|Imaginal Discs: The Genetic and Cellular Logic of Pattern Formation |
by Lewis I. Held, Jr.
|The links listed below include a preface, table of contents, description of models and bibliography from Lewis Held's book on pattern formation in Drosophila melanogaster imaginal discs (Cambridge University Press, 2002). This section of The Interactive Fly is courtesy of Lewis Held.|
Table of Contents
With the elucidation of the complete fly genome, traditional fly genetics is in more demand than ever. Genetics will lead to an explanation of the role of each of the 14,000 genes, many of which are involved in the development of imaginal discs. These hollow sacs of cells make adult structures during metamorphosis, and their study is crucial to comprehending how a larva becomes a fully functioning fly.
This book examines the genetic circuitry of the well-known "fruit fly," tackling questions of cell assemblage and pattern formation, of the hows and whys behind the development of the fly. The book first establishes that fly development relies primarily on intercellular signaling, and then discusses how this signaling occurs. After an initial examination of the proximity versus pedigree imperatives, the book delves into bristle pattern formation and disc development, with entire chapters devoted to the leg, wing, and eye. Extensive appendices include a glossary of protein domains, catalogs of well-studied genes, and an outline of signaling pathways. More than 30 wiring diagrams, among over 60 detailed schematics, clarify the text. The text goes beyond the Internet databases insofar as it puts these myriad facts into both a conceptual framework and a historical context. Overall, the aim is to provide a comprehensive reference guide for students and researchers exploring this fascinating, but often bewildering, field.
Lewis I. Held, Jr. is Associate Professor in the Department of Biology at Texas Tech University.
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