Cyclin E


REFERENCES

Ables, E. T. and Drummond-Barbosa, D. (2013). Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals. Development 140: 530-540. PubMed ID: 23293285

Alevizopoulos, K, et al. (1997). Cyclin E and c-Myc promote cell proliferation in the presence of p16(INK4a) and of hypophosphorylated retinoblastoma family proteins. EMBO J. 16(17): 5322-5333. PubMed Citation: 9311992

Andersen, D. S., et al. (2010). Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription. Mol. Cell. Biol. 30(19): 4744-55. PubMed Citation: 20679484

Araki, M., Yu, H. and Asano, M. (2005). A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo. Genes Dev. 19: 2458-2465. Medline abstract: 16195415

Badenhorst, P. (2001). Tramtrack controls glial number and identity in the Drosophila embryonic CNS. Development 128: 4093-4101. 11641231

Baig, J., et al. (2010). The chromatin-remodeling Protein Osa interacts with CyclinE in Drosophila eye imaginal discs. Genetics 184: 731-744. PubMed Citation: 20008573

Barrios, N., Gonzalez-Perez, E., Hernandez, R. and Campuzano, S. (2015). The homeodomain Iroquois proteins control cell cycle progression and regulate the size of developmental fields. PLoS Genet 11: e1005463. PubMed ID: 26305360

Berger, C., Pallavi, S. K., Prasad, M., Shashidhara, L. S. and Technau, G. M. (2005). A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat. Cell Biol. 7(1): 56-62. Medline abstract: 15580266

Bhaskar, V. and Courey, A. J. (2002). The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist. Gene 299(1-2): 173-84. PubMed Citation: 12459265

Bhat, K. M. and Apsel, N. (2004). Upregulation of Mitimere and Nubbin acts through Cyclin E to confer self-renewing asymmetric division potential to neural precursor cells. Development 131: 1123-1134. 14973280

Biedermann, B., et al. (2009). Translational repression of Cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis. Dev. Cell 17: 355-364. PubMed Citation: 19758560

Brodigan, T. M., et al. (2003). Cyclin E expression during development in Caenorhabditis elegans. Dev. Bio. 254: 102-115. 12606285

Britton, J. S. and Edgar, B. A. (1998). Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms. Development 125(11): 2149-58. PubMed Citation: 9570778

Brumby, A. M., et al. (2002). Drosophila cyclin E interacts with components of the Brahma complex. EMBO J. 21: 3377-3389. 12093739

Brumby, A. M. and Richardson, H. E. (2003). scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 22: 5769-5779. 14592975

Brumby, A., Secombe, J., Horsfield, J., Coombe, M., Amin, N., Coates, D., Saint, R. and Richardson, H. (2004). A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. Genetics 168(1): 227-51. 15454540

Buttitta, L. A., Katzaroff, A. J., Perez, C. L., de la Cruz, A. and Edgar B. A. (2007). A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev. Cell 12(4): 631-43. Medline abstract: 17419999

Cai, Y., et al. (2010). Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J. Biol. Chem. 285: 4268-4272. PubMed Citation: 20018852

Caldwell, M. C. and Datta, S. (1998). Expression of Cyclin E or DP/E2F rescues the G1 arrest of trol mutant neuroblasts in the Drosophila larval central nervous system. Mech. Dev. 79(1-2): 121-130. PubMed Citation: 10349625

Calvi, B. R., Lilly, M. A. and Spradling, A. C. (1998). Cell cycle control of chorion gene amplification. Genes Dev. 12(5): 734-744. PubMed Citation: 9499407

Castano, E., Kleyner, Y. and Dynlacht, B. D. (1998). Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor. Mol. Cell. Biol. 18(9): 5380-91. PubMed Citation: 9710622

Chang, J., et al. (2000). The CNS midline cells coordinate proper cell cycle progression and identity determination of the Drosophila ventral neuroectoderm. Dev. Biol. 227: 307-323. PubMed Citation: 11071757

