eyeless

Adachi, Y., et al. (2003). Conserved cis-regulatory modules mediate complex neural expression patterns of the eyeless gene in the Drosophila brain. Mech. Dev. 120: 1113-1126. 14568101

Agoston, Z., Heine, P., Brill, M. S., Grebbin, B. M., Hau, A. C., Kallenborn-Gerhardt, W., Schramm, J., Gotz, M. and Schulte, D. (2014). Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb. Development 141: 28-38. PubMed ID: 24284204

Altmann, C. R., et al. (1997). Lens induction by Pax-6 in Xenopus laevis. Dev. Biol. 185(1): 119-123. PubMed Citation: 9169055

Anderson A. M., Weasner B. M., Weasner B. P. and Kumar J. P. (2012). Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development. Development 139: 991-1000. PubMed Citation: 22318629

Anderson, J., Salzer, C. L. and Kumar, J. P. (2006). Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. Dev. Biol. 297(2): 536-49. 16780828

Aota, S.-i., et al. (2003). Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene. Dev. Biol. 257: 1-13. 12729563

Araki, I. and Nakamura, H. (1999). Engrailed defines the position of dorsal di-mesencephalic boundary by repressing diencephalic fate. Development 126: 5127-5135. PubMed Citation: 10529429

Asami, M., et al. (2011). The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex. Development 138(23): 5067-78. PubMed Citation: 22031545

Atkins, M., Jiang, Y., Sansores-Garcia, L., Jusiak, B., Halder, G. and Mardon, G. (2013). Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation. PLoS Genet 9: e1003731. PubMed ID: 24009524

Bäumer, N., et al. (2002). Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development 129: 4535-4545. 12223410

Benassayag, C., et al. (2003). Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development. Development 130: 575-586. 12490563

Berger, J., et al. (2007). Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis. Development 134(7): 1311-22. Medline abstract: 17329367

Ashery-Padan, R., et al. (2000). Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 14: 2701-2711. PubMed Citation: 11069887

Bäumer, N., et al. (2003). Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130: 2903-2915. 12756174

Bayraktar, O. A. and Doe, C. Q. (2013). Combinatorial temporal patterning in progenitors expands neural diversity. Nature 498: 449-455. PubMed ID: 23783519

Bell, E., et al. (2001). Dynamic domains of gene expression in the early avian forebrain. Dev. Bio. 236: 76-88. 11456445

Bernier, G., et al. (2001). Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium. Development 128: 3987-3994. 11641222

Bertet, C., Li, X., Erclik, T., Cavey, M., Wells, B., Desplan, C. (2014) Temporal patterning of neuroblasts controls Notch-mediated cell survival through regulation of Hid or Reaper. Cell 158: 1173-1186. PubMed ID: 25171415

Bertrand, N., Medevielle, G. and Pituello, F. (2000). FGF signalling controls the timing of Pax6 activation in the neural tube. Development 127: 4837-4843. PubMed Citation: 11044398

Bessa, J., et al. (2002). Combinatorial control of Drosophila eye development by Eyeless, Homothorax, and Teashirt. Genes Dev. 16: 2415-2427. 12231630

Bhatia, S., Monahan, J., Ravi, V., Gautier, P., Murdoch, E., Brenner, S., van Heyningen, V., Venkatesh, B. and Kleinjan, D. A. (2014). A survey of ancient conserved non-coding elements in the PAX6 locus reveals a landscape of interdigitated cis-regulatory archipelagos. Dev Biol 387: 214-228. PubMed ID: 24440152

Bishop, K. M., Goudreau, G. and O'Leary, D. D. M. (2000). Regulation of area identity in the mammalian neocortex by Emx2 and Pax6. Science 288: 344-349. PubMed Citation: 10764649

Bishop, K. M., Rubenstein, J. L. R. and O'Leary. D. D. M. (2002). Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J. Neurosci. 22(17): 7627-7638. 12196586

Blader, P., et al. (2004). Conserved and acquired features of neurogenin1 regulation. Development 131: 5627-5637. 15496438

Bonini, N. M., et al. (1997). The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates. Development 124(23): 4819-4826. PubMed Citation: 9428418

Braid, L. R. and Verheyen, E. M. (2008). Drosophila nemo promotes eye specification directed by the retinal determination gene network. Genetics 180(1): 283-99. PubMed Citation: 18757943

Breitling, R. and Gerber, J.-K. (2000). Origin of the paired domain. Dev. Genes Evol. 210: 644-650. 21025774

