Goosecoid


DEVELOPMENTAL BIOLOGY

Embryonic

GSC is first detected at cellularization (Stage 4) as a dorsoanterior stripe 2-3 cells wide, appearing in a strong horseshoe-like pattern across the dorsal side of the embryo anterior to the appearing cephalic furrow [Images]. This region corresponds to an extreme anterior-dorsal position of most insects, because the head neuraxis of Drosophila is bent dorsally. At germband extension (Stage 8) GSC is down-regulated in the dorsal-most region of the embryo and the horseshoe pattern resolves into a large cluster of cells on each side of the presumptive head. These positive cells migrate laterally and, by stage 10, GSC is restricted to three small clusters that migrate inside the embryo at germband retraction and are then associated with the brain hemispheres (Goriely, 1996 and Hahn, 1996).

A second domain of expression is seen as a cluster of cells at the time the stomodeum is first visible. This cluster follows the movements of foregut invagination and is incorporated into the roof of the stomodeum abutting the endodermic anterior midgut territory. These cells appear to be part of the anterior foregut, the ring gland and the stomatogastric nervous system, a tissue that is modified in a mutant lacking Gsc function (Goriely, 1996 and Hahn, 1996)


REFERENCES

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Goosecoid: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology

date revised: 10 February 2014 

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