fork head


REFERENCES

Abrams, E. W. and Andrew, D. J. (2005). CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. Development 132(12): 2743-58. 15901661

Abrams, E. W., Mihoulides, W.K. and Andrew, D. J. (2006) Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. Development 133: 3517-3527. PubMed Citation: 16914497

Ang, S. L., et al. (1993). The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119: 1301-15. PubMed Citation: 8306889

Azzaria, M., et al. (1996). A fork head/HNF-3 homolog expressed in the pharynx and intestine of the Caenorhabditis elegans embryo. Dev. Biol. 178: 289-303. PubMed Citation: 8812130

Bernardo, G. M., et al. (2010). FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development 137(12): 2045-54. PubMed Citation: 20501593

Bossard, P. and Zaret, K. S. (1998). GATA transcription factors as potentiators of gut endoderm differentiation. Development 125(24): 4909-17. PubMed Citation: 9811575

Brissette, J. L., et al. (1996). The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation. Genes Dev. 10(17): 2212-21. PubMed Citation: 8804315

Brunet, A., et al. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96(6): 857-68. PubMed Citation: 10102273

Buchberger, A., et al. (1998). Chicken winged-helix transcription factor cFKH-1 prefigures axial and appendicular skeletal structures during chicken embryogenesis. Dev. Dyn. 212(1): 94-101. PubMed Citation: 9603427

Bulow, M. H., Aebersold, R., Pankratz, M. J. and Junger, M. A. (2010). The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin. PLoS One 5: e15171. PubMed ID: 21217822

Chandrasekaran, V. and Beckendorf, S. K. (2003). senseless is necessary for the survival of embryonic salivary glands in Drosophila. Development 130: 4719-4728. 12925597

Chang, B. E., et al. (1997). Axial (HNF3ß) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter. EMBO J. 16(13): 3955-3964. PubMed Citation: 9233805

Chen, X., Rubock, M. J. and Whitman, M. (1996). A transcriptional partner for MAD proteins in TGF-ß signalling. Nature 383: 691-696. PubMed Citation: 8878477

Chen, X., et al. (1997). Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389(6646): 85-89. PubMed Citation: 9288972

Cheng, P.-Y., et al. (2008). Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation. Development 135: 941-952. PubMed Citation: 18234726

Cirillo, L. A., et al. (1998). Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome. EMBO J. 17: 244-254. 9427758

Corbo, J. C., et al. (1997). Dorsoventral patterning of the vertebrate neural tube is conserved in a protochordate. Development 124: 2335-2344. PubMed Citation: 9199360

Crispi, S., et al. (2001). Functional analysis of regulatory elements controlling the expression of the ecdysone-regulated Drosophila ng-1 gene. Mech. Dev. 100: 25-35. 11118881

Dasen, J. S. et al. (2008). Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1. Cell 134: 304-316. PubMed Citation: 18662545

Di Gregorio, A., Corbo, J. C. and Levine, M. (2001). The regulation of forkhead/HNF-3beta expression in the Ciona embryo. Dev. Biol. 229: 31-43. 11133152

Dirksen, M. L. and Jamrich, M. (1995). Differential expression of fork head genes during early Xenopus and zebrafish development. Dev. Genet. 17: 107-116. PubMed Citation: 7586752

Drerup, C. M., Wiora, H. M., Topczewski, J. and Morris, J. A. (2009). Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development 136(15): 2623-32. PubMed Citation: 19570850

Dufort, D., et al. (1998). The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development 125(16): 3015-3025. PubMed Citation: 9671576

Duncan, S. A., et al. (1998). Regulation of a transcription factor network required for differentiation and metabolism. Science 281(5378): 692-695. PubMed Citation: 9685261

Enard, W., et al. (2009). A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 137(5): 961-71. PubMed Citation: 19490899

Epstein, D. J., McMahon, A. P. and Joyner, A. L. (1999). Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development 126(2): 281-292. PubMed Citation: 9847242

Farrington, S. M., Belaoussoff, M. and Baron, M. H. (1997). Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Mech. Dev. 62 (2): 197-211. PubMed Citation: 9152011