Briscoe, J., et al. (1999). Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature 398(6728): 622-7. PubMed Citation: 10217145

Brown, N. L., et al. (1998). Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development 125(23): 4821-4833. PubMed Citation: 9806930

Bui, Q. T., et al. (2000). Functional analysis of an eye enhancer of the Drosophila eyes absent gene: Differential regulation by eye specification genes. Dev. Biol. 221: 355-364. PubMed Citation: 10790331

Burrill, J.D., et al. (1997). PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development. Development 124(22): 4493-4503. PubMed Citation: 9409667

Caballero, I. M., Manuel, M. N., Molinek, M., Quintana-Urzainqui, I., Mi, D., Shimogori, T. and Price, D. J. (2014). Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer. Cell Rep 8: 1405-1418. PubMed ID: 25176648

Callaerts, P., et al. (1999). Isolation and expression of a Pax-6 gene in the regenerating and intact planarian Dugesia(G)tigrina. Proc. Natl. Acad. Sci. 96(2): 558-63. PubMed Citation: 9892672

Callaerts, P., et al. (2001). Drosophila Pax-6/eyeless is essential for normal adult brain structure and function. J. Neurobiol. 46: 73-88. 11153010

Caric, D., et al. (1997). Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6. Development 124(24): 5087-5096. PubMed Citation: 9362466

Carriere, C., et al. (1995). Nuclear localization signals, DNA binding, and transactivation properties of quail Pax-6 (Pax-QNR) isoforms. Cell Growth Differ. 6(12): 1531-40. PubMed Citation: 9019158

Catmull, J., et al. (1998). Pax-6 origins - implications from the structure of two coral pax genes. Dev. Genes Evol. 208(6): 352-6. PubMed Citation: 9716726

Chang, T., et al. (2001). Dpp and Hh signaling in the Drosophila embryonic eye field. Development 128: 4691-4704. 11731450

Chapouton, P., Gartner, A. and Gotz, M. (1999). The role of Pax6 in restricting cell migration between developing cortex and basal ganglia Development 126: 5569-5579. PubMed Citation: 10572034

Chen, R., et al. (1997). Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila. Cell 91(7): 893-903. PubMed Citation: 9428513

Cheyette, B.N.R., et al. (1994). The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron 12: 977-96. PubMed Citation: 7910468

Cinar, H. N. and Chisholm, A. D. (2004). Genetic analysis of the Caenorhabditis elegans pax-6 locus: roles of paired domain-containing and nonpaired domain-containing isoforms. Genetics 168(3): 1307-22. 15579687

Chisholm, A. D. and Horvitz, H. R. (1995). Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3. Nature 377: 52-55. PubMed Citation: 7659159

Chow, R. L., et al. (1999). Pax6 induces ectopic eyes in a vertebrate. Development 126: 4213-4222. PubMed Citation: 10477290

Clements, J., Hens, K., Francis, C., Schellens, A. and Callaerts, P. (2008). Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons. Proc. Natl. Acad. Sci. 105(42): 16183-8. PubMed Citation: 18852455

Collinson, J. M., Hill, R. E. and West, J. D. (2000). Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. Development 127: 945-956. PubMed Citation: 10662634

Collinson, J. M., et al. (2003). The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo. Dev. Bio. 255: 303-312. 12648492

Collombat, P., et al. (2005). The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development 132(13): 2969-80. 15930104

Cras-Méneur, C., Li, L., Kopan, R. and Permutt, M. A. (2009). Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes Dev. 23(17): 2088-101. PubMed Citation: 19723764

Cremazy, F., Berta, P. and Girard, F. (2000). Sox neuro, a new Drosophila Sox gene expressed in the developing central nervous system. Mech. Dev. 93(1-2): 215-9. PubMed Citation: 10781960

Czerny T., et al. (1999). twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development. Mol. Cell 3(3): 297-307. PubMed Citation: 10198632

Denes, A. S., et al. (2007). Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria. Cell 129(2): 277-88. Medline abstract: 17448990

Di Lullo, E., et al. (2011). Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Development 138(22): 4991-5001. PubMed Citation: 22028031

Dimanlig, P. V., et al. (2001). The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Development 128: 4415-4424. 11714668

Dominguez, M., Ferres-Marco, D., Gutierrez-Avino, F. J., Speicher, S. A. and Beneyto, M. (2004). Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster. Nat. Genet. 36: 31-39. 14702038

Dozier, C., et al. (2001). The Caenorhabditis elegans Six/sine oculis class homeobox gene ceh-32 is required for head morphogenesis. Dev. Bio. 236: 289-303. 11476572

Duncan, M. K., et al. (1998). Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes. Mol. Cell. Biol. 18(9): 5579-86. PubMed Citation: 9710641

Engelkamp, D., et al. (1999). Role of Pax6 in development of the cerebellar system. Development 126: 3585-3596

Epstein, J. A., et al. (1994). Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev. 8: 2022-34. PubMed Citation: 7958875.

