Abl tyrosine kinase


REFERENCES

Agami, R., et al. (1999). Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature 399(6738): 809-13. PubMed Citation: 10391250

Azam, M., Latek, R. L. and Daley, G. Q. (2003). Mechanisms of autoinhibition and STI-571/Imatinib resistance revealed by mutagenesis of BCR-ABL. Cell 112: 831-843. 12654249

Barila, D., et al. (2000). A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK. EMBO J. 19: 273-281. PubMed Citation: 10637231

Bashaw, G. J., et al. (2000). Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the Roundabout receptor. Cell 101: 703-715. PubMed Citation: 10892742

Baskaran, R., Chiang, G. C. and Wang, J. Y. (1996). Identification of a binding site in c-Ab1 tyrosine kinase for the C-terminal repeated domain of RNA polymerase II. Mol. Cell. Biol. 16: 3361-3369. PubMed Citation:. PubMed Citation: 8668151

Bateman, J., Shu, H. and Van Vactor, D. (2000). The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron 26: 93-106.. PubMed Citation: 10798395

Baum, B. and Perrimon, N. (2001). Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat. Cell Biol. 3: 883-890. 11584269

Bear, J. E., et al. (2000). Negative regulation of fibroblast motility by Ena/VASP proteins. Cell 101: 717-728. PubMed Citation: 10892743

Bennett, R. L. and Hoffmann, F. M. (1992). Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development 116 (4): 953-966. PubMed Citation: 1295746

Bhat, A., et al. (1997). Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells. J. Biol. Chem. 272(26): 16170-16175. PubMed Citation: 9195915

Birchenall-Roberts. M. C., et al. (1995). Nuclear localization of v-Abl leads to complex formation with cyclic AMP response element (CRE)-binding protein and transactivation through CRE motifs. Mol. Cell. Biol. (11): 6088-6099. PubMed Citation: 7565761

Birchenall-Roberts, M. C., et al. (1997). The p120-v-Abl Protein Interacts with E2F-1 and Regulates E2F-1 Transcriptional Activity. J. Biol. Chem. 272: 8905-8911.. PubMed Citation: 9083010

Bothwell, M. and Giniger, E. (2000). Alzheimer's disease: neurodevelopment converges with neurodegeneration. Cell 102: 271-273. 10975517

Boyle, S. N., et al. (2007). A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation. Curr. Biol. 17(5): 445-51. Medline abstract: 17306540

Brasher, B. B. and Van Etten, R. A. (2000). c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines. J. Biol. Chem. 275: 35631-35637. 10964922

Brasher, B. B., Roumiantsev, S., and Van Etten, R. A. (2001). Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain. Oncogene 20: 7744-7752. 11753652

Brittle, A. L., and Ohkura, H. (2005). Mini spindles, the XMAP215 homologue, suppresses pausing of interphase microtubules in Drosophila. EMBO J. 24: 1387-1396. PubMed Citation: 15775959

Brouhard, G. J., et al. (2008). XMAP215 is a processive microtubule polymerase. Cell 132: 79-88. PubMed Citation: 18191222

Buckles, G. R., et al. (2001). four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg. Development 128: 3533-3542. 11566858

Carpino, N., et al. (1997). p62dok: a constitutively tyrosine-phosphorylated GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 88: 197-204. PubMed Citation: 9008160

Cong, F., et al. (2000). Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation. Mol. Cell 6: 1413-1423. 11163214

Crowner, D., et al. (2003). Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr. Biol. 13: 967-972. 12781136

Dai, Z., et al. (1998). Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. Genes Dev. 12(10): 1415-1424. PubMed Citation: 9585502

Dajas-Bailador, F., Jones, E. V. and Whitmarsh, A. J. (2008). The JIP1 scaffold protein regulates axonal development in cortical neurons. Curr. Biol. 18(3): 221-6. PubMed Citation: 18261906

Danial, N. N., Pernis, A. and Rothman, P. B. (1995). Jak-STAT signaling induced by the v-abl oncogene. Science 269: 1875-1877. PubMed Citation: 10851051

Danial, N. N., et al., (1998). Direct interaction of jak1 and v-Abl is required for v-abl-induced activation of STATs and proliferation. Mol. Cell. Biol. 18(11): 6795-804. PubMed Citation: 9774693