Chen, X., Lu, C., Morillo Prado, J. R., Eun, S. H. and Fuller, M. T. (2011). Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. Development 138: 2441-2450. PubMed ID: 21610025

Choksi, S. P., et al. (2006). Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev. Cell 11(6): 775-89. Medline abstract: 17141154

Chu, I., et al. (2007). p27 phosphorylation by Src regulates inhibition of Cyclin E-Cdk2. Cell 128: 281-294. Medline abstract: 17254967

Clurman, B. E., Sheaff, R. J., Thress, K., Groudine, M. and Roberts. J. M. (1996). Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev. 10: 1979-1990

Coats, S., et al. (1999). A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells. Curr. Biol. 9(4): 163-73

Coleman, T. R., Carpenter, P. B. and Dunphy, W. G. (1996). The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87: 53-63

Collarini, E. J., Kuhn, R., Marshall, C. J., Monuki, E. S., Lemke, G. and Richardson, W. D. (1992). Down-regulation of the POU transcription factor SCIP is an early event in oligodendrocyte differentiation in vivo. Development 116: 193-200. 1483387

Cook, J. G., et al. (2002). Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc. Natl. Acad. Sci. 99(3): 1347-52. 11805305

Coverley, D., Laman, H. and Laskey, R. A. (2002). Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat. Cell Biol. 4: 523-528. 12080347

Crack, D., et al. (2002).Analysis of Drosophila Cyclin EI and II function during development: Identification of an inhibitory zone within the morphogenetic furrow of the eye imaginal disc that blocks the function of Cyclin EI but not Cyclin EII. Dev. Biol. 241(1): 157-71. 11784102

Dahiya, A., et al. (2001). Linking the Rb and Polycomb pathways. Mol. Cell 8: 557-568. 11583618

D'Angiolella, V., et al. (2001). Role for cyclin-dependent kinase 2 in mitosis exit. Curr. Bio. 11: 1221-1226. 11516956

Deb, D. K., Tanaka-Matakatsu, M., Jones, L., Richardson, H. E. and Du, W. (2008). Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells. Mech. Dev. 125(9-10): 857-64. PubMed Citation: 18606221

Deed, R. W., et al. (1997). Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol. Cell. Biol. 17(12): 6815-6821

de Nooij, J. C., Graber, K. H. and Hariharan, I. K. (2000). Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by Cyclin E. Mech. Dev. 97: 73-83.

Doronkin, S., Djagaeva, I. and Beckendorf, S. K. (2003). The COP9 signalosome promotes degradation of cyclin E during early Drosophila oogenesis. Developmental Cell 4: 699-710. 12737805

Du, W., et al. (1996). RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10: 1206-1218

Duman-Scheel, M., et al. (2002). Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417: 299-304. 12015606

Duman-Scheel, M., Johnston, L. A. and Du, W. (2004). Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc. Natl. Acad. Sci. 101(11): 3857-62. 15001704

Duong, H. A., et al. (2008). Transformation of eye to antenna by misexpression of a single gene. Mech. Dev. 125: 130-141. PubMed Citation: 18037276

Duronio, R. J., et al. (1995a). The transcription factor E2F is required for S phase during Drosophila oogenesis. Genes & Dev. 9: 1445-55

Duronio, R. J. and O'Farrell, P. H. (1995b). Developmental control of the G1 to S transition in Drosophila: Cyclin E is a limiting downstream target of E2F. Genes & Dev. 9: 1456-68

Duronio, R. J., et al. (1996). E2F-induced S phase requires cyclin E. Genes Dev. 10: 2505-13

Fay, D. S. and Han, M. (2000). Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development. Development 127: 4049-4060

Felzien, L. K., et al. (1999). Specificity of Cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator. Mol. Cel. Bio. 19: 4241-4246

Finley, R. L., et al. (1996). Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase. Proc. Natl. Acad. Sci. 93: 3011-3015