Ericson, J., et al. (1997). Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90(1): 169-180. PubMed Citation: 9230312

Ermakova, G. V., et al. (1999). The homeobox gene, Xanf-1, can control both neural differentiation and patterning in the presumptive anterior neurectoderm of the Xenopus laevis embryo. Development 126: 4513-4523. PubMed Citation: 10498686

Estivill-Torrus, G., Vitalis, T., Fernandez-Llebrez, P. and Price, D. J. (2001). The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ. Mech Dev. 109(2): 215-24. 11731235

Estivill-Torrus, G., et al. (2002). Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors. Development 129: 455-466. 11807037

Faber, S. C., et al. (2001). Fgf receptor signaling plays a role in lens induction. Development 128: 4425-4438. 11714669

Favor, J., et al. (2001). Molecular characterization of Pax6^2Neu through Pax6^10Neu: An extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus. Genetics 159: 1689-170. 11779807

Galliot, I. and Miller, I, (2000) Origin of anterior patterning. How old is our head? Trends Genet. 16: 1-5. PubMed Citation: 10637621.

Glardon, S., et al. (1997). Conservation of Pax-6 in a lower chordate, the ascidian Phallusia mammillata. Development 124: 817-825 . PubMed Citation: 9043063

Glardon, S., et al. (1998). Isolation and developmental expression of the amphioxus pax-6 gene (AmphiPax-6): insights into eye and photoreceptor evolution. Development 125(14): 2701-2710. PubMed Citation: 9636084

Glaser, T., et al. (1994). PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects. Nature Genet. 7: 463-71. PubMed Citation: 7951315

Goulding, M. D., Lumsden, A. and Gruss, P. (1993). Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. Development 117: 1001-16. PubMed Citation: 8100762

Halder, G., Callaerts, P. and Gehring, W.J. (1995). Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267(5205): 1788-1792. PubMed Citation: 7892602

Halder, G., et al. (1998). Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development 125: 2181-2191 . PubMed Citation: 9584118

Hartmann, B., et al. (2002). Pax6 in the sepiolid squid Euprymna scolopes: evidence for a role in eye, sensory organ and brain development. Mech. Dev. 120: 177-183. 12559490

Hasegawa, E., Kitada, Y., Kaido, M., Takayama, R., Awasaki, T., Tabata, T. and Sato, M. (2011). Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. Development 138: 983-993. PubMed ID: 21303851

Hasegawa, E., Kaido, M., Takayama, R. and Sato, M. (2013). Brain-specific-homeobox is required for the specification of neuronal types in the Drosophila optic lobe. Dev Biol 377: 90-99. PubMed ID: 23454478

Haubst, N., Berger, J., Radjendirane, V., Graw, J., Favor, J., Saunders, G. F., Stoykova, A. and Gotz, M. (2004). Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development 131(24): 6131-40. 15548580

Hauck, B., Gehring, W. J. and Walldorf, U. (1999). Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila. Proc. Natl. Acad. Sci. 96(2): 564-9. PubMed Citation: 9892673

Hoang, C. Q., Burnett, M. E., Curtiss, J. (2010). Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development. Dev. Dyn. 239: 2367-2385. PubMed Citation: 20730908

Hochstim, C., Deneen, B., Lukaszewicz, A., Zhou, Q. and Anderson, D. J. (2008). Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell 133(3): 510-22. PubMed Citation: 18455991

Holst, B. D., et al. (1997). A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord. Proc. Natl. Acad. Sci. 94 (4): 1465-1470. PubMed Citation: 9037076

Hornyak, T. J., et al. (2001). Transcription factors in melanocyte development: distinct roles for Pax-3 and Mitf. Mech. Dev. 101: 47-59. 11231058

Hummel, T., Attix, S., Gunning, D. and Zipursky, S. L. (2002).Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes. Neuron 33: 193-203. 11804568

Irvine, S. Q., Fonseca, V. C., Zompa, M. A. and Antony, R. (2008). Cis-regulatory organization of the Pax6 gene in the ascidian Ciona intestinalis. Dev. Biol. 317(2): 649-59. PubMed Citation: 18342846