Ferri, A. L., et al. (2007). Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development 134: 2761-2769. PubMed Citation: 17596284

Fritzenwanker, J. H., Saina, M. and Technau, U. (2004). Analysis of forkhead and snail expression reveals epithelial-mesenchymal transitions during embryonic and larval development of Nematostella vectensis. Dev. Biol. 275(2): 389-402. 15501226

Friedle, H., et al. (1998). Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1' in Xenopus embryos. EMBO J. 17: 2298-2307. PubMed Citation: 9545242

Filosa, S., et al. (1997). Goosecoid and HNF-3ß genetically interact to regulate neural tube patterning during mouse embryogenesis. Development 124(14): 2843-2854. PubMed Citation: 9226455

Foucher, I., et al. (2002). Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors. Development 129: 4065-4074. 12163409

Foucher, I., et al. (2003). Joint regulation of the MAP1B promoter by HNF3ß/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors. Development 130: 1867-1876. 12642491

Furumoto, T. A., et al. (1999). Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Dev. Biol. 210(1): 15-29. PubMed Citation: 10364424

Gaudet, J. and Mango, S. E. (2002). Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4. Science 295: 821-825. PubMed Citation: 11823633

Gaul, U. and Weigel, D. (1990). Regulation of Kruppel expression in the anlage of the Malpighian tubules in the Drosophila embryo. Mech. Dev. 1: 57-67. PubMed Citation: 1982922

Gofflot, F., Hall, M. and Morriss-Kay, G. M. (1997). Genetic patterning of the developing mouse tail at the time of posterior neuropore closure. Dev. Dyn. 210(4): 431-45.

Grinblat, Y., Gamse, J., Patel, M. and Sive, H. (1998). Determination of the zebrafish forebrain: induction and patterning. Development 125(22): 4403-4416

Grosshans, H., Johnson, T., Reinert, K. L., Gerstein, M. and Slack, F. J. (2005). The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Dev. Cell 8(3): 321-30. 15737928

Hacker, U., et al. (1992). Developmentally regulated Drosophila gene family encoding the forkhead domain. Proc. Natl. Acad. Sci. 89: 8734-58. PubMed Citation: 1356269

Hacker, U., et al. (1995). The Drosophila fork head domain protein crocodile is required for the establishment of head structures. EMBO J. 14: 5306-5317. PubMed Citation: 7489720

Haberman, A. S., Isaac, D. D. and Andrew, D. J. (2003). Specification of cell fates within the salivary gland primordium. Dev. Biol. 258: 443-453. 12798300

Hallonet, M., et al. (2002). Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: A study using HNF3ß/Foxa2 conditional mutants. Dev. Biol. 243: 20-33. 11846474

Harada, Y., et al. (1996). Spatial expression of a forkhead homolog in the sea urchin embryo. Mech. Dev. 60: 163-173

Hashimoto, H., Enomoto, A., Kumano, G. and Nishida, H. (2011). The transcription factor FoxB mediates temporal loss of cellular competence for notochord induction in ascidian embryos. Development 138(12): 2591-600. PubMed Citation: 21610035

Hatzis, P. and Talianidis, I. (2003). Dynamics of enhancer-promoter communication during differentiation-induced gene activation. Mol. Cell 10: 1467-1477. 12504020

Hiemisch, H., Schutz, G. and Kaestner, K. H. (1997). Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis. EMBO J. 16(13): 3995-4006. 9233809

Hisaoka, T., Nakamura, Y., Senba, E. and Morikawa, Y. (2010). The forkhead transcription factors, Foxp1 and Foxp2, identify different subpopulations of projection neurons in the mouse cerebral cortex. Neuroscience 166(2): 551-63. PubMed Citation: 20040367

Hoch, M. and Pankratz, M. J. (1996). Control of gut development by fork head and cell signaling molecules in Drosophila. Mech. Dev. 58: 3-14. PubMed Citation: 8887312

Hoch, M. and Jackle, H. (1998). Kruppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of Drosophila. EMBO J. 17(19): 5766-75. PubMed Citation: 9755176

Horner, M. A., et al. (1998). pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans. Genes Dev. 12(13): 1947-1952. PubMed Citation: 9649499