Follette, P. J., Duronio, R. J. and O'Farrell, P. H. (1998). Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Curr. Biol. 8(4): 235-238

Fox, P. M., et al. (2011). Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline. Development 138: 2223-2234. PubMed Citation: 21558371

Frolov, M. V., et al. (2001). Functional antagonism between E2F family members Genes Dev. 15: 2146-2160. 11511545

Fuss, B., et al. (2001). Control of endoreduplication domains in the Drosophila gut by the knirps and knirps-related genes. Mech. Dev. 100: 15-23. 11118880

Galaktionov, K., Chen, X. and Beach, D. (1996). Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382: 511-517

Geng, Y., et al. (1999). Rescue of Cyclin D1 deficiency by knockin Cyclin E. Cell 97: 767-777

Ghiani, C. A. and Gallo, V. (2001). Inhibition of Cyclin E-Cyclin-dependent kinase 2 complex formation and activity is associated with cell cycle arrest and withdrawal in oligodendrocyte progenitor cells. J. Neurosci. 21(4): 1274-1282. 11160398

Gomez Lahoz, E., et al. (1999). Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo. Mol. Cell. Biol. 19(1): 353-63

Gonzalez, M. A., Tachibana, K. E., Adams, D. J., van der Weyden, L., Hemberger, M., Coleman, N., Bradley, A. and Laskey, R. A. (2006). Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Genes Dev. 20: 1880-1884. PubMed Citation: 16847348

Griffiths, R. L. and Hidalgo, A. (2004). Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons. EMBO J. 23: 2440-2450. 15167898

Grosskortenhaus, R. and Sprenger, F. (2002). Rca1 inhibits APC-Cdh1Fzr and is required to prevent cyclin degradation in G2. Dev. Cell 2: 29-40. 11782312

Gudas, J. M., et al. (1999). Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. Mol. Cell. Biol. 19(1): 612-22

Hara, E., Hall, M. and Peters, G. (1997). Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors. EMBO J. 16: 332-342

Hartley, R. S., et al. (1997). A role for cyclin E/Cdk2 in the timing of the midblastula transition in xenopus embryos. Dev. Biol. 188(2):312-321

Harvey, K. F., Pfleger, C. M. and Hariharan, A. K. (2003). The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114: 457-467. 12941274

Higa, L. A., et al. (2006). Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Cell Cycle 5(1): 71-7. Medline abstract: 16322693

Hinchcliffe, E. H., et al. (1999). Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 283(5403): 851-4

Honda, R., et al. (2005). The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. EMBO J. 24: 452-463. 15660127

Hong, A., et al. (2003). The p27cip/kip ortholog dacapo maintains the Drosophila oocyte in prophase of meiosis I. Development 130: 1235-1242. 12588841

Howe, J. A. and Newport, J. W. (1996). A developmental timer regulates degradation of cyclin E1 at the midblastula transition during Xenopus embryogenesis. Proc. Natl. Acad. Sci 93: 2060-64

Huang, J., Wu, S., Barrera, J., Matthews, K. and Pan, D. (2005). The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell 122: 421-434. 16096061

Huang, J. and Kalderon, D. (2014). Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation. J Cell Biol 205(3):325-38. PubMed ID: 24798736

Iovino, N., Ciabrelli, F. and Cavalli, G. (2013). PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes. Dev Cell 26: 431-439. PubMed ID: 23932903

Jeon, H. M., et al. (2008). Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes Dev. 22(15): 2028-33. PubMed Citation: 18676808

Jiao, R., et al. (2001). Headless flies generated by developmental pathway interference. Development 128: 3307-3319. 11546747

Jia, J., Zhang, W., Wang, B., Trinko, R., and Jiang, J.(2003). The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev. 17: 2514-2519. 14561774

Johnson, D. G., Ohtani, K. and Nevins, J. R. (1994). Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8: 1514-25. PubMed Citation: 7958836

