Ras oncogene at 85D

REFERENCES (part 1/3)

Asha, H., et al. (2003). Analysis of Ras-induced overproliferation in Drosophila hemocytes. Genetics 163: 203-215. 12586708

Abdellatif, M., et al., (1998). A ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: implications for cardiac hypertrophy. Mol. Cell. Biol. 18(11): 6729-36.

Adams, A., et al. (2000). Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways. J. Biol Chem. 275: 27414-27420. 10851244

Albanese, C., et al. (1995). Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270: 23589-23597.

Ancrile, B., Lim, K. H. and Counter, C. M. (2007). Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 21(14): 1714-9. PubMed citation: 17639077

Arsenian, S., et al. (1998). Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J. 17(21): 6289-6299.

Artero, R. D., Castanon, I. and Baylies, M. K. (2001). The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling. Development 128: 4251-4264. 11684661

Artero, R., et al. (2003). Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis. Development 130: 6257-6272. 14602676

Asha, H., et al. (1999). The Rap1 GTPase functions as a regulator of morphogenesis in vivo. EMBO J. 18(3): 605-15.

Astigarraga, S., et al. (2007). A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J. 26(3): 668-77. Medline abstract: 17255944

Ayllon, V., et al. (2000). Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis. EMBO J. 19: 2237-2246.

Baonza, A., Roch, F. and Martin-Blanco, E. (2000). DER signaling restricts the boundaries of the wing field during Drosophila development. Proc. Natl. Acad. Sci. 97: 7331-7335.

Beiman, M., Shilo, B.-Z. and Volk, T. (1996). Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. Genes Dev. 10: 2993-3002

Belden, W. J., et al. (2007). The band mutation in Neurospora crassa is a dominant allele of ras-1 implicating RAS signaling in circadian output. Genes Dev. 21: 1494-1505. Medline abstract: 17575051

Bergmann, A., et al. (1998). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95(3): 331-41.

Boguski, M. S. and McCormick, F. (1993). Proteins regulating Ras and its relatives. Nature 366: 643-654

Bohmann, D., et al. (1994). Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell 78: 973-986.

Boriack-Sjodin, P. A., et al. (1998). The structural basis of the activation of Ras by Sos. Nature 394: 337-343.

Boube, M., et al. (1997). Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity. Genetics 146(2): 619-628.

Boyer, B., et al. (1997). Src and Ras are involved in separate pathways in epithelial cell scattering. EMBO J. 16(19): 5904-5913

Brambilla, R., et al. (1997). A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature 390(6657): 281-286.

Brock, H. W. (1987). Sequence and genomic structure of ras homologues Dmras85D and Dmras64B of Drosophila melanogaster. Gene 51 (2-3): 129-137

Brtva, T. R., et al. (1995). Two distinct Raf domains mediate interaction with Ras. J. Biol. Chem. 270: 9809-12.

Bruinsma, J. J., et al. (2002). Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling. Developmental Cell 2: 567-578. 12015965

Brumby, A. M. and Richardson, H. E. (2003). scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 22: 5769-5779. 14592975

Brückner, K., et al. (2004). The PDGF/VEGF receptor controls blood cell survival in Drosophila. Dev. Cell 7: 73-84. 15239955

Brunner, D., Ducker, K., Oellers, N., Hafen, E., Scholz, H. and Klambt, C. (1994). The ETS domain protein pointed-P2 is the target of MAP kinase in the sevenless signal transduction pathway. Nature 370: 386-9.

Busca, R., et al. (2000). Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes. EMBO J. 19: 2900-2910.

Byrne, J. L., Paterson, H. F. and Marshall, C. J. (1996). p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus. Oncogene 13 (10): 2055-2065

Cabernard, C. and Affolter, M. (2005). Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev. Cell 9(6): 831-42. 16326394

Cacace, A. M., et al. (1999). Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. Mol. Cell. Biol. 19(1): 229-40.

