The Interactive Fly

Evolutionarily conserved developmental pathways

Lateral inhibition - The Notch pathway

The Notch pathway functions in neurogenesis and other developmental pathways to assure that cell fate is restricted to a limited number of progenitors. Notch and Wingless pathways talk to each other through Dishevelled, which is an integral part of the Wingless pathway and physically interactions with the Notch carboxyl terminus.

Drosophila                  Homologs in other species
----------                  -------------------
Notch                       C. elegans: Glp-1 and Lin-12
                            Xenopus: Xnotch 
                            Chicken: C-Notch-1
                            Mammalian: Notch1 and Notch2

Delta                       C. elegans: Lag-2, Apx-1
                            Chicken: C-Delta-1
                            Mouse: Dll1 (delta-like gene 1)

Suppressor of hairless      Mammalian: CBF1 (JkappaRBP)

Deltex

Dishevelled                 Xenopus: Xdsh
                            Mammals: Dvl-1 and Dvl-2 

Numb                        Mammals: Numb

Enhancer of split           Mammalian: Hairy enhancer of split (HES-1)

Serrate                     Mammalian: C-Serrate-1

date revised: 13 Oct 96

Developmental Pathways conserved in Evolution

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