Jones, L., Richardson, H. and Saint, R. (2000). Tissue-specific regulation of cyclin E transcription during Drosophila melanogaster embryogenesis. Development 127: 4619-4630. PubMed Citation: 11023865

Kalaszczynska, I., et al. (2009). Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138(2): 352-65. PubMed Citation: 19592082

Kango-Singh, M., et al. (2002). Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129: 5719-5730. 12421711

Kannan, R., Berger, C., Myneni, S., Technau, G. M. and Shashidhara, L. S. (2010). Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system. Mech. Dev. 127(1-2): 137-45. PubMed Citation: 19799999

Kerber, B., Fellert, S. and Hoch, M., (1998). Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney. Genes Dev. 12(12): 1781-1786

Knoblich, J. A., et al. (1994). Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell 77: 107-20

Kondo, T. and Hayashi, S. (2013). Mitotic cell rounding accelerates epithelial invagination. Nature 494: 125-129. PubMed ID: 23334416

Lacey, K. R., Jackson, P. K. and Stearns, T. (1999). Cyclin-dependent kinase control of centrosome duplication. Proc. Natl. Acad. Sci. 96(6): 2817-22

Lai, Z.-C., et al. (2005). Control of cell proliferation and apoptosis by Mob as tumor suppressor Mats. Cell 12: 675-685. 15766530

Lane, M. E., et al. (2000). A screen for modifiers of Cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2. Genetics 155: 233-244.

Le Cam, L., et al. (1999). Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex. EMBO J. 18(7): 1878-1890

Lecona, E., Rojas, L. A., Bonasio, R., Johnston, A., Fernandez-Capetillo, O. and Reinberg, D. (2013). Polycomb Protein SCML2 Regulates the Cell Cycle by Binding and Modulating CDK/CYCLIN/p21 Complexes. PLoS Biol 11: e1001737. PubMed ID: 24358021

Leng, X., et al. (1997). S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation. Curr. Biol. 7(9): 709-712

Leone, G., et al. (1997). Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387 (6631): 422-426

Leone G., et al. (1998). E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 12(14): 2120-2130

Lessard, J., Schumacher, A., Thorsteinsdottir, U., van Lohuizen, M., Magnuson, T. and Sauvageau, G. (1999). Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation. Genes Dev 13: 2691-2703. PubMed ID: 10541555

Li, L., Anderson, S., Secombe, J. and Eisenman, R. N. (2013). The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth. Development 140: 4776-4787. PubMed ID: 24173801

Li. Q.-J., Pazdera, T. M. and Minden, J. S. (1999). Drosophila embryonic pattern repair: how embryos respond to cyclin E-induced ectopic division. Development 126: 2299-2307

Lilly, M. A. and Spradling, A. C. (1996). The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S-phase completion. Genes Dev. 10: 2514-26

Liu, Q. X., Wang, X. F., Ikeo, K., Hirose, S., Gehring, W. J., Gojobori, T. (2014) Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin E during eye development. Proc Natl Acad Sci U S A 111: 9497-9502. PubMed ID: 24979795

Lu, A. and Pfeffer, S. R. (2013). Golgi-associated RhoBTB3 targets Cyclin E for ubiquitylation and promotes cell cycle progression. J Cell Biol 203: 233-250. PubMed ID: 24145166

Lu, J., Ruhf, M. L., Perrimon, N. and Leder, P. (2007). A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc. Natl. Acad. Sci. 104(22): 9381-6. Medline abstract: 17517653

Lukas, J., et al. (1997). Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev. 11(11): 1479-1492

Lundberg, A. S. and Weinberg, R. A. (1998). Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18(2): 753-761

Ma, T., et al. (2000). Cell cycle-regulated phosphorylation of p220NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 14: 2298-2313.

