Interactive Fly, Drosophila

sans fille


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Allain, F. H. T., et al. (1997). Structural basis of the RNA-binding specificity of human U1A protein. EMBO J. 16(18): 5764-5772. PubMed Citation: 9312034

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Ashe, M. P., Pearson, L. H. and Proudfoot, N. J. (1997). The HIV-1 5' LTR poly(A) site is inactivated by U1 snRNP interaction with the downstream major splice donor site. EMBO J. 16(18): 5752-5763. PubMed Citation: 9312033

Bach, M., Krol, A. and Luhrmann, R. (1990). Structure-probing of U1 snRNPs gradually depleted of the U1-specific proteins A, C and 70k. Evidence that A interacts differentially with developmentally regulated mouse U1 snRNA variants. Nucleic Acids Res. 18: 449-57. PubMed Citation: 2137909

Berg, M. G., Singh, L. N., Younis, I., Liu, Q., Pinto, A. M., Kaida, D., Zhang, Z., Cho, S., Sherrill-Mix, S., Wan, L. and Dreyfuss, G. (2012). U1 snRNP determines mRNA length and regulates isoform expression. Cell 150: 53-64. PubMed ID: 22770214

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Chau, J., Kulnane, L. S. and Salz, H. K. (2009). Sex-lethal facilitates the transition from germline stem cell to committed daughter cell in the Drosophila ovary. Genetics 182(1): 121-32. PubMed Citation: 19237687

Cline, T. W., et al. (1999). Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf+ gene dose effects. Proc. Natl. Acad. Sci. 96(25): 14451-8. PubMed Citation: 10588726

Crispino, J. D., et al. (1996). Cis-acting elements distinct from the 5' splice site promote U1-independent pre-mRNA splicing. RNA 2: 664-673. PubMed Citation: 8756409

Deckert, J., et al. (2006). Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Mol. Cell. Biol. 26: 5528-5543. PubMed Citation: 16809785

Deshpande, G., Samuels, M. E. and Schedl, P. D. (1996). Sex-lethal interacts with splicing factors in vitro and in vivo. Mol. Cell. Biol. 16: 5036-5047. PubMed Citation: 8756662

Du, H. and Rosbash, M. (2002). The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairing. Nature 419: 86-90. 12214237

Eldridge, A. G., et al. (1999). The SRm160/300 splicing coactivator is required for exon-enhancer function. Proc. Natl. Acad. Sci. 96(11): 6125-30. PubMed Citation: 10339552

Flickinger, T. W. and Salz, H. K. (1994). The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein. Genes Dev. 8: 914-925. PubMed Citation: 7926776

Hilleren, P. J., Kao, H. Y. and Siliciano, P. G. (1995). The RRM domain is dispensable for yeast U1-70K function. Nucleic Acids Symp. Ser. 33: 244-247. PubMed Citation: 8643384

Fortes, P., et al. (1999). Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition. Genes Dev. 13: 2425-2438. PubMed Citation: 10500099

Gao, J. P. and Herrera, R. J. (1995). U1 snRNA variants coexist in Bombyx mori cells. Insect Mol. Biol. 4: 193-202. PubMed Citation: 8589846

Graham, P. L., Yanowitz, J. L., Penn, J. K., Deshpande, G. and Schedl, P. (2011). The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster. PLoS Genet. 7(7): e1002185. PubMed Citation: 21829374

Gunderson, S. I., et al. (1994). The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase. Cell 76: 531-41. PubMed Citation: 8313473

Gunderson, S., et al. (1997). Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation. Genes Dev. 11:761-773. PubMed Citation: 9087430

Gunnewiek, J. M., et al. (1995). Homodimerization of the human U1 snRNP-specific protein C. Nucleic Acids Res. 23: 4864-4871. PubMed Citation: 8532530

Gunnewiek, J. M. T. K., et al. (1997). Nuclear accumulation of the U1 snRNP-specific protein C is due to diffusion and retention in the nucleus. Exp. Cell Res. 235(1): 265-273. PubMed Citation: 9281376

Hager, J. H. and Cline, T. W. (1997). Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination. Development 124(24): 5033-5048. PubMed Citation: 9362474

Harper, D. S., Fresco, L. D. and Keene, J. D. (1992). RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins. Nucleic Acids Res. 20: 3645-50. PubMed Citation: 1386424

Heinrichs, V. and Baker, B. S. (1995). The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J. 14: 3987-4000. PubMed Citation: 7664738

