CrebB-17A
Nakajima, T., et al. (1997a). Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors. Genes Dev. 11:738-747. PubMed Citation: 9087428
Nakajima, T., et al. (1997b). RNA helicase A mediates association of CBP with RNA polymerase II. Cell 90(6): 1107-1112. PubMed Citation: 9323138
Naruse, Y., et al. (2004). Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol. Cell. Biol. 24(14): 6278-87. 15226430
Obrietan, K., Impey, S. and Storm, D. R. (1999). Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei. Nature Neurosci. 1(8): 693-700. PubMed Citation: 10196585
Ogryzko, V. V., et al. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87: 953-959. PubMed Citation: 8945521
Oury, F., et al. (2010). CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes Dev. 24(20): 2330-42. PubMed Citation: 20952540
Parker, D., et al. (1996). Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol. Cell. Biol. 16(2): 694-703. PubMed Citation: 8552098
Parlato, R., Otto, C., Begus, Y., Stotz, S. and Schutz, G. (2007). Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis. Development 134(9): 1663-70. Medline abstract: 17376811
Perkins, K. K., Dailey, G. M. and Tjian, R. (1988a). Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1. EMBO J. 7: 4265-73. PubMed Citation: 3149584
Perkins, K. K., Dailey, G. M. and Tjian, R. (1988b). In vitro analysis of the Antennapedia P2 promoter: identification of a new Drosophila transcription factor. Genes Dev. 2: 1615-1626. PubMed Citation: 3215512
Persengiev, S. P., Devireddy, L. R. and Green, M. R. (2002). Inhibition of apoptosis by ATFx: a novel role for a member of the ATF/CREB family of mammalian bZIP transcription factors. Genes Dev. 16: 1806-1814. 12130540
Pham, T. A., et al. (1999). CRE-mediated gene transcription in neocortical neuronal plasticity during the developmental critical period. Neuron 22(1): 63-72. PubMed Citation: 10027290
Placais, P. Y., Trannoy, S., Friedrich, A. B., Tanimoto, H. and Preat, T. (2013). Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila. Cell Rep 5: 769-780. PubMed ID: 24209748
Pons, S., et al. (2001). Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation. Development 128: 1481-1492. 11290288
Radhakrishnan, I., et al. (1997). Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell 91(6): 741-752. PubMed Citation: 9413984
Rajadhyaksha, A., et al. (1999). L-Type Ca2+ channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. J. Neurosci. 19(15): 6348-6359. PubMed Citation: 10414964
Rajasethupathy, P., et al. (2009). Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron 63(6): 803-17. PubMed Citation: 19778509
Redmond, L., Kashani, A. H. and Ghosh, A. (2002). Calcium regulation of dendritic growth via CaM Kinase IV and CREB-mediated transcription Neuron 34: 999-1010. 12086646
Riccio, A., et al. (1997). An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons. Science 277(5329): 1097-1100. PubMed Citation: 9262478
Riccio, A., et al. (1999). Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286: 2358-2361. PubMed Citation: 10600750
Roberson, E. D., et al. (1999). The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus. J. Neurosci. 19(11): 4337-48. PubMed Citation: 10341237
Rolli, M., et al. (1999). Stress-induced stimulation of early growth response gene-1 by p38/Stress-activated protein kinase 2 Is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. J. Biol. Chem. 274(28): 19559-19564 . PubMed Citation: 10391889
Sato, N., et al. (1997). Elevated amyloid beta protein(1-40) level induces CREB phosphorylation at serine-133 via p44/42 MAP kinase (Erk1/2)-dependent pathway in rat pheochromocytoma PC12 cells. Biochem. Biophys. Res. Commun. 232(3): 637-642. PubMed Citation: 9126327
Schurov, I. L., et al. (1999). Glutamatergic induction of CREB phosphorylation and Fos expression in primary cultures of the suprachiasmatic hypothalamus in vitro is mediated by co-ordinate activity of NMDA and non-NMDA receptors. J. Neuroendocrinol. 11(1): 43-51. PubMed Citation: 9918228