Matsumoto, Y., Hayashi, K. and Nishida, E. (1999). Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Curr. Biol. 9(8): 429-32

Matsumoto, Y. and Maller, J. L. (2004). A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science 306: 885-888. PubMed Citation: 15514162

Mendjan, S., et al. (2006). Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. Mol. Cell 21: 811-823. PubMed Citation: 16543150

Meyer, C. A., et al. (2000). Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 19: 4533-4542

Meyer, C. A., et al. (2002). Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression. Development 129: 319-328. 11807025

Milán, M., Campuzano, S. and García-Bellido, A. (1996). Cell cycling and patterned cell proliferation in the Drosophila wing during metamorphosis. Proc. Natl. Acad. Sci. 93: 11687-92

Minella, A. C. (2002). p53 and p21 form an inducible barrier that protects cells against Cyclin E-cdk2 deregulation. Curr. Biol. 12: 1817-1827. 12419181

Minella, A. C., et al. (2008). Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev. 22: 1677-1689. PubMed Citation: 18559482

Mitra, K., Wunder, C., Roysam, B., Lin, G. and Lippincott-Schwartz, J. (2009). A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase. Proc Natl Acad Sci U S A 106: 11960-11965. PubMed ID: 19617534

Moberg, K. H., et al. (2002). Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 413(6853): 311-6. 11565033

Moberg, K. H., Mukherjee, A., Veraksa, A., Artavanis-Tsakonas, S. and Hariharan, I. K. (2004). The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol 14: 965-974. PubMed ID: 15182669

Montagnoli, A., et al. (1999). Ubiquitination of p27 is regulated by cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13(9): 1181-9

Moore, J. D., et al. (1999). Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. J. Cell Biol. 144(2): 213-24

Morris, T. A., DeLorenzo, R. J. and Tombes, R. M. (1998). CaMK-II inhibition reduces cyclin D1 levels and enhances the association of p27kip1 with Cdk2 to cause G1 arrest in NIH 3T3 cells. Exp. Cell Res. 240(2): 218-227

Muller, D., et al. (2000). Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60, EMBO J. 19: 2168-2180

Murphy, T. D. (2003). Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. J Cell Sci. 116(Pt 11): 2321-32. 12730292

Mussman, J. G., et al. (2000). Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene 19(13): 1635-46.

Nagahara, H., et al. (1999). Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Proc. Natl. Acad. Sci. 96(26): 14961-6.

Nakayama, K., et al. (2000). Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication. EMBO J. 19: 2069-2081

Narbonne-Reveau, K., et al. (2008). APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle. Development 135: 1451-1461. PubMed Citation: 18321983

Nakamura, K., Ida, H. and Yamaguchi, M. (2008). Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathway. Nucleic Acids Res. 36: 3905-3915. PubMed Citation: 18511465

Narbonne-Reveau, K. and Lilly, M. (2009). The Cyclin-dependent kinase inhibitor Dacapo promotes genomic stability during premeiotic S phase. Mol Biol Cell 20: 1960-1969. PubMed ID: 19211840

Ohlmeyer, J. T. and Schüpbach, T. (2003). Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis. Development 130: 6339-6349. 14623823

Ohtani, K., deGregori, J. and Nevins, J. R. (1995). Regulation of the Cyclin E gene by the E2F1 transcription factor. Proc Natl. Acad. Sci. 92: 12146-50

Okuda, M., et al. (2000). Nucleophosmin/B23 is a target of CDK2/Cyclin E in centrosome duplication. Cell 103: 127-140.

Ou, C.-Y., Lin, Y.-F. Chen, Y.-J. and Chien, C.-T. (2002). Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 16: 2403-2414. 12231629

Pantalacci, S., Tapon, N. and Leopold, P. (2003). The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol. 5(10): 921-7. 14502295

Parisi, T., et al. (2003). Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 22: 4794-4803. 12970191

Perkins, N. D., et al. (1997). Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator. Science 275: 523-627.

