FMRFamide

Allan, D., St. Pierre, S. E., Miguel-Aliaga, I. and Thor, S. (2003). Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Cell 113: 73-86. 12679036

Allan, D. W., Park, D., St. Pierre, S. E., Taghert, P. H. and Thor, S. (2005). Regulators acting in combinatorial codes also act independently in single differentiating neurons. Neuron 45: 689-700. 15748845

Askwith, C. C., et al. (2000). Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron 26: 133-141. PubMed Citation: 10798398

Belkin, K. J. and Abrams, T. W. (1998). The effect of the neuropeptide FMRFamide on Aplysia californica siphon motoneurons involves multiple ionic currents that vary seasonally. J. Exp. Biol. 201: 2225-34. PubMed Citation: 9662493

Benveniste, R. J., et al. (1998). Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. Development 125: 4757-4765. PubMed Citation: 9806924

Blau, H. M. and Baltimore, D. (1991). Differentiation requires continuous regulation. J. Cell Biol. 112: 781-783. PubMed Citation: 1999456

Bowman, J. W. (1995). Nitric oxide mediates the inhibitory effects of SDPNFLRFamide, a nematode FMRFamide-related neuropeptide, in Ascaris suum. J. Neurophysiol. 74: 1880-1888. PubMed Citation: 8592181

Brezden, B. L., Benjamin, R. P. and Gardner, D. R. (1992). Activation of a divalent cation-conducting channel in heart ventricle muscle cells of the snail Lymnaea stagnalis by the molluscan cardioactive peptide FMRFamide. Acta Biol. Hung. 43: 25-38. PubMed Citation: 1284361

Brownlee, D. J., et al. (1995). The action of serotonin and the nematode neuropeptide KSAYMRFamide on the pharyngeal muscle of the parasitic nematode, Ascaris suum. Parasitology 111: 379-384. PubMed Citation: 7567105

Cazzamali, G. and Grimmelikhuijzen, C. J. P. (2002). Molecular cloning and functional expression of the first insect FMRFamide receptor. Proc. Natl. Acad. Sci. 99: 12073-12078. 12218185

Chin, A. C., Reynolds, E. R. and Scheller, R. H. (1990). Organization and expression of the Drosophila FMRFamide-related prohormone gene. DNA Cell Biol. 9: 263-71. PubMed Citation: 2350439

Chin, G. J., et al. (1994). Characterization and solubilization of the FMRFamide receptor of squid. Biol. Bull. 187: 185-199. PubMed Citation: 7811788

Coscoy S., et al. (1998). The Phe-Met-Arg-Phe-amide-activated sodium channel is a tetramer. J. Biol. Chem. 273(14): 8317-22. PubMed Citation: 9525939

Devillers, J. P., et al. (1994). Characterization of a potent agonist for NPFF receptors: binding study on rat spinal cord membranes. Neuropharmacology 33: 661-669. PubMed Citation: 7936102

Devillers, J. P., et al. (1995). Release of neuropeptide FF, an anti-opioid peptide, in rat spinal cord slices is voltage- and Ca(2+)-sensitive: possible involvement of P-type Ca2+ channels. J. Neurochem. 64: 1567-75. PubMed Citation: 7891084

Duttlinger, A., Mispelon, M. and Nichols, R. (2003). The structure of the FMRFamide receptor and activity of the cardioexcitatory neuropeptide are conserved in mosquito. Neuropeptides 37: 120-126. 12747944

Eade, K. T. and Allan, D. W. (2009). Neuronal phenotype in the mature nervous system is maintained by persistent retrograde bone morphogenetic protein signaling. J. Neurosci. 29: 3852-3864. PubMed Citation: 19321782

Eade, K. T., Fancher, H. A., Ridyard, M. S. and Allan, D. W. (2012). Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system. PLoS Genet. 8(2): e1002501. PubMed Citation: 22383890

Edison, A. S., Messinger, L. A. snf Stretton, A. O. (1997). afp-1: a gene encoding multiple transcripts of a new class of FMRFamide-like neuropeptides in the nematode Ascaris suum. Peptides 18(7): 929-35. PubMed Citation: 9357048