Jang, C.-C., et al. (2003). Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development. Development 130: 2939-2951. 12756177

Jiao, R., et al. (2001). Headless flies generated by developmental pathway interference. Development 128: 3307-3319. 11546747

Jimeno-Martin, A., Sousa, E., Brocal-Ruiz, R., Daroqui, N., Maicas, M. and Flames, N. (2022). Joint actions of diverse transcription factor families establish neuron-type identities and promote enhancer selectivity.. Genome Res 32(3): 459-473. PubMed ID: 35074859

Johnson, R. W. and Chamberlin, H. M. (2008).Positive and negative regulatory inputs restrict pax-6/vab-3 transcription to sensory organ precursors in Caenorhabditis elegans. Mech. Dev. 125(5-6): 486-97. PubMed Citation: 18313275

Jones, L., et al. (2002). Pax6 is required for the normal development of the forebrain axonal connections. Development 129: 5041-5052. 12397112

Jun, S., and Desplan, C. (1996). Cooperative interactions between paired domain and homeodomain. Development 122: 2639-50. PubMed Citation: 8787739

Kamachi, Y., et al. (2001). Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development. Genes Dev. 15: 1272-1286. 11358870

Kammandel, B., et al. (1999). Distinct cis-essential modules direct the time-space pattern of the pax6 gene activity. Dev. Biol. 205(1): 79-97. PubMed Citation: 9882499

Kammermeier, L., et al. (2001). Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development. Mech. Dev. 103: 71-78. 11335113

Kango-Singh, M., Singh, A. and Sun, Y. H. (2003). Eyeless collaborates with Hedgehog and Decapentaplegic signaling in Drosophila eye induction. Dev. Bio. 256: 48-60. 12654291

Kawahara, A. and Dawid, I. B. (2002). Developmental expression of zebrafish emx1 during early embryogenesis. Gene Expr. Patterns 2(3-4): 201-6. Medline abstract: 12617801

Kawakami, A., et al. (1997). Distributions of PAX6 and PAX7 proteins suggest their involvement in both early and late phases of chick brain development. Mech. Dev. 66(1-2): 119-130. PubMed Citation: 9376315

Kawahara, A., Chien, C.-B. Dawid, I. B. (2002). The homeobox gene mbx is involved in eye and tectum development. Dev. Bio. 248: 107-117. 12142024

Kenyon, K. L., Zaghloul, N. and Moody, S. A. (2001). Transcription factors of the anterior neural plate alter cell movements of epidermal progenitors to specify a retinal fate. Dev. Biol. 240(1): 77-91. 11784048

Kenyon, K. L., Ranade, S. S., Curtiss, J. Mlodzik, M. and Pignoni, F. (2003). Coordinating proliferation and tissue specification to promote regional identity in the Drosophila head. Dev. Cell 5: 403-414. 12967560

Kim, A. S., et al. (2001). Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS. J. Neurosci. 21: RC132: 1-5. 11222670

Klimova, L. and Kozmik, Z. (2014). Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development 141: 1292-1302. PubMed ID: 24523460

Kozmik, Z., et al. (2003). Role of Pax genes in eye evolution: A Cnidarian paxb gene uniting Pax2 and Pax6 functions. Dev. Cell 5: 773-785. 14602077

Kronhamn, J., et al. (2002). Headless flies produced by mutations in the paralogous Pax6 genes eyeless and twin of eyeless. Development 129: 1015-1026. 11861484

Kumar, J. P. and Moses, K. (2001a).EGF receptor and Notch signaling act upstream of Eyeless/Pax6 to control eye specification. Cell 104: 687-697. 11257223

Kumar, J. P. and Moses, K. (2001b). Expression of evolutionarily conserved eye specification genes during Drosophila embryogenesis. Dev. Genes Evol. 211: 406-414. 11685574

Kurata, S., et al. (2000). Notch signaling and the determination of appendage identity. Proc. Natl. Acad. Sci. 97: 2117-2122. PubMed Citation: 10681430

Kurusu, M., et al. (2000). Genetic control of development of the mushroom bodies, the associative learning centers in the Drosophila brain, by the eyeless, twin of eyeless, and dachshund genes. Proc. Natl. Acad. Sci. Vol. 97: 2140-2144. PubMed Citation: 10681433

Larsson, L.-I., et al. (1998). Pax 4 and 6 regulate gastrointestinal endocrine cell development. Mech. Dev. 79(1-2): 153-159. PubMed Citation: 10349628

Lee, J. D. and Treisman, J. E. (2001). The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc. Development 128: 1519-1529. 11290291