David-Cordonnier, M. H., et al. (1998). The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures. Biochemistry 37(17): 6065-76. PubMed Citation: 9558345

de Jong, R., et al. (1997). Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. Oncogene 14 (5): 507-513. PubMed Citation: 9053848

Dorey, K., Engen, J. R., Kretzschmar, J., Wilm, M., Neubauer, G., Schindler, T., and Superti-Furga, G. (2001). Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase. Oncogene 20: 8075-8084. 11781820

Dorsten, J. N., et al. (2010). In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS. PLoS One 5(3): e9822. PubMed Citation: 20352105

Dupraz, P., et al (1997). The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl. J. Virol. 71: 2615-2620. PubMed Citation: 9060613

Duyster, J., Baskaran, R. and Wang, J. Y. (1995). Src homology 2 domain as a specificity determinant in the c-Abl-mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain. Proc. Natl. Acad. Sci. 92: 1555-1559. PubMed Citation: 7533294

Echarri, A. and Pendergast, A. E. (2001). Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway. Cur. Bio. 11: 1759-1765. 11719217

Elkins, T., et al. (1990). Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelsona tyrosine kinase mutations. Cell 60: 565-575. PubMed Citation: 2406026

Engel, U., Zhan, Y., Long, J. B., Boyle, S. N., Ballif, B. A., Dorey, K., Gygi, S. P., Koleske, A. J. and Van Vactor, D. (2014). Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. Cytoskeleton (Hoboken) [Epub ahead of print]. PubMed ID: 24520051

Foray, N., et al. (2002). Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. Mol. Cell. Biol. 22(12): 4020-32. 12024016

Forsthoefel, D. J., Liebl, E. C., Kolodziej, P. A. and Seeger, M. A. (2005). The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila. Development 132(8): 1983-94. 15790972

Fox, D. T. and Peifer, M. (2007). Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134(3): 567-78. Medline abstract: 17202187

Garcia-Alonso, L. VanBerkum, M., Grenningloh, G., Schuster, C. and Goodman, C.S. (1995). Fasciclin II controls proneural gene expression in Drosophila. Proc. Natl. Acad. Sci. 92: 10501-10505. PubMed Citation: 7479828

Gertler, F. B., et al. (1989). Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58: 103-13. PubMed Citation: 2502313

Gertler, F. B., Doctor, J. S. and Hoffmann, F. M. (1990). Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog. Science 248: 857-860. PubMed Citation: 2188361

Gertler, F. B., et al. (1993). Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate. Genes Dev. 7 (3): 441-453. PubMed Citation: 7680635

Gertler, F. B., et al. (1995). enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Genes Dev. 9: 521-533. PubMed Citation: 7535279

Giniger, E. (1998). A role for Abl in Notch signaling. Neuron 20: 667-681. PubMed Citation: 9581760

Goldberg, Z., et al. (2002). Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J. 21: 3715-3727. 12110584

Gong, J. G., et al. (1999). The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399(6738): 806-9. PubMed Citation: 10391249

Grevengoed, E. E., Loureiro, J. J., Jesse, T. L. and Peifer, M. (2001). Abelson kinase regulates epithelial morphogenesis in Drosophila. J. Cell Biol. 155: 1185-1198. 11756472

Grevengoed, E. E., Fox, D. T., Gates, J. and Peifer, M. (2003). Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. J. Cell Biol. 163: 1267-1279. 14676307

Hantschel, O., et al. (2003). A myristoyl/phosphotyrosine switch regulates c-Abl. Cell 112: 845-857. 12654250

Henkemeyer, M. J., et al. (1988). DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol. Cell. Biol. 8 (2): 843-853. PubMed Citation: 2832740

Henkemeyer, M. J., et al. (1990). A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization. Cell 63 (5): 949-960. PubMed Citation: 2175256

Hernández, S. E., Settleman, J. and Koleske, A. J. (2004). Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase. Curr. Biol. 14: 691-696. 15084284

Hill, K. K., et al. (1995). Genetic interactions between the Drosophila Abelson (Abl) tyrosine kinase and failed axon connnections (Fax), a novel protein in axon bundles. Genetics 141: 595-606. PubMed Citation: 8647396

