alpha Spectrin

Avery, A. W., Thomas, D. D. and Hays, T. S. (2017). beta-III-spectrin spinocerebellar ataxia type 5 mutation reveals a dominant cytoskeletal mechanism that underlies dendritic arborization. Proc Natl Acad Sci U S A 114(44): E9376-E9385. PubMed ID: 29078305

Bennett, V. and Gilligan, D. M. (1993). The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane. Ann. Rev. Cell Biol. 9: 27-66. PubMed ID: 8280463

Blunk, A. D., Akbergenova, Y., Cho, R. W., Lee, J., Walldorf, U., Xu, K., Zhong, G., Zhuang, X. and Littleton, J. T. (2014). Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction. Mol Cell Neurosci. PubMed ID: 25066865

Bonfanti, P., et al. (1992). The molecular architecture of an insect midgut brush border cytoskeleton. Eur J Cell Biol 57: 298-307. PubMed ID: 1511705

Byers, T. J., et al. (1989). Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin. J. Cell Biol. 109: 1633-41. PubMed ID: 2677025

Byers, T. J., et al. (1992). The complete sequence of Drosophila beta-spectrin reveals supra-motifs comprising eight 106-residue segments. Proc. Natl. Acad. Sci. 89: 6187-91. PubMed ID: 1631106

Clark, M. B., et al. (1994). Brain alpha erythroid spectrin: identification, compartmentalization, and beta spectrin associations. Brain Res. 663: 223-236. PubMed ID: 7874505

Das, A., Base, C., Dhulipala, S. and Dubreuil, R. R. (2006). Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway. J. Cell Biol. 175(2):325-35. Medline abstract: 17060500

Davis, L. H. and Bennett, V. (1994). Identification of two regions of beta G spectrin that bind to distinct sites in brain membranes. J Biol Chem 269: 4409-16. PubMed ID: 8308011

de Cuevas, M., Lee, J. K. and Spradling, A. C. (1996). alpha-spectrin is required for germline cell division and differentiation in the Drosophila ovary. Development 122: 3959-3968. PubMed ID: 9012516

de Cuevas, M and Spradling, A. C. (1998). Morphogenesis of the Drosophila fusome and its implications for oocyte specification. Development 125(15): 2781-2789. PubMed ID: 9655801

Deng, H., et al. (1995). Drosophila development requires spectrin network formation. J. Cell Biol. 128: 71-79. PubMed ID: 7822424

Deng, H., Wang, W., Yu, J., Zheng, Y., Qing, Y. and Pan, D. (2015). Spectrin regulates Hippo signaling by modulating cortical actomyosin activity. Elife 4: e06567. PubMed ID: 25826608

Deng, W. and Lin, H. (1997). Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila. Dev. Biol. 189(1): 79-94. PubMed ID: 9281339

Ding, D., Parkhurst, S. M. and Lipshitz, H. D. (1993). Different genetic requirements for anterior RNA localization revealed by the distribution of Adducin-like transcripts during Drosophila oogenesis. Proc. Natl. Acad. Sci. 90: 2512-6. PubMed ID: 7681599

Discher, D., et al. (1993). Mechanochemistry of the alternatively spliced spectrin-actin binding domain in membrane skeletal protein 4.1. J. Biol. Chem. 268: 7186-95. PubMed ID: 8463254

Dubreuil, R. R., et al. (1989). The complete swquence of Drosophila alpha-Spectrin: conservation of structural domains between alpha-spectrins and alpha-actinin. J. Cell Biol. 109: 2197-2205. PubMed ID: 2808524

Dubreuil, R. R., et al. (1990). A beta-spectrin isoform from Drosophila (beta H) is similar in size to vertebrate dystrophin. J. Cell Biol. 111: 1849-58. PubMed ID: 2229176

Dubreuil, R. R., et al. (1991). Structure, calmodulin-binding, and calcium-binding properties of recombinant alpha-spectrin polypeptides. J. Biol. Chem. 266: 7189-7193. PubMed ID: 2016322

Dubreuil, R. R. and Yu, J. (1994). Ankyrin and beta-spectrin accumulate independently of alpha-spectrin in Drosophila. Proc. Natl. Acad. Sci. 91: 10285-10289. PubMed ID: 7937942

Dubreuil, R. R., et al. (1996). Neuroglian-mediated cell adhesion induces assembly of the membrane skeleton at cell contact sites. J. Cell Biol. 133: 647-655. PubMed ID:

Dubreuil, R. R., et al. (1998). Mutations of alpha Spectrin and labial block cuprophilic cell differentiation and acid secretion in the middle midgut of Drosophila larvae. Dev. Biol. 194(1): 1-11. PubMed ID: 9473327