Endo, S., et al. (1995). Protein phosphatase-1 regulates outward K+ currents in sensory neurons of Aplysia californica. J. Neurochem. 64: 1833-40. PubMed Citation: 7891112

Evans, C. G., et al. (1999). Modulation of radula opener muscles in Aplysia. J. Neurophysiol. 82(3): 1339-51. PubMed Citation: 10482753

Favrel, P., et al. (1994). A new biological activity for the neuropeptide FMRFamide: experimental evidence for a secretagogue effect on amylase secretion in the scallop Pecten maximus. Experientia 50: 1106-1110. PubMed Citation: 7527347

Gauthier, S. A. and Hewes, R. S. (2006). Transcriptional regulation of neuropeptide and peptide hormone expression by the Drosophila dimmed and cryptocephal genes. J. Exp. Biol. 209: 1803-1815. 16651547

Gouarderes, C., et al. (1993). Antinociceptive effects of intrathecally administered F8Famide and FMRFamide in the rat. Eur. J. Pharmacol. 237: 73-81. PubMed Citation: 8102975

Hewes, R. S., et al. (1998). Functional redundancy of FMRFamide-related peptides at the Drosophila larval neuromuscular junction. J. Neurosci. 18(18): 7138-51. PubMed Citation: 9736637

Hewes, R. S., Gu, T., Brewster, J. A., Qu, C. and Zhao, T. (2006). Regulation of secretory protein expression in mature cells by DIMM, a basic helix-loop-helix neuroendocrine differentiation factor. J. Neurosci. 26(30): 7860-9. 16870731

Jiang, N., et al. (2000). Phm is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila. Dev. Biol. 226: 118-136. 10993678

Keating, C. and Lloyd. P. E.(1999). Differential modulation of motor neurons that innervate the same muscle but use different excitatory transmitters in aplysia. J. Neurophysiol. 82(4): 1759-67. PubMed Citation: 10515965

Kemenes, G., et al. (1992). Distinct receptors for Leu- and Met-enkephalin on the metacerebral giant cell of Aplysia. Cell Mol. Neurobiol. 12: 107-19. PubMed Citation: 1318164

Kontinen, V. K., et al. (1997). Neuropeptide FF in the rat spinal cord during carrageenan inflammation. Peptides 18(2): 287-92. PubMed Citation: 9149302

Kim, Y. J., Zitnan, D., Galizia, C. G., Cho, K. H. and Adams, M. E. (2006). A command chemical triggers an innate behavior by sequential activation of multiple peptidergic ensembles. Curr. Biol. 16: 1395-1407. 16860738

Lange, A. B., Peeff, N. M. and Orchard, I. (1994). Isolation, sequence, and bioactivity of FMRFamide-related peptides from the locust ventral nerve cord. Peptides 15: 1089-1094. PubMed Citation: 7991453

Lange, A. B., et al. (1995). A nonpeptide agonist of the invertebrate receptor for SchistoFLRFamide (PDVDHVFLRFamide), a member of a subfamily of insect FMRFamide-related peptides. Proc. Natl. Acad. Sci. 92: 9250-9253. PubMed Citation: 7568111

Lingueglia, E., et al. (1995). Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature 378: 730-733. PubMed Citation: 7501021

Liu, G. J. and Takeuchi, H. (1995). Suppressing effects of neuroactive peptides on the inward current caused by achatin-I, an Achatina endogenous peptide. Gen. Pharmacol. 26: 765-772. PubMed Citation: 7543426

Miguel-Aliaga, I., Allan, D. W. and Thor, S. (2004). Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification. Development 131: 5837-5848. 15525669

Marks, N. J., et al. (1995). Isolation of AF2 (KHEYLRFamide) from Caenorhabditis elegans: evidence for the presence of more than one FMRFamide-related peptide-encoding gene. Biochem. Biophys. Res. Commun. 217: 845-851. PubMed Citation:

Marks, N. J., et al. (1997). APEASPFIRFamide, a novel FMRFamide-related decapeptide from Caenorhabditis elegans: structure and myoactivity. Biochem. Biophys. Res. Commun. 231(3): 591-5. PubMed Citation: 9070852

Marks, N. J., et al. (1998). KSAYMRFamide (PF3/AF8) is present in the free-living nematode, Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 248(2): 422-5. PubMed Citation: 9675153

Marqués, G., et al. (2003). Retrograde Gbb signaling through the Bmp type 2 receptor Wishful Thinking regulates systemic FMRFa expression in Drosophila. Development 130: 5457-5470. 14507784

McGaw, I. J. and McMahon, B. R. (1995). The FMRFamide-related peptides F1 and F2 alter hemolymph distribution and cardiac output in the crab Cancer magister. Biol. Bull. 188: 186-196. PubMed Citation: 7742390

Milakovic, M., Ormerod, K. G., Klose, M. K. and Mercier, J. (2014). Mode of action of a Drosophila FMRFamide in inducing muscle contraction. J Exp Biol. PubMed ID: 24526728

Mitgutsch, C., Hauser, F., Grimmelikhuijzen, C. J. (1999). Expression and developmental regulation of the Hydra-RFamide and Hydra-LWamide Preprohormone genes in Hydra: Evidence for transient phases of head formation. Dev. Biol. 207(1): 189-203. PubMed Citation: 10049574

Muthal, A. V. and Chopde, C. T. (1994). Anxiolytic effect of neuropeptide FMRFamide in rats. Neuropeptides 27: 105-108. PubMed Citation: 7991064

Muthal, A. V. and Chopde, C. T. (1995). Effect of neuropeptide FMRFamide on immobile behavior in rats. Indian J. Exp. Biol. 33: 182-185. PubMed Citation: 7601488

Muthal, A. V., Mandhane, S. N. and Chopde, C. T. (1997). Central administration of FMRFamide produces antipsychotic-like effects in rodents. Neuropeptides 31(4): 319-22. PubMed Citation: 9308017

Nadim, F. and Calabrese, R. L. (1997). A slow outward current activated by FMRFamide in heart interneurons of the medicinal leech. J. Neurosci. 17: 4461-4472. PubMed Citation: 9151763

Nambu, J. R., et al. (1988). Isolation and characterization of a Drosophila neuropeptide gene. Neuron 1: 55-61. PubMed Citation: 3272155

Nelson, L. S., Rosoff, M. L. and Li, C. (1998). Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans. Science 281(5383): 1686-1690. PubMed Citation: 9733518

Nichols, R., Schneuwly, S. A. and Dixon, J. E. (1988). Identification and characterization of a Drosophila homolog to the vertebrate neuropeptide cholecystokinin. J. Biol. Chem. 263: 12167-70. PubMed Citation: 2842322

Nichols, R. (1992a). Isolation and structural characterization of Drosophila TDVDHVFLRFamide and FMRFamide-containing neural peptides. J. Mol. Neurosci. 3: 213-8. PubMed Citation: 1390001

Nichols, R. (1992b). Isolation and expression of the Drosophila drosulfakinin neural peptide gene product, DSK-I. Mol. Cell. Neurosci. 3: 342-347. PubMed Citation: 19912877

Nichols, R., et al. (1995a). Cellular expression of the Drosophila melanogaster FMRFamide neuropeptide gene product DPKQDFMRFamide. Evidence for differential processing of the FMRFamide polypeptide precursor. J. Mol. Neurosci. 6: 1-10. PubMed Citation: 8562315

Nichols, R., et al. (1995b). Spatial and temporal analysis of the Drosophila FMRFamide neuropeptide gene product SDNFMRFamide: evidence for a restricted expression pattern. Neuropeptides 29: 205-213. PubMed Citation: 8584138

Nichols, R. (2006). FMRFamide-related peptides and serotonin regulate Drosophila melanogaster heart rate: mechanisms and structure requirements. Peptides 27(5): 1130-7. 16516344