Prall, O. W. J., et al. (1998). c-Myc or cyclin D1 mimics estrogen effects on cyclin E-cdk2 activation and cell cycle reentry. Mol. Cell. Biol. 18(8): 4499-4508

Prestel, M., et al. (2010). The activation potential of MOF is constrained for dosage compensation. Mol. Cell 38: 815-826. PubMed Citation: 20620953

Raja, S. J., et al. (2010). The nonspecific lethal complex is a transcriptional regulator in Drosophila. Mol. Cell 38: 827-841. PubMed Citation: 20620954

Reber, A., Lehner, C. F. and Jacobs, H. W. (2006). Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development 133(16): 3201-11. 16854973

Richardson, H. E., et al. (1993). A Drosophila G1-specific Cyclin E homolog exhibits different modes of expression during embryogenesis. Development 119: 673-90

Richardson, H. E., et al. (1995). Ectopic Cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development 121: 3371-79

Richter, C., Oktaba, K., Steinmann, J., Muller, J. and Knoblich, J. A. (2011). The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. Nat Cell Biol 13: 1029-1039. PubMed ID: 21857667

Rosner, M. H., Vigano, M. A., Ozato, K., Timmons, P. M., Poirier, F., Rigby, P. W. J. and Staudt, L. M. (1990). A POU-domain transcription factor in early stem cells and germ cells of mammalian embryo. Nature 345: 686-692. 1972777

Royzman, I., Whittaker, A. J. and Orr-Weaver, T. L. (1997). Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes & Dev. 11: 1999-2011

Saha, P., et al. (1997). p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases. Mol. Cell. Biol. 17: 4338-4345

Sauer, K., et al. (1995). Distinct modes of Cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Genes Dev 9: 1327-1339

Sauvageau, M. and Sauvageau, G. (2010). Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 7: 299-313. PubMed ID: 20804967

Secombe, J., et al. (1998). Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for Cyclin E in cell proliferation control during eye imaginal disc development. Genetics 149(4): 1867-1882

Seghezzi, W., et al. (1998). Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells. Mol. Cell. Biol. 18(8): 4526-4536

Shanahan F., et al. (1999). Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. Mol. Cell. Biol. 19(2): 1460-9

Shcherbata, H. R., et al. (2004). The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions. Development 131: 3169-3181. 15175253

Sheaff, R. J., et al. (1997). Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev. 11(11): 1464-1478. PubMed Citation: 9192873

Sherr, C. J. (1993). Mammalian G1 cyclins. Cell 73: 1059-1065

Steiner, P., et al. (1995). Identification of a Myc-dependent step during formation of active G1 cyclin-cdk complexes. EMBO J 14: 4814-26. PubMed Citation: 7588611

Shibutani, S. T. et al. (2008). Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev. Cell 15: 890-900. PubMed Citation: 19081076

Shimizu, T., Ho, L. L. and Lai, Z. C. (2008). The mob as tumor suppressor gene is essential for early development and regulates tissue growth in Drosophila. Genetics 178(2): 957-65. PubMed Citation: 18245354

Sigrist, S. J. and Lehner, C. F. (1997). Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90(4): 671-681. PubMed Citation: 9288747

Singer, J. D., et al. (1999). Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 13: 2375-2387. PubMed Citation: 10500095

Staropoli, J. F., McDermott, C., Martinat, C., Schulman, B., Demireva, E. and Abeliovich, A. (2003). Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 37(5): 735-49. 12628165

Stewart, Z. A., Leach, S. D. and Pietenpol, J. A. (1999). p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol. Cell. Biol. 19(1): 205-15. PubMed Citation: 9858545

Strausfeld, U. P., et al. (1994). CIP1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases. Curr. Biol. 4: 876-883. PubMed Citation: 7850420

Strohmaier, H., Spruck, C. H., Kaiser, P., Won, K. A., Sangfelt, O., and Reed, S. I. (2001). Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413: 316-322. 11565034

Su, T. T. and O'Farrell, P. H. (1997). Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. J. Cell Biol. 139(1): 13-21. PubMed Citation: 9314525