Dubreuil, R. R., et al. (2000). Drosophila ß spectrin functions independently of spectrin to polarize the Na,K ATPase in epithelial cells. J. of Cell Biol. 149: 647-656. PubMed ID: 10791978

Fares, H., Peifer, M. and Pringle, J. R. (1995). Localization and possible functions of Drosophila septins. Mol. Biol. Cell 6(12): 1843-1859

Fehon, R. G., Dawson, I. A. and Artavanis-Tsakonas, S. (1994). The Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development 120: 545-557

Featherstone, D. E., et al. (2001). Drosophila alpha- and ß-Spectrin mutations disrupt presynaptic neurotransmitter release. J. Neurosci. 21(12): 4215-4224. 11404407

Field, C. M. and Alberts, B. M. (1995). Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex. J. Cell Biol. 131(1): 165-178

Garbe, D. S., Das, A., Dubreuil, R. R. and Bashaw, G. J. (2007). β-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS. Development 134: 273-284. Medline abstract: 17121810

Gelot, A., et al. (1994). Developmental change of alpha-spectrin mRNA in the rat brain. Brain Res. Dev. Brain Res. 81: 240-246

Fletcher, G.C., Elbediwy, A., Khanal, I., Ribeiro, P.S., Tapon, N. and Thompson, B.J. (2015). The Spectrin cytoskeleton regulates the Hippo signalling pathway. EMBO J. 34(7): 940-54. PubMed ID: 25712476

Godi, A., et al. (1998). ADP ribosylation factor regulates spectrin binding to the golgi complex. Proc. Natl. Acad. Sci. 95(15): 8607-8612

Hammarlund, M., Davis, W. S. and Jorgensen, E. M. (2000). Mutations in ß-Spectrin disrupt axon outgrowth and aarcomere structure. J. Cell Biol. 149: 931-942. PubMed ID: 10811832

Hayes, N. V. and Baines, A. J. (1994). Axonal membrane-skeletal protein A60: association with a brain spectrin-binding activity and entry into cerebellar axons at a stage after the initiation of axonal growth. J. Neurochem. 62: 300-6

Hime, G. R., Brill, J. A. and Fuller, M. T. (1996). Assembly of ring canals in the male germ line from structural components of the contractile ring. J. Cell Sci. 109( Pt 12): 2779-2788

Hu, R. J., Watanabe, M. and Bennett, V. (1992). Characterization of human brain cDNA encoding the general isoform of beta-spectrin. J. Biol. Chem. 267: 18715-22

Hu, R.-J., Moorthy, S. and Bennett, V. (1995). Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells. J. Cell Biol. 128: 1069-80.

Hülsmeier, J., et al. (2007). Distinct functions of alpha-Spectrin and β-Spectrin during axonal pathfinding. Development 134: 713-722. Medline abstract: 17215305

Jia, R., Chai, Y., Xie, C., Liu, G., Zhu, Z., Huang, K., Li, W. and Ou, G. (2020). The spectrin-based membrane skeleton is asymmetric and remodels during neural development in C. elegans. J Cell Sci 133(15). PubMed ID: 32620698

Khanna, M. R., Mattie, F. J., Browder, K. C., Radyk, M. D., Crilly, S. E., Bakerink, K. J., Harper, S. L., Speicher, D. W. and Thomas, G. H. (2015). Spectrin tetramer formation is not required for viable development in Drosophila. J Biol Chem 290(2): 706-15. PubMed ID: 25381248

Kong, D., Zhao, S., Xu, W., Dong, J. and Ma, X. (2022). Fat body-derived Spz5 remotely facilitates tumor-suppressive cell competition through Toll-6-α-Spectrin axis-mediated Hippo activation. Cell Rep 39(12): 110980. PubMed ID: 35732124

Lambert, S. and Bennett, V. (1993). Postmitotic expression of ankyrinR and beta R-spectrin in discrete neuronal populations of the rat brain. J Neurosci 13: 3725-35.

Lee, J. K., et al. (1993). Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster. J. Cell Biol. 123: 1797-809

Lee, J. K., et al. (1997). alpha-Spectrin is required for ovarian follicle monolayer integrity in Drosophila melanogaster. Development 124: 353-362. PubMed ID: 9053311

Lin, H., Yue, L. and Spradling, A. C. (1994). The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation. Development 120: 947-956

Lin, H. and Spradling, A. C. (1995). Fusome asymmetry and oocyte determination in Drosophila. Dev. Genet. 1645: 6-12

Lombardo, C., et al. (1994). Human recombinant alpha-catenin binds to spectrin. Mol. Biol. Cell 5: 47a

Lyford, G. L., et al. (1995). Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14: 433-445

Ma, Y., et al. (1993). The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences. Brain Res. Mol. Brain Res. 18: 87-99