Nishimura, M., et al. (2000). Role of FMRFamide-activated brain sodium channel in salt-sensitive hypertension. Hypertension 35: 443-50. PubMed Citation: 10642339

O'Brien, M. A., Schneider, L. E. and Taghert, P. H. (1991). In situ hybridization analysis of the FMRFamide neuropeptide gene in Drosophila. II. Constancy in the cellular pattern of expression during metamorphosis. J. Comp. Neurol. 304: 623-38. PubMed Citation: 1672877

Peter, N., et al. (1994). Decrease in growth cone-neurite fasciculation by sensory or motor cells in vitro accompanies downregulation of Aplysia cell adhesion molecules by neurotransmitters. J. Neurosci. 14: 1413-21. PubMed Citation: 7907362

Pieroni, J. P. and Byrne, J. H. (1992). Differential effects of serotonin, FMRFamide, and small cardioactive peptide on multiple, distributed processes modulating sensorimotor synaptic transmission in Aplysia. J Neurosci 12: 2633-47. PubMed Citation: 1319479

Pivovarov, A. S., Sharma, R. and Walker, R. J. (1995). Inhibitory action of SKPYMRFamide on acetylcholine receptors of Helix aspersa neurons: role of second messengers. Gen. Pharmacol. 26: 495-505. PubMed Citation: 7789722

Santama, N., Benjamin, P. R. and Burke, J. F. (1995). Alternative RNA splicing generates diversity of neuropeptide expression in the brain of the snail lymnaea: in situ analysis of mutually exclusive transcripts of the FMRFamide gene. Eur. J. Neurosci. 7: 65-76. PubMed Citation: 7711938

Santarelli, L., Montarolo, P. and Schacher, S. (1996). Neuropeptide localization in varicosities of Aplysia sensory neurons is regulated by target and neuromodulators evoking long-term synaptic plasticity. J. Neurobiol. 31: 297-308. PubMed Citation: 8910788

Schinkmann, K. and Li, C. (1994). Comparison of two Caenorhabditis genes encoding FMRFamide(Phe-Met-Arg-Phe-NH2)-like peptides. Brain Res. Mol. Brain Res. 24: 238-246. PubMed Citation: 7968363

Schneider, L. E. and Taghert, P. H. (1988). Isolation and characterization of a Drosophila gene that encodes multiple neuropeptides related to Phe-Met-Arg-Phe-NH2 (FMRFamide). Proc. Natl. Acad. Sci. 85: 1993-7. 88158119

Schneider, L. E. and Taghert, P. H. (1990). Organization and expression of the Drosophila Phe-Met-Arg-Phe-NH2 neuropeptide gene. J. Biol. Chem. 265: 6890-5. PubMed Citation: 2324103

Schneider, L. E., O'Brien, M. A. and Taghert, P. H. (1991). In situ hybridization analysis of the FMRFamide neuropeptide gene in Drosophila. I. Restricted expression in embryonic and larval stages. J. Comp. Neurol. 304: 608-22. PubMed Citation: 1672876.

Schneider, L. E., et al. (1993a). An immunocytochemical study of the FMRFamide neuropeptide gene products in Drosophila. J. Comp. Neurol. 337: 446-60. PubMed Citation: 8282851

Schneider, L. E., Roberts, M. S. and Taghert, P. H. (1993b). Cell type-specific transcriptional regulation of the Drosophila FMRFamide neuropeptide gene. Neuron 10: 279-91. PubMed Citation: 8439413

Scott, M. L., Brezina, V. and Weiss, K. R. (1997). Ion currents and mechanisms of modulation in the radula opener muscles of Aplysia. J. Neurophysiol. 78(5): 2372-87. PubMed Citation: 9356389

Skerrett, M., et al. (1995). Physiological effects of two FMRFamide-related peptides from the crayfish Procambarus clarkii. J. Exp. Biol. 198: 109-116. PubMed Citation: 9317440

