Abdou, M., et al (2011). Wnt signaling cross-talks with JH signaling by suppressing Met and gce expression. PLoS One 6(11): e26772. PubMed Citation: 22087234

Ahmad, K. F., Engel, C. K. and Prive, G. G. (1998). Crystal structure of the BTB domain from PLZF. Proc. Natl. Acad. Sci. 95(21): 12123-8. PubMed Citation: 9770450

Appel, L.F., Prout, M., Abu-Shumays, R., Hammonds, A., Garbe, J.C., Fristrom, D., and Fristrom, J. (1993). The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis. Proc. Natl. Acad. Sci. 90: 4937-4941. 6289325

Ashok, M., Turner, C. and Wilson, T. G. (1998). Insect juvenile hormone resistance gene homology with the bHLH-PAS family of transcriptional regulators. Proc. Natl. Acad. Sci. U.S.A. 95: 2761-2766. 9501163

Bardwell, V. J. and Treisman, R. (1994). The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 8: 1664-1677. PubMed Citation: 7958847

Bayer, C. A., Holley, B. and Fristrom, J. W. (1996). A switch in Broad-Complex zinc-finger isoform expression is regulated posttranscriptionally during the metamorphosis of Drosophila imaginal discs. Dev. Biol. 177: 1-14. PubMed Citation: 8660872

Bayer, C. A., von Kalm, L. and Fristrom, J. W. (1997). Relationships between protein isoforms and genetic functions demonstrate functional redundancy at the Broad-Complex during Drosophila metamorphosis. Dev. Biol. 187(2): 267-282. PubMed Citation: 9242423

Beckstead, R. B., Lam, G. and Thummel, C. S. (2005). The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biol 6: R99. PubMed ID: 16356271

Bernardo, T. J., Dubrovskaya, V. A., Xie, X. and Dubrovsky, E. B. (2014). A view through a chromatin loop: insights into the ecdysone activation of early genes in Drosophila. Nucleic Acids Res. PubMed ID: 25143532

Biyasheva, A., et al. (2001). Glue secretion in the Drosophila salivary gland: a model for steroid-regulated exocytosis. Dev. Bio. 231: 234-251. 11180965

Boyle, M. J., et al (2010). Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube. Dev. Biol. 346 68-79. PubMed Citation: 20659448

Brennan, C. A., Ashburner, M. and Moses, K. (1998). Ecdysone pathway is required for furrow progression in the developing Drosophila eye. Development 125: 2653-2664. PubMed Citation: 9636080

Brennan, C. A., et al. (2001). Broad-complex, but not Ecdysone receptor, is required for progression of the morphogenetic furrow in the Drosophila eye. Development 128: 1-11. PubMed Citation: 11092806

Buszczak, M., et al. (1999). Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development 126: 4581-4589. PubMed Citation: 10498692

Chen, G-C., Gajowniczek, P. and Settleman, J. (2004). Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis. Current Biol. 14: 309-313. 14972681

Chen, L., O'Keefe, S. L. and Hodgetts, R. B. (2002). Control of Dopa decarboxylase gene expression by the Broad-Complex during metamorphosis in Drosophila. Mech. Dev. 119: 145-156. 12464428

Cheung, L. S., Simakov, D. S., Fuchs, A., Pyrowolakis, G. and Shvartsman, S. Y. (2013). Dynamic model for the coordination of two enhancers of broad by EGFR signaling. Proc Natl Acad Sci U S A. PubMed ID: 24127599

Chronis, C., Fiziev, P., Papp, B., Butz, S., Bonora, G., Sabri, S., Ernst, J. and Plath, K. (2017). Cooperative binding of transcription factors orchestrates reprogramming. Cell 168(3): 442-459 e420. PubMed ID: 28111071

Crossgrove, K., et al. (1996). A cluster of 10 salivary gland-specific secondary response L71 late genes is dependent on the BR-C rbp+ genetic function. Dev. Biol. 180(2): 745-58. PubMed Citation: 8954742

Daish, T. J., Cakouros, D. and Kumar, S. (2003). Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc. Cell Death Dif. 10: 1348-1356. 12970673

Dalton, J. E., Lebo, M. S., Sanders, L. E., Sun, F. and Arbeitman, M. N. (2009). Ecdysone receptor acts in fruitless- expressing neurons to mediate drosophila courtship behaviors. Curr Biol 19: 1447-1452. PubMed ID: 19646872

D'Avino, P. P., et al. (1995). The role of the BR-C locus on the expression of genes located at the ecdysone-regulated 3C puff of Drosophila melanogaster. Mech. Dev. 49: 161-171. PubMed Citation: 7734390

