1833066
Lewis, P. W., et al. (2004). Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev. 18: 2929-2940. 15545624
Lewis, P. W., Sahoo, D., Geng, C., Bell, M., Lipsick, J. S. and Botchan, M. R. (2012). Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex. Mol Cell Biol 32: 3218-3227. PubMed ID: 22688510
Linke, S. P., et al. (1997). p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression. Oncogene 15(3): 337-345
Lipinski, M. M., et al. (2001). Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system. EMBO J. 20: 3402-3413. 11432828
Liu, D. X., et al. (2005). Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev. 19: 719-732. 15769944
Liu, X. and Marmorstein, R. (2007). Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. Genes Dev. 21(21): 2711-6. PubMed citation: 17974914
Longworth, M. S., Herr, A., Ji, J. Y. and Dyson, N. J. (2008). RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev 22: 1011-1024. PubMed ID: 18367646
Longworth, M. S. and Dyson, N. J. (2010). pRb, a local chromatin organizer with global possibilities. Chromosoma 119: 1-11. PubMed ID: 19714354
Longworth, M. S., Walker, J. A., Anderssen, E., Moon, N. S., Gladden, A., Heck, M. M., Ramaswamy, S. and Dyson, N. J. (2012). A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity. PLoS Genet 8: e1002618. PubMed ID: 22496667
Lu, X. and Horvitz, R. (1998). lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell 95: 981-991
Lukas, J., et al. (1997). Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev. 11(11): 1479-1492
Luo, R. X., Postigo, A. A. and Dean, D. C. (1998). Rb interacts with histone deacetylase to repress transcription. Cell 92: 463-473
Lundberg, A. S. and Weinberg, R. A. (1998). Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18(2): 753-761
MacPherson, D., et al. (2004). Cell type-specific effects of Rb deletion in the murine retina. Genes Dev. 18: 1681-1694. 15231717
Magnaghi-Jaulin, L., et al. (1998). Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391(6667): 601-605
Manning, A. L., Longworth, M. S. and Dyson, N. J. (2010). Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev. 24(13): 1364-76. PubMed Citation: 20551165
Mantela, J., et al. (2005). The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development 132: 2377-2388. 15843406
Marino, S., et al. (2003). Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence. Development 130: 3359-3368. 12810584
Martelli, F. and Livingston, D. M. (1999). Regulation of endogenous E2F1 stability by the retinoblastoma family proteins. Proc. Natl. Acad. Sci. 96(6): 2858-63
Matsui, T., Nieto-Estevez, V., Kyrychenko, S., Schneider, J. W. and Hsieh, J. (2017). RB controls growth, survival, and neuronal migration in human cerebral organoids. Development 144(6):1025-1034. PubMed ID: 28087635
McCaffery, P., et al. (1999). Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. Mech. Dev. 82(1-2): 119-130
Meloni, A. R., Smith, E. J. and Nevins, J. R. (1999). A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc. Natl. Acad. Sci. 96: 9574-9579
Meyer, C. A., et al. (2000). Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 19: 4533-4542
Milet, C., Rincheval-Arnold, A., Morieras, A., Clavier, A., Garrigue, A., Mignotte, B. and Guenal, I. (2014). Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis. PLoS One 9: e102902. PubMed ID: 25089524
Moberg, K., Starz, M. A. and Lees, J. A. (1996). E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol. 16: 1436-1449
Moon, N. S., Di Stefano, L. and Dyson, N. (2006). A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol. Cell Biol. 26(20): 7601-15. Medline abstract: 16954388
Murphy, D. J. Hardy, S. and Engel, D. A. (1999). Human SWI-SNF component BRG1 represses transcription of the c-fos gene. Mol. Cell. Biol. 19: 2724-2733
Narita, M., et al. (2003). Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113: 703-716. 12809602
Nasmyth, K. and Haering, C. H. (2005). The structure and function of SMC and kleisin complexes. Annu Rev Biochem 74: 595-648. PubMed ID: 15952899
Nead, N. A., et al. (1998). Rb binds c-Jun and activates transcription. EMBO J. 17: 2342-2352
Nicolay, B. N., et al. (2011). Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. Genes Dev. 25(4): 323-35. PubMed Citation: 21325133
Niculescu, A. B., et al. (1998). Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol. 18(1): 629-643.
