Suppressor of Hairless


REFERENCES

Abhiman, S., Iyer, L. M. and Aravind, L. (2008). BEN: a novel domain in chromatin factors and DNA viral proteins. Bioinformatics 24: 458-461. PubMed ID: 18203771

Andres, M. E, et al. (1999). CoREST: a functional corepressor required for regulation of neural-specific gene expression. Proc. Natl. Acad. Sci. 96: 9873-9878. 10449787

Anthony, T. E, Mason, H. A., Gridley, T., Fishell, G. and Heintz, N. (2005). Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev. 19(9): 1028-33. 15879553

Apidianakis, Y., et al. (1999). Overexpression of the m4 and malpha genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition. Mech. Dev. 86(1-2): 39-50. PubMed Citation: 1044626

Apitz, H., Strunkelnberg, M., de Couet, H. G. and Fischbach, K. F. (2005). Single-minded, Dmef2, Pointed, and Su(H) act on identified regulatory sequences of the roughest gene in Drosophila melanogaster. Dev. Genes Evol. 215(9): 460-69. 16096801

Apitz, H., Kambacheld, M., Höhne, M., Ramos, R. G. P., Straube, A. and Fischbach, K. F. (2004). Identification of regulatory modules mediating specific expression of the roughest gene in Drosophila melanogaster. Dev. Genes Evol. 214: 453-459. 15278452

Aster, J. C., et al. (1997). Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. J Biol Chem 272 (17): 11336-11343. PubMed Citation: 9111040

Auer, J. S., Nagel, A. C., Schulz, A., Wahl, V. and Preiss, A. (2014). MAPK-dependent phosphorylation modulates the activity of Suppressor of Hairless in Drosophila. Cell Signal 27: 115-124. PubMed ID: 25452105

Auer, J. S., Nagel, A. C., Schulz, A., Wahl, V. and Preiss, A. (2015). Local overexpression of Su(H)-MAPK variants affects Notch target gene expression and adult phenotypes in Drosophila. Data Brief 5: 852-863. PubMed ID: 26702412

Bachmann, A. and Knust, E. (1998). Positive and negative control of Serrate expression during early development of the Drosophila wing. Mech. Dev. 76(1-2): 67-78. PubMed Citation: 9767116

Bailey, A.M. and Posakony, J.W. (1995). Suppressor of Hairless directly activates transcription of Enhancer of split Complex genes in response to Notch receptor activity. Genes Dev. 9: 2609-2622. PubMed Citation: 7590239

Bardin, A. J. and Schweisguth, F. (2006). Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. Dev. Cell 10(2): 245-55. Medline abstract: 16459303

Bardin, A. J., et al. (2010). Transcriptional control of stem cell maintenance in the Drosophila intestine. Development 137(5): 705-14. PubMed Citation: 20147375

Barolo, S., et al. (2000). A Notch-independent activity of Suppressor of Hairless is required for normal mechanoreceptor physiology. Cell 103: 957-969. PubMed Citation: 11136980

Barolo, S. and Posakony, J. W. (2002a). Three habits of highly effective signaling pathways: Principles of transcriptional control by developmental cell signaling. Genes Dev. 16: 1167-1181. 12023297

Barolo, S., et al. (2002b). Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev. 16: 1964-1976. 12154126

Beatus, P., et al. (1999). The Notch 3 intracellular domain represses Notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters. Development 126: 3925-3935. PubMed Citation: 10433920

Beatus, P., et al. (2001). The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity. Mech. of Dev. 104: 3-20. 11404076

Bernard, F., Krejci, A., Housden, B., Adryan, B. and Bray, S. J. (2010). Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Development 137(16): 2633-42. PubMed Citation: 20610485

Bettler, D., Pearson, S. and Yedvobnick, B. (1996). The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions. Genetics 143(2): 859-875. PubMed Citation: 8725234

Brou, C., et al. (1994). Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and of its human homolog, KBF2/RBP-Jkappa, by direct protein-protein interaction with Drosophila Hairless. Genes Dev. 8: 2491-2503. 7958912