Deng, W. M. and Bownes, M. (1997). Two signalling pathways specify localised expression of theBroad-Complex in Drosophila eggshell patterning andmorphogenesis. Development 124(22): 4639-4647. PubMed Citation: 9409680

Dhordain, P., et al. (1997). Corepressor SMRT binds the BTB/POZ repressing domain of theLAZ3/BCL6 oncoprotein. Proc. Natl. Acad. Sci. 94(20): 10762-10767. PubMed Citation: 9380707

DiBello, P. R., et al. (1991). The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers. Genetics 129: 385-97. PubMed Citation: 1743483

Dressel, U., et al. (1999). Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol. Cell. Biol. 19: 3383-3394. PubMed Citation: 10207062

Dubrovsky, E. B., Dretzen, G. and Bellard, M. (1994). The Drosophila broad-complex regulates developmentalchanges in transcription and chromatin structure of the 67B heat-shock gene cluster. J. Mol. Biol. 241: 353-362. PubMed Citation: 8064852

Dubrovsky, E. B., et al. (1996). The Broad-Complex gene is a tissue-specific modulator of the ecdysone response of the Drosophila hsp23 gene. Mol. Cell. Biol. 16: 6542-55. PubMed Citation: 17616185

Dunne, J. C., Kondylis, V. and Rabouille, C. (2002). Ecdysone triggers the expression of golgi genes in Drosophila imaginal discs via Broad-Complex. Dev. Biol. 245: 172-186. 11969264

Erezyilmaz, D. F., Riddiford, L. M. and Truman, J. W. (2006). The pupal specifier broad directs progressive morphogenesis in a direct-developing insect. Proc. Natl. Acad. Sci. 103(18): 6925-30. 16641104

Emery, I. F., Bedian, V. and Guild, G. M. (1994). Differential expression of Broad-Complex transcriptionfactors may forecast tissue-specific developmental fatesduring Drosophila metamorphosis. Development 120: 3275-3287. PubMed Citation: 7720567

Fisk, G. J. and Thummel, C. S. (1998). The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis. Cell 93(4): 543-555. PubMed Citation: 9604930

Fletcher, J. C. and Thummel, C. S. (1995).The ecdysone-inducible Broad-complex and E74 early genes interact to regulate target gene transcription and Drosophila metamorphosis. Genetics 141: 1025-1035. PubMed Citation: 8582609

Fletcher, J. C., D'Avino, P. P. and Thummel, C. S. (1997). A steroid-triggered switch in E74 transcription factor isoforms regulates the timing of secondary-response gene expression. Proc. Natl. Acad. Sci. 94 (9): 4582-4586. PubMed Citation: 9114033

Fuchs, A., et al. (2012). Transcriptional interpretation of the EGF receptor signaling gradient. Proc. Natl. Acad. Sci. 109(5): 1572-7. PubMed Citation: 22307613

Geneste, O., Copeland, J.W., and Treisman, R. (2002). LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics. J. Cell Biol. 157: 831-838. 12034774

Ghbeish, N., et al. (2001). The dual role of Ultraspiracle, the Drosophila retinoid X receptor, in the ecdysone response. Proc. Natl. Acad. Sci. 98: 3867-3872. 11274407

Ghbeish, N. and McKeown, M. (2002). Analyzing the repressive function of ultraspiracle, the Drosophila RXR, in Drosophila eye development. Mech. Dev. 111(1-2): 89-98. 11804781

Gotwals, P. J. and Fristrom, J. W. (1991). Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in Drosophila. Genetics 127: 747-59

Guo, Y., Flegel, K., Kumar, J., McKay, D.J. and Buttitta, L.A. (2016). Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells. Biol Open 5(11):1648-1661. PubMed ID: 27737823

Halsell, S. R. and Kiehart, D, P. (1998). Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis. Genetics 148(4):1845-1863

Huang, Y. C., Lu, Y. N., Wu, J. T., Chien, C. T. and Pi, H. (2014). The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence. PLoS Genet 10: e1004760. PubMed ID: 25393278

Hodgetts, R. B., et al. (1995). Hormonal induction of Dopa decarboxylase in the epidermis of Drosophila is mediated by the Broad-Complex. Development 121: 3913-3922

Huet, F., Puiz, C. and Richards, G. (1993). Puffs and PCR: the in vivo dynamics of early gene expression during ecdysone responses in Drosophila. Development 118: 613-627

Huynh, K. D. and Bardwell, V. J. (1998). The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 1998 Nov 12;17(19):2473-84

Jiang, C., et al. (2000). A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Molec. Cell 5: 445-455.

