Enhancer of split


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Bailey, A. M. and Posakony, J. W. (1995). Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev 9: 2609-2622. PubMed Citation: 7590239

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Bishop, S. A., et al. (1999). Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch. Development 126: 2993-3003. PubMed Citation: 10357942

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Cave, J. W., Xia, L. and Caudy, M. A. (2009). The Daughterless N-terminus directly mediates synergistic interactions with Notch transcription complexes via the SPS+A DNA transcription code. BMC Res. Notes 2: 65. PubMed Citation: 19400956

Cave, J. W., Xia, L. and Caudy, M. (2011). Differential regulation of transcription through distinct Suppressor of Hairless DNA binding site architectures during Notch signaling in proneural clusters. Mol. Cell Biol. 31(1): 22-9. PubMed Citation: 21041480

Cooper, M. T. and Bray, S. J. (1999). Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Nature 397(6719): 526-30. PubMed Citation: 10028969

Cooper, M. T. D., et al. (2000a). Spatially restricted factors cooperate with Notch in the regulation of Enhancer of split genes. Dev. Biol. 221: 390-403. PubMed Citation: 10790334

Cooper, M. T. D. and Bray, S. J. (2000b). R7 photoreceptor specification requires Notch activity. Curr. Biol. 10: 1507-1510. 11114517

Cossins, J., et al. (2002). Hes6 regulates myogenic differentiation. Development 129: 2195-2207. 11959828

Cowden, J. and Levine, M. (2002). The Snail repressor positions Notch signaling in the Drosophila embryo. Development 129: 1785-1793. 11923213

Culi, J. and Modolell, J. (1998). Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling. Genes Dev. 12(13): 2036-2047. PubMed Citation: 9649507

Dawson, S. R., et al. (1995). Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression. Mol Cell Biol 15: 6923-6931. PubMed Citation: 8524259

de Celis, J. F., et al. (1996). Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex, the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development 122: 2719-28. PubMed Citation: 8787746

Deladakis, C. and Artavanis-Tsakonas, S. (1992). The Enhancer of split [E(spl)] locus o Drosophila encodes seven independent helix-loop-helix proteins. Proc. Natl. Acad. Sci. 89: 8731-35. PubMed Citation: 1528887

Dokucu, M. E., Zipursky, S. L. and Cagan, R. L. (1996). Atonal, Rough and the resolution of proneural clusters in the developing Drosophila retina Development 122: 4139-4147. PubMed Citation: 9012533

Djiane, A., Zaessinger, S., Babaoglan, A. B., Bray, S. J. (2014). Notch inhibits yorkie activity in Drosophila wing discs. PLoS One 9: e106211. PubMed ID: 25157415

Dumstrei, K., et al. (1998). EGFR signaling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosophila embryonic head. Development 125(17): 3417-3426. PubMed Citation: 9693145

Eastman, D. S., et al. (1997). Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression. Mol. Cell. Biol. 17(9): 5620-5628. PubMed Citation: 9271437

Escudero, L. M., et al. (2003). Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Development 130: 6305-6316. 14623820

Fryer, C. J., White, J. B. and Jones, K. A. (2004). Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol. Cell 16: 509-520. PubMed Citation: 15546612

Furriols, M. and Bray, S. (2001). A model Notch response element detects Suppressor of Hairless-dependent molecular switch. Curr. Biol. 11: 60-64. 11166182

Giagtzoglou, N., et al. (2003). Two modes of recruitment of E(spl) repressors onto target genes. Development 130: 259-270. Medline abstract: 12466194

Giebel, B. and Campos-Ortega, J. A. (1997). Functional dissection of the Drosophila Enhancer of split protein, a suppressor of neurogenesis. Proc. Natl. Acad. Sci. 94 (12): 6250-6254. 9177203

Giebel, B., et al. (1999). The Notch signaling pathway is required to specify muscle progenitor cells in Drosophila. Mech. Dev. 86: 137-145. PubMed Citation: 10446272

Gigliani, F., et al. (1996). Interactions among the bHLH domains of the proteins encoded by the Enhancer of split and achaete-scute gene complexes in Drosophila. Mol. Gen. Genet. 251: 628-634. PubMed Citation: 8757393

Gratton, M.-O. et al. (2003). Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. Mol. Cell. Biol. 23: 6922-6935. Medline abstract: 12972610

Heitzler, P., et al. (1996). Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development 122: 161-171. PubMed Citation: 8565827

Huang, A. M., Rusch, J., and Levine, M. (1997). An anteroposterior Dorsal gradient in the Drosophila embryo. Genes Dev. 11(15): 1963-1973. PubMed Citation: 9271119

