G protein oalpha 47A


REFERENCES

Bainton, R. J., Tsai, L. T.-Y., Schwabe, T. DeSalvo, M., Gaul, U. and Heberlein, U. (2005). moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell 123: 145-156. 16213219

Bikkavilli, R. K., Feigin, M. E. and Malbon, C. C. (2008). G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells. J Cell Sci. 121(Pt 2): 234-45. PubMed Citation: 18187455

Bodmer, R., et al. (1997). Heart development in Drosophila. Adv. Dev. Biol. 5: 201-236

Boto, T., Louis, T., Jindachomthong, K., Jalink, K. and Tomchik, S. M. (2014). Dopaminergic Modulation of cAMP Drives Nonlinear Plasticity across the Drosophila Mushroom Body Lobes. Curr Biol 24(8): 822-31. PubMed ID: 24684937

Busconi, L. and Denker, B. M. (1997). Analysis of the N-terminal binding domain of Go alpha. Biochem J. 328 (Pt 1): 23-31. PubMed Citation: 9359829

Campbell, V., et al. (1999). Inhibition of the interaction of G protein G(o) with calcium channels by the calcium channel beta-subunit in rat neurones. J. Physiol. (Lond) 485 ( Pt 2): 365-72. PubMed Citation: 7666364

Colombo, K., et al. (2003). Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science 300(5627): 1957-61. 12750478

Costa, M., Wison, E. and Wieschaus, E. (1994). A putative cell signal encoded by folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation. Cell 76: 1075-1089. PubMed Citation: 8137424

Dahdal, D., et al. (2010). Drosophila pacemaker neurons require G protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms. Neuron 68(5): 964-77. PubMed Citation: 21145008

D'Amico, L., Scott, I. C., Jungblut, B. and Stainier, D. Y. (2007). A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. Curr. Biol. 17: 252-259. PubMed Citation: 17276918

David, N. B., et al. (2005). Drosophila Ric-8 regulates G?i cortical localization to promote G?i-dependent planar orientation of the mitotic spindle during asymmetric cell division. Nat. Cell Biol. 7: 1083-1090. PubMed Citation: 16228010

de Sousa, S. M., et al. (1989). The Drosophila Go alpha-like G protein gene produces multiple transcripts and is expressed in the nervous system and in ovaries. J. Biol. Chem. 264(31): 18544-51. PubMed Citation: 2509463

De Vries, L., Lou, X., Zhao, G., Zheng, B. and Farquhar, M. G. (1998). GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc Natl Acad Sci U S A 95: 12340-12345. PubMed ID: 9770488

Djiane, A. and Mlodzik, M. (2010). The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. PLoS One 5: e11228. PubMed ID: 20574526

Duc-Goiran, P., et al. (1999). Identification and expression of Go1 and Go2 alpha-subunit transcripts in human myometrium in relation to pregnancy. Biol. Reprod. 60(6): 1528-35. PubMed Citation: 10330115

Edison, R. J. and Muenke, M. (2005). Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly. N. Engl. J. Med. 352: 2759. PubMed Citation: 15987932

Egger-Adam, D. and Katanaev, V. L. (2009). The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway. Dev. Dyn. 239(1): 168-83. PubMed Citation: 19705439

Exner, T., et al. (1999). Posttranslational modification of Galphao1 generates Galphao3, an abundant G protein in brain. Proc. Natl. Acad. Sci. 96(4): 1327-32. PubMed Citation: 9990023

Ferris, J., Ge, H., Liu, L. and Roman, G. (2006). Go signaling is required for Drosophila associative learning. Nat. Neurosci. 9(8): 1036-40. PubMed Citation: 16845387

Frémion, F., et al. (1999). The heterotrimeric protein Go is required for the formation of heart epithelium in Drosophila. J. Cell Biol. 145(5): 1063-76. PubMed Citation: 10352022

Gasman, S., et al. (1998). Identification of a potential effector pathway for the trimeric Go protein associated with secretory granules. J. Biol. Chem. 273: 16913-16920. PubMed Citation: 9642253

Gajewski, K., Y., et al. (1997). D-mef2 is a target for Tinman activation during Drosophila heart development. EMBO J. 16: 515-522. PubMed Citation: 9034334

Gervasi, N., Tchenio, P., Preat, T. (2010). PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase. Neuron 65: 516-529. PubMed ID: 20188656