Buszczak, M., Paterno, S. and Spradling, A. C. (2009). Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny. Science 323: 248-251. PubMed Citation: 19039105

Casso, D. J. Biehs, B. and Kornberg, T. B. (2011). A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing. Genetics 187(2): 485-99. PubMed Citation: 21098717

Castro, B., Barolo, S., Bailey, A. M. and Posakony, J. W. (2005). Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless. Development. 132(15): 3333-44. 15975935

Cave, J. W., Loh, F., Surpris, J. W., Xia, L. and Caudy, M. A. (2005). A DNA transcription code for cell-specific gene activation by notch signaling. Curr. Biol. 15(2): 94-104. 15668164

Cave, J. W., Xia, L. and Caudy, M. A. (2009). The Daughterless N-terminus directly mediates synergistic interactions with Notch transcription complexes via the SPS+A DNA transcription code. BMC Res. Notes 2: 65. PubMed Citation: 19400956

Cave, J. W., Xia, L. and Caudy, M. (2011). Differential regulation of transcription through distinct Suppressor of Hairless DNA binding site architectures during Notch signaling in proneural clusters. Mol. Cell Biol. 31(1): 22-9. PubMed Citation: 21041480

Chandra, S., Ahmed, A. and Vaessin, H. (2003). The Drosophila IgC2 domain protein Friend-of-Echinoid, a paralogue of Echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway. Dev Biol. 256(2): 302-16. 12679104

Chen, Y., Fischer, W. H. and Gill, G. N. (1997). Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH. J. Biol. Chem. 272 (22): 14110-14114. PubMed Citation: 9162037

Christensen, S., et al. (1996). lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H). Development 122: 1373-1383. PubMed Citation: 8625826

Contreras, A. N., Yuan, Z. and Kovall, R. A. (2015). Thermodynamic binding analysis of Notch transcription complexes from D. melanogaster. Protein Sci [Epub ahead of print]. PubMed ID: 25650119

Cooper, M. T. D., et al. (2000). Spatially restricted factors cooperate with Notch in the regulation of Enhancer of split genes. Dev. Biol. 221: 390-403. PubMed Citation: 10790334

Cordoba, S. and Estella, C. (2014). The bHLH-PAS transcription factor Dysfusion regulates tarsal joint formation in response to Notch activity during Drosophila leg development. PLoS Genet 10: e1004621. PubMed ID: 25329825

Crozatier M., et al. (2004). Cellular immune response to parasitization in Drosophila requires the EBF orthologue collier. PLoS Biol. 2: E196. PubMed Citation: 15314643

Dahl, R., Wani, B., and Hayman, M. J. (1998). The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. Oncogene. 16: 1579-1586. PubMed Citation: 9569025

Dai, Q., Ren, A., Westholm, J. O., Serganov, A. A., Patel, D. J. and Lai, E. C. (2013). The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors. Genes Dev 27: 602-614. PubMed ID: 23468431

Dallman, J. E., et al. (2004). A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation. J. Neurosci. 24: 7186-7193. 15306652

Davis, R. L., et al. (2001). Molecular targets of vertebrate segmentation: Two mechanisms control segmental expression of Xenopus hairy2 during somite formation. Dev. Cell 1: 553-565. 11703945

de Celis, J. F., et al. (1996). Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex, the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development 122: 2719-28. PubMed Citation: 8787746

De Koning, L., Corpet, A. Haber, J. E. and Almouzni, G. (2007). Histone chaperones: an escort network regulating histone traffic. Nat. Struct. Mol. Biol. 14: 997-1007. PubMed Citation: 17984962

de la Pompa, J. L., et al. (1997). Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 124: 1139-1148. PubMed Citation: 9102301

De Renzis, S., Yu, J., Zinzen, R. and Wieschaus, E. (2006). Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway. Dev. Cell 10(2): 257-64. Medline abstract: 16459304

Diaz-Benjumea, F. J. and Cohen, S. M. (1995). Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development 121: 4215-25. PubMed Citation: 8575321

Dong, Y., et al. (2010). RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development 137(9): 1461-71. PubMed Citation: 20335360