Holland, G. D., et al. (1990). Conservation of function of Drosophila melanogaster abl and murine v-abl proteins in transformation of mammalian cells. J. Virol. 64 (5): 2226-2235. PubMed Citation: 2157882

Howell, B. W., Gertler, F. B. and Cooper, J. A. (1997). Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. EMBO J. 16 (1): 121-132. PubMed Citation: 9009273

Hsouna, A., Kim, Y. S. and VanBerkum, M.F. (2003). Abelson tyrosine kinase is required to transduce midline repulsive cues. J. Neurobiol. 57: 15-30. 12973825

Hsouna, A. and VanBerkum, M. F. (2008). Abelson tyrosine kinase and Calmodulin interact synergistically to transduce midline guidance cues in the Drosophila embryonic CNS. Int. J. Dev. Neurosci. 26(3-4): 345-54. PubMed Citation: 18243630

Hu, S., Sonnenfeld, M., Stahl, S. and Crews, S. T. (1998). Midline Fasciclin: a Drosophila Fasciclin-I-related membrane protein localized to the CNS midline cells and trachea. J. Neurobiol. 35(1): 77-93.. PubMed Citation: 9552168

Huang, C. H., Lin, T. Y., Pan, R. L. and Juang, J. L. (2007). The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells. J. Biol. Chem. 282(44): 32442-32452. PubMed Citation: 17804420

Iijima, K., et al. (2008). Aβ42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. PLoS ONE 3(2): e1703. PubMed Citation: 18301778

Ilaria, R. L., and Van Etten, R. A. (1996). P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J. Biol. Chem. 271 (49): 31704-31710. PubMed Citation: 8940193

Jin, S., et al. (1997). Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit. J. Biol. Chem. 272(40): 24763-24766. PubMed Citation: 9312071

Juang, J. L. and Hoffmann, F. M. (1999). Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. Oncogene 18: 5138-5147. PubMed Citation: 10498863

Kannan, R., Kuzina, I., Wincovitch, S., Nowotarski, S. H., Giniger, E. (2014). The Abl/Enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons. Mol Biol Cell [Epub ahead of print]. PubMed ID: 25103244

Kharbanda, S., et al.(1997). Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature 386 (6626): 732-735. PubMed Citation: 9109492

Kharbanda, S., et al. (2000). Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. Curr. Biol. 10: 568-575. PubMed Citation: 10837221

Kipreos, E. T. and Wang, J. Y. J. (1992). Cell cycle-regulated binding of c-Abl tyrosine kinase to DNA. Science 256: 382-385. PubMed Citation: 1566087

Klejman, A., et al. (2002). The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. EMBO J. 21: 5766-5774. 12411494

Klug, C. A., et al. (1994). The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes. Genes Dev. 8: 678-687. PubMed Citation: 7926758

Koleske, A. J., et al. (1998). Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron 21(6): 1259-72. PubMed Citation: 9883720

Kondylis, V., van Nispen tot Pannerden, H. E., Herpers, B., Friggi-Grelin, F. and Rabouille, C. (2007). The golgi comprises a paired stack that is separated at G2 by modulation of the actin cytoskeleton through Abi and Scar/WAVE. Dev Cell 12: 901-915. PubMed ID: 17543863

Kraut, R.,K. et al. (1996). Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383: 50-55. PubMed Citation: 8779714

Knudsen, E. S. and Wang, J. Y. (1997). Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol.17(10): 5771-5783. PubMed Citation: 9315635

Kumar, V., et al. (2000). Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase. J. Biol. Chem. 275(15): 10779-87. PubMed Citation: 10753870

Kuzina, I., Song, J. K. and Giniger, E. (2011). How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. Development 138(9): 1839-49. PubMed Citation: 21447553

Lee, H., et al. (2004). The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. Neuron 42: 913-926. 15207236

Lewis, J. M., et al. (1996). Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc. Natl. Acad. Sci. 93 (26): 15174-15179. PubMed Citation: 8986783

Leyssen, M., et al. (2005). Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J. 24: 2944-2955. PubMed Citation: 16052209

Li, B., Cong, F., Tan, C. P., Wang, S. X. and Goff, S. P. (2002). Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. J. Biol. Chem. 277(32): 28870-. 12021275

Li, B., et al. (2004). Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase Cdelta. Genes Dev. 18: 1824-1837. 15289456