Nielsen, S. J., et al. (2001). Rb targets histone H3 methylation and HP1 to promoters. Nature 412: 561-565. 11484059
Ono, T., Fang, Y., Spector, D. L. and Hirano, T. (2004). Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. Mol Biol Cell 15: 3296-3308. PubMed ID: 15146063
Otterson, G. A., et al. (1997). Incomplete penetrance of familial retinoblastoma linked to germ-line mutations that result in partial loss of RB function. Proc. Natl. Acad. Sci. 94(22): 12036-12040
Papadimou, E., et al. (2005). Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage. EMBO J. 24: 1750-1761. 15861132
Park, M. S., et al. (1999). p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice. Proc. Natl. Acad. Sci. 96(11):6382-7
Pasder, O., et al. (2006). Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene 25(30): 4194-206. 16732323
Payankaulam, S., Yeung, K., McNeill, H., Henry, R.W. and Arnosti, D.N. (2016). Regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein. Sci Rep 6: 22879. PubMed ID: 26971715
Peeper, D. S., et al. (1997). Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 386: 177-181
Pelletier, G., et al. (2000). Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. Mol. Cell 6: 1059-1066.
Porrello, A., et al. (2000). p53 regulates myogenesis by triggering the differentiation activity of pRb. J. Cell Biol. 151(6): 1295-304. 11121443
Pradhan, S., and Kim, G.-D. (2002). The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity. EMBO J. 21: 779-788. 11847125
Raj, N., Zhang, L., Wei, Y., Arnosti, D. N. and Henry, R. W. (2012). Rbf1 degron dysfunction enhances cellular DNA replication. Cell Cycle 11: 3731-3738. PubMed ID: 22895052
Rajasekaran, S., Siddiqui, J., Rakijas, J., Nicolay, B., Lin, C., Khan, E., Patel, R., Morris, R., Wyler, E., Boukhali, M., Balasubramanyam, J., Ranjith Kumar, R., Van Rechem, C., Vogel, C., Elchuri, S. V., Landthaler, M., Obermayer, B., Haas, W., Dyson, N. and Miles, W. (2021). Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses. Commun Biol 4(1): 977. PubMed ID: 34404904
Rand, T. A., Sutou, K., Tanabe, K., Jeong, D., Nomura, M., Kitaoka, F., Tomoda, E., Narita, M., Nakamura, M., Nakamura, M., Watanabe, A., Rulifson, E., Yamanaka, S. and Takahashi, K. (2018). MYC releases early reprogrammed human cells from proliferation pause via retinoblastoma protein inhibition. Cell Rep 23(2): 361-375. PubMed ID: 29641997
Reddien, P. W., Andersen, E. C., Huang, M. C. and Horvitz, H. R. (2007). DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics 175(4): 1719-33. PubMed citation: 17237514
Ren, S. and Rollins, B. J. (2004). Cyclin C/Cdk3 promotes Rb-dependent G0 exit. Cell 117: 239-251. 15084261
Reyes, J. C., et al. (1998). Altered control of cellular proliferation in the absence of mammalian brahma (SNF2). EMBO J. 17: 6979-6991
Ribeiro, P. S., et al. (2010). Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Mol. Cell 39: 521-534. PubMed Citation: 20797625
Riley, D. J., Liu, C. Y. and Lee, W. H. (1997). Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression. Mol. Cell. Biol. 17(12): 7342-7352
Robanus-Maandag, E., et al. (1998). p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 12(11): 1599-1609
Rohde, M., et al. (1996). The retinoblastoma protein modulates expression of genes coding for diverse classes of proteins including components of the extracellular matrix. Oncogene 12: 2393-2401
Rossi, F., et al. (2002). p107 and p130 coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development. Dev. Bio. 247: 271-285. 12086466
Ruiz, S., et al. (2004). Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development 131: 2737-2748. 15148303
Sage, J., et al. (2000). Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization. Genes Dev. 14: 3037-3050. 11114892
Sage, J., et al. (2003). Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424(6945): 223-8. 12853964
Sala, A., et al. (1997). B-myb promotes S phase and is a downstream target of the negative regulator p107 in human cells. J. Biol. Chem. 271: 9363-9367