Duan, H., et al. (2011). Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. EMBO J. 30(15): 3120-33. PubMed Citation: 21765394

Eastman, D. S., et al. (1997). Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression. Mol. Cell. Biol. 17(9): 5620-5628. PubMed Citation: 9271437

Endo, K,, et al. (2011). Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat. Neurosci. 15(2): 224-33. PubMed Citation: 22197833

Flores, G. V., et al. (2000). Combinatorial signaling in the specification of unique cell fates. Cell 103: 75-85. PubMed Citation: 11051549

Fortini, M. E. and Artavanis-Tsakonas, S. (1994). The suppressor of hairless protein participates in Notch signalling. Cell 79: 273-82. PubMed Citation: 7954795

Friedmann, D. R. and Kovall, R. A. (2010). Thermodynamic and structural insights into CSL-DNA complexes. Protein Sci. 19(1): 34-46. PubMed Citation: 19866488

Frise, E., et al. (1996). The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc. Natl. Acad. Sci. 93: 11925-32. PubMed Citation: 8876239

Fryer, C. J., White, J. B. and Jones, K. A. (2004). Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol. Cell 16: 509-520. PubMed Citation: 15546612

Fu, W. and Baker, N. E. (2003). Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development. Development 130: 5229-5239. 12954721

Fujiwara, S., Corbo, J. C. and Levine, M. (1998). The Snail repressor establishes a muscle/notochord boundary in the Ciona embryo. Development 125(13): 2511-2520. PubMed Citation: 9609834

Furriols M. and Bray, S. (2000). Dissecting the mechanisms of Suppressor of Hairless function. Dev. Bio. 227: 520-532. PubMed Citation: 11071771

Furriols, M. and Bray, S. (2001). A model Notch response element detects Suppressor of Hairless-dependent molecular switch. Curr. Biol. 11: 60-64. 11166182

Furukawa, T., et al. (1992). The Drosophila homolog of the immunoglobulin recombinization signal-binding protein regulates peripheral nervous system development. Cell 69: 1191-7. PubMed Citation: 1617729

Fusse, B. and Hoch, M. (2002). Notch signaling controls cell fate specification along the dorsoventral axis of the Drosophila gut. Curr. Biol. 12: 171-179. 11839268

Fuwa, T. J., et al. (2006). The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. Mol. Genet. Genomics 275(3):251-63. 16395579

Garcia, T. X., Farmaha, J. K., Kow, S. and Hofmann, M. C. (2014). RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Development 141: 4468-4478. PubMed ID: 25406395

Ghai, V. and Gaudet, J. (2008). The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans. Dev. Biol. 322(2): 334-44. PubMed Citation: 18706403

Gho, M., et al. (1996). Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. Development 122: 1673-82. PubMed Citation: 8674407

Giebel, B. (1999). The Notch signaling pathway is required to specify muscle progenitor cells in Drosophila. Mech. Dev. 86: 137-145. PubMed Citation: 10446272

Go, M. J., Eastman, D. S. and Artavanis-Tsakonas, S. (1998). Cell proliferation control by Notch signaling in Drosophila development. Development 125: 2031-2040. PubMed Citation: 9570768

Goodfellow, H., Krejcí, A., Moshkin, Y., Verrijzer, C. P., Karch, F. and Bray, S. J. (2007). Gene-specific targeting of the histone chaperone asf1 to mediate silencing. Dev. Cell 13(4): 593-600. PubMed citation: 17925233

Grego-Bessa, J., et al. (2007). Notch signaling is essential for ventricular chamber development. Dev. Cell 12(3): 415-29. Medline abstract: 17336907

Gupta, B. P. and Sternberg, P. W. (2002). Tissue-specific regulation of the LIM homeobox gene lin-11 during development of the Caenorhabditis elegans egg-laying system. Dev. Bio. 247: 102-115. 12074555

Guss, K. A. et al. (2001). Control of a genetic regulatory network by a selector gene. Science 292: 1164-1167. 11303087

Han, Z. and Bodmer, R. (2003). Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development 130: 3039-3051. 12756185

Hayakawa, T., et al. (2007). RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. Genes Cells 12: 811-826. PubMed Citation: 17573780