Jin, H., Kim, V. N. and Hyun, S. (2012). Conserved microRNA miR-8 controls body size in response to steroid signaling in Drosophila. Genes Dev 26: 1427-1432. Pubmed: 22751499

Johnson, F. B., Parker, E. and Krasnow, M. A. (1995). Extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction. Proc. Natl. Acad. Sci. 92: 739-743

Konopova, B. and Jindra, M. (2008). Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis. Development 135: 559-568. PubMed Citation: 18171683

Kiss, I., et al. (1988). Interactions and developmental effects of mutations in the Broad-Complex of Drosophila melanogaster. Genetics 118: 247-259

Karim, F. D., Guild, G. M. and Thummel, C. S. (1993). The Drosophila Broad-Complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis. Development 118: 977-988

Lam, G. T., Jiang, C., and Thummel, C. S. (1997). Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis. Development 124 (9): 1757-1769

Lee, C.-Y. and Baehrecke, E. H. (2001). Steroid regulation of autophagic programmed cell death during development. Development 128: 1443-1455. 11262243

Lee, C.-Y., Cooksey, B. A. and Baehrecke, E. H. (2002). Steroid regulation of midgut cell death during Drosophila development. Dev. Bio. 250: 101-111. 12297099

Lee, C. Y., et al. (2003). Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila. Curr. Biol. 13: 350-357. 12593803

Lehmann, M. and Korge, G. (1995). Ecdysone regulation of the Drosophila Sgs-4 gene is mediated by the synergistic action of ecdysone receptor and SEBP 3. EMBO J. 14: 716-726

Li, T.-R. and Bender, M. (2000). A conditional rescue system reveals essential functions for the ecdysone receptor(EcR) gene during molting and metamorphosis in Drosophila. Development 127: 2897-2905.

Li, X., et al. (1997). Overexpression, purification, characterization, and crystallization of the BTB/POZ domain from the PLZF oncoprotein. J. Biol. Chem. 272(43): 27324-27329

Lovato, T. L., Benjamin, A. R. and Cripps, R. M. (2005). Transcription of Myocyte enhancer factor-2 in adult Drosophila myoblasts is induced by the steroid hormone ecdysone. Dev. Biol. 288(2): 612-21. 16325168

Major, R. J. and Irvine, K. D. (2005). Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing. Development 132(17): 3823-33. 16049109

Martin, D. N. and Baehrecke, E. H. (2004). Caspases function in autophagic programmed cell death in Drosophila. Development 131: 275-284. 14668412

Maurange, C., Cheng, L. and Gould, A. P. (2008). Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila. Cell 133(5): 891-902. PubMed Citation: 18510932

Minakuchi, C., Zhou, X. and Riddiford, L. M. (2008). Krüppel homolog 1 (Kr-h1) mediates juvenile hormone action during metamorphosis of Drosophila melanogaster. Mech. Dev. 125(1-2): 91-105. PubMed citation: 18036785

Minakuchi, C., Namiki, T. and Shinoda, T. (2009). Krüppel homolog 1, an early juvenile hormone-response gene downstream of Methoprene-tolerant, mediates its anti-metamorphic action in the red flour beetle Tribolium castaneum. Dev. Biol. 325(2): 341-50. PubMed Citation: 19013451

Miura, K., Oda, M., Makita, S and Chinzei, Y. (2005). Characterization of the Drosophila Methoprene-tolerant gene product. FEBS J. 272: 1169-1178. 15720391

Mugat, B., et al. (2000). Dynamic expression of Broad-complex isoforms mediates temporal control of an ecdysteroid target gene at the onset of Drosophila metamorphosis. Dev. Bio. 227: 104-117.