Giese, A. P., Ezan, J., Wang, L., Lasvaux, L., Lembo, F., Mazzocco, C., Richard, E., Reboul, J., Borg, J. P., Kelley, M. W., Sans, N., Brigande, J. and Montcouquiol, M. (2012). Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear. Development 139: 3775-3785. PubMed ID: 22991442

Guillèn, A., et al. (1990). A Go-like protein in Drosophila melanogaster and its expression in memory mutants. EMBO J. 9(5): 1449-55. PubMed Citation: 2109694

Guillèn, A., et al. (1991). The transduction signalling protein Go during embryonic development of Drosophila melanogaster. Cell Signal 3: 341-352. PubMed Citation: 1931484

Hajdu-Cronin, Y. M., et al. (1999). Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity. Genes Dev. 13(14): 1780-93. PubMed Citation: 10421631

Hall, A. (1998). G proteins and small GTPases: distant relatives keep in touch. Science. 280: 2074-2075. PubMed Citation: 9669963

Hamm, H. E. (1998). The many faces of G protein signaling. J. Biol. Chem. 273: 669-672. PubMed ID: 9422713

Harris, K. E. and Beckendorf, S. K. (2007). Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development 134: 2017-2025. PubMed Citation: 17507403

Hess, H. A., et al. (2004). RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans. Cell 119: 209-218. 15479638

Horgan, A. M., Lagrange, M. T. and Copenhaver, P. F. (1995). A developmental role for the heterotrimeric G protein Go alpha in a migratory population of embryonic neurons. Dev. Biol. 172(2): 640-53. PubMed ID: 8612978

Hoxha, V., Lama, C., Chang, P. L., Saurabh, S., Patel, N., Olate, N. and Dauwalder, B. (2013). Sex-specific signaling in the blood-brain barrier is required for male courtship in Drosophila. PLoS Genet 9: e1003217. PubMed ID: 23359644

Hsu, W. H., et al. (1990). Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein. J. Biol. Chem. 265(19): 11220-6

Jiang, M., et al. (1998). Multiple neurological abnormalities in mice deficient in the G protein Go. Proc. Natl. Acad. Sci. 95(6): 3269-74

Katanayeva, N., Kopein, D., Portmann, R., Hess, D. and Katanaev, V. L. (2010). Competing activities of heterotrimeric G proteins in Drosophila wing maturation. PLoS One. 5(8): e12331. PubMed Citation: 20808795

Katanaev, V. L., et al. (2005). Trimeric G protein-dependent Frizzled signaling in Drosophila. Cell 120: 111-122. 15652486

Kindt, K. S., et al. (2002). Serotonin promotes Go-dependent neuronal migration in Caenorhabditis elegans. Curr. Biol. 12: 1738-1747. 12401168

Kleuss, C., et al. (1991). Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature. 353: 43-48

Kopein, D. and Katanaev, V. L. (2009). Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling. Mol. Biol. Cell 20(17): 3865-77. PubMed Citation: 19570914

Krieger, J., et al. (1999). Selective activation of G protein subtypes in the vomeronasal organ upon stimulation with urine-derived compounds. J. Biol. Chem. 274(8): 4655-62

Kula-Eversole, E., Nagoshi, E., Shang, Y., Rodriguez, J., Allada, R. and Rosbash, M. (2010). Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. Proc. Natl. Acad. Sci. 107: 13497-502. PubMed Citation: 20624977

Kunwar, P. S., et al. (2003). Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells. PLoS Biol. 1: e8. 14691551

Kuzin, A., Brody, T., Moore, A. W. and Odenwald, W. F. (2005). Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS. Dev. Biol. 277: 347-365. 15617679

Lagriffoul, A., et al. (1996). Secretion of protease nexin-1 by C6 glioma cells is under the control of a heterotrimeric G protein, Go1. J. Biol. Chem. 271: 31508-31516

Lang, J., et al. (1995). Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and Go or by the expression of their active G alpha subunits. EMBO J. 14: 3635-3644

Lans, H., Rademakers, S. and Jansen, G. (2004). A network of stimulatory and inhibitory Galpha-subunits regulates olfaction in Caenorhabditis elegans. Genetics 167(4): 1677-87. 15342507

Lee, Y. J., et al. (1990). dgq: A Drosophila gene encoding a visual system-specific G alpha molecule. Neuron 5(6): 889-98. PubMed Citation: 2125225