Howell, M. and Hill, C. S. (1997). XSmad2 directly activates the activin-inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos. EMBO J. 16(24): 7411-7421. 9405370

Hulander, M., et al. (1998). The winged helix transcription factor Fkh10 is required for normal development of the inner ear. Nat. Genet. 20(4): 374-6. PubMed Citation: 9843211

Iida, K., et al. (1997). Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development 124(22): 4627-4638. PubMed Citation: 9409679

Ikeda, T. and Satou, Y. (2016). Differential temporal control of Foxa.a and Zic-r.b specifies brain versus notochord fate in the ascidian embryo. Development [Epub ahead of print]. PubMed ID: 27888196

Jacob, A., Budhiraja, S. and Reichel, R. R. (1997). Differential induction of HNF-3 transcription factors during neuronal differentiation. Exp. Cell Res. 234(2): 277-284. PubMed Citation: 9260895

Jacob, J., et al. (2007). Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat. Neurosci. 10: 1433-1439. PubMed Citation: 17922007

Jones, N.A., Kuo, Y.M., Sun, Y.H., Beckendorf, S.K. (1998). The Drosophila pax gene eye gone is required for embryonic salivary duct development. Development 125(21): 4163-4174. PubMed Citation: 9753671

Joshi, R., et al. (2007). Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell 131: 530-543. PubMed Citation: 17981120

Joshi, R., Sun, L. and Mann, R. (2010). Dissecting the functional specificities of two Hox proteins. Genes Dev. 24(14): 1533-45. PubMed Citation: 20634319

Kalb, J. M., et al. (1998). pha-4 is Ce-fkh-1, a fork head/HNF-3(alpha),beta,(gamma) homolog that functions in organogenesis of the C. elegans pharynx. Development 125(12): 2171-2180. PubMed Citation: 9584117

Kalodimos, C. G., et al. (2004) Structure and flexibility adaptation in nonspecific and specific protein–DNA complexes. Science 305: 386–389. PubMed Citation: 15256668

Kaufman, E., Hoch, M. and Jackle, H. (1994). The interaction of DNA with the DNA-binding domain encoded by the Drosophila gene forkhead. Eur. J. Biochem. 223(2): 329-37. PubMed Citation: 8055900

Kaestner, K. H., et al. (1995). The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization. J. Biol. Chem. 270: 30029-30035. PubMed Citation: 8530406

Kiefer, J. C., Smith, P. A. and Mango, S. E. (2007). PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut. Dev. Biol. 303: 611-624. PubMed Citation: 17250823

Klingensmith, J., et al. (1999). Neural induction and patterning in the mouse in the absence of the node and its derivatives. Dev. Biol. 216(2): 535-49. PubMed Citation: 10642791

Knoetgen, H., Viebahn, C. and Kessel, M. (1999). Head induction in the chick by primitive endoderm of mammalian, but not avian origin. Development 126(4): 815-825. PubMed Citation: 9895328

Kokubo, H., et al. (1997). Involvement of the Bombyx Scr gene in development of the embryonic silk gland. Dev. Biol. 186(1): 46-57. PubMed Citation: 9188752

Koranda, M., et al. (2000). Forkhead-like transcription factors recruit Ndd1 to the chromatin of G2/M-specific promoters. Nature 406: 94-98. PubMed Citation: 10894549

Kubo, A., et al. (2010). Genomic cis-regulatory networks in the early Ciona intestinalis embryo. Development 137(10): 1613-23. PubMed Citation: 20392745

Kume, T., et al. (1998). The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell 93(6): 985-996. PubMed Citation: 9635428

Kuzin, A., Brody, T., Moore, A. W. and Odenwald, W. F. (2005). Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS. Dev. Biol. 277: 347-365. PubMed Citation: 15617679

Kusch, T. and Reuter, R. (1999). Functions for Drosophila brachyenteron and forkhead in mesoderm specification and cell signalling. Development 126: 3991-4003. PubMed Citation: 10457009

Kuo, Y. M., et al. (1996). Salivary duct determination in Drosophila: roles of the EGF receptor signaling pathway and the transcription factors Fork head and Trachealess. Development 122: 1909-17. PubMed Citation: 8674429