Moeller, M. E., Danielsen, E. T., Herder, R., O'Connor, M. B. and Rewitz, K. F. (2013). Dynamic feedback circuits function as a switch for shaping a maturation-inducing steroid pulse in Drosophila. Development 140: 4730-4739. PubMed ID: 24173800

Niepielko, M. G., Hernáiz-Hernández, Y. and Yakoby, N. (2011). BMP signaling dynamics in the follicle cells of multiple Drosophila species. Dev. Biol. 354(1): 151-9. PubMed Citation: 21402065

Niu, H., Ye, B. H. and Dalla-Favera, R. (1998). Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 12(13): 1953-1961

O'Keefe, S., Schouls, M. and Hodgetts, R. (1995). Epidermal cell-specific quantitation of dopa decarboxylase mRNA in Drosophila by competitive RT-PCR: an effect of Broad-Complex mutants. Dev. Genet. 1645: 77-84

Parthasarathy, A., Tan, A., Bai, H. and Palli, S. R. (2008). Transcription factor broad suppresses precocious development of adult structures during larval-pupal metamorphosis in the red flour beetle, Tribolium castaneum. Mech. Dev. 125: 299-313. PubMed Citation: 18083350

Peri, F., Bokel, C. and Roth, S. (1999). Local gurken signaling and dynamic MAPK activation during Drosophila oogenesis. Mech. Dev. 81(1-2): 75-88.

Peri, F. and Roth, S. (2000). Combined activities of Gurken and Decapentaplegic specify dorsal chorion structures of the Drosophila egg. Development 127: 841-850

Renault, N., King-Jones, K. and Lehmann, M. (2001). Downregulation of the tissue-specific transcription factor Fork head by Broad-Complex mediates a stage-specific hormone response. Development 128: 3729-3737. 11585799

Restifo, L. L. and White, K. (1991). Mutations in a steroid hormone-regulated gene disrupt the metamorphosis of the central nervous system in Drosophila. Dev. Biol. 148: 174-94

Restifo, L. L. and Merrill, V. K. (1994). Two Drosophila regulatory genes, Deformed and the Broad-Complex, share common functions in development of adult CNS, head, and salivary glands. Dev. Biol. 162: 465-485

Restifo, L. L. and Hauglum, W. (1998). Parallel molecular genetic pathways operate during CNS metamorphosis in Drosophila. Mol. Cell. Neurosci. 11: 134-48

Rewitz, K. F., Yamanaka, N. and O'Connor, M. B. (2010). Steroid hormone inactivation is required during the juvenile-adult transition in Drosophila. Dev Cell 19: 895-902. PubMed ID: 21145504

Riddiford, L. M. and Ashburner, M. (1991). Effects of juvenile hormone mimics on larval development and metamorphosis of Drosophila melanogaster. Gen. Comp. Endocrinol. 82: 172-183. 1906823

Sandstrom, D. J., et al. (1997). Broad-Complex transcription factors regulate muscle attachment in Drosophila. Dev. Biol. 181: 168-185

Sandstrom, D. J. and Restifo, L. L. (1999). Epidermal tendon cells require Broad Complex function for correct attachment of the indirect flight muscles in Drosophila melanogaster. J. Cell Sci. 112: 4051-4065

Schubiger, M. and Truman, J. W. (2000). The RXR ortholog USP suppresses early metamorphic processes in Drosophila in the absence of ecdysteroids. Development 127: 1151-1159

Sedkov, Y., et al. (2003). Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. Nature 426(6962): 78-83. 14603321

Sempere, L. F., et al. (2003). Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity. Dev. Biol. 259: 9-18. 12812784

Shemshedini, L. and Wilson, T. G. (1990). Resistance to juvenile hormone and an insect growth regulator in Drosophila is associated with an altered cytosolic juvenile hormone binding protein. Proc. Natl. Acad. Sci. 87: 2072-2076. 2107540

Sorrentino, R. P., Carton, Y. and Govind, S. (2002). Cellular immune response to parasite infection in the Drosophila lymph gland is developmentally regulated. Dev. Biol. 243: 65-80. 11846478

Sotiropoulos, A., Gineitis, D., Copeland, J. and Treisman, R. (1999). Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell 98: 159-169. 10428028

Spokony, R. F. and Restifo, L. L. (2007). Anciently duplicated Broad Complex exons have distinct temporal functions during tissue morphogenesis. Dev. Genes Evol. 217(7): 499-513. PubMed Citation: 17530286

Sugawara, M., et al. (1994). A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein. Mol. Cell. Biol. 14: 8438-8450

Suzuki, Y., Truman, J. M. and Riddiford, L. M. (2008). The role of Broad in the development of Tribolium castaneum: implications for the evolution of the holometabolous insect pupa. Development 135: 569-577. PubMed Citation: 18171684

Syed, M. H., Mark, B. and Doe, C. Q. (2017). Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity. Elife 6 [Epub ahead of print]. PubMed ID: 28394252

Terashima, J. and Bownes, M. (2004). Translating available food into the number of eggs laid by Drosophila melanogaster. Genetics 167(4): 1711-9. 15342510