Caldwell, P.E., Walkiewicz, M., and Stern, M. (2005). Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release. Curr. Biol. 15: 1785-1795. Medline abstract: 16182526

Cardone, M. H., et al. (1998). Regulation of cell death protease caspase-9 by phosphorylation. Science 282(5392): 1318-21. 9812896

Carlier, M. F., et al. (2000). GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex. J. Biol. Chem. 275(29): 21946-52. 10781580

Carmena, A., et al. (2002). Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Dev. Biol. 244: 226-242. 11944933

Carter, B. D., Zirrgiebel, U and Barde, Y. A. (1995). Differential regulation of p21ras activation in neurons by nerve growth factor and brain-derived neurotrophic factor. J. Biol. Chem. 270: 21751-21757.

Casci, T., Vinos, J. and Freeman, M. (1999). Sprouty, an intracellular inhibitor of Ras signaling. Cell 96(5): 655-65.

Chang, C., Hopper, N. A. and Sternberg, P. W. (2000). Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals. EMBO J. 19: 3283-3294.

Chang, H. C., et al. (1995). phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell 80: 463-472

Chang, H. C. and Rubin, G. M. (1997). 14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila. Genes. Dev. 11: 1132-39

Chaudhary, A., et al. (2000). Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr. Biol. 10: 551-554.

Chen, F., Barkett, M., Ram, K. T., Quintanilla, A. and Hariharan, I. K. (1997). Biological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1. Proc. Natl. Acad. Sci. 94(23): 12485-12490.

Chen, H.-J., et al. (1998). A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron 895-904.

Cheng, A. M., et al. (1998). Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell 95(6): 793-803.

Chin, L., et al. (1997). Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev. 11(21): 2822-2834

Chin, L., et al. (1999). Essential role for oncogenic Ras in tumour maintenance. Nature 400(6743): 468-72.

Choy, E., et al. (1999). Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell 98: 69-80.

Church, D. L., Guan, K. L. and Lambie, E. J. (1995). Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans. Development 121: 2525-2535.

Clark, G. J., et al. (1996). Peptides containing a consensus Ras binding sequence from Raf-1 and the GTPase activating protein NF1 inhibit Ras function. Proc. Natl. Acad. Sci. 93: 1577-1581.

Clarke, N., et al. (1998). Epidermal growth factor induction of the c-jun promoter by a Rac pathway. Mol. Cell. Biol. 18(2): 1065-1073.

Corbalan-Garcia, S., et al. (1998). Regulation of Sos activity by intramolecular interactions. Mol. Cell. Biol. 18(2): 880-886.

Corbley, M. J. (1997). Transformation by ras suppresses expression of the neurotrophic growth factor pleiotrophin. J. Biol. Chem. 272(39): 24696-24702 .

Cosgaya, J. M., Latasa, M. J. and Pascual, A. (1996). Nerve growth factor and ras regulate beta-amyloid precursor protein gene expression in PC12 cells. J. Neurochem. 67: 98-104.

Cutler, R. E., et al. (1998). Autoregulation of the raf-1 serine/threonine kinase. Proc. Natl. Acad. Sci. 95(16): 9214-9219.

Daga, A., et al. (1996). Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1. Genes Dev. 10: 1194-1205.

Danen, E. H., et al. (2000). Dual stimulation of Ras/Mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression. J. Cell Biol. 151(7): 1413-1422. 11134071

Datta, S. R., et al. (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241.

Delmas, V., et al. (2007). β-catenin induces immortalization of melanocytes by suppressing p16^INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev. 21(22): 2923-35. PubMed citation: 18006687

Dent, P., et al. (1995). Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro. Mol. Cell. Biol. 15: 4125-4135.

de Rooij, J., et al. (1998). Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396(6710): 474-7.

Dhillon, A. S., et al. (2002). Regulation of Raf-1 activation and signalling by dephosphorylation. EMBO J. 21: 64-71. 11782426

Diaz-Benjumea, F. J. and Hafen, E. (1994). The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120: 569-78

Douziech, M., et al. (2003). Bimodal regulation of RAF by CNK in Drosophila. EMBO J. 22: 5068-5078. 14517245

Downward, J. (1994). The GRB2/Sem-5 adaptor protein. FEBS Lett. 338 (2): 113-117 (1994)

Drugan, J. K., et al. (1995). Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation. J. Biol. Chem. 271: 233-237.