Lesaffre, B., Joliot, A., Prochiantz, A. and Volovitch, M. (2007). Direct non-cell autonomous Pax6 activity regulates eye development in the zebrafish. Neural Develop. 2: 2. Medline abstract: 17229313

Li, X., Erclik, T., Bertet, C., Chen, Z., Voutev, R., Venkatesh, S., Morante, J., Celik, A. and Desplan, C. (2013). Temporal patterning of Drosophila medulla neuroblasts controls neural fates. Nature 498: 456-462. PubMed ID: 23783517

Liu, A. and Joyner, A. L. (2001). EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Development 128: 181-191. 11124114

Loosli, F., et al. (2001). Medaka eyeless is the key factor linking retinal determination and eye growth. Development 128: 4035-4044. 11641226

Lowe, C. J., et al. (2003). Anteroposterior patterning in hemichordates and the origins of the chordate nervous system. Cell 113: 853-865. 12837244

Luan, Q., Chen, Q. and Friedrich, M. (2014). The Pax6 genes eyeless and twin of eyeless are required for global patterning of the ocular segment in the Tribolium embryo. Dev Biol 394(2):367-81. PubMed ID: 25149513

Macdonald, R. and Wilson, S. W., (1997). Spatial and temporal distribution of Pax6 was studied in the Zebrafish eye. Dev. Genes Evol. 206: 363-369. PubMed Citation:

Makarenkova, H. P., et al. (2000). FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127(12): 2563-72. PubMed Citation:

Manuel, M., et al. (2007). Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization. Development 134: 545-555. Medline abstract: 17202185

Marquardt, T., et al. (2001).Pax6 is required for the multipotent state of retinal progenitor cells.Cell 105: 43-55. 11301001

Mastick, G., et al. (1997). Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain. Development 124: 1985-1997. PubMed Citation: 9169845

Mathers, P. H., et al. (1997). The Rx homeobox gene is essential for vertebrate eye development. Nature 387 (6633): 603-607. PubMed Citation: 9177348

Matsunaga, E., Araki, I. and Nakamura, H. (2000). Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2. Development 127: 2357-2365. PubMed Citation: 1080417

Meech, R., et al. (1999). A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins. Proc. Natl. Acad. Sci. 96(5): 2420-2425. PubMed Citation: 10051657

Meighan, C. M. and Schwarzbauer, J. E. (2007). Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors. Genes Dev. 21(13): 1615-20. Medline abstract: 17606640

Mikkola, I., et al. (1999). Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. J. Biol. Chem. 274(21): 15115-26. PubMed Citation: 10329718

Miller, D. J., et al. (2000). Pax gene diversity in the basal cnidarian Acropora millepora (Cnidaria, Anthozoa): Implications for the evolution of the Pax gene family. Proc. Natl. Acad. Sci. 97: 4475-4480. PubMed Citation: 10781047.

Michaut, L., Flister, S., Neeb, M., White, K. P., Certa, U. and Gehring, W. J. (2003). Analysis of the eye developmental pathway in Drosophila using DNA microarrays. Proc. Natl. Acad. Sci. 100(7): 4024-9. 12655063

Mizuno, M., et al. (1997). pax-6 gene expression in newt eye development. Dev. Genes Evol. 207: 167-176

Morante, J. and Desplan, C. (2008). The color-vision circuit in the medulla of Drosophila. Curr Biol 18: 553-565. PubMed ID: 18403201

Morante, J., Erclik, T. and Desplan, C. (2011). Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. Development 138: 687-693. PubMed ID: 21208993

Murakami, Y., et al. (2001). Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates. Development 128: 3521-3531. 11566857

Muzio, L. and Mallamaci, A. (2003). Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex. Cereb. Cortex 13(6): 641-7. Medline abstract: 12764040

Nfonsam, L. E., Cano, C., Mudge, J., Schilkey, F. D. and Curtiss, J. (2012). Analysis of the transcriptomes downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch signaling pathways in Drosophila melanogaster. PLoS One 7(8): e44583. PubMed Citation: 22952997

Niimi, T., et al. (1999). Direct regulatory interaction of the Eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila. Development 126: 2253-2260. PubMed Citation: 10207149

Nomura, T. and Osumi, N. (2004). Misrouting of mitral cell progenitors in the Pax6/small eye rat telencephalon. Development 131: 787-796. PubMed Citation: 14736749

Noveen, A., Daniel, A. and Hartenstein, V. (2000). Early development of the Drosophila mushroom body: the roles of eyeless and dachshund. Development 127: 3475-3488. 10903173

