The Interactive Fly
Evolutionarily conserved developmental pathways
Forkhead is not required in Drosophila for the development of gut endoderm but instead for ectodermal gut derivatives. forkhead expression marks both the anterior and posterior gut primordia. Anterior derivatives include the foregut (pharynx and esophagus); the posterior derivative consists of the hindgut (proctodeum). In vertebrates there is a bewildering array of forkhead derivatives, many involved in mesoderm determination, and some expressed in anterior gut derivatives. The C. elegans Forkhead homolog, like Drosophila Forkhead, is expressed in ectodermal gut derivatives.
HNF-4 is required in Drosophila for gut formation. The vertebrate homolog plays a pivotal role in gut differentiation and expression of genes expressed in gut and other endodermal derivatives.
Serpent, the GATA homolog required for endodermal gut differentiation, is also required in mesoderm for hemocyte formation. This dual requirement is evolutionarily conserved. As many as six vertebrate GATA factors are involved in gut and/or erythrocyte determination and differentiation.
Drosophila Homologs in other species ---------- ---------------------------- Forkhead C. elegans: Ce-fkh-1 Xenopus: XFKH1/Pintallavis/XFD1 Mammalian: HNF-3 HNF-4 Xenopus: HNF-4 alpha and beta Mammalian: HNF-4 Serpent Xenopus: GATA-4, -5 and -6 Mammals: GATA-4, -5 and -6
date revised: 24 FEB 97
Developmental Pathways conserved in Evolution
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