Screaton, R. A., et al. (2004). The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119: 61-74. 15454081
Shimizu, M., et al. (1998). Activation of the rat cyclin a promoter by ATF2 and Jun family members and its suppression by ATF4. Exp. Cell Res. 239(1): 93-103. PubMed Citation: 9511728
Shyu, W. H., Chiu, T. H., Chiang, M. H., Cheng, Y. C., Tsai, Y. L., Fu, T. F., Wu, T. and Wu, C. L. (2017). Neural circuits for long-term water-reward memory processing in thirsty Drosophila. Nat Commun 8: 15230. PubMed ID: 28504254
Sindreu, C. B., Scheiner, Z. S. and Storm, D. R. (2007). Ca2+-stimulated adenylyl cyclases regulate ERK-dependent activation of MSK1 during fear conditioning. Neuron 53(1): 79-89. Medline abstract: 17196532
Slutsky, I., Abumaria, N., Wu, L.J., Huang, C., Zhang, L., Li, B., Zhao, X., Govindarajan, A., Zhao, M.G., Zhuo, M., et al. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron. 65: 165-177. PubMed Citation: 20152124
Sordella, R., et al. (2002). Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Dev. Cell 2: 553-565. 12015964
Sun, P., et al. (1994). Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. Genes Dev. 8: 2527-39. PubMed Citation: 9511728
Sundaram, N., et al. (2003). The role of maternal CREB in early embryogenesis of Xenopus laevis. Dev. Biol. 261: 337-352. 14499645
Suzuki, A., et al. (2011). Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci 31: 8786-8802. PubMed ID: 21677163
Swanson, D. J., Zellmer, E. and Lewis, E. J. (1997). The homeodomain protein Arix interacts synergistically with cyclic AMP to regulate expression of neurotransmitter biosynthetic genes. J. Biol. Chem. 272(43): 27382-27392. PubMed Citation: 9341190
Syed, S., Saez, L. and Young, M. W. (2011). Kinetics of doubletime kinase-dependent degradation of the Drosophila period protein. J. Biol. Chem. 286(31): 27654-62. PubMed Citation: 21659538
Tabernero, A. et al. (1998). The neuron-glia signal beta neuregulin induces sustained CREB phosphorylation on Ser-133 in cultured rat schwann cells. Mol. Cell. Neurosci. 10: 309-22. PubMed Citation: 9618221
Tao, X., et al. (1998). Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20(4): 709-726. PubMed Citation: 9581763
Tentler, J. J., Hadcock, J. R. and Gutierrez-Hartmann, A. (1997). Somatostatin acts by inhibiting the cyclic 3',5'-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency. Mol. Endocrinol. 11(7): 859-866. PubMed Citation: 9178746
Tian, X., et al. (2004). Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. EMBO J. 23(7): 1567-75. Medline abstract: 15029245
Tubon, T. C., Jr., Zhang, J., Friedman, E. L., Jin, H., Gonzales, E. D., Zhou, H., Drier, D., Gerstner, J. R., Paulson, E. A., Fropf, R. and Yin, J. C. (2013). dCREB2-mediated enhancement of memory formation. J Neurosci 33: 7475-7487. PubMed ID: 23616553
Vale-Cruz, D. S., et al. (2008). Activating transcription factor-2 affects skeletal growth by modulating pRb gene expression. Mech. Dev. 125: 843-856. PubMed Citation: 18638549
Vanhoutte, P., et al. (1999). Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices. Mol. Cell. Biol. 19(1): 136-46. PubMed Citation: 9858538
Vattem, K. M. and Wek, R. C. (2004). Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells, Proc. Natl. Acad. Sci. 101: 11269-11274. Medline abstract: 15277680
von Gall, C., et al. (1998). CREB in the mouse SCN: A molecular interface coding the phase-adjusting stimuli light, glutamate, PACAP, and melatonin for clockwork access. J. Neurosci. 18(24): 10389-10397. PubMed Citation: 9852576
Walker, W. H., Girardet, C. and Habener, J. F. (1996). Alternative exon splicing controls a translational switch from activator to repressor isoforms of transcription factor CREB during spermatogenesis. J. Biol. Chem. 271(33): 20145-21050. PubMed Citation: 8702738
Waltzer, L. and Bienz, M. (1998). Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature 395(6701): 521-5. PubMed Citation: 9774110
Wang, B., et al. (2008).The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab. 7(5): 434-44. PubMed Citation: 18460334