Li, Y., et al. (1996). Maintenance of cellular levels of G-proteins: different efficiencies of alpha s and alpha o synthesis in GH3 cells. Biochem. J. 318 (Pt 3): 1071-7

Llédo, P.M., et al. (1992). Differential G protein-mediated coupling of D2 dopamine receptors to K+ and Ca2+ currents in rat anterior pituitary cells. Neuron 8: 455-463

Lin, C. and Katanaev, V. L. (2013). Kermit interacts with gαo, vang, and motor proteins in Drosophila planar cell polarity. PLoS One 8: e76885. PubMed ID: 24204696

Luchtenborg, A. M., Solis, G. P., Egger-Adam, D., Koval, A., Lin, C., Blanchard, M. G., Kellenberger, S. and Katanaev, V. L. (2014). Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton. Development 141: 3399-3409. PubMed ID: 25139856

Madalan, A., et al. (2011). G(o) activation is required for both appetitive and aversive memory acquisition in Drosophila. Learn Mem. 19(1): 26-34. PubMed Citation: 22190729

Mao, Z., Davis, R. L. (2009). Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity. Front Neural Circuits 3: 5. PubMed ID: 19597562

McIntire, W. E., et al. (1998a). Characterization of the major bovine brain Go alpha isoforms. Mapping the structural differences between the alpha subunit isoforms identifies a variable region of the protein involved in receptor interactions. J. Biol. Chem. 273(50): 33135-41

McIntire, W. E., et al. (1998b). A major G protein alpha O isoform in bovine brain is deamidated at Asn346 and Asn347, residues involved in receptor coupling. Biochemistry 37(42): 14651-8

McIntire, W. E., et al. (1999). The relationship of G(o)alpha subunit deamidation to the tissue distribution, nucleotide binding properties, and betagamma dimer interactions of G(o)alpha subunit isoforms. J. Neurochem. 73(2): 633-40

Medioni, C. et al. (2008). Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation. J. Cell Biol. 182: 249-261. PubMed Citation: 18663140

Mende, U., et al. (1998). Effect of deletion of the major brain G-protein alpha subunit (alphao) on coordination of G-protein subunits and on adenylyl cyclase activity. J. Neurosci. Res. 54(2): 263-72

Mendel, J. E., et al. (1995). Participation of the protein Go in multiple aspects of behavior in C. elegans. Science 267(5204): 1652-5

Moriarty, T.M., et al. (1990). Go protein as signal transducer in the pertussis toxin-sensitive phosphatidylinositol pathway. Nature. 343: 79-82

Nawy, S. (1999). The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells. J. Neurosci. 19(8): 2938-44

Nusse, O. and Neer, E. J. (1996). Localization of G alpha 0 to growth cones in PC12 cells: role of G alpha 0 association with receptors and G beta gamma. J. Cell Sci. 109 ( Pt 1): 221-8

Padrell, E., et al. (1991). Two forms of the bovine brain Go that stimulate the inositol trisphosphate-mediated Cl- currents in Xenopus oocytes. Distinct guanine nucleotide binding properties. J. Biol. Chem. 266(15): 9771-7

Parks, S., and Wieschaus. E. (1991). The Drosophila gastrulation gene concertina encodes a Galpha-like protein. Cell 64: 447-458. PubMed Citation: 1899050

Provost, N., D. Somers, and J. Hurley. (1988). A Drosophila melanogaster G-protein alpha-subunit gene is expressed primarily in embryos and pupae. J. Biol. Chem. 263: 12070-12076. PubMed Citation: 3136172

Quan, F. and Forte, M. (1990). Two forms of Drosophila melanogaster Gsalpha are produced by alternate splicing involving an unusual splice site. Mol. Cell. Biol. 10: 910-917. PubMed Citation: 2106072

Quan, F., Wolfgang, W. and Forte, M. (1993). A Drosophila G-protein alpha subunit, Gfalpha, is expressed in a spatially and temporally restricted pattern during Drosophila development. Proc. Natl. Acad. Sci. 90: 4236-4240. PubMed Citation: 7683429

Schandar, M., et al. (1998). Odorants selectively activate distinct G protein subtypes in olfactory cilia. J. Biol. Chem. 273(27): 16669-77

Schmidt CJ., et al. (1989). Neuronal expression of a newly identified Drosophila melanogaster G protein alpha 0 subunit. Cell Regul. 1(1): 125-34. 92096479

Schwabe, T., et al. (2005). GPCR signaling is required for blood-brain barrier formation in Drosophila. Cell 123: 133-144. 16213218