Hilleren, P. J., Kao, H. Y. and Siliciano, P. G. (1995). The RRM domain is dispensable for yeast U1-70K function. Nucleic Acids Symp. Ser. 33: 244-247. PubMed Citation: 8643384

Hwang, D. Y. and Cohen, J. B. (1997). U1 small nuclear RNA-promoted exon selection requires a minimal distance between the position of U1 binding and the 3' splice site across the exon. Mol. Cell. Biol. 17(12): 7099-7107. PubMed Citation: 9372941

Jamison, S. F., et al. (1995). U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. Nucleic Acids Res. 23: 3260-3267. PubMed Citation: 7667103

Jantsch, M. F. and Gall, J. G. (1992). Assembly and localization of the U1-specific snRNP C protein in the amphibian oocyte. J. Cell Biol. 119: 1037-46. PubMed Citation: 1447287

Jurica, M. S. and Moore, M. J. (2003). Pre-mRNA splicing: awash in a sea of proteins. Mol. Cell 12: 5-14. PubMed Citation: 12887888

Kaida, D., Berg, M. G., Younis, I., Kasim, M., Singh, L. N., Wan, L. and Dreyfuss, G. (2010). U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation. Nature 468(7324): 664-8. PubMed Citation: 20881964

Kambach, C. and Mattaj, I. W. (1992). Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA. J. Cell Biol. 118: 11-21. PubMed Citation: 1618898

Klein Gunnewiek, J. M., (1997). Nuclear accumulation of the U1 snRNP-specific protein C is due to diffusion and retention in the nucleus. Exp. Cell Res. 235(1): 265-273. PubMed Citation: 9281376

Kohtz, J. D., et al. (1994). Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. Nature 368: 119-24. PubMed Citation: 8139654

Kroiss, M., Schultz, J., Wiesner, J., Chari, A., Sickmann, A. and Fischer, U. (2008). Evolution of an RNP assembly system: a minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster. Proc. Natl. Acad. Sci. 105(29): 10045-50. PubMed Citation: 18621711

Labourier, E., Adams, M. D. and Rio, D. C. (2001). Modulation of P-element pre-mRNA splicing by a direct interaction between PSI and U1 snRNP 70K protein. Mol Cell 8(2): 363-73. 11545738

Lai, H. T., et al. (2005). The PSEA promoter element of the Drosophila U1 snRNA gene is sufficient to bring DmSNAPc into contact with 20 base pairs of downstream DNA. Nucleic Acids Res. 33(20): 6579-86. 16314318

Laird-Offringa, I. A., and Belasco, J. G. (1995). Analysis of RNA-binding proteins by in vitro genetic selection: identification of an amino acid residue important for locking U1A onto its RNA target. Proc. Natl. Acad. Sci. 92: 11859-11863

Lewis, J. D., et al. (1996). A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site. Genes Dev. 10: 1683-1698

Li, Y. and Blencowe, B. J. (1999). Distinct factor requirements for exonic splicing enhancer function and binding of U2AF to the polypyrimidine tract. J. Biol. Chem. 274: 35074-35079.

Liao, X. C., Tang, J. and Rosbash, M. (1993). An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing. Genes Dev. 7: 419-28

Lo, P. C. and Mount, S. M. (1990). Drosophila melanogaster genes for U1 snRNA variants and their expression during development. Nucleic Acids Res. 18: 6971-9

Lutz, C. S., et al. (1996). Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro. Genes Dev. 10: 325-337

Lutz-Freyermuth, C., Query, C. C. and Keene, J. D. (1990). Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. Proc. Natl. Acad. Sci. 87: 6393-7.

Nagengast, A. A., et al. (2003). Sex-lethal splicing autoregulation in vivo: interactions between SEX-LETHAL, the U1 snRNP and U2AF underlie male exon skipping. Development 130: 463-471. 12490553

Nelissen, R. L., et al. (1991). Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. Nucleic Acids Res. 19: 449-54. PubMed Citation: 1826349

Nelissen, R. L., et al. (1994). The association of the U1-specific 70K and C proteins with U1 snRNPs is mediated in part by common U snRNP proteins. EMBO J. 13: 4113-4125. PubMed Citation: 8076607

Oliver, B., Perrimon, N. and Mahowald, A. P. (1988). Genetic evidence that the sans fille locus is involved in Drosophila sex determination. Genetics 120: 159-171. PubMed Citation: 3220249

Palacios, I., et al. (1997). Nuclear import of U snRNPs requires importin beta. EMBO J. 16(22): 6783-6792. PubMed Citation: 9362492