Hitoshi, S., et al. (2002). Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev. 16: 846-858. 11937492

Hori, K., et al. (2008). A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev. 22(2): 166-78. PubMed citation: 18198335

Housden, B. E., Terriente-Felix, A. and Bray, S. J. (2014). Context-dependent enhancer selection confers alternate modes of Notch regulation on argos. Mol Cell Biol 34: 664-672. PubMed ID: 24324007

Hsieh, J. J., et al. (1996). Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol. Cell. Biol. 16: 952-959. PubMed Citation: 8622698

Hsieh, J. J., et al. (1997). Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J. Virol. 71(3): 1938-1945. PubMed Citation: 9032325

Hsieh, J. J., et al. (1999). CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc. Natl. Acad. Sci. 96(1): 23-8. PubMed Citation: 9874765

Islam, R., Wei, S. Y., Chiu, W. H., Hortsch, M. and Hsu, J. C. (2003). Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway. Development. 130(10): 2051-9. 12668620

Jarriault, S., et al. (1995). Signalling downstream of activated mammalian Notch. Nature 377: 355-358. PubMed Citation: 7566092

Janody, F. and Treisman, J. E. (2011). Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Dev. Dyn. 240(9): 2051-9. PubMed Citation: 21793099

Jung S.-H., et al. (2005). The Drosophila lymph gland as a developmental model of hematopoiesis. Development 132: 2521-2533. PubMed Citation: 15857916

Kannabiran, C., Zeng, X. and Vales, L. D. (1997). The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression. Mol. Cell. Biol. 17(1): 1-9. PubMed Citation: 8972179

Kao, H. Y., et al. (1998). A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev. 12(15): 2269-77. PubMed Citation: 9694793

Kao, H. Y., et al. (1998). A histone deacetylase corepressor complex regulates the notch signal transduction pathway. Genes Dev. 12(15): 2269-2277. PubMed Citation: 9694793

Kato, H., et al. (1997). Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development 124(20): 4133-4141. PubMed Citation: 9374409

Kidd, S., Lieber, T. and Young, M. W. (1998). Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev. 23: 3728-3740. PubMed Citation: 9851979

Klein, T., Brennan, K. and Arias, A. M. (1997). An intrinsic dominant negative activity of Serrate that is modulated during wing development in Drosophila. Dev. Biol. 189(1): 123-134. PubMed Citation: 9281342

Klein, T. and Martinez Arias, A. (1999). The Vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila. Development 126: 913-925. PubMed Citation: 9927593

Klein, T., et al. (2000). Two different activities of Suppressor of Hairless during wing development in Drosophila. Development 127: 3553-3566. 10903180

Klein, T., et al. (2003). The tumor suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development. Dev. Bio. 255: 313-333. 12648493

Koelzer, S. and Klein, T. (2003). A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development 130: 1973-1988. 12642500

Koelzer, S. and Klein, T. (2006). Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev. Biol. 289(1): 77-90. 16307735

Korutla, L., Degnan, R., Wang, P. and Mackler, S. A. (2007). NAC1, a cocaine-regulated POZ/BTB protein interacts with CoREST. J Neurochem 101: 611-618. PubMed ID: 17254023

Krebs, L. T., et al. (2003). Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev. 17: 1207-1212. 12730124

Krebs, L. T., et al. (2004). Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev. 18: 2469-2473. 15466160

Krejcí, A. and Bray, S. (2007). Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev. 21(11): 1322-7. PubMed citation: 17545467

Krejci, A., Bernard, F., Housden, B. E., Collins, S. and Bray, S. J. (2009). Direct response to Notch activation: signaling crosstalk and incoherent logic. Sci. Signal. 2, ra1. PubMed Citation: 19176515

Krzemien J., et al. (2007). Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre. Nature 446: 325-328. PubMed Citation: 17361184

Kurth, P., Preiss, A., Kovall, R. A. and Maier, D. (2011). Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless. PLoS One 6(11): e27986. PubMed Citation: 22125648

