Alexandre, C., Lecourtois, M. and Vincent, J.-P. (1999). Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals. Development 126: 5689-5698. PubMed Citation: 10572045

Axelrod J. D., et al. (1996). Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science 271: 1826-1832. PubMed Citation: 8596950

Bachmann, A. and Knust, E. (1998a). Dissection of cis-regulatory elements of the Drosophila gene Serrate. Dev. Genes Evol. 208(6): 346-51. PubMed Citation: 9716725

Bachmann, A. and Knust, E. (1998b). Positive and negative control of Serrate expression during early development of the Drosophila wing. Mech. Dev. 76(1-2): 67-78. PubMed Citation: 9767116

Bash, J., et al. (1999). Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J. 18(10): 2803-2811. PubMed Citation: 10329626

Bishop, S. A., et al. (1999). Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch. Development 126: 2993-3003. PubMed Citation: 10357942

Buckles, G. R., et al. (2001). four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg. Development 128: 3533-3542. 11566858

Capilla, A., et al. (2012). Planar cell polarity controls directional Notch signaling in the Drosophila leg. Development 139(14): 2584-93. PubMed Citation: 22736244

Chen, C. W. J., et al. (1997). Asymmetric expression of Notch/Delta/Serrate is associated with the anterior-posterior axis of feather buds. Dev. Biol. 188(1): 181-187. PubMed Citation: 9245521

Chen, J., Moloney, D. J. and Stanley, P. (2001). PMC Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1. Proc. Natl. Acad. Sci. 98(24): 13716-21. 11707585

Chern, J. J., and and Choi, K. W. (2002). Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. Development 129: 4005-4013. 12163404

Chillakuri, C. R., Sheppard, D., Ilagan, M. X., Holt, L. R., Abbott, F., Liang, S., Kopan, R., Handford, P. A. and Lea, S. M. (2013). Structural analysis uncovers lipid-binding properties of Notch ligands. Cell Rep. PubMed ID: 24239355

Cho, K.-O., et al. (2000). Novel signaling from the peripodial membrane Is essential for eye disc patterning in Drosophila. Cell 103: 331-342. PubMed Citation: 11057905

Ciechanska, E., Dansereau, D. A., Svendsen, P. C., Heslip, T. R. and Brook, W. J. (2007). dAP-2 and defective proventriculus regulate Serrate and Delta expression in the tarsus of Drosophila melanogaster. Genome 50(8): 693-705. PubMed Citation: 17893729

Daudet, N., Ariza-McNaughton, L. and Lewis, J. (2007). Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development 134: 2369-2378. Medline abstract: 17537801

de Celis, J.F., Barrio, R., del Arco, A. and Garcia-Bellido, A. (1993). Genetic and molecular characteriation of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila. Proc. Natl. Acad. Sci. 90: 4037-41. PubMed Citation: 8483919

de Celis, J.F. and Garcia-Bellido, A. (1994). Modifications of the Notch function by Abruptex mutations in Drosophila melanogaster. Genetics 136: 183-94. PubMed Citation: 8138156

de Celis, J. F. and Bray. S. (1997). Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development 124(17): 3241-3251. PubMed Citation: 9310319

de Celis, J. F., et al. (1998). Notch signalling mediates segmentation of the Drosophila leg. Development 125: 4617-4626. PubMed Citation: 9806911

de Celis, J. F. and Bray, S. J. (2000). The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe. Development 127: 1291-1302. PubMed Citation: 10683181

Diaz-Benjumea, F.J. and Cohen, S.M. (1995). Serrate signals through Notch to establish a wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development 121: 4215-4225. PubMed Citation: 8575321

Doherty, D., et al (1996). Delta is a ventral dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev. 10: 421-434. PubMed Citation: 8600026

Duvic, B., et al. (2002). Notch signaling controls lineage specification during Drosophila larval hematopoiesis. Curr. Biol. 12: 1923-1927. 12445385

Eddison, M., Le Roux, I. and Lewis, J. (2000). Notch signaling in the development of the inner ear: Lessons from Drosophila. Proc. Natl. Acad. Sci. 97: 11692-11699. PubMed Citation: 11050197

Fitzgerald, K. and Greenwald, I. (1995). Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. Development 121: 4275-4282. PubMed Citation: 8575327

Fleming, R. J., Scottgale, T.N., Diederich, R.J. and Artavanis-Tsakonas, S. (1990).The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev. 4: 2188-2201. PubMed Citation: 2125287

Fleming, R. J., Gu, Y., and Hukriede, N. A. (1997). Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124(15): 2973-2981. PubMed Citation: 9247339

Fuwa, T. J., et al. (2006). The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. Mol. Genet. Genomics 275(3):251-63. 16395579

Gallet, A. and Therond, P. P. (2005). Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment. Dev. Biol. 277(1): 51-62. 15572139

Gibson, M. C. and Schubiger, G. (2000). Peripodial cells regulate proliferation and patterning of Drosophila imaginal discs. Cell 103: 343-350. PubMed Citation:

Glittenberg, M., Pitsouli, C., Garvey, C., Delidakis, C. and Bray, S. (2006). Role of conserved intracellular motifs in Ser signalling, cis-inhibition and endocytosis. EMBO J. 25: 4697-4706. PubMed citation: 17006545

Gu, Y., Hukriede, N.A. and Fleming, R.J. (1995). Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development 121: 855-865. PubMed Citation:

Gunage, R. D., Reichert, H. and VijayRaghavan, K. (2014). Identification of a new stem cell population which generates Drosophila flight muscles. Elife: e03126. PubMed ID: 25135939

Haberman, A. S., Isaac, D. D. and Andrew, D. J. (2003). Specification of cell fates within the salivary gland primordium. Dev. Biol. 258: 443-453. 12798300

Heilig, J. S., Freeman, M., Laverty, T., Lee, K. J., Campos, A. R., Rubin, G. M. and Steller, H. (1991). Isolation and characterization of the disconnected gene of Drosophila melanogaster. EMBO J. 10: 809-815. PubMed Citation:

Hukriede, N. A. and Fleming, R. J. (1997a). Beaded of Goldschmidt, an antimorphic allele of Serrate, encodes a protein lacking transmembrane and intracellular domains. Genetics 145: 359-374

Hukriede, N. A., Gu, Y. and Fleming, R. J. (1997b). A dominant-negative form of Serrate acts as a general antagonist of Notch activation. Development 124(17): 3427-3437

Ikeuchi, T. and Sisodia, S. S. (2003). The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent 'gamma-secretase' cleavage. J. Biol. Chem. 278(10): 7751-4. 12551931

Jack, J. and DeLotto, Y. (1992). Effect of wing scalloping mutations on cut expression and sense organ differentiation in the Drosophila wing margin. Genetics 131: 353-63

Jiang, R., et al. (1998). Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 12(7): 1046-1057

Jönsson, F. and Knust, E. (1996). Distinct functions of the Drosophila genes Serrate and Delta revealed by ectopic expression during wing development. Dev. Genes Evol. 206: 91-101

Kim, J., Irvine, K.D. and Carroll, S.B. (1995). Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell 82: 795-802

Kiyota, T., et al. (2001). X-Serrate-1 is involved in primary neurogenesis in Xenopus laevis in a complementary manner with X-Delta-1. Dev. Genes Evol. 211: 367-376. 11685570

Kiyota, T. and Kinoshita, T. (2004). The intracellular domain of X-Serrate-1 is cleaved and suppresses primary neurogenesis in Xenopus laevis. Mech Dev. 121(6): 573-85. 15172688

Klein, T., Brennan, K. and Arias, A. M. (1997). An intrinsic dominant negative activity of Serrate that is modulated during wing development in Drosophila. Dev. Biol. 189(1): 123-134

Klein, T. and Arias, A. M. (1998). Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development. Development 125(15): 2951-2962

Klein, T., et al. (2003). The tumor suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development. Dev. Bio. 255: 313-333. 12648493

Klueg, K. M. and Muskavitch, M. A. T. (1999). Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila. J. of Cell Sci. 112: 3289-3297

Kuo, Y. M., et al. (1996). Salivary duct determination in Drosophila: roles of the EGF receptor signaling pathway and the transcription factors Fork head and Trachealess. Development 122: 1909-17

Kuure, S., et al. (2005). Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching. Mech. Dev. 122(6): 765-80. 15905075

Laufer, E., et al. (1997). Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation. Nature 386: 366-373

LaVoie, M. J. and Selkoe, D. J. (2003). The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J. Biol. Chem. 278(36): 34427-37. 12826675

Lawrence, N., et al. (2000). Structural requirements for Notch signaling with Delta and Serrate during the development and patterning of the wing disc of Drosophila. Development 127: 3185-3195.

Lawrence, P. A. and Struhl, G. (1996). Morphogens, compartments and pattern: Lessons from Drosophila. Cell 85: 951-961

Le Borgne, R., Remaud, S., Hamel, S. and Schweisguth, F. (2005). Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol. 3(4): e96. 15760269

Lei, L., Xu, A., Panin, V. M. and Irvine, K. D. (2003). An O-fucose site in the ligand binding domain inhibits Notch activation. Development 130: 6411-6421. Medline abstract: 14627724

Liu, S., Bonner, J. M., Chanet, S., Commisso, C., Skwarek, L. C., Schweisguth, F. and Boulianne, G. L. (2012). Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling. Mol Cell Biol 32: 4933-4945. PubMed ID: 23045391

Luo, B., et al. (1997). Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol. Cell. Biol. 17(10): 6057-6067

Micchelli, C. A., Rulifson, E. J. and Blair, S. S. (1997). The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124 (8): 1485-1495

Milan, M., Diaz-Benjumea, F. J. and Cohen, S. M. (1998). Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function. Genes Dev. 12(18): 2912-2920

Milan, M. and Cohen, S. M. (2000). Temporal regulation of Apterous activity during development of the Drosophila wing. Development 127: 3069-3078