Li, W., Li, Y. and Gao, F. B. (2005). Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila. Dev. Dyn. 234(3): 512-22. 16003769

Liebl, E. C., Forsthoefel, D. J., Franco, L. S., Sample, S. H., Hess, J. E., Cowger, J. A., Chandler, M. P., Jackson, A. M. and Seeger, M. A. (2000). Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trios role in axon pathfinding. Neuron 25: 107-118. PubMed Citation: 10798396

Liebl, E. C., et al. (2003). Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding. Development 130: 3217-3226. 12783792

Lin, H. and Spradling, A. C. (1995). Fusome asymmetry and oocyte determination in Drosophila. Dev. Genet. 1645: 6-12. PubMed Citation: 7758245

Lin, H., Lin, T. Y. and Juang, J. L. (2007). Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration. Cell Death Differ. 14(3): 607-15. Medline abstract: 16932754

Lin, T.-Y., et al. (2009). Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis. Development 136: 3099-3107. PubMed Citation: 19675132

Liu, L. and Wu, C. F. (2014). Distinct effects of abelson kinase mutations on myocytes and neurons in dissociated Drosophila embryonic cultures: mimicking of high temperature. PLoS One 9: e86438. PubMed ID: 24466097

Loureiro, J. and Peifer, M. (1998). Roles of Armadillo, a Drosophila catenin, during central nervous system development. Curr. Biol. 8(11): 622-32. PubMed Citation: 9635189

Lowery, L. A., et al. (2010). Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila. Genetics 185(4): 1311-25. PubMed Citation: 20498300

Lundberg, A. S. and Weinberg, R. A. (1998). Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18(2): 753-761. PubMed Citation: 9447971

Lyulcheva, E., et al. (2008). Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation. Dev. Cell 15: 680-690. PubMed Citation: 19000833

Mattioni, T., Mayer, B. J. and Picard, D. (1996). Growth inhibition by Abl requires an interplay of its SH2 and tyrosine kinase domains. FEBS Lett. 390 (2): 170-174. PubMed Citation: 8706852

Meyer-Luehmann, M., et al. (2006). Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 313: 1781-1784. PubMed Citation: 16990547

Michael, M., Vehlow, A., Navarro, C. and Krause, M. (2010). c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis. Curr. Biol. 20(9): 783-91. PubMed Citation: 20417104

Miller, A. L., Wang, Y., Mooseker, M. S. and Koleske, A. J. (2004). The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. J. Cell Biol. 165: 407-419. 15138293

Moore, K. L. and Kinsey, W. H. (1994). Identification of an abl-related protein tyrosine kinase in the cortex of the sea urchin egg: possible role at fertilization. Dev. Biol. 164: 444-455. PubMed Citation: 8045347

Nagar, B., et al. (2002). Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res. 62: 4236-4243. 12154025

Nagar, B., Hantschel, O., Young, M. A., Scheffzek, K., Veach, D., Bornmann, W., Clarkson, B., Superti-Furga, G., and Kuriyan, J. (2003). Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell 112: 859-871. 12654251

Petkova, A. T., et al. (2005). Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science 307: 262-265. PubMed Citation: 15653506

Plattner, R., et al. (1999). c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev. 13: 2400-11. PubMed Citation: 10500097

Pluk, H., Dorey, K. and Superti-Furga, G. (2002). Autoinhibition of c-Abl. Cell 108: 247-259. 11832214

Popov, A. V. and Karsenti, E. (2003). Stu2p and XMAP215: turncoat microtubule-associated proteins? Trends Cell Biol. 13: 547-550. PubMed Citation: 14573345

Puil, L., et al. (1994). Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J. 13: 764-773. PubMed Citation: 8112292

Raffel, G. D., Parmar, K, and Rosenberg, N. (1996). In vivo association of v-Abl with Shc mediated by a non-phosphotyrosine-dependent SH2 interaction. J. Biol. Chem. 271 (9): 4640-4645. PubMed Citation: 8617726

Roumiantsev, S., et al. (2002). Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proc. Natl. Acad. Sci. 99(16): 10700-5. 12149456

Salgia, R., et al. (1996). p210 BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl. Exp. Hematol. 24: 310-313. PubMed Citation: 8641358

Sanchez-Garcia, I. and Martin-Zanca, D. (1997). Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras. J. Mol. Biol. 267 (2): 225-228. PubMed Citation: 9096220