Su, T. T. and O'Farrell, P. H. (1998). Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles. J. Cell Biol. 140(3): 451-460. PubMed Citation: 9456309

Sudarsan, V., et al. (2002). A genetic hierarchy establishes mitogenic signaling and mitotic competence in the renal tubules of Drosophila. Development 129: 935-944. 11861476

Sugano, W., Ohno, K., Yoneda-Kato, N., Kato, J. Y. and Yamaguchi, M. (2008). The myeloid leukemia factor interacts with COP9 signalosome subunit 3 in Drosophila melanogaster. FEBS J 275: 588-600. Pubmed: 18199288

Szuplewski, S., Sandmann, T., Hietakangas, V. and Cohen, S. M. (2009). Drosophila Minus is required for cell proliferation and influences Cyclin E turnover. Genes Dev. 23(17): 1998-2003. PubMed Citation: 19723762

Tapon, N., et al. (2001). The Drosophila Tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105: 345-355. 11348591

Tapon, N., et al. (2002). salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110: 467-478. 12202036

Thomer, M., et al. (2004). Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2. Development 131(19): 4807-18. 15342466

Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C. and Halder, G. (2003). Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat. Cell Biol. 5(10): 914-20. 14502294

Vidwans, S. J., et al. (2002). Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos. Curr. Biol. 12: 829-833. 12015119

Vlach, J., Hennecke, S. and Amati, B. (1997). Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 16(17): 5334-5344. PubMed Citation: 9311993

Voit, R., Hoffmann, M. and Grummt, I. (1999). Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. EMBO J. 18(7): 1891-1899. PubMed Citation: 10202152

Weiss, A., et al. (1998). Continuous Cyclin E expression inhibits progression through endoreduplication cycles in Drosophila. Curr. Biol. 8(4): 239-242. PubMed Citation: 9501988

Welcker, M., et al. (2003). Multisite phosphorylation by Cdk2 and GSK3 controls Cyclin E degradation. Molec. Cell 12: 381-392. 14536078

Weng, Li., Zhu, C., Xu, J. and Du, W. (2003). Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J. 22: 3865-3875. 12881421

Whittaker, A. J., Royzman, I. and and Orr-Weaver, T. L. (2000). Drosophila Double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts. Genes Dev. 14: 1765-1776. PubMed Citation: 10898791

Wiellette, E. L., et al. (1999). spen encodes an RNP motif protein that interacts with hox pathways to repress the development of head-like sclerites in the Drosophila trunk. Development 126: 5373-5385. PubMed Citation: 10556062

Won, K. A., et al. (1998). Maturation of human Cyclin E requires the function of eukaryotic chaperonin CCT. Mol. Cell. Biol. 18(12): 7584-7589. PubMed Citation: 9819444

Wu, S., Huang, J., Dong, J., and Pan, D. (2003). hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114: 445-456. 12941273

Yamamoto, A., et al. (2000). Cyclin E as a coactivator of the androgen receptor. J. Cell Biol. 150: 873-880. 10953010

Zerfass-Thome, K., et al. (1997). p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell. Biol. 17: 407-415. PubMed Citation: 8972221

Zhang, H. S., et al. (2000). Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101: 79-89. PubMed Citation: 10778858

Zhao, J., et al. (1998). Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 12(4): 456-461. PubMed Citation: 9472014

Zhao, J., et al. (2000). NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev. 14: 2283-2297

Zhu, L., Harlow, E. and Dynlacht, B. D. (1995a). p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9: 1740-52. PubMed Citation: 7622038

Zhu, L., et al. (1995b). The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J. 14: 1904-13. PubMed Citation: 7743997

Zielke, N., et al. (2011). Control of Drosophila endocycles by E2F and CRL4CDT2. Nature 480(7375): 123-7. PubMed Citation: 22037307Zraly, C. B., Marenda, D. R., Dingwall, A. K. (2004). SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex. Genetics 168(1): 199-214. 15454538


Cyclin E: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 10 June 2014

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.