Lam, L. T. and Bresnick, E. H. (1998). Identity of the beta-globin locus control region binding protein HS2NF5 as the mammalian homolog of the Notch-regulated transcription factor Suppressor of hairless. J. Biol. Chem. 273(37): 24223-31. PubMed Citation: 9727046

Lamar, E., et al. (2001). Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev. 15: 1885-1899. 11485984

Lamar, E. and Kintner, C. (2005). The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors. Development 132(16): 3619-30. 16077089

Lecourtois, M. and Schweisguth, F. (1995). The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of Split Complex genes triggered by Notch signaling. Genes Dev. 9: 2598-2608. PubMed Citation: 7590238

Lecourtois, M. and Schweisguth, F. (1998). Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos. Curr. Biol. 8(13): 771-4. PubMed Citation: 9651681

Lee, N., Erdjument-Bromage, H., Tempst, P., Jones, R. S. and Zhang, Y. (2009). The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3. Mol. Cell Biol. 29: 1401-1410. PubMed Citation: 19114561

Li, Y. and Baker, N. E. (2001). Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye Curr. Biol. 11: 330-338. 11267869

Liang, Y., et al. (2002). The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Genes Dev. 16: 1977-1989. 12154127

Liefke, R., et al. (2010). Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev. 24(6): 590-601. PubMed Citation: 20231316

Ligoxygakis, P., et al. (1998). A subset of Notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex. Development 125(15): 2893-2900. PubMed Citation: 9655811

Liotta, D., et al. (2007). The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila. Curr. Biol. 17: 1409-1413. PubMed Citation: 17702578

Liu, F. and Posakony, J. W. (2012). Role of architecture in the function and specificity of two Notch-regulated transcriptional enhancer modules. PLoS Genet 8: e1002796. PubMed ID: 22792075

Liu, F., Posakony, J. W. (2014). An enhancer composed of interlocking submodules controls transcriptional autoregulation of Suppressor of Hairless. Dev. Cell 29: 88–101. PubMed ID: 24735880

Lu, F. M. and Lux, S. E. (1996). Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element. Proc. Natl. Acad. Sci. 93: 5663-67. PubMed Citation: 8643633

Ma, X., et al. (2007). Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation. Mol. Cell. Biol. 27: 3056-3064. PubMed Citation: 17283045

Maier, D., Marquart, J., Thompson-Fontaine, A., Beck, I., Wurmbach, E., Preiss, A. (1997). In vivo structure-function analysis of Drosophila Hairless. Mech. Dev. 67(1): 97-106. PubMed Citation: 9347918

Maier D, Kurth P, Schulz A, Russell A, Yuan Z, et al. (2011) Structural and functional analysis of the repressor complex in the Notch signaling of D. melanogaster. Mol. Biol. Cell 22: 3242-3252. PubMed Citation: 21737682

Maier, D., Praxenthaler, H., Schulz, A. and Preiss, A. (2013). Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities. PLoS One 8: e81578. PubMed ID: 24282610

Maier, P., et al. (1999). Subcellular localization of Hairless protein shows a major focus of activity within the nucleus. Mech. Dev. 89: 195-199. PubMed Citation: 10559498

Majumdar, A., Nagaraj, R. and Banerjee, U. (1997). strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin in Drosophila. Genes Dev. 11: 1341-1353. PubMed Citation: 9171377

Mandal L., et al. (2007). A Hedgehog- and Antennapedia-dependent niche maintains Drosophila hematopoietic precursors. Nature 446: 320-324. PubMed Citation: 17361183

Markstein, M., et al. (2004). A regulatory code for neurogenic gene expression in the Drosophila embryo. Development 131: 2387-2394. 15128669

Marygold, S. J., Walker, C., Orme, M. and Leevers, S. (2011). Genetic characterization of ebi reveals its critical role in Drosophila wing growth. Fly (Austin) 5(4). [Epub ahead of print]. PubMed Citation: 22041576

Matsuda, Y., et al. (2005). Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development. Development 132(12): 2783-93. 15930109

Matsuno, K., et al. (1997). Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements. Development 124(21): 4265-4273. PubMed Citation: 9334275