Kuzin, B., Tillib, S., Sedkov, Y., Mizrokhi, L. and Mazo, A. (1994). The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene forkhead. Genes Dev. 8(20): 2478-90. PubMed Citation: 7958911

Labbe, E., et al. (1998). Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell (1): 109-20. PubMed Citation: 9702197

Labosky, L., et al. (1997). The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. Development 124, 1263-1274 . PubMed Citation: 9118797

Lee, C. S., Friedman, J. R., Fulmer, J. T. and Kaestner, K. H. (2005). The initiation of liver development is dependent on Foxa transcription factors. Nature 435(7044): 944-7. 15959514

Lee, D., Prowse, D. M. and Brissette, J. L. (1999). Association between mouse nude Gene expression and the initiation of epithelial terminal differentiation. Dev. Biol. 208(2): 362-374. PubMed Citation: 10191051

Lehmann, M., Wattler, F. and Korge, G. (1997). Two new regulatory elements controlling the Drosophila Sgs-3 gene are potential ecdysone receptor and fork head binding sites. Mech. Dev. 62 (1): 15-27. PubMed Citation: 9106163

Levinson-Dushnik, M. and Benvenisty, N. (1997). Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells. Mol. Cell. Biol. 17(7): 3817-3822. PubMed Citation: 9199315

Lim, L., Zhou, H. and Costa, R. H. (1997). The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Proc. Natl. Acad. Sci. 94 (7): 3094-3099 . PubMed Citation: 9096351

Lin, KL., et al. (1997). daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278(5341): 1319-1322. PubMed Citation: 9360933

Liu, X. and Lengyel. J. A. (2000). Drosophila arc encodes a novel adherens junction-associated PDZ domain protein required for wing and eye development. Dev. Biol. 221: 419-434. PubMed Citation: 10790336

Mach, V., et al. (1996). The Drosophila fork head factor directly controls larval salivary gland-specific expression of the glue protein gene Sgs3. Nucleic Acids Res. 24: 2387-2394. PubMed Citation: 8710511

Mann, R. S., Lelli, K. M. and Joshi, R. (2009). Hox specificity unique roles for cofactors and collaborators. Curr. Top. Dev. Biol. 88: 63-101. PubMed Citation: 19651302

Marshall, S. D. G. and McGhee, J. D. (2001). Coordination of ges-1 expression between the Caenorhabditis pharynx and intestine. Dev. Bio. 239: 350-363 . PubMed Citation: 11784040

Martinez, D. E., et al. (1997). Budhead, a fork head/HNF-3 homologue, is expressed during axis formation and head specification in hydra. Dev. Biol. 192(2): 523-536. PubMed Citation: 9441686

McKinney, K., Mattia, M., Gottifredi, V. and Prives, C. (2004). p53 linear diffusion along DNA requires its C terminus. Mol. Cell 16(3): 413-24. PubMed Citation: 15525514

Merabet, S., et al. (2007). A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax. Proc. Natl. Acad. Sci. 104: 16946-16951. PubMed Citation: 17942685

Miguel-Aliaga, I., Thor, S. and Gould, A. P. (2008). Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons. PLoS Biol. 6(3): e58. PubMed Citation: 18336071

Mohler, J., Mahaffey, J.W., Deutsch, E., and Vani, K. (1995). Control of Drosophila head segment identity by the bZIP homeotic gene cnc. Development 121: 237-247. PubMed Citation: 7867505

Molin, L., et al. (2000). Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues. Development 127: 4825-4835 . PubMed Citation: 11044397

Monaghan, A. P., et al. (1993). Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development 119: 567-78. PubMed Citation: 8187630

Maruyama, R., Grevengoed, E., Stempniewicz, P. and Andrew, D. J. (2011). Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head. PLoS One. 6(6): e20901. PubMed Citation: 21698206

Myat, M. M. and Andrew, D. J. (2000). Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands. Development 127: 4217-4226. PubMed Citation: 10976053

Nash, B., et al. (2000). The Forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor in C. elegans. Genes Dev. 14: 2486-2500. PubMed Citation: 11018016

