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Evolutionarily conserved developmental pathways

Proneural pathway - Achaete-Scute homologs and interacting proteins

The proneural pathway is involved in fate determination of neuroblasts in central and peripheral nervous systems and cell fate determination in other tissues (Malpighian tubules, for example).

Drosophila                  Homologs in other species
----------                  -------------------
Achaete                     C. elegans: Lin-32
                            Zebrafish: Zash-1a and Zash-1b
                            Xenopus:  Xash-3, X-Neurogenin-related 1, NeuroD
                            Chicken: Cash-1
                            Mammals: Mash-1, Neurogenin, Math1 and Math2

Atonal                      Xenopus: ATH-3
                            Mammalian: ATH-3, MATH-4A


Araucan and Caupolican      Xenopus: Xiro1 and Xiro2


Daughterless                Zebrafish: HE12
                            Xenopus: Xe12 
                            Human: E2A (E12) and E2-2

Extra machrochaete          Mammalian: Id-1, Id-2, Id-3 and Id-4

date revised: 3 March 98

Developmental Pathways conserved in Evolution

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