Munoz-Descalzo S., et al. (2010). Wingless modulates the ligand independent traffic of Notch through Dishevelled. Fly (Austin) 4(3): 182-193. PubMed Citation: 20495361

Myat, A., et al. (1996). A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis. Dev. Biol. 174: 233-247

Okajima, T., K. D. (2002). Regulation of Notch signaling by O-linked fucose. Cell 111: 893-904. 12526814

Okajima, T., Xu, A. and Irvine, K. D. (2003). Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. J. Biol. Chem. 12909620

Palmer, W. H., Jia, D. and Deng, W. M. (2014). Cis-interactions between Notch and its ligands block ligand-independent Notch activity. Elife 3. PubMed ID: 25486593

Panin, V. M., et al. (1997). Fringe modulates Notch-ligand interactions. Nature 387(6636): 908-912

Panin, V. M., Shao, L., Lei, L., Moloney, D. J., Irvine, K. D. and Haltiwanger, R. S. (2002). Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. J. Biol. Chem. 277: 29945-29952. 12036964

Papayannopoulos, V., et al. (1998). Dorsal-ventral signaling in the Drosophila eye. Science 281(5385): 2031-4

Perez-Gomez, R., Slovakova, J., Rives-Quinto, N., Krejci, A. and Carmena, A. (2013). Serrate-Notch-Canoe complex mediates glial-neuroepithelial cell interactions essential during Drosophila optic lobe development J Cell Sci. [Epub ahead of print] PubMed ID: 23970418

Pitsouli, C. and Delidakis, C. (2005). The interplay between DSL proteins and ubiquitin ligases in Notch signaling. Development 132(18): 4041-50. 16093323

Rauskolb, C. and Irvine, K. D. (1999). Notch-mediated segmentation and growth control of the Drosophila leg. Dev. Biol. 210(2): 339-50

Rauskolb, C. (2001). The establishment of segmentation in the Drosophila leg. Development 128: 4511-4521. 11714676

Rodriguez-Esteban, C., et al. (1997). Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb. Nature 386: 360-366

Rones, M. S., et al. (2000). Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis. Development 127: 3865-3876

Sagner, A., Merkel, M., Aigouy, B., Gaebel, J., Brankatschk, M., Jülicher, F. and Eaton, S. (2012). Establishment of global patterns of planar polarity during growth of the Drosophila wing epithelium. Curr. Biol. 22(14): 1296-301. PubMed Citation: 22727699

Sasamura, T., et al. (2003). neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development 130: 4785-4795. 12917292

Singh, A. and Choi, K.-W. (2003). Initial state of the Drosophila eye before dorsoventral specification is equivalent to ventral. Development 130: 6351-6360. 14623824

Sidow, A., et al. (1997). Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature 389(6652): 722-725

Singh, A., et al. (2004). Dorso-ventral asymmetric functions of teashirt in Drosophila eye development depend on spatial cues provided by early DV patterning genes. Mech. Dev. 121: 365-370. 15110046

Singh, A., Shi, X., Choi, K.W. (2006). Lobe and Serrate are required for cell survival during early eye development in Drosophila. Development 133(23): 4771-4781. PubMed Citation: 17090721

Sivasankaran, R., et al. (2000). The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family. Mech. Dev. 427-431.

Small, C., Ramroop, J., Otazo, M., Huang, L. H., Saleque, S. and Govind, S. (2013). An unexpected link between Notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila. Genetics [Epub ahead of print]. PubMed ID: 24318532

Speicher, S.A., Thomas, U., Hinz, U. and Knust, E. (1994). The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation. Development 120: 535-44

Sun, X. and Artavanis-Tsakonas, S. (1997). Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development 124(17): 3439-3448

Tax, F. E., Yeargers, J.J. and Thomas, J.H. (1994). Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature 368: 150-154

Thomas, U., Speicher, S.A. and Knust, E. (1991).The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs. Development 111: 749-61

Thomas, U., et al. (1995). Phenotypic and molecular characterization of SerD, a dominant allele of the Drosophila gene Serrate. Genetics 139: 203-213

Troost, T. and Klein, T. (2012). Sequential Notch signalling at the boundary of fringe expressing and non-expressing cells. PLoS One 7: e49007. PubMed ID: 23152840

Valsecchi, V., et al. (1997). JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial--mesenchymal interactions. Mech. Dev. 69(1-2): 203-207

Wiellette, E. L. and McGinnis, W. (1999). Hox genes differentially regulate Serrate to generate segment-specific structures. Development 126(9): 1985-1995

Xie, X., Cho, B. and Fischer, J. A. (2012). Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules. Dev. Biol. 363(2): 399-412. PubMed Citation: 22265678

Yan, S.-J., et al. (2004). Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development 131: 285-298. 14701680

Zeng, C., et al. (1998). Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage. Genes Dev.12: 1086-1091

Zine, A., Van De Water, T. R. and de Ribaupierre, F. (2000). Notch signaling regulates the pattern of auditory hair cell differentiation in mammals Development 127: 3373-3383

Serrate: Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

date revised: 25 March 2015 

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