Nehls, M., et al. (1994). New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature 372(6501): 103-7. PubMed Citation: 7969402

Nehls, M., et al. (1996). Two genetically separable steps in the differentiation of thymic epithelium. Science 272(5263): 886-9. PubMed Citation: 8629026 >

Nishizaki, Y., et al. (2001). Identification of essential sequence motifs in the node/notochord enhancer of Foxa2 (Hnf3ß) gene that are conserved across vertebrate species. Mech. Dev. 102: 57-66. 11287181

Noro, B., Lelli, K., Sun, L. and Mann, R. S. (2011). Competition for cofactor-dependent DNA binding underlies Hox phenotypic suppression. Genes Dev. 25(22): 2327-32. PubMed Citation: 22085961

Norton, W. H., et al. (2005). Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones. Development 132(4): 645-58. 15677724

Odenthal, J., et al. (2000). Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev. Biol. 219: 350-363. PubMed Citation: 10694427

Ogg, S., et al. (1997). The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389(6654): 994-999. PubMed Citation: 9353126 [

Olsen, C. L. and Jeffery, W. R. (1997). A forkhead gene related to HNF-3beta is required for gastrulation and axis formation in the ascidian embryo. Development 124: 3609-3619. PubMed Citation: 9342053

Olsen, C. L., Natzle, J. E. and Jeffery, W. R. (1999). The forkhead gene FH1 is involved in evolutionary modification of the ascidian tadpole larva. Mec. Dev. 85(1-2): 49-58. PubMed Citation: 10415346

Ono, H., Kozmik, Z., Yu, J. K. and Wada, H. (2014). A novel N-terminal motif is responsible for the evolution of neural crest-specific gene-regulatory activity in vertebrate FoxD3. Dev Biol 385: 396-404. PubMed ID: 24252777

Overdier, D. G., et al. (1997). The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney. J. Biol. Chem. 272 (21): 13725-13730. PubMed Citation: 9153225

Page, D. T. (2002). Inductive patterning of the embryonic brain in Drosophila Development 129: 2121-2128. 11959822

Paradis, S. and Ruvkun, G. (1998). Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12(16): 2488-2498. PubMed Citation: 9716402

Perea-Gómez, A., et al. (1999). HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development 126: 4499-4511. PubMed Citation: 10498685

Peterson, R. S., et al. (1997). The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives Mech. Dev. 69(1-2): 53-69. PubMed Citation: 9486531

Pic, A., et al. (2000). The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF. EMBO J. 19: 3750-3761. PubMed Citation: 10899128

Rausa, F., et al. (1997). The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. Dev. Biol. 192(2): 228-246. PubMed Citation: 9441664

Renault, N., King-Jones, K. and Lehmann, M. (2001). Downregulation of the tissue-specific transcription factor Fork head by Broad-Complex mediates a stage-specific hormone response. Development 128: 3729-3737. 11585799

Rastegar, S., et al. (2003). A floor plate enhancer of the zebrafish netrin1 gene requires Cyclops (Nodal) signaling and the winged helix transcription factor FoxA2. Dev. Bio. 252: 1-14. 12453456

Ribes, V., et al. (2010). Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 24(11): 1186-200. PubMed Citation: 20516201

Roth, G. E., et al. (1999). Structure and regulation of the salivary gland secretion protein gene Sgs-1 of Drosophila melanogaster. Genetics 153: 753-762. PubMed Citation: 10511555

Rousso, D. L. (2008). Coordinated actions of the Forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron 59: 226-240. PubMed Citation: 18667151

Ryoo, H. D, and Mann, R. S. (1999). The control of trunk Hox specificity and activity by Extradenticle. Genes Dev. 13: 1704-1716. PubMed Citation: 10398683

Sarafi-Reinach, T. R. and Sengupta, P. (2000). The forkhead domain gene unc-130 generates chemosensory neuron diversity in C. elegans. Genes Dev. 14: 2472-2485. PubMed Citation: 11018015

Sasaki, H. and Hogan, B. L. M. (1993). Differentail expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118: 47-59. PubMed Citation: 8375339