Schwartzberg, P. L., et al. (1991). Mice homozygous for the Abl m1 mutation show poor viability and depletion of selected B and T cell populations. Cell 65: 1165-75. PubMed Citation: 2065353

Shafman, T., et al. (1997). Interaction between ATM protein and c-Abl in response to DNA damage. Nature 387 (6632): 520-523. PubMed Citation: 9168117

Sheffield, M., Loveless, T., Hardin, J. and Pettitt, J. (2007). C. elegans Enabled exhibits novel interactions with N-WASP, Abl, and cell-cell junctions. Curr. Biol. 17(20): 1791-6. Medline abstract: 17935994

Shi, Y., Alin, K. and Goff, S. P. (1995). Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Genes Dev. 9: 2583-2597. PubMed Citation: 7590237

Shishido, T., et al. (2000). The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation. Proc. Natl. Acad. Sci. 97: 6439-6444. PubMed Citation: 10829062

Shivalkar, M. and Giniger, E. (2012). Control of dendritic morphogenesis by Trio in Drosophila melanogaster. PLoS One 7: e33737. PubMed ID: 22438988

Shore, S. K., et al. (1994). Structural alterations in the carboxyl-terminal domain of the BCRABL gene product activate its fibroblastic transforming potential. J. Biol. Chem. 269: 5413-5419. PubMed Citation: 8106523

Singh, J., Aaronson, S. A. and Mlodzik, M. (2010a). Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways. Oncogene 29(28): 4033-45. PubMed Citation: 20453880

Singh, J., Yanfeng, W. A., Grumolato, L., Aaronson, S. A. and Mlodzik, M. (2010b). Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation. Genes Dev. [Epub ahead of print]. PubMed Citation: 20837657

Sini, P., Cannas, A., Koleske, A. J., Di Fiore, P. P. and Scita, G. (2004). Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation. Nat. Cell. Biol. 6: 268-274. 15039778

Skorski, T., et al. (1998). BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac. Proc. Natl. Acad. Sci. 95(20): 11858-62. PubMed Citation: 9751755

Smith, K. M., Yacobi, R., and Van Etten, R. A. (2003). Autoinhibition of Bcr-Abl through its SH3 domain. Molec. Cell 12: 27-37. 12887890

Soldano, A., Okray, Z., Janovska, P., Tmejova, K., Reynaud, E., Claeys, A., Yan, J., Atak, Z. K., De Strooper, B., Dura, J. M., Bryja, V. and Hassan, B. A. (2013). The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. PLoS Biol 11: e1001562. PubMed ID: 23690751

Song, J. K., Giniger, E. and Desai, C. J. (2007). The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila. Mech. Dev. 125(3-4): 247-56. PubMed Citation: 18160268

Sousa, A., et al. (2007). The Drosophila CLASP homologue, Mast/Orbit regulates the dynamic behaviour of interphase microtubules by promoting the pause state. Cell Motil. Cytoskeleton 64: 605-620. PubMed Citation: 17487886

Speicher, S., et al. (1998). Neurotactin functions in concert with other identified CAMs in growth cone guidance in Drosophila. Neuron 20(2): 221-33. PubMed Citation: 9491984

Stephan, R., Grevelhörster, A., Wenderdel, S., Klämbt, C. and Bogdan, S. (2008). Abi induces ectopic sensory organ formation by stimulating EGFR signaling. Mech. Dev. 125(3-4): 183-95. PubMed Citation: 18221859

Stevens, T. L., et al. (2008). Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila. Mol. Biol. Cell 19(1): 378-93. PubMed Citation: 17959833

Stine, R. R., Greenspan, L. J., Ramachandran, K. V. and Matunis, E. L. (2014). Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis. PLoS Genet 10: e1004713. PubMed ID: 25375180

Stradal, T., et al. (2001). The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. Curr. Biol. 11: 891-895. PubMed Citation: 11516653

Taagepera, S., et al. (1998). Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc. Natl. Acad. Sci. 95(13): 7457-7462. PubMed Citation: 9636171

Telford, J., et al. (1985). Alternative processing and developmental control of the transcripts of the Drosophila abl oncogene homolog. EMBO J. 10: 2609-15. PubMed Citation: 3932065