Okamoto, N., Nishimori, Y. and Nishimura, T. (2012). Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression. Proc. Natl. Acad. Sci. 109(7): 2406-11. PubMed Citation: 22308399

Onuma, Y., et al. (2002). Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies Proc. Natl. Acad. Sci. 99: 2020-2025. 11842182

Oron-Karni, V., et al. (2008). Dual requirement for Pax6 in retinal progenitor cells. Development 135(24): 4037-47. PubMed Citation: 19004853

Ostrin, E. J., et al. (2006). Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Genome Res. 16(4): 466-76. 16533912

Osumi, N., et al. (1997). Pax-6 is involved in the specification of hindbrain motor neuron subtype. Development 124(15): 2961-2972. PubMed Citation: 9247338

Pan, D. and Rubin, G. M. (1998). Targeted expression of teashirt induces ectopic eyes in Drosophila. Proc. Natl. Acad. Sci. 95(26): 15508-12. PubMed Citation: 9860999

Papatsenko, D., Nazina, A. and Desplan, C. (2001). A conserved regulatory element present in all Drosophila rhodopsin genes mediates Pax6 functions and participates in the fine-tuning of cell-specific expression. Mech. Dev. 101: 143-153. 11231067

Pappu, K. S., et al. (2003). Mechanism of hedgehog signaling during Drosophila eye development. Development 130: 3053-3062. 12756186

Pignoni, F., et al. (1997). The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell 91(7): 881-891. PubMed Citation: 9428512

Pituello, F. et al. (1999). Activation of Pax6 depends on somitogenesis in the chick embryo cervical spinal cord. Development. 126: 587-596. PubMed Citation: 9876187

Pauli, T. Seimiya, M., Blanco, J. and Gehring, W. J. (2005). Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog. Development 132: 2771-2782. 15901665

Plaza, S., Dozier, C. and Saule, S. (1993). Quail Pax-6 (Pax-QNR) encodes a transcription factor able to bind and trans-activate its own promoter. Cell Growth Differ. 4(12): 1041-50. PubMed Citation: 8117618

Plaza, S., et al. (1994). Pax-QNR/Pax-6, a paired- and homeobox-containing protein, recognizes Ets binding sites and can alter the transactivating properties of Ets transcription factors. Gene Expr. 4(1-2): 43-52. PubMed Citation: 7841787

Plaza, S., et al. (1995a). Identification and characterization of a neuroretina-specific enhancer element in the quail Pax-6 (Pax-QNR) gene. Mol. Cell. Biol. 15(2): 892-903. PubMed Citation: 7529875

Plaza, S., et al. (1995b). C-Myb acts as transcriptional activator of the quail PAX6 (PAX-QNR) promoter through two different mechanisms. Oncogene10(2): 329-40. PubMed Citation: 7838532

Plaza, S., et al. (1995c). Quail Pax-6 (Pax-QNR) mRNAs are expressed from two promoters used differentially during retina development and neuronal differentiation. Mol. Cell. Biol. 15(6): 3344-53. PubMed Citation: 7760830

Plaza, S., et al. (1997). The homeobox-containing Engrailed (En-1) product down-regulates the expression of Pax-6 through a DNA binding-independent mechanism. Cell Growth Differ. 8(10): 1115-25. PubMed Citation: 9342190

Plaza, S., Saule, S. and Dozier, C. (1999). High conservation of cis-regulatory elements between quail and human for the Pax-6 gene. Dev. Genes Evol. 209(3): 165-73. PubMed Citation: 10079359

Plaza, S., et al. (2001). Molecular basis for the inhibition of Drosophila eye development by Antennapedia. EMBO J. 20: 802-811. 11179224

Plageman, T. F. et al. (2010). Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination. Development 137(3): 405-15. PubMed Citation: 20081189

Porter, F. D., et al. (1997). Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development 124(15): 2935-2944. PubMed Citation: 9247336

Posnien, N., Koniszewski, N. D., Hein, H. J. and Bucher, G. (2011). Candidate gene screen in the red flour beetle Tribolium reveals six3 as ancient regulator of anterior median head and central complex development. PLoS Genet. 7(12): e1002416. PubMed Citation: 22216011

Pratt, T., et al. (2000). A role for Pax6 in the normal development of dorsal thalamus and its cortical connections. Development 127(23): 5167-78. PubMed Citation: 11060242.