Ishibashi, M., et al. (1995). Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis and severe neural tube defects. Genes and Dev 9: 3136-3148. PubMed Citation: 8543157

Jafar-Nejad, H., et al. (2003). Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev. 17: 2966-2978. 14665671

Jagla, T., et al. (1998). ladybird determines cell fate decisions during diversification of Drosophila somatic muscles. Development 125(18): 3699-3708. PubMed Citation: 9716535

Janody, F. and Treisman, J. E. (2011). Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Dev. Dyn. 240(9): 2051-9. PubMed Citation: 21793099

Jarreault, S., et al. (1995). Signaling downstream of activated mammalian Notch. Nature 377: 355-358 . PubMed Citation:

Jennings, B., et al. (1995). Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins. Development 121: 3745-52 . PubMed Citation:

Jimenez, G. and Ish-Horowicz, D. (1997). A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression. Mol. Cell. Biol. 17: 4355-4362. PubMed Citation: 9234693

Kahali, B., Bose, A., Karandikar, U., Bishop, C. P. and Bidwai, A. (2009). On the mechanism underlying the divergent retinal and bristle defects of M8* (E(spl)D) in Drosophila. Genesis 47(7): 456-68. PubMed Citation: 19415625

Karandikar, U., et al. (2004). Drosophila CK2 regulates eye morphogenesis via phosphorylation of E(spl)M8. Mech. Dev. 121: 273-286. Medline abstract: 15003630

Knust, E., Tietz, K. and Campos-Ortega, J. A. (1987). Molecular analysis of the neurogenic locus Enhancer of split of Drosophila melanogaster.EMBO J. 6: 4113-4123

Koelzer, S. and Klein, T. (2003). A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development 130: 1973-1988. 12642500

Kramatschek, B. and Campos-Ortega, J. A. (1994). Neuroectodermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes. Development 120: 815-826

Kugler, S. J. and Nagel, A. C. (2010). A novel Pzg-NURF complex regulates Notch target gene activity. Mol. Biol. Cell 21(19): 3443-8. PubMed Citation: 20685964

Lai, E. C., Burks, C. and Posakony, J. W. (1998a). The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts. Development 125(20): 4077-88. PubMed Citation: 9735368

Lai, E. C. and Posakony, J. W. (1998b). Regulation of Drosophila neurogenesis byRNA:RNA duplexes? Cell 93: 1103-1104 . PubMed Citation: 9657143

Lai, E. C. (2002). Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat. Genet. 30(4): 363-4. 11896390

Lecourtois, M. and Schweisguth, F. (1995). The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split Complex genes triggered by Notch signaling. Genes and Dev. 9:2598-2608. PubMed Citation: 7590238

Lesokhin, A. M., et al. (1999). Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila. Dev. Biol. 205(1): 129-44. PubMed Citation: 9882502

Liang, Z. and Biggin, M. D. (1998). Eve and Ftz regulate a wide array of genes in blastoderm embryos: the selector homeoproteins directly or indirectly regulate most genes in Drosophila. Development 125(22): 4471-4482. PubMed Citation: 9778506

Ligoxygakis, P., et al. (1998). A subset of Notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex. Development 125(15): 2893-2900. PubMed Citation: 9655811

Ligoxygakis, P., et al. (1999). Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila. Development 126: 2205-2214. PubMed Citation: 10207145

Lim, J., Jafar-Nejad, H., Hsu, Y. C. and Choi, K. W. (2008). Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye. EMBO Rep. 9(11): 1128-33. PubMed Citation: 18758436

Lobe, C. G. (1997). Expression of the helix-loop-helix factor, Hes3, during embryo development suggests a role in early midbrain-hindbrain patterning. Mech. Dev. 62 (2): 227-237. PubMed Citation: 9152013

Majumdar, A., Nagaraj, R. and Banerjee, U. (1997). strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin in Drosophila. Genes Dev. 11: 1341-1353. PubMed Citation: 9171377

Meir, E., et al. (2002).Robustness, flexibility, and the role of lateral inhibition in the neurogenic network.Curr. Biol. 12: 778-786. 12015114

Müller, M., Weizsäcker, E. v. and Campos-Ortega, J. A. (1996). Transcription of a zebrafish gene of the hairy-Enhancer of split family delineates the midbrain anlage in the neural plate. Dev. Genes Evol. 206: 153-160. PubMed Citation:

Nagel, A. C. and Preiss, A. (1999). Notchspl Is deficient for inductive processes in the Eye, and E(spl)D Enhances split by interfering with proneural activity. Dev. Biol. 208(2): 406-415. PubMed Citation: 10191054.