Savvidou, E., Cobbe, N., Steffensen, S., Cotterill, S. and Heck, M. M. (2005). Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids. J Cell Sci 118: 2529-2543. PubMed ID: 15923665
Sawado, T., et al. (1998). dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 251(2): 409-15
Schertel, C. and Conradt, B. (2007). C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development 134(20): 3691-701. PubMed citation: 17881492
Schulze, A., et al. (1994). Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1. Oncogene 9: 3475-82
Shao, Z., et al. (1997). Rb interacts with TAF(II)250/TFIID through multiple domains. Oncogene 15(4): 385-392
Sherr, C. J. (1993). Mammalian G1 cyclins. Cell 73: 1059-1065
Shih, H. H., Tevosian, S. G. and Yee, A. S. (1998). Regulation of differentiation by HBP1, a target of the retinoblastoma protein. Mol. Cell. Biol. 18: 4732-4743. 9671483
Siegert, J. L. and Robbins, P. D. (1999). Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250. Mol. Cell. Biol. 19(1): 846-54
Singh, P., Coe, J. and Hong, W. (1995). A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. Nature 374: 562-565. 7700385
Sowa, Y., et al. (1997). Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. Cancer Res. 57(15): 3145-3148
Starostik, P., Chow, K. N. and Dean, D. C. (1996). Transcriptional repression and growth suppression by the p107 pocket protein. Mol. Cell. Biol. 16: 3606-3614.
Stevaux, O., et al. (2002). Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. EMBO J. 21: 4927-4937. 12234932
Stevaux, O., Dimova, D., Ji, J.-Y., Moon, N. S., Frolov, M. and Dyson, N. (2005). Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Cell Cycle 4: 1272-1280. Medline abstract: 16082225
Strober, B. E., et al. (1996). Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins. Mol. Cell. Biol. 16: 1576-1583
Svoboda, D. S., Paquin, A., Park, D. S. and Slack, R. S. (2013). Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis. Dev Biol 384: 101-113. PubMed ID: 24056077
Tevosian, S. G., et al. (1997). HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev. 11: 383-396
Thomas, D. M., et al. (2001). The Retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Molec. Cell 8: 303-316. 11545733
Thomas, J. H., et al. (2003). New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans. Genetics 164: 135-151. 12750327
Truscott, M., Islam, A. B., Lightfoot, J., Lopez-Bigas, N. and Frolov, M. V. (2014). An intronic microRNA links Rb/E2F and EGFR signaling. PLoS Genet 10: e1004493. PubMed ID: 25058496
Tsai, K. Y., et al. (1998). Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2(3): 293-304. PubMed Citation: 9774968
Tsai, K. Y., et al. (1999). Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2(3): 293-304. PubMed Citation: 9774968
Tschöp, K., et al. (2011). A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev. 25(8): 814-30. PubMed Citation: 21498571
Uchida, C., et al. (2005). Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J. 24(1): 160-9. 15577944
Ullah, Z., Buckley, M. S., Arnosti, D. N. and Henry, R. W. (2007). Retinoblastoma protein regulation by the COP9 signalosome. Mol. Biol. Cell 18(4): 1179-86. PubMed Citation: 17251548
Umen, J. G. and Goodenough, U. W. (2001). Control of cell division by a retinoblastoma protein homolog in Chlamydomonas. Genes Dev. 15: 1652-1661. 11445540
Vale-Cruz, D. S., et al. (2008). Activating transcription factor-2 affects skeletal growth by modulating pRb gene expression. Mech. Dev. 125: 843-856. PubMed Citation: 18638549
van Gurp, M. F., et al. (1999). The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A. Cancer Res. 59(23): 5980-8. 10606245
van Harn, T., et al. (2010). Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling. Genes Dev. 24(13): 1377-88. PubMed Citation: 20551164
Veal E., et al. (1998). A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. Mol. Cell. Biol. 18(9): 5032-41
Vernier M, et al. (2011). Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev. 25(1): 41-50. PubMed Citation: 21205865