Segalat, L., Elkes, D. A. and Kaplan, J. M. (1995). Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans. Science 267(5204): 1648-51

Shyn, S. I., Kerr, R. and Schafer, W. R. (2003). Serotonin and Go modulate functional states of neurons and muscles controlling C. elegans egg-laying behavior. Curr. Biol. 13: 1910-1915. 14588249

Talluri, S., Bhatt, A. and Smith, D. (1995). Identification of a Drosophila G-protein alpha subunit (dGqalpha-3) expressed in chemosensory cells and central nervous system. Proc. Natl. Acad. Sci. 92: 11475-11479. PubMed Citation: 8524786

Tan, C., Deardorff, M. A., Saint-Jeannet, J. P., Yang, J., Arzoumanian, A. and Klein, P. S. (2001). Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development. Development 128: 3665-3674. PubMed ID: 11585793

Tauc, H. M., Mann, T., Werner, K. and Pandur, P. (2012). A role for Drosophila Wnt-4 in heart development. Genesis 10.1002/dvg.22021. PubMed Citation: 22371299

Thambi, N. C., et al. (1989). Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system. J. Biol. Chem. 264(31): 18552-60. PubMed Citation: 2509464

Tomchik, S. M., Davis, R. L. (2009). Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway. Neuron 64: 510-521. PubMed ID: 19945393

Valat, J., et al. (1995). Immunocytochemical localization of the GTP-binding protein G0 alpha in the vestibular epithelium and ganglion of the guinea-pig. J. Neurocytol. 24(12): 916-24. PubMed Citation: 8719819

Valenzuela, D., et al. (1997). G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. Proc. Natl. Acad. Sci. 94(5):1727-32. PubMed Citation: 9050846

Van Biesen, T., et al. (1996). G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. J. Biol. Chem. 271: 1266-1269. PubMed Citation: 8576109

Van Dongen, A. M., et al. (1988). Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. Science. 242: 1433-1437. 89072715

Van Doren, M., Broihier, H. T., Moore, L. A. and Lehmann, R. (1998). HMG-CoA reductase guides migrating primordial germ cells. Nature 396: 466-469. 9853754

van Swinderena, B., et al. (2001). Goalpha regulates volatile anesthetic action in Caenorhabditis elegans. Genetics 158: 643-655. 11404329

Vecsey, C. G., Pirez, N. and Griffith, L. C. (2014). The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons. J Neurophysiol 111: 1033-1045. PubMed ID: 24353297

Vitale, N., et al. (1993). Exocytosis in chromaffin cells. Possible involvement of the heterotrimeric GTP-binding protein G(o). J. Biol. Chem. 268: 14715-14723. PubMed Citation: 7686903

Wilcox, M. D., et al. (1995). Bovine brain GO isoforms have distinct gamma subunit compositions. J. Biol. Chem. 270(9): 4189-92. PubMed Citation: 7876173

Wolfgang, W. J., et al. (1990). Immunolocalization of G protein alpha-subunits in the Drosophila CNS. J. Neurosci. 10(3): 1014-24. PubMed Citation: 2108229

Wolfgang, W. J., et al. (1991). Restricted spatial and temporal expression of G-protein alpha-subunits during Drosophila embryogenesis. Development 113: 527-538. PubMed Citation: 1782864

Wu, V. M., et al. (2004). Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. J. Cell Biol. 164: 313-323. PubMed Citation: 14734539

Yi, P., Han, Z., Li, X. and Olson, E. N. (2006). The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Gγ1. Science 313: 1301-1303. PubMed Citation: 16857902

Yi, P., Johnson, A. N., Han, Z., Wu, J. and Olson, E. N. (2008). Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila. Dev. Cell 15(5): 704-13. PubMed Citation: 19000835

Yoon, J., et al. (1989). Molecular characterization of Drosophila gene encoding G0 alpha subunit homolog. J. Biol. Chem. 264(31): 18536-43. PubMed Citation: 2509462

Zaffran, S., et al. (1995). Cellular interactions during heart morphogenesis in the Drosophila embryo. Biol. Cell 84(1-2): 13-24. PubMed Citation: 8574195

Zhang, S., Roman, G. (2013). Presynaptic inhibition of gamma lobe neurons is required for olfactory learning in Drosophila. Curr Biol 23: 2519-2527. PubMed ID: 24291093


G protein oalpha 47A: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 10 June 2014

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.