Nakayama, H., et al. (1997). Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway. Dev. Genet. 21(1): 21-30. PubMed Citation: 9291577

Nègre, N., Ghysen, A. and Martinez, A. M. (2003). Mitotic G2-arrest is required for neural cell fate determination in Drosophila. Mech. Dev. 120: 253-265. 12559497

Nellesen, D. T., Lai, E. C. and Posakony, J. W. (1999). Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev. Biol. 213(1): 33-53. PubMed Citation: 10452845

Nicholson, S. C., Nicolay, B. N., Frolov, M. V. and Moberg, K. H. (2011). Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development 138(2): 251-60. PubMed Citation: 21148181

Nolo, R., Abbott, L. A. and Bellen, H. J. (2000), Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell. 102(3): 349-62. 10975525

Oellers, N., Dehio, M. and Knust, E. (1994). bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes. Mol Gen Genet 244: 465-473

Pineda, D., et al. (2002). The genetic network of prototypic planarian eye regeneration is Pax6 independent. Development 129: 1423-1434. 11880351

Powell, P. A., et al. (2001). Scabrous complexes with Notch to mediate boundary formation. Nature 409: 626-630. 11214322

Rohrbaugh, M., et al. (2002).Notch activation of yan expression is antagonized by RTK/Pointed signaling in the Drosophila eye. Curr. Biol. 12: 576-581. 11937027

Rossner, M. J., et al. (1998). SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Mol. Cell. Neurosci. 10(3-4): 460-75. PubMed Citation: 9532582

San Juan, B. P., Andrade-Zapata, I. and Baonza, A. (2012). The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development. Biol Open 1: 667-676. PubMed ID: 23213460

Seugnet, L., Simpson, P. and Haenlin, M. (1997a). Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila. Development 124: 2015-2025. PubMed Citation: 9169848

Singson, A., et al. (1994). Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev. 8: 2058-71 . PubMed Citation: 7958878

Strom, A., et al. (1997). Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation. Genes Dev. 11(23): 3168-3181. PubMed Citation: 9389649

Takakayashi, K., et al. (1994). Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. J. Biol Chem 269: 5150-56. PubMed Citation: 7906273

Takke, C., et al. (1999a). her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of notch signalling. Development 126(9): 1811-1821. PubMed Citation: 10101116

Takke, C. and Campos-Ortega, J. A. (1999b). her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development. Development 126, 3005-3014. PubMed Citation: 10357943

Tata, F., and Hartley, D. A. (1995). Inhibition of cell fate in Drosophila by Enhancer of split genes. Mech. Dev. 51: 305-315. PubMed Citation: 7547476

Tomita, K., et al. (1996). Mammalian hairy and Enhancer of split homolog 1 regulates differentiation of retinal neurons and is essential for eye morphogenesis. Neuron 16: 723-734. PubMed Citation: 8607991

Tun, T., et al. (1994). Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. Nucleic Acids Res 22: 965-971. PubMed Citation: 8152928

Wang, W., Liu, W., Wang, Y., Zhou, L., Tang, X. and Luo, H. (2011). Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. Dev. Biol. 350(2): 414-28. PubMed Citation: 21146517

Welshons, W.J. (1956). Dosage experiments with split mutations in the presense of an enhancer of split. Drosophila Inform. Serv. 30: 157-158. PubMed Citation:

Wurmbach, E., Wech, I. and Preiss, A. (1999). The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes. Mech. Dev. 80(2): 171-80. PubMed Citation: 10072784

Younossi-Hartenstein, A., et al. (1996). Early neurogenesis of the Drosophila brain. J. Comp. Neur. 370: 313-329. PubMed Citation: 8799858

Zacharioudaki, E., Magadi, S. S. and Delidakis, C. (2012) bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation. Development 139: 1258-1269. PubMed Citation: 22357926

zur Lage, P., Jan, Y. N. and Jarman, A. P. (1997). Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters. Curr. Biol. 7: 166-175. PubMed Citation: 9395407

zur Lage, P. and Jarman, A. P. (1999). Antagonism of EGFR and Notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors. Development 126: 3149-3157. PubMed Citation: 10375505

Enhancer of split: Biological Overview | Evolutionary Homologs | Regulation | Targets of Activity | Protein Interactions and Post-transcriptional Regulation and Post-transcriptional Regulation | Developmental Biology | Effects of Mutation

date revised: 10 October 2014

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