Egan, S. E., et al. (1993). Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363 (6424): 45-51

Emerson, S. D., et al. (1995). Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface. Biochemistry 34: 6911-6918.

Fan, W. T., et al. (1998). The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Curr. Biol. 8(16): 935-8.

Farnsworth, C. L., et al. (1995). Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature 376: 524-527.

Feldmann P., et al. (1999). Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 ras-GTPase-activating protein. Mol. Cell. Biol. 19(3): 1928-37.

Fincham, V. J., Chudleigh, A. and Frame, M. C. (1999). Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation. J. Cell Sci. 112 ( Pt 6): 947-56.

Foschi, M., et al. (1997). Biphasic activation of p21(ras) by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase. EMBO J. 16(21): 6439-6451

Freeman, M. (1994). The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Mech. Dev. 48: 25-33

Freedman, T. S., et al. (2006). A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc. Natl. Acad. Sci 103: 16692-16697. Medline abstract: 17075039

Fritz, J. L. and VanBerkum, M. F. A. (2000). Calmodulin and Son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS. Development 127: 1991-2000

Fritz, J. L. and VanBerkum, M. F. A. (2002). Regulation of rho family GTPases is required to prevent axons from crossing the midline. Dev. Bio. 252: 46-58. 12453459

Gadbut, A. P., et al. (1997). Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for Ras in regulating the expression of muscarinic receptors and G proteins. EMBO J. 16(24): 7250-7260.

Gaengel, K. and Mlodzik, M. (2003). Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6. Development 130: 5413-5423. 14507782

Galaktionov, K., Jessus, c. and Beach, D. (1995). Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev. 9: 1046-1058

Gallio, M., et al. (2004). Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. Development 131: 3605-3614. 15229181

Gaul, U., Mardon, G. and Rubin, G. M. (1992). A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell 68(6): 1007-19.

Gayko, U., et al. (1999). Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase. Proc. Natl. Acad. Sci. 96(2): 523-8.

Gazin, C., Wajapeyee, N., Gobeil, S., Virbasius, C. M. and Green, M. R. (2007). An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449(7165): 1073-7. PubMed citation: 17960246

Gerald, D., et al. (2004). JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 118(6): 781-94. 15369676

Ghiglione, C., Perrimon, N. and Perkins, L. A. (1999). Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila. Dev. Biol. 205(1): 181-93.

Ghosh, S. and Bell, R. M. (1994). Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras. J. Biol. Chem. 269: 30785-30788.

Giese, K. P., et al. (2001). Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology 41: 791-800. 11640934

Giglione, C. and Parmeggiani, A. (1998). Raf-1 is involved in the regulation of the interaction between guanine nucleotide exchange factor and Ha-ras. Evidences for a function of Raf-1 and phosphatidylinositol 3-kinase upstream to Ras. J. Biol. Chem. 273(52): 34737-44.

Gille, H. and Downward, J. (1999). Multiple ras effector pathways contribute to G(1) cell cycle progression. J. Biol. Chem. 274(31): 22033-40.

Ginty, D. D., Bonni, A. and Greenberg, M. E. (1994). Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 77: 713-25

Goldstein, J. L., Glossip, D., Nayak, S. and Kornfeld, K. (2006), The CRAL/TRIO and GOLD domain protein CGR-1 promotes induction of vulval cell fates in Caenorhabditis elegans and interacts genetically with the Ras signaling pathway. Genetics 172(2): 929-42. 16219793

Golembo, M., Raz, E. and Shilo, B.-Z. (1996). The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Development 122: 3363-3370

Grammatikakis. N., et al. (1999). p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. Mol. Cell. Biol. 19(3): 1661-72.

Greenwood, S. and Struhl, G. (1997). Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos. Development 124(23): 4879-4886.

Greenwood, S. and Struhl, G. (1999). Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway. Development 126: 5795-5808

Gupta, S., et al. (2007). Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 129(5): 957-68. PubMed citation: 17540175

Hajnal, A., Whitfield, C. W. and Kim, S. K. (1997). Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase. Genes Dev. 11(20): 2715-2728.

Halachmi, N., et al. (1995). Rop and Ras2, members of the Sec1 and Ras families, are localized in the outer membranes of labyrinthine channels and vesicles of Drosophila nephrocyte, the garland cell. Eur. J. Cell Biol. 67: 275-283.