Verona, R., et al. (1997). E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol. Cell. Biol. 17(12): 7268-7282
Versteege, I., Medjkane, S., Rouillard, D. and Delattre O. (2002). A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle. Oncogene 21: 6403-6412. 12226744
Voit, R., Schafer, K. and Grummt, I. (1997). Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein. Mol. Cell. Biol. 17(8): 4230-4237
Voit, R., Schafer, K. and Grummt, I. (1997). Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein. Mol. Cell. Biol. 17(8): 4230-7
Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E. and Orkin, S. H. (2007). Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 129(6): 1081-95. PubMed citation: 17574022
Wang, S., et al. (1999). Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. EMBO J. 18(6): 1559-1570
Wartiovaara, K., et al. (2002). N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J. Neurosci. 22(3): 815-824. 11826111
Weng, Li., Zhu, C., Xu, J. and Du, W. (2003). Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J. 22: 3865-3875. 12881421
Wenzel, P. L., et al. (2007). Rb is critical in a mammalian tissue stem cell population. Genes Dev. 21: 85-97. Medline abstract: 17210791
Whitaker, L. L., et al. (1998). Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket. Mol. Cell. Biol. 18(7): 4032-4042
White, R. J., et al. (1996). Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature 382: 88-90
White, J., Stead, E., Faast, R., Conn, S., Cartwright, P. and Dalton, S. (2005). Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol. Biol. Cell 16: 2018-2027. Medline abstract: 15703208
Wiggan, O., Taniguchi-Sidle, A. and Hamel, P. A. (1998). Interaction of the pRB-family proteins with factors containing paired-like homeodomains. Oncogene 16(2): 227-36
Wikenheiser-Brokamp, K. A. (2004). Rb family proteins differentially regulate distinct cell lineages during epithelial development. Development 131: 4299-4310. 15294860
Woo, M. S., Sanchez, I. and Dynlacht, B. D. (1997). p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity. Mol. Cell. Biol. (7): 3566-3579
Wu, L., de Bruin, A., Saavedra, H. I., Starovic, M., Trimboli, A., Yang, Y., Opavska, J., Wilson, P., Thompson, J. C., Ostrowski, M. C. et al. (2003). Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421: 942-947. Medline abstract: 12607001
Xiao, Z. X., et al. (1996). Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. 93: 4633-4637
Xin, S., Weng, L., Xu, J. and Du, W. (2002). The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development 129: 1345-1356. 11880344
Yang, H.-S. and Hinds, P. W. (2003). Increased Ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. Molec. Cell 11: 1163-1176. 12769842
Yuan, S. S., et al. (1999). Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev. Biol. 207(1): 62-75
Zacksenhaus, E., et al. (1996). pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 10: 3051-3064
Zappia, M. P., Rogers, A., Islam, A. and Frolov, M. V. (2019). Rbf activates the myogenic transcriptional program to promote skeletal muscle differentiation. Cell Rep 26(3): 702-719. PubMed ID: 30650361
Zarkowska, T. and Mittnacht, S. (1997). Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272(19): 12738-12746
Zerfass-Thome, K., et al. (1997). p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell. Biol. 17: 407-415
Zhang, H. S., Postigo, A. A. and Dean, D. C. (1999). Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition. Cell 97(1): 53-61. PubMed ID: 10199402
Zhang, H. S., et al. (2000). Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101: 79-89. PubMed ID: 10778858
Zhang, L., Wei, Y., Pushel, I., Heinze, K., Elenbaas, J., Henry, R. W. and Arnosti, D. N. (2014). Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein. J Biol Chem [Epub ahead of print]. PubMed ID: 25049232
Zhu, L., Harlow, E. and Dynlacht, B. D. (1995a). p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9: 1740-52
Zhu, L., et al. (1995b). The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J. 14: 1904-13
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