McDermott, S. M., Yang, L., Halstead, J. M., Hamilton, R. S., Meignin, C. and Davis, I. (2014). Drosophila Syncrip modulates the expression of mRNAs encoding key synaptic proteins required for morphology at the neuromuscular junction. RNA 20(10): 1593-606. PubMed ID: 25171822

McKearin, D. (1997).The Drosophila fusome, organelle biogenesis and germ cell differentiation: if you build it.... Bioessays 19: 147-152

Morrow, J. S., et al. (1989). Ankyrin links fodrin to the alpha subunit of Na,K-ATPase in Madin-Darby canine kidney cells and in intact renal tubule cells. J. Cell Biol. 108: 455-65 89139564

Mosca, T. J., Hong, W., Dani, V. S., Favaloro, V. and Luo, L. (2012). Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice. Nature 484: 237-241. Pubmed: 22426000

Muresan, V., et al. (2001). Dynactin-dependent, dynein-driven vesicle transport in the absence of membrane proteins: A role for spectrin and acidic phospholipids. Mol. Cell 7: 173-183. PubMed ID: 11172722

Nelson, W. J. and Veshnock, P. (1987). Ankyrin binding to (Na+ + K+)ATPase and implications for the organization of membrane domains in polarized cells. Nature 328: 533-6. 87287227

Ng, B. F., Selvaraj, G. K., Mateos, C. S., Grosheva, I., Alvarez-Garcia, I., Martin-Bermudo, M. D. and Palacios, I. M. (2016). Alpha-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a mono-layered follicular epithelium. Development 143(8):1388-99. PubMed ID: 26952981

Pasacreta, T. C., et al. (1989). Drosophila spectrin: the membrane skeleton during embryogenesis. J. Cell Biol. 108: 1697-709. 89234159

Pielage, J., Fetter, R. D. and Davis, G. W. (2006). A postsynaptic Spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction. J. Cell Biol. 175: 491-503. Medline abstract: 17088429

Ralston, G., Cronin, T. and Branton, D. (1996). Self-association of spectrin's repeating segments. Biochemistry 35: 5257-5263

Rimm, D. L., et al. (1995). Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc. Natl. Acad. Sci. 92: 8813-8817

Salomao, M., (2006). Mammalian alpha I-spectrin is a neofunctionalized polypeptide adapted to small highly deformable erythrocytes. Proc. Natl. Acad. Sci. 103(3): 643-8. Medline abstract: 16407147

Scoles, D. R., et al. (1998). Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin. Nat. Genet. 18(4): 354-359

Simonovic, M., Zhang, Z., Cianci, C. D., Steitz, T. A. and Morrow, J. S. (2006). Structure of the calmodulin alphaII-spectrin complex provides insight into the regulation of cell plasticity. J. Biol. Chem. 281(45): 34333-40. Medline abstract: 16945920

Sisson, J. C., et al. (2000). Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization. J. Cell Bio. 151: 905-918. 11076973

Thomas, G. H. and Kiehart, D. P. (1994). Beta heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis. Development 120: 2039-50

Viel, A. and Branton, D. (1994). Interchain binding at the tail end of the Drosophila spectrin molecule. Proc. Natl. Acad. Sci. 91: 10839-10843

Voas, M. G., (2007). alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons. Curr. Biol. 17(6): 562-8. Medline abstract: 17331725

Volk, T. (1992). A new member of the spectrin superfamily may participate in the formation of embryonic muscle attachments in Drosophila. Development 116: 721-30

Winardi, R., et al. (1995). Evolutionarily conserved alternative pre-mRNA splicing regulates structure and function of the spectrin-actin binding domain of erythroid protein 4.1. Blood 86: 4315-4322

Wodarz, A., et al. (1995). Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 82: 67-76

Wood, S. J. and Slater, C. R. (1998). beta-spectrin is colocalized with both voltage-gated sodium channels and AnkyrinG at the adult rat neuromuscular junction. J. Cell Biol. 140(3): 675-684. PubMed ID: 9456326

Woods, D. F., et al. (1996). Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia. J. Cell Biol. 134: 1469-82

Yasuda, G. K. Baker, J. and Schubiger, G. (1991). Independent roles of centrosomes and DNA in organizing the Drosophila cytoskeleton. Development 111: 379-91

Zhang, P., et al. (1995). Solution structure of the pleckstrin homology domain of Drosophila beta-spectrin. Structure 3: 1185-1195

Zhou, D., Ursitti, J. A. and Bloch, R. J. (1998). Developmental expression of spectrins in rat skeletal muscle. Mol. Biol. Cell 9(1): 47-61. PubMed ID: 9436990

Zimmer, W. E., et al. (1992). Developmental expression of brain beta-spectrin isoform messenger RNAs. Brain Res. 594: 75-83

date revised: 2 November 2020

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