Small, S. A., et al. (1992). Identified FMRFamide-immunoreactive neuron LPL16 in the left pleural ganglion of Aplysia produces presynaptic inhibition of siphon sensory neurons. J Neurosci 12: 1616-27. PubMed Citation: 1349637

Sun, Z. Y., Kauderer, B. and Schacher, S. (1996). Differential distribution of functional receptors for neuromodulators evoking short-term heterosynaptic plasticity in Aplysia sensory neurons. J. Neurosci. 16: 7540-9. PubMed Citation: 8922410

Sweatt, J. D., et al. (1989). FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons. Nature 342: 275-8. PubMed Citation: 2554147

Taghert, P. H. and Schneider, L. E. (1990). Interspecific comparison of a Drosophila gene encoding FMRFamide-related neuropeptides. J. Neurosci. 10: 1929-42. PubMed Citation: 2113087

Taghert, P. H., et al. (2000). Metamorphosis of tangential visual system neurons in Drosophila. Dev. Biol. 222: 471-485. PubMed Citation: 10837134

Taghert, P. H., et al. (1992). Molecular genetic analysis of the FMRFamide-related neuropeptides in Drosophila. Prog. Brain Res. 92: 163-74. PubMed Citation: 1302876

Ude, J. and Agricola, H. (1995). FMRFamide-like and allatostatin-like immunoreactivity in the lateral heart nerve of Periplaneta americana: colocalization at the electron-microscopic level. Cell Tissue Res. 282: 69-80. PubMed Citation: 8581928

van Meyel, D. J., et al. (2000). Chip is an essential cofactor for Apterous in the regulation of axon guidance in Drosophila. Development 127: 1823-1831. PubMed Citation: 10751171

Vilim, F. S., et al. (1999). Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by noxious stimuli. Mol. Pharmacol. 55(5): 804-11. PubMed Citation: 10220558

Vogler, G. and Urban, J. (2008). The transcription factor Zfh1 is involved in the regulation of neuropeptide expression and growth of larval neuromuscular junctions in Drosophila melanogaster. Dev. Biol. 319(1): 78-85. PubMed Citation: 18499094

Wang, Z., et al. (1995a). Binding and activation regions of the decapeptide PDVDHVFLRFamide (SchistoFLRFamide). Neuropeptides 28: 261-266. PubMed Citation: 7603586

Wang, Z., Lange, A. B. and Orchard, I. (1995b). Coupling of a single receptor to two different G proteins in the signal transduction of FMRFamide-related peptides. Biochem. Biophys. Res. Commun. 212: 531-538. PubMed Citation: 7626067

Wenning, A., et al. (1993). Sensory and neurosecretory innervation of leech nephridia is accomplished by a single neurone containing FMRFamide. J. Exp. Biol. 182: 81-96. PubMed Citation: 8228785

Witten, J. L. and Truman, J. W. (1996). Developmental plasticity of neuropeptide expression in motoneurons of the moth, Manduca sexta: steroid hormone regulation. J. Neurobiol. 29 (1): 99-114. PubMed Citation: 8748375

Worden, M. K., Kravitz, E. A. and Goy, M. F. (1995). Peptide F1, an N-terminally extended analog of FMRFamide, enhances contractile activity in multiple target tissues in lobster. J. Exp. Biol. 198: 97-108. PubMed Citation: 7891041

Wu, F. and Schacher, S. (1994). Pre- and postsynaptic changes mediated by two second messengers contribute to expression of Aplysia long-term heterosynaptic inhibition. Neuron 12: 407-21. PubMed Citation: 7906529

Zhu, H., Wu, F. and Schacher, S. (1995). Changes in expression and distribution of Aplysia cell adhesion molecules can influence synapse formation and elimination in vitro. J Neurosci 15: 4173-4183. PubMed Citation: 7790903

Zitnan, D., Sehnal, F. and Bryant, P. J. (1993). Neurons producing specific neuropeptides in the central nervous system of normal and pupariation delayed Drosophila. Dev. Biol. 156: 117-135. PubMed Citation: 8449364

date revised: 20 December 2012
 

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.