Pratt, T., et al. (2002). Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1. J. Neurosci. 22(19): 8523-8531. 12351726

Punzo, C., Kurata, S. and Gehring, W. J. (2001). The eyeless homeodomain is dispensable for eye development in Drosophila. Genes Dev. 15: 1716-1723. 11445545

Punzo, C., et al. (2002). Differential interactions of eyeless and twin of eyeless with the sine oculis enhancer. Development 129: 625-634. 11830564

Punzo, C., et al. (2004). Functional divergence between eyeless and twin of eyeless in Drosophila melanogaster. Development 131: 3943-3953. 15253940

Quinn, J. C., West, J. D. and Hill, R. E. (1996). Multiple functions for Pax6 in mouse eye and nasal development. Genes Dev. 10: 435-446. PubMed Citation: 8600027

Quiring, R. (1994). Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science 265: 785-789. PubMed Citation: 7914031

Renoncourt, Y., et al. (1998). Neurons derived in vitro from ES cells express homeoproteins characteristic of motoneurons and interneurons. Mech. Dev. 79(1-2): 185-197. PubMed Citation: 10349632

Roignant, J. Y., Legent, K., Janody, F. and Treisman, J. E. (2010). The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. Development 137(2): 273-81. PubMed Citation: 20040493

Rowan, S., et al. (2010). Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes Dev. 24(10): 980-5. PubMed Citation: 20413611

Sander, M., et al. (1997). Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev. 11:1662-1673. PubMed Citation: 9224716

Sansom, S. N., et al. (2009). The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 5(6): e1000511. PubMed Citation: 19521500

Scardigli, R., et al. (2001). Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 31: 203-217. 11502253

Scardigli, R., et al. (2003). Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6. Development 130: 3269-3281. 12783797

Schedl, A., et al. (1996). Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities. Cell 86: 71-82. PubMed Citation: 8689689

Schwarz, M., et al. (1999). Pax2/5 and Pax6 subdivide the early neural tube into three domains. Mech. Dev. 82(1-2): 29-39. PubMed Citation: 10354469

Schwarz, M., et al. (2000). Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Development 127: 4325-4334. PubMed Citation: 11003833

Seimiya, M. and Gehring, W. J. (2000). The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism. Development 127: 1879-1886. PubMed Citation: 10751176

Shaham, O., et al. (2009). Pax6 is essential for lens fiber cell differentiation. Development 136(15): 2567-78. PubMed Citation: 19570848

Shen, W. and Mardon, G. (1997). Ectopic eye development in Drosophila induced by directed dachshund expression. Development 124: 45-52. 9006066

Sheng, G., et al. (1997). Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors. Genes Dev. 11: 1122-31. PubMed Citation: 9159393

Sivak, J. M., et al. (2000). Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B. Dev. Biol. 222: 41-54. PubMed Citation: 10885745.

Song, N. I., et al (2007). pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. Development 134: 1873-1885. Medline abstract: 17428831

Stenman, J., et al. (2003). Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development 130: 1113-1122. 12571103

Stoykova, A., et al. (1996). Forebrain patterning defects in Small eye mutant mice. Development 122, 3453-3465. 8951061

Stoykova, A., et al. (1997). Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain. Development 124(19): 3765-3777. PubMed Citation: 9367432

Sultana, H., Verma, S. and Mishra, R. K. (2011). A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. Nucleic Acids Res. 39(9): 3543-57. PubMed Citation: 21247873

Sun, H., et al. (1997). Evolution of paired domains: isolation and sequencing of jellyfish and hydra Pax genes related to Pax-5 and Pax-6. Proc. Natl. Acad. Sci. 94 (10): 5156-5161. PubMed Citation: 9144207

Suzanne, M., Estella, C., Calleja, M. and Sánchez-Herrero, E. (2003). The hernandez and fernandez genes of Drosophila specify eye and antenna. Dev. Bio. 260: 465-483. 12921746

Suzuki, T., Kaido, M., Takayama, R. and Sato, M. (2013). A temporal mechanism that produces neuronal diversity in the Drosophila visual center. Dev Biol 380: 12-24. PubMed ID: 23665475

Takahashi, M. and Osumi, N. (2002). Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains. Development 129: 1327-1338. 11880342

Talamillo, A., et al. (2003). Pax6 regulates regional development and neuronal migration in the cerebral cortex. Dev. Bio. 255: 151-163. 12618140

Tang, H. K., Singh, S. and Saunders, G. F. (1998). Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6. J. Biol. Chem. 273(13): 7210-7221. PubMed Citation: 9516413

Tomarev, S. I., et al. (1997). Squid Pax-6 and eye development. Proc. Natl. Acad. Sci. 94: 2421-26. PubMed Citation: 9122210

Toresson, H., Potter, S. S. and Campbell, K. (2000). Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2. Development 127: 4361-4371. PubMed Citation: 11003836.