Terashima, J., Takaki, K., Sakurai, S. and Bownes, M. (2005). Nutritional status affects 20-hydroxyecdysone concentration and progression of oogenesis in Drosophila melanogaster. J. Endocrinol. 187(1): 69-79. 16214942

Tsurumi, A., Dutta, P., Yan, S. J., Sheng, R. and Li, W. X. (2013). Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling. Sci Rep 3: 2894. PubMed ID: 24100631

Tzolovsky, G, et al. (1999). The function of the Broad-Complex during Drosophila melanogaster oogenesis. Genetics 153: 1371-1383

Urness, L. D. and Thummel, C. S. (1995). Molecular analysis of a steroid-induced regulatory hierarchy: the Drosophila E74A protein directly regulates L71-6 transcription. EMBO J 14 (24): 6239-6246

Uyehara, C. M., Nystrom, S. L., Niederhuber, M. J., Leatham-Jensen, M., Ma, Y., Buttitta, L. A. and McKay, D. J. (2017). Hormone-dependent control of developmental timing through regulation of chromatin accessibility. Genes Dev 31(9):862-875. PubMed ID: 28536147

Verma, P. and Tapadia, M. G. (2015). Early gene Broad complex plays a key role in regulating the immune response triggered by ecdysone in the Malpighian tubules of Drosophila melanogaster. Mol Immunol 66: 325-339. PubMed ID: 25931442

von Kalm, L., et al. (1994). The Broad-Complex directly controls a tissue-specific response to the steroid hormone ecdysone at the onset of Drosophila metamorphosis. EMBO J. 13: 3505-3516

Ward, E. J. and Berg, C. A. (2005). Juxtaposition between two cell types is necessary for dorsal appendage tube formation. Mech. Dev. 122(2): 241-55. 15652711

Ward, E. J., et al. (2006). Border of Notch activity establishes a boundary between the two dorsal appendage tube cell types. Dev. Biol. 297(2): 461-70. 16828735

Ward, R. E., et al. (2003). GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis. Dev. Biol. 256: 389-402. 12679111

Wilson, T. G., and Fabian, J. (1986). A Drosophila melanogaster mutant resistant to a chemical analog of juvenile hormone. Dev. Biol. 118: 190-201. 3095161

Wilson, T. G. (1996). Genetic evidence that mutants of the Methoprene-tolerant gene of Drosophila melanogaster are null mutants. Arch. Insect Biochem. Physiol. 32: 641-649. 8756311

Wilson, T. G., Yerushalmi, Y., Donell, D. M. and Restifo, L. L. (2006). Interaction between hormonal signaling pathways in Drosophila melanogaster as revealed by genetic interaction between Methoprene-tolerant and Broad-Complex. Genetics 172(1): 253-64. 16204218

Xiang, Y., Liu, Z. and Huang, X. (2010). br regulates the expression of the ecdysone biosynthesis gene npc1. Dev. Biol. 344(2): 800-8. PubMed Citation: 20621708

Yakoby, N., Lembong, J., Schupbach, T. and Shvartsman, S. Y. (2008a). Drosophila eggshell is patterned by sequential action of feedforward and feedback loops. Development 135: 343-351. PubMed Citation: 18077592

Yakoby, N., et al. (2008b). A combinatorial code for pattern formation in Drosophila oogenesis. Dev. Cell 15(5): 725-37. PubMed Citation: 19000837

Zartman, J. J., et al. (2011). Pattern formation by a moving morphogen source. Phys Biol. 8(4): 045003. PubMed Citation: 21750363

Zhou, B., et al. (1998). Juvenile hormone prevents ecdysteroid-induced expression of broad complex RNAs in the epidermis of the tobacco hornworm, Manduca sexta. Dev. Biol. 203(2): 233-44. PubMed Citation: 9808776

Zhou, X. and Riddiford, L. M. (2002). Broad specifies pupal development and mediates the 'status quo' action of juvenile hormone on the pupal-adult transformation in Drosophila and Manduca. Development 129: 2259-2269. 11959833

Zhou, B., Williams, D. W., Altman, J., Riddiford, L. M. and Truman, J. W. (2009). Temporal patterns of broad isoform expression during the development of neuronal lineages in Drosophila. Neural Dev. 4: 39. PubMed Citation: 19883497

Zollman, S., et al. (1994). The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc. Natl. Acad. Sci. 91: 10717-10721. PubMed Citation: 7938017

broad: Biological Overview | Evolutionary Homologs | Regulation | Targets of Activity | Developmental Biology | Effects of Mutation

date revised: 23 August 2017

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