Halfar, K., et al. (2001). Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity. Development 128: 1687-1696. 11290305

Hamad, N. M., et al. (2002). Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev. 16: 2045-2057. 12183360

Hamlet, M. R. J. and Perkins, L. A. (2001). Analysis of Corkscrew signaling in the Drosophila Epidermal growth factor receptor pathway during myogenesis. Genetics 159: 1073-1087. 11729154

Hannan, F., et al. (2006). Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. Human Mol. Genet. 15(7): 1087-1098. 16513807

Hara, M., and Han, M. (1995). Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans. Proc. Natl. Acad. Sci. 92: 3333-3337.

Harden, N., et al. (1999). Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis. J. Cell Sci. 112: 273-84.

Hay, B. A., Maile, R. and Rubin, G. M. (1997). P element insertion-dependent gene activation in the Drosophila eye. Proc. Natl. Acad. Sci. 94(10): 5195-5200.

Hayashi, T. and Saigo, K. (2001). Diversification of cell types in the Drosophila eye by differential expression of prepattern genes. Mech. Dev. 108: 13-27. 11578858

He, H., et al. (1998). Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation. Mol. Cell. Biol. 18(7): 3829-3837.

Heberlein, U., Hariharan, I. K. and Rubin, G. M. (1993). Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Ras1. Dev. Biol. 160: 51-63

Held, L. I., Jr. (2002). Bristles induce bracts via the EGFR pathway on Drosophila legs. Mech. Dev. 117: 225-234. 12204262

Henkemeyer, M., et al. (1995). Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 377: 695-701.

Heo, W. D. and Meyer, T. (2003). Switch-of-function mutants based on morphology classification of ras superfamily small GTPases. Cell 113: 315-328. 12732140

Herbst, R., et al. (1996). Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during Sevenless signaling. Cell 85(6): 899-909.

Heumann, R., et al. (2000). Transgenic activation of Ras in neurons promotes hypertrophy and protects from lesion-induced degeneration. J. Cell Biol. 151: 1537-1548. 11134081

Hidalgo, H., et al. (2001). The Drosophila neuregulin Vein maintains glial survival during axon guidance in the CNS. Developmental Cell 1: 679-690. 11709188

Holgado-Madruga, M., et al. (1997). Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc. Natl. Acad. Sci. 94(23): 12419-12424.

Hou, X. S., et al. (1995). The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Cell 81 (1): 63-71

Howard, R. M. and Sundaram, M. V. (2002). C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component. Genes Dev. 16: 1815-1827. 12130541

Hsu, T., McRackan, D., Vincent, T. S. and de Couet, H. G. (2001). Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. Nature Cell Biol. 3: 538-543. 11389437

Hu, K-Q. and Settleman, J. (1997). Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. EMBO J. 16: 473-483

Huang, A. M. and Rubin, G. M. (2000). A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Genetics 156(3): 1219-30. 11063696

Igaki, T., et al. (2006). Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr. Biol. 16: 1139-1146. 16753569

Innocenti, M., et al. (2002). Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J. Cell Biol. 156: 125-136. Medline abstract: 11777939

Iritani, B. M., et al. (1997). Control of B cell development by Ras-mediated activation of Raf. EMBO J. 16(23): 7019-7031

Ishimaru, S., et al. (1999). Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1. EMBO J. 18: 145-155

Jaffe, A. B., Aspenstrom, P. and Hall, A. (2004). Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Mol. Cell Biol. 24(4): 1736-46. 14749388

James, K. E., Dorman, J. B. and Berg, C. A. (2002). Mosaic analyses reveal the function of Drosophila Ras in embryonic dorsoventral patterning and dorsal follicle cell morphogenesis. Development 129: 2209-2222. 11959829

Jazwinska, A., Ribeiro, C. and Affolter, M. (2003). Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Nat. Cell Biol. 5: 895-901. 12973360

Jiang, Y., et al. (1998). The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. Nature 395(6704): 808-13.