Torres, M., Gómez-Pardo, E and Gruss, P. (1996). Pax2 contributes to inner ear patterning and optic nerve trajectory. Development 122, 3381-3391. PubMed Citation: 8951055

Turque, N., et al. (1994). Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells. Mol. Endocrinol. 8(7): 929-38. PubMed Citation: 7984154

Urbach, R. and Technau, G. M. (2003). Molecular markers for identified neuroblasts in the developing brain of Drosophila. Development 130: 3621-3637. 12835380

van Raamsdonk, C. D. and Tilghman, S. M. (2000). Dosage requirement and allelic expression of PAX6 during lens placode formation. Development 127: 5439-5448. PubMed Citation: 11076764

Wang, C. W. and Sun, Y. H. (2012). Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila. Development 139(18): 3413-21. PubMed Citation: 22912416

Wang, S., Tulina, N., Carlin, D. L. and Rulifson, E. J. (2007). The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis. Proc. Natl. Acad. Sci. 104(50): 19873-8. PubMed citation: 18056636

Warren, N. and Price, D. J. (1997). Roles of Pax-6 in murine diencephalic development. Development 124: 1573-1582. PubMed Citation: 9108373

Wawersik, S., et al. (1999). BMP7 acts in murine lens placode development. Dev. Biol. 207(1): 176-188 . PubMed Citation: 10049573

Williams, S. C., et al. (1998). A highly conserved lens transcriptional control element from the Pax-6 gene. Mech. Dev. 73(2): 225-229. PubMed Citation: 9622640

Xu, H. E., et al. (1999). Crystal structure of the human pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev. 13(10): 1263-75. PubMed Citation: 10346815

Xu, P.-X.. et al., (1997). Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development 124: 219-231. PubMed Citation: 9006082

Xu, P.-X., et al. (1999). Regulation of Pax6 expression is conserved between mice and flies. Development 126: 383-395. PubMed Citation: 9847251

Yamasaki, T., et al. (2001). Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum. Development 128: 3133-3144. 11688562

Yan, Q., et al. (2007). Protein phosphatase-1 modulates the function of Pax-6, a transcription factor controlling brain and eye development. J. Biol. Chem. 282(19): 13954-65. PubMed citation: 17374606

Yao, J. G. and Sun, Y. H. (2005). Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development. EMBO J. 24: 2602-2612. PubMed Citation: 15973436

Yao, J. G., et al. (2008). Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila. Dev. Biol. 315(2): 535-51. PubMed Citation: 18275947

Zhang, X., et al. (2002). Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev. 16: 2097-2107. 12183364

Zhang, Y. and Emmons, S. W. (1995). Specification of sense-organ identity by a Caenorhabditis elegans Pax-6 homologue. Nature 377: 55-59. PubMed Citation: 7659160

Zhang, T., et al. (2006). Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So. Development 133(24): 4881-9. Medline abstract: 17108002

Zhang, Y., et al. (1998). Regulated nuclear entry of the C. elegans Pax-6 transcription factor. Mech. Dev. 78 (1-2): 179-187. PubMed Citation: 9858725

Zhou, Q., Zhang, T., Jemc, J. C., Chen, Y., Chen, R., Rebay, I. and Pignoni, F. (2013). Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So bindings sites within two distant enhancers. Dev Biol. 386(1): 152-64. PubMed ID: 24247006

Zhu, J., Palliyil, S., Ran, C. and Kumar, J. P. (2017). Drosophila Pax6 promotes development of the entire eye-antennal disc, thereby ensuring proper adult head formation. Proc Natl Acad Sci U S A 114(23): 5846-5853. PubMed ID: 28584125

Zimmerman, J. E., Bui, Q. T., Liu, H. and Bonini, N. M. (2000). Molecular genetic analysis of Drosophila eyes absent mutants reveals an eye enhancer element. Genetics 154: 237-246. Medline abstract: 10628984

Zuber, M. E., et al. (2003). Specification of the vertebrate eye by a network of eye field transcription factors. Development 130: 5155-5167. 12944429

Zygar, C. A., Cook, T. L. and Grainger, R. M. (1998). Gene activation during early stages of lens induction in Xenopus. Development 125(17): 3509-3519. PubMed Citation: 9693153

date revised: 22 December 2017
 

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