Sasaki, H., et al. (1997). A binding site for Gli proteins is essential for HNF-3ß floor plate enhancer activity in transgenics and can respond to Shh in vitro Development 124, 1313-1322. PubMed Citation: 9118802

Sawada, A., et al. (2005). Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor. Development 132(21): 4719-29. 16207754

Schlake, T., et al. (1997). The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system. Proc. Natl. Acad. Sci. 94(8): 3842-7. PubMed Citation: 9108066

Schuddekopf, K., Schorpp, M. and Boehm, T. (1996). The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain. Proc. Natl. Acad. Sci. 93(18): 9661-4. PubMed Citation: 8790387

Sekiya, T., Muthurajan, U. M., Luger, K., Tulin, A. V. and Zaret, K. S. (2009). Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA. Genes Dev. 23(7): 804-9. PubMed Citation: 19339686

Seshaiah, P., Miller, B., Myat, M. M. and Andrew, D. J. (2001). pasilla, the Drosophila homologue of the human Nova-1 and Nova-2 proteins, is required for normal secretion in the salivary gland. Dev. Biol. 239: 309-322. PubMed Citation: 11784037

Shim, E. Y., Woodcock, C. and Zaret, K. S. (1998). Nucleosome positioning by the winged helix transcription factor HNF3. Genes Dev. 12(1): 5-10. PubMed Citation: 9420326

Shimamura, K. and Rubenstein, J. L. (1997). Inductive interactions direct early regionalization of the mouse forebrain. Development 124(14): 2709-2718. PubMed Citation: 9226442

Shimauchi, Y., Yasuo, H. and Satoh, N. (1997). Autonomy of ascidian fork head/HNF-3 gene expression. Mech. Dev. 69(1-2): 143-154. PubMed Citation: 9486537

Shimeld, S. M. (1997). Characterisation of Amphioxus HNF-3 genes: conserved expression in the notochord and floor plate. Dev. Biol. 183: 74-85. PubMed Citation: 9119116

Sia, G. M., Clem, R. L. and Huganir, R. L. (2013). The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice. Science 342(6161): 987-91. PubMed ID: 24179158

Silvestri, C., et al. (2008). Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev. Cell 14(3): 411-23. PubMed Citation: 18331719

Smith-Vikos, T., de Lencastre, A., Inukai, S., Shlomchik, M., Holtrup, B. and Slack, F. J. (2014). MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors. Curr Biol 24: 2238-2246. PubMed ID: 25242029

Strahle, U., et al. (1993). Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos. Genes Dev. 7: 1436-46. PubMed Citation: 7687227

Sund, N. J., et al. (2001). Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev. 15: 1706-1715. PubMed Citation: 11445544

Sund, N. J., et al. (2001). Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev. 15: 1706-1715. PubMed Citation: 11445544

Takiya, S., Gazi, and Mach, V. (2003). The DNA binding of insect Fork head factors is strongly influenced by the negative cooperation of neighboring bases. Insect Biochem. Mol. Biol. 33: 1145-1154. PubMed Citation: 14563365

Taniue K, et al. (2010) Sunspot, a link between Wingless signaling and endoreplication in Drosophila. Development 137: 1755-1764. PubMed Citation: 20430750

Terazawa, K. and Satoh. N. (1997). Formation of the chordamesoderm in the amphioxus embryo: Analysis with Brachyury and fork head/HNF-3 genes. Dev. Genes Evol. 207: 1-11

Tichelaar, J. W., et al. (1999). HNF-3/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in vivo. Dev. Biol. 213(2): 405-17. PubMed Citation: 10479457

Vogg, M. C., Owlarn, S., Perez Rico, Y. A., Xie, J., Suzuki, Y., Gentile, L., Wu, W. and Bartscherer, K. (2014). Stem cell-dependent formation of a functional anterior regeneration pole in planarians requires Zic and Forkhead transcription factors. Dev Biol 390: 136-148. PubMed ID: 24704339

von Both, I., et al. (2004). Foxh1 is essential for development of the anterior heart field. Dev. Cell 7: 331-345. 15363409

Vorbruggen, G., et al. (1997). Embryonic expression and characterization of a Ptx1 homolog in Drosophila. Mech. Dev. 68(1-2): 139-47. PubMed Citation: 9431811