Micchelli, C. A. and Perrimon, N. (2006). Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439(7075): 475-9. 16340959

Miller, S. W., Avidor-Reiss, T., Polyanovsky, A. and Posakony, J. W. (2009). Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. Dev. Biol. 329(2): 386-99. PubMed Citation: 19232522

Mizutani, K., Yoon, K., Dang, L., Tokunaga, A. and Gaiano, N. (2007). Differential Notch signalling distinguishes neural stem cells from intermediate progenitors. Nature 449(7160): 351-5. Medline abstract: 17721509

Morales, A. V., Yasuda, Y. and Ish-Horowicz, D. (2002). Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling. Dev. Cell 3: 63-74. 12110168

Morel, V. and Schweisguth, F. (2000). Repression by Suppressor of Hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev. 14: 377-388. 10673509

Morel, V., et al. (2001). Transcriptional repression by Suppressor of Hairless involves the binding of a Hairless-dCtBP complex in Drosophila. Curr. Biol. 11: 789-792. 11378391

Moshkin, Y. M., et al. (2009). Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. Mol. Cell 35: 782-793. PubMed Citation: 19782028

Nagel, A. C., Maier, D. and Preiss, A. (2000). Su(H)-independent activity of Hairless during mechano-sensory organ formation in Drosophila. Mech. Dev. 94: 3-12. PubMed Citation: 10842054

Nagel, A. C., Wech, I. and Preiss, A. (2001). scalloped and strawberry notch are target genes of Notch signaling in the context of wing margin formation in Drosophila. Mech. Dev. 109: 241-251. 11731237

Nagel, A. C., et al. (2005). Hairless-mediated repression of Notch target genes requires the combined activity of Groucho and CtBP corepressors. Mol. Cell. Biol. 25(23): 10433-41. 16287856

Nam, Y., et al. (2007). Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc. Natl. Acad. Sci. 104: 2103-2108. Medline abstract: 17284587

Negeri, D., Eggert, H., Gienapp, R. and Saumweber, H. (2002). Inducible RNA interference uncovers the Drosophila protein Bx42 as an essential nuclear cofactor involved in Notch signal transduction. Mech. Dev. 117(1-2): 151-62. PubMed Citation: 12204255

Nellesen, D. T., Lai, E. C. and Posakony, J. W. (1999). Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev. Biol. 213(1): 33-53. PubMed Citation: 10452845

Neumann, C. J. and Cohen, S. M. (1996). A heirarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing. Development 122, 3477-3485. PubMed Citation: 8951063

Nicholson, S. C., Nicolay, B. N., Frolov, M. V. and Moberg, K. H. (2011). Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development 138(2): 251-60. PubMed Citation: 21148181

Olave, I., Reinberg, D. and Vales, L. D. (1998). The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription. Genes Dev. 12(11): 1621-1637. PubMed Citation: 9620850

Oswald, F., et al. (1998). NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol. Cell. Biol. 18(4): 2077-2088. PubMed Citation: 9528780

Oswald, F., et al. (2002). SHARP is a novel component of the Notch/RBP-J signaling pathway. EMBO J. 21: 5417-5426. 12374742

Oswald, F. F., et al. (2005). RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol. Cell Biol. 2: 10379-10390. PubMed citation: 16287852

Pallavi, S. K., Ho, D. M., Hicks, C., Miele, L. and Artavanis-Tsakonas, S. (2012). Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. EMBO J. 31(13): 2895-907. PubMed Citation: 22580825

Petcherski, A. G. and Kimble, J. (2000). Mastermind is a putative activator for Notch. Curr. Biol. 10: R471-R473. PubMed Citation: 10898989

Pezeron, G., Millen, K., Boukhatmi, H. and Bray, S. (2014). Notch directly regulates cell morphogenesis genes, Reck, talin and trio, in adult muscle progenitors. J Cell Sci 127(21): 4634-44. PubMed ID: 25217625

Qin, H., Wang, J., Liang, Y., Taniguchi, Y., Tanigaki, K. and Han, H. (2004). RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2. Nucleic Acids Res. 32(4): 1492-501. 14999091