Wang, B., Goode, J., Best, J., Meltzer, J., Schilman, P. E., Chen, J., Garza, D., Thomas, J. B. and Montminy, M. (2008). The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab 7: 434-444. PubMed ID: 18460334
Wang, E. H., Zou, S., and Tjian, R. (1997). TAFII250-dependent transcription of cyclin A is directed by ATF activator proteins. Genes Dev. 11(20): 2658-2669. PubMed Citation: 9334328
Wang, G. L. and Goldstein, E. S. (1994). Transcription of Djun from D. melanogaster is positively regulated by DTF-1, AP-1, and CREB binding sites. Exp Cell Res 214: 389-399 . PubMed Citation: 8082742
Wang, R., et al. (2006). Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB. Mol. Cell. Biol. 26(4): 1347-54. 16449647
Wei, F., et al. (2002). Genetic elimination of behavioral sensitization in mice lacking Calmodulin-stimulated adenylyl cyclases. Neuron 36: 713-726. 12441059
Wolfgang, W. J., Clay, C., Parker, J., Delgado, R., Labarca, P., Kidokoro, Y. and Forte, M. (2004). Signaling through Gs alpha is required for the growth and function of neuromuscular synapses in Drosophila. Dev Biol 268: 295-311. PubMed ID: 15063169
Xie, S., et al. (1997). Dominant-negative CREB inhibits tumor growth and metastasis of human melanoma cells. Oncogene 15(17): 2069-2075. PubMed Citation: 9366524
Xing, L, Gopal, V. K. and Quinn, P. Q. (1995). cAMP response element-binding protein (CREB) interacts with transcription factors IIB and IID. J. Biol. Chem. 270: 17488-17493. PubMed Citation: 7615553
Xing, J., Ginty, D. D. and Greenberg, M. E. (1996). Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273(5277): 959-63. PubMed Citation: 8688081
Xing, J., et al. (1998). Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol. Cell. Biol. 18(4): 1946-1955. PubMed Citation: 9528766
Yang, E. J., Yoon, J. H. and Chung, K. C. (2004). Bruton's tyrosine kinase phosphorylates cAMP-responsive element-binding protein at serine 133 during neuronal differentiation in immortalized hippocampal progenitor cells. J. Biol. Chem. 279(3): 1827-37. 14597636
Lin, H. W., Chen, C. C., Jhang, R. Y., Chen, L., de Belle, J. S., Tully, T. and Chiang, A. S. (2022). CREBB repression of protein synthesis in mushroom body gates long-term memory formation in Drosophila. Proc Natl Acad Sci U S A 119(50): e2211308119. PubMed ID: 36469774
Yin, J. C., Del Vecchio, M., Zhou, H. and Tully, T. (1995). CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81(1): 107-115. PubMed ID: 7720066
Yin, J. C., Del Vecchio, M., Zhou, H. and Tully, T. (1995). CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81(1): 107-115. PubMed ID: 7720066
Yin, J.C. (1994). Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila . Cell 79: 49-58 . PubMed Citation: 7923376
Yin, J.C., et al. (1995a). A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. Molecular and Cellular Biology 15: 5123-30. PubMed Citation: 7651429
Yin, J.C., Del Vecchio, M., Zhou, H. and Tully, T. (1995b). CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long term memory in Drosophila. Cell 81(1): 107-15. PubMed Citation: 7720066
Yuan, Q., Xiang, Y., Yan, Z., Han, C., Jan, L. Y. and Jan, Y. N. (2011). Light-induced structural and functional plasticity in Drosophila larval visual system. Science 333: 1458-1462. Pubmed: 21903815
Yoshizumi, M., et al. (1997). Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein. J. Biol. Chem. 272(35): 22259-22264. PubMed Citation: 9268374
Zhang, J., et al. (2006). Cyclic AMP inhibits p38 activation via CREB-induced Dynein light chain. Mol. Cell. Biol. 26: 1223-1234. 16449637
Zhang, J., Tanenhaus, A. K., Davis, J. C., Hanlon, B. M. and Yin, J. C. (2014). Spatio-temporal in vivo recording of dCREB2 dynamics in Drosophila long-term memory processing. Neurobiol Learn Mem 118C: 80-88. PubMed ID: 25460038
Zhou, Y., Wu, H., Li, S., Chen, Q., Cheng, X. W., Zheng, J., Takemori, H. and Xiong, Z. Q. (2006). Requirement of TORC1 for late-phase long-term potentiation in the hippocampus. PLoS One 1: e16. PubMed ID: 17183642
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