Penn, J. K., et al. (2008). Functioning of the Drosophila Wilms'-tumor-1-associated protein homolog, Fl(2)d, in Sex-lethal-dependent alternative splicing. Genetics 178(2): 737-48. PubMed Citation: 18245840

Puig, O., et al. (1999). Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection. Genes Dev. 13(5): 569-580. PubMed Citation: 10072385

Roca, X., et al. (2012). Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides. Genes Dev. 26(10): 1098-109. PubMed Citation: 22588721

Romac, J. M., Graff, D. H. and Keene, J. D. (1994). The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain. Mol. Cell. Biol. 14: 4662-70

Romac, J. M. and Keene, J. D (1995). Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA. Genes Dev. 9: 1400-1410

Ruby, S. W. (1997). Dynamics of the U1 small nuclear ribonucleoprotein during yeast spliceosome assembly. J. Biol. Chem. 272(28): 17333-17341

Salz, H. K. (1992). The genetic analysis of snf: a Drosophila sex determination gene required for activation of Sex-lethal in both the germline and the soma. Genetics 130: 547-54

Salz, H. K. and Flickinger, T. W. (1996). Both loss-of-function and gain-of-function mutations in snf define a role for snRNP proteins in regulating Sex-lethal pre-mRNA splicing in Drosophila development. Genetics 144: 95-108

Salz, H. K., Mancebo, R. S., Nagengast, A. A., Speck, O., Psotka, M. and Mount, S. M. (2004). The Drosophila U1-70K protein is required for viability, but its arginine-rich domain is dispensable. Genetics 168(4): 2059-65. 15611175

Scherly, D., et al. (1991). Conserved amino acid residues within and outside of the N-terminal ribonucleoprotein motif of U1A small nuclear ribonucleoprotein involved in U1 RNA binding. J. Mol. Biol. 219: 577-84

Siebel, C. W., Fresco, L. D. and Rio, D. C. (1992). The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding. Genes Dev. 6: 1386-401

Staknis, D. and Reed, R. (1994). SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol. Cell. Biol. 14: 7670-7682.

Staknis, D. and Reed, R. (1995). Members of a family of proteins (the RD family) detected by a U1 70K monoclonal antibody are present in spliceosomal complexes. Nucleic Acids Res. 23: 4081-4086

Steinmann-Zwicky, M. (1988). Sex determination in Drosophila: the X-chromosomal gene liz is required for Sxl activity. EMBO J. 7: 3889-3898

Tarn, W. Y. and Steitz, J. A. (1994). SR proteins can compensate for the loss of U1 snRNP functions in vitro. Genes Dev. 8: 2704-17

Tarn, W. Y. and Steitz, J. A. (1995). Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps. Proc. Natl. Acad. Sci. 92: 2504-2508

Terns, M. P., Lund, E. and Dahlberg, J. E. (1993). A pre-export U1 snRNP in Xenopus laevis oocyte nuclei. Nucleic Acids Res. 21: 4569-73

Tewari, M., Beidler, D. R. and Dixit, V. M. (1995). CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis. J. Biol. Chem. 270: 18738-18741

van Gelder, C. W., et al. (1993). A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation. EMBO J. 12: 5191-200

Wang, Y. and Stumph, W. E. (1998). Identification and topological arrangement of Drosophila proximal sequence element (PSE)-binding protein subunits that contact the PSEs of U1 and U6 small nuclear RNA genes. Mol. Cell. Biol. 18(3): 1570-1579

Welin Henriksson, E., et al. (1999). Key residues revealed in a major conformational epitope of the U1-70K protein. Proc. Natl. Acad. Sci. 96(25): 14487-92

Wu, J. Y. and Maniatis, T. (1993). Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 75: 1061-70

Xiao, S.-H. and Manley, J. L. (1997). Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev. 11: 334-344

Xue, D., et al. (2000). U snRNP assembly in yeast involves the La protein. EMBO J. 19: 1650-1660

Yong, J., Pellizzoni, L. and Dreyfuss, G. (2002). Sequence-specific interaction of U1 snRNA with the SMN complex. EMBO J. 21: 1188-1196. 11867547

Zahler, A. M., and Roth, M. B. (1995). Distinct functions of SR proteins in recruitment of U1 small nuclear ribonucleoprotein to alternative 5' splice sites. Proc. Natl. Acad. Sci. 92: 2642-2646

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sans fille : Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

date revised: 15 July 2013 

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