Ramain, P., et al. (2001). Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Cur. Bio. 11: 1729-1738. 11719214

Rangarajan, A., et al. (2001). Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 20: 3427-3436. 11432830

Rebeiz, M., Reeves, N. L. and Posakony, J. W. (2002). SCORE: A computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Proc. Natl. Acad. Sci. 99: 9888-9893. PubMed Citation: 12107285

Rebeiz, M., Stone, T. and Posakony, J. W. (2005). An ancient transcriptional regulatory linkage. Dev. Biol. 281: 299-308. PubMed Citation: 1589398

Rebeiz, M., Miller, S. W. and Posakony, J. W. (2011). Notch regulates numb: integration of conditional and autonomous cell fate specification. Development 138(2): 215-25. PubMed Citation: 21148185

Rebeiz, M., et al. (2012). Ancestral and conserved cis-regulatory architectures in developmental control genes. Dev. Biol. 362: 282-294. PubMed Citation: 22185795

Reizis, B. and Leder, P. (2002). Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 16: 295-300. 11825871

Robertson, E. S., Lin, J. and Kieff, E. (1996). The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa). J. Virol. 70: 3068-3074. PubMed Citation: 8627785

Roehl, H., et al. (1996). Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor. EMBO J. 15: 7002-12. PubMed Citation: 9003776

Rohrbaugh, M., et al. (2002). Notch activation of yan expression is antagonized by RTK/Pointed signaling in the Drosophila eye. Curr. Biol. 12: 576-581. 11937027

Rones, M. S., et al. (2000). Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis. Development 127: 3865-3876. PubMed Citation: 10934030

Rusconi, J. C. and Corbin, V. (1999). A widespread and early requirement for a novel Notch function during Drosophila embryogenesis. Dev. Biol. 215(2): 388-398. PubMed Citation: 10545245

Rossi, F., et al. (2002). p107 and p130 coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development. Dev. Bio. 247: 271-285. 12086466

Sathyan, K. M., Shen, Z., Tripathi, V., Prasanth, K. V. and Prasanth, S. G. (2011). A BEN-domain-containing protein associates with heterochromatin and represses transcription. J Cell Sci 124: 3149-3163. PubMed ID: 21914818

Schweisguth, F., Nero, P. and Posakony, J. W. (1994). The sequence similarity of the Drosophila Suppressor of Hairless Protein to the integrase domain has no functional singificance in Vivo. Dev. Biol. 166: 812-814. PubMed Citation: 7813798

Schweisguth, F. (1995). Suppressor of Hairless is required for signal reception during lateral inhibition in Drosophila pupal notum. Development 121: 1875-1888

Schweisguth, F. and Posakony, J. W. (1994). Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis. Development 120: 1433-41. PubMed Citation: 8050354

Schweisguth, F. and Lecourtois, M. (1998). The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction. Dev. Genes Evol. 208(1): 19-27. PubMed Citation: 9518521

Shi, Y. and Noll, M. (2009). Determination of cell fates in the R7 equivalence group of the Drosophila eye by the concerted regulation of D-Pax2 and TTK88. Dev. Biol. 331: 68-77. PubMed Citation: 19406115

Sieger, D., Tautz, D. and Gajewski, M. (2003). The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis. Mech. Dev. 120: 1083-1094. 14550536

Sinenko S. A., et al. (2009). Dual role of Wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila. Dev. Cell 16: 756-763. PubMed Citation: 19460351

Skalska, L., Stojnic, R., Li, J., Fischer, B., Cerda-Moya, G., Sakai, H., Tajbakhsh, S., Russell, S., Adryan, B. and Bray, S. J. (2015). Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation. EMBO J 34(14):1889-904. PubMed ID: 26069324

Spencer, S. A. and Cagan, R. L. (2003). Echinoid is essential for regulation of Egfr signaling and R8 formation during Drosophila eye development. Development 130: 3725-3733. 12835389

Swanson, C. I., Evans, N. C. and Barolo, S. (2010). Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer. Dev. Cell 18: 359-370. PubMed Citation: 20230745