Jiao, H., et al. (1998). Arachidonic acid mediates angiotensin II effects on p21ras in renal proximal tubular cells via the tyrosine kinase-Shc-Grb2-Sos pathway. Proc. Natl. Acad. Sci. 95(13): 7417-7421.

Johnson, L., et al. (1997). K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11(19): 2468-2481.

Joneson T., et al. (1998). Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. J. Biol. Chem. 273(13): 7743-7748.

Kang, J. S. and Krauss, R. S. (1996). Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events. Mol. Cell. Biol. 16: 3370-3380.

Karim, F. and Rubin, G. (1998). Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development 125(1): 1-9

Karlovich, C. A., et al. (1995). In vivo functional analysis of the Ras exchange factor son of sevenless. Science 268 (5210): 576-579

Kawada, M., et al. (1997). Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 15(6): 629-637.

Kayne, P. S. and Sternberg, P. W. (1995). Ras pathways in Caenorhabditis elegans. Curr. Opin. Genet. Dev. 5: 38-43.

Kelly, P. A. and Rahmani, Z. (2005). DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. Mol. Biol. Cell 16(8): 3562-73. 15917294

Kikuchi, A. and Williams, L. T. (1996). Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase. J. Biol. Chem. 271: 588-594.

Kim, H. A., et al. (1995). Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes. Oncogene 11: 325-335.

Kim, J. H., et al. (1998). SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 20(4): 683-691.

Kim, M. J., et al. (2005). Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking. Neuron 46: 745-760. 15924861

Kishida, S., et al. (1997). Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator. Oncogene 15(24): 2899-907.

King, A. J., et al. (1998). The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 396(6707): 180-3.

Kinoshita, T., et al. (1997). Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells. Oncogene 15(6): 619-627.

Kockel, L., et al. (1997a). Requirement for Drosophila 14-3-3 eta in Raf-dependent photoreceptor development. Genes Dev. 11: 1140-47

Kockel, L., et al. (1997b). Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev. 11:1748-1758

Koera, K., et al. (1997). K-ras is essential for the development of the mouse embryo. Oncogene 15(10): 1151-1159.

Koh, Y.-H., Ruiz-Canada, C., Gorczyca, M. and Budnik, V. (2002). The Ras1-Mitogen-activated protein kinase signal transduction pathway regulates synaptic plasticity through Fasciclin II-mediated cell adhesion. J. Neurosci. 22(7): 2496-2504. 11923414

Kornfeld, K., Hom, D. B. and Horvitz, H. R. (1995). The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell 83: 903-913.

Kouhara, H., et al. (1997). A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89 (5): 693-702.

Kranenburg, O., et al. (1997). Gi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc. EMBO J. 16(11): 3097-3105.

Krapivinsky, G., et al. (2003). The NMDA receptor is coupled to the ERK Pathway by a direct interaction between NR2B and RasGRF1. Neuron 40: 775-784. 14622581

Kretzschmar, M., et al. (1999). A mechanism of repression of TGFbeta/Smad signaling by oncogenic Ras. Genes Dev. 13(7): 804-816.

Kundra, B., et al. (1995). The chemotactic response to PDGF-BB: evidence of a role for Ras. J. Cell Biol. 130: 725-731.

Kurada, P. and White, K. (1998). Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95(3): 319-29.

Kuriyama, M., et al. (1996). Identification of AF-6 and canoe as putative targets for Ras. J. Biol. Chem. 271(2): 607-610.

Kuo, W. L., Chung, K. C. and Rosner, M. R. (1997). Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src. Mol. Cell. Biol. 17: 4633-4643.

Kurzik-Dumke, U., Phannavong, B., Gundacker, D. and Gateff, E. (1992). Genetic, cytogenetic and developmental analysis of the Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (1(2)tid). Differentiation 51: 91-104. 1473626

Kurzik-Dumke, U., Gundacker, D., Renthrop, M. and Gateff, E. (1995). Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog. Dev. Genet. 16: 64-76. 7758246

Kussick, S. J., Basler, K. and Cooper, J. A. (1993). Ras1-dependent signaling by ectopically-expressed Drosophila src gene product in the embryo and developing eye. Oncogene 8 (10): 2791-2803

Continued Ras85 References: part 2/3 | part 3/3

Ras85D: Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Effects of Mutation

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