Wang, J. C., et al. (2000). Transducin-like enhancer of split proteins, the human homologs of Drosophila Groucho, interact with hepatic nuclear factor 3{beta}. J. Biol. Chem. 275(24): 18418-23. PubMed Citation: 10748198

Wang, S., Tulina, N., Carlin, D. L. and Rulifson, E. J. (2007). The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis. Proc. Natl. Acad. Sci. 104: 19873-19878. PubMed Citation: 18056636

Warga, R. M. and Nusslein-Volhard, C. (1999). Origin and development of the zebrafish endoderm. Development 126(4): 827-838. PubMed Citation: 9895329

Wehr, R., et al. (1997). Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body. Development 124(22): 4447-4456. PubMed Citation: 9409663

Weigel, D. (1989). The homeotic gene forkhead encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. Cell 57: 645-658. PubMed Citation: 2566386

Weigel, D., Seifer, E., Reuter, D. and Jackle, H. (1990a). Regulatory elements controlling expression of the Drosophila homeotic gene forkhead. EMBO J. 9: 1199-1207. PubMed Citation: 1969795

Weigel, D. (1990b). The forkhead domain: a novel DNA binding motif of Eukaryotic transcription factors? Cell 63: 455-456. PubMed Citation: 2225060

Wheeler, S. R., Kearney, J. B., Guardiola, A. R. and Crews, S. T. (2006). Single-cell mapping of neural and glial gene expression in the developing Drosophila CNS midline cells. Dev. Biol. 294: 509-524. PubMed Citation: 16631157

Winnier, G. E., et al. (1997) The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 11: 926-940. PubMed Citation: 9106663

Winnier, G. E., et al. (1999). Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev. Biol. 213(2): 418-31. PubMed Citation: 10479458

Wu, K. L., et al. (1997). Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol. Cell. Biol. 17(10): 6002-6013. PubMed Citation: 9315659

Wu, S. C.-Y., et al. (1998a). Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. Mech. Dev. 70: 3-13. PubMed Citation: 9510020

Wu, L. H. and Lengyel, J. A. (1998b). Role of caudal in hindgut specification and gastrulation suggests homology between Drosophila amnioproctodeal invagination and vertebrate blastopore. Development 125: 2433-2442. PubMed Citation: 9609826

Yi, S. H., He, X. B., Rhee, Y. H., Park, C. H., Takizawa, T., Nakashima, K. and Lee, S. H. (2014). Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation. Development 141: 761-772. PubMed ID: 24496614

Yoon, S. J., et al. (2011). HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25(15): 1654-61. PubMed Citation: 21828274

Zhang, Y., et al. (2010). Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 24(16): 1746-57. PubMed Citation: 20713518

Zhong, X., Chowdhury, M., Li, C. F. and Yu, X. Q. (2017). Transcription factor Forkhead regulates expression of antimicrobial peptides in the tobacco hornworm, Manduca sexta. Sci Rep 7(1): 2688. PubMed ID: 28578399

Zhou, B. and Beckendorf, S.K. (1995). fkh transcription in embryonic salivary glands: activation by Scr, maintained by fkh itself, repression by spitz group genes. A. Conf. Dros. Res. 36: 174B . PubMed Citation:

Zhou, B., Bagri, A. and Beckendorf, S. K. (2001). Salivary gland determination in drosophila: a salivary-specific, fork head enhancer integrates spatial pattern and allows fork head autoregulation. Dev. Bio. 237: 54-67. 11518505

Zhou, J., et al. (2010). Attenuation of Forkhead signaling by the retinal determination factor DACH1. Proc. Natl. Acad. Sci. 107(15): 6864-9. PubMed Citation: 20351289

Zhou, L., et al. (1997). Hepatocyte nuclear factor-3beta limits cellular diversity in the developing respiratory epithelium and alters lung morphogenesis in vivo. Dev. Dyn. 210(3): 305-314. PubMed Citation: 9389455


fork head: Biological Overview | Evolutionary Homologs | Regulation | Targets of Activity | Developmental Biology | Effects of Mutation

date revised: 10 April 2014

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