Swanson, C. I., Schwimmer, D. B. and Barolo, S. (2011). Rapid evolutionary rewiring of a structurally constrained eye enhancer. Curr. Biol. 21(14): 1186-96. PubMed Citation: 21737276

Taniguchi, Y., et al. (1998). LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein. Mol. Cell. Biol. 18(1): 644-654. PubMed Citation: 9418910

Taylor, M. K., Yeager, K. and Morrison, S. J. (2007). Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development 134: 2435-2447. Medline abstract: 17537790

Tokusumi, Y., Tokusumi, T., Stoller-Conrad, J. and Schulz, R. A. (2010). Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis. Development 137(21): 3561-8. PubMed Citation: 20876645

Tsuda, L., et al. (2002). An EGFR/Ebi/Sno pathway promotes Delta expression by inactivating Su(H)/SMRTER repression during inductive Notch signaling. Cell 110: 625-637. 12230979

Tsuda, L., et al. (2006). An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila. EMBO J. 25(13): 3191-202. 16763555

Umesono, Yl, Hiromi, Y. and Hotta, Y. (2002). Context-dependent utilization of Notch activity in Drosophila glial determination. Development 129: 2391-2399. 11973271

van der Flier, L. G., van Gijn, M. E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D. E., Begthel, H., van den Born, M., Guryev, V., Oving, I., van Es, J. H., Barker, N., Peters, P. J., van de Wetering, M. and Clevers, H. (2009). Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell 136(5): 903-912. PubMed ID: 19269367

Vasquez-Del Carpio, R. et al. (2011). Assembly of a Notch transcriptional activation complex requires multimerization. Mol. Cell Biol. 31(7): 1396-408. PubMed Citation: 21245387

Wang, G. G., et al. (2009). Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature 459: 847-851. PubMed Citation: 19430464

Wang, H., et al. (2011). Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc. Natl. Acad. Sci. 108: 14908-14913. PubMed Citation: 21737748

Wang, S., Younger-Shepherd, S., Jan, L. Y. and Jan, Y. N. (1997). Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless. Development 124(22): 4435-4446. PubMed Citation: 9409662

Wang, W., Liu, W., Wang, Y., Zhou, L., Tang, X. and Luo, H. (2011). Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. Dev. Biol. 350(2): 414-28. PubMed Citation: 21146517

Wettstein, D. A., Turner, D. L. and Kintner, C. (1997). The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis. Development 124, 693-702. PubMed Citation: 9043084

Wilson, J. J. and Kovall, R. A. (2006). Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell 124(5): 985-96. 16530045

Wu, L., et al. (2000). MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet. 26(4): 484-9. 11101851

Wurmbach, E., Wech, I. and Preiss, A. (1999). The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes. Mech. Dev. 80(2): 171-80. PubMed Citation: 10072784

Yamamoto, N., et al. (2003). Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells. Curr. Biol. 13: 333-338. 12593800

Yan, S.-J., et al. (2004). Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development 131: 285-298. 14701680

Yeh, T. S., Lin, Y. M, Hsieh, R. H. and Tseng, M. J. (2003). Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch. J. Biol. Chem. 278(43): 41963-9. 12913000

Zhang, J., et al. (2001). Epstein-Barr virus BamHI-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. J. Virol. 75: 2946-2956. PubMed Citation: 11222720

Zhou, S., et al. (2000a). SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function. Mol. Cell. Biol. 20: 2400-2410. PubMed Citation: 10713164

Zhou, S., et al. (2000b). A role for SKIP in EBNA2 activation of CBF1-repressed promoters J. Virol. 74: 1939-1947. PubMed Citation: 10644367

Zinzen, R. P., et al. (2006). Evolution of the ventral midline in insect embryos. Devel. Cell 11: 895-902. Medline abstract: 17141163

Zhou, S., et al. (2000a). A role for SKIP in EBNA2 activation of CBF1-repressed promoters. J. Virol. 74(4): 1939-47. PubMed Citation: 10644367

Zhou, S., et al. (2000b). SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function. Mol. Cell. Biol. 20(7): 2400-10. PubMed Citation: 10713164


Suppressor of Hairless: Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

date revised: 5 July 2015

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.