Trommsdorff, M., Borg, J. P., Margolis, B. and Herz, J. (1998). Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem. 273(50): 33556-60. PubMed Citation: 9837937

Tsvetkov, A. S., et al. (2007). Microtubule-binding proteins CLASP1 and CLASP2 interact with actin filaments. Cell Motil. Cytoskeleton 64: 519-530. PubMed Citation: 17342765

Tybulewicz, V. L. J., et al. (1991). Neonatal lethality and lymphopenia in mice with homozygous disruption of the c-Abl proto-oncogene. Cell 65: 1153-63. PubMed Citation: 2065352

Uemura, N., et al. (1997). The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins. Leukemia 11 (3): 376-385. PubMed Citation: 9067577

Van Etten, R. A., et al. (1994). The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity. J. Cell Biol. 124: 325-40. PubMed Citation: 8294516

Van Etten, R. A., et al. (1995). Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro. Oncogene 10 (10): 1977-1988. PubMed Citation: 7539119

Wang, J. Y. (1993). Abl tyrosine kinase in signal transduction and cell-cycle regulation. Curr. Opin. Genet. Dev. 3: 35-43. PubMed Citation: 8453272

Watanabe, T., et al. (2009). Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. J. Cell Sci. 122: 2969-2979. PubMed Citation: 19638411

Welch, P. J. and Wang, J. Y. (1995). Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms. Mol. Cell. Biol. 15 (10): 5542-5551. PubMed Citation: 7565706

Wen, S. T., Jackson, P. K. and Van Etten, R. A. (1996). The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J. 15: 1583-1595. PubMed Citation: 8612582

Wen, S. T. and Van Etten, R. A. (1997). The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. Genes Dev. 11(19): 2456-2467. PubMed Citation: 9334312

Westphal, R. S., et al. (2000). Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. EMBO J. 19(17): 4589-600. 10970852

Wills, Z., et al. (1999a). Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Neuron 22(2): 291-9. PubMed Citation: 10069335

Wills, Z., et al. (1999b). The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance. Neuron 22(2): 301-12. PubMed Citation: 10069336

Wills, Z., et al. (2002). A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding Neuron 36: 611-622. PubMed Citation: 12441051

Wong, K. K., et al. (1995). v-Abl activates c-myc transcription through the E2F site. Mol. Cell. Biol. 15(12): 6535-6544. PubMed Citation: 8524218

Xiong, W., Dabbouseh, N. M. and Rebay, I. (2009). Interactions with the abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. Dev. Cell 16(2): 271-9. PubMed Citation: 19217428

Xiong, W., Morillo, S. A. and Rebay, I. (2013). The Abelson tyrosine kinase regulates Notch endocytosis and signaling to maintain neuronal cell fate in Drosophila photoreceptors. Development 140: 176-184. PubMed ID: 23175629

Xu, X. X., et al. (1998). Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene 16(12):1561-1569. PubMed Citation: 9569023

Yamanashi, Y. and Baltimore, D. (1997). Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell 88 (2): 205-211. PubMed Citation: 9008161

Yuan, Z. M., et al. (1997a). Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc. Natl. Acad. Sci. 94 (4): 1437-1440. PubMed Citation: 9037071

Yuan, Z. M., et al. (1997b). Inhibition of Phosphatidylinositol 3-Kinase by c-Abl in the Genotoxic Stress Response. J. Biol. Chem. 272(38): 23485-23488. PubMed Citation: 9295282

Zambrano, N., et al. (2001). The ß-Amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. J. Biol. Chem. 276: 19787-19792. 11279131

Zhu, J. and Shore, S. K. (1996). c-ABL tyrosine kinase activity is regulated by association with a novel SH2-domain-binding protein. Mol. Cell. Biol. 16: 7054-62. PubMed Citation: 8943360

Zhu, Z. and Bhat, K. M. (2011). The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. Dev. Biol. 357(2): 283-94. PubMed Citation: 21726548

Zipfel, P. A., et al. (2004). Requirement for Abl kinases in T cell receptor signaling. Curr. Biol. 14: 1222-1231. 15268851

Zou, X., et al. (1997). Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras, Raf1, and cyclin-dependent kinases Genes Dev. 11: 654-662. PubMed Citation: 9119229


Abl tyrosine kinase: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 15 March 2015

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.