nanos

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Bhata, K. M. (1999). The posterior determinant Gene nanos Is required for the maintenance of the adult germline stem cells during Drosophila oogenesis. Genetics 151: 1479-1492.

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Curtis, D., Apfeld, J. and Lehmann, R. (1995). nanos is an evolutionarily conserved organizer of anterior-posterior polarity. Development 121: 1899-1910

Curtis, D., et al. (1997). A CCHC metal-binding domain in Nanos is essential for translational regulation. EMBO J. 16: 834-843

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Gavis, E. R. and Lehmann, R. (1994). Translational regulation of nanos by RNA localization. Nature 369: 315-8

Gavis, E. R., Curtis, D. and Lehmann, R. (1996a). Identification of cis-acting sequences that control nanos RNA localization. Dev. Biol. 176: 36-50

Gavis, E. R., et al. (1996b). A conserved 90 nucleotide element mediates translational repression of nanos RNA. Development 12: 2791-2800

Gavis, E. R., Chatterjee, S., Ford, N. R. and Wolff, L. J. (2008). Dispensability of nanos mRNA localization for abdominal patterning but not for germ cell development. Mech. Dev. 125(1-2): 81-90. PubMed citation: 18036786

Gilboa, L., and Lehmann, R. (2004). Repression of primordial germ cell differentiation parallels germ line stem cell maintenance. Curr. Biol. 14: 981-986. 15182671

Goldstrohm, A. C., Hook, B. A., Seay, D. J. and Wickens, M. (2006). PUF proteins bind Pop2p to regulate messenger RNAs. Nat. Struct. Mol. Biol. 13: 533-539. Medline abstract: 16715093

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Heller, A. and Steinmann-Zwicky, M. (1998). No premature gene expression in germ cells of embryos deriving from nos females. Mech. Dev. 72(1-2): 169-173.

Jeske, M., Meyer, S., Temme, C., Freudenreich, D. and Wahle, E. (2006). Rapid ATP-dependent deadenylation of nanos mRNA in a cell-free system from Drosophila embryos. J. Biol. Chem. 281: 25124-25133. Medline abstract: 16793774

Kadyrova, L. Y., Habara, Y., Lee, T. H. and Wharton, R. P. (2007). Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Development 134(8): 1519-27. Medline abstract: 17360772

Kalifa, Y., Huang, T., Rosen, L. N., Chatterjee, S. and Gavis, E. R. (2006). Glorund, a Drosophila hnRNP F/H homolog, is an ovarian repressor of nanos translation. Dev. Cell 10(3): 291-301. 16516833

Kang, D. Pilon, M. Weisblat, D. A. (2002). Maternal and zygotic expression of a nanos-class gene in the leech Helobdella robusta: Primordial germ cells arise from segmental mesoderm. Dev. Biol. 245: 28-41. 11969253

Keyes, L. N. and Spradling, A. C. (1997). The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes. Development 124: 1419-1431.

Kim-Ha, J., Kerr, K. and Macdonald, P. M. (1995). Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential. Cell 81: 403-412

Kobayashi, S., et al. (1996). Essential role of the posterior morphogen Nanos for germline development in Drosophila. Nature 380 (6576): 708-711.

Köprunner, M., et al. (2001). A zebrafish nanos-related gene is essential for the development of primordial germ cells. Genes Dev. 15: 2877-2885. 11691838

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Kraemer, B., et al. (1999). NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans. Curr. Biol. 9(18): 1009-1018.

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Lehmann, R. and Nusslein-Volhard, C. (1991). The pole plasm is required for germ cell formation and contains the determinant of posterior polarity, encoded by nanos. Development 112: 679-91

Lloyd, T. E., et al. (2002). Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108: 261-26. 11832215

MacArthur, H., et al. (1999). Xcat RNA is a translationally sequestered germ plasm component in Xenopus. Mec. Dev. 84 (1-2): 75-88.

Markesich, D. C., et al. (2000). bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery. Development 127: 559-572. 10631177

Mochizuki, K., et al. (2000). Expression and evolutionary conservation of nanos-related genes in Hydra. Dev. Genes Evol. 210: 591-602. 21025766

Morris, J. Z., Hong, A., Lilly, M. A. and Lehmann, R. (2005). twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesis. Development 132(6): 1165-74. Medline abstract: 15703281

Mosquere, L., et al. (1993). An mRNA localized to the vegetal cortex of Xenopus oöcytes encodes a protein with a nanos-like zinc finger. Development 117: 377-386

Murata, Y. and Wharton, R. P. (1995). Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos. Cell 80: 747-756

Nakahata, S., et al. (2001). Biochemical identification of Xenopus Pumilio as a sequence-specific Cyclin B1 mRNA-binding protein that physically interacts with a Nanos homolog, Xcat-2, and a cytoplasmic polyadenylation element-binding protein. J. Biol. Chem. 276: 20945-20953. 11283000

Pelegri, F. and Lehmann, R. (1994) A role of Polycomb group genes in the regulation of Gap gene expression in Drosophila.. Genetics 136:1341-1353.

Pilon, M. and Weisblat, D. A. (1997). A nanos homolog in leech. Development 124: 1771-1780.

Rittenhouse, K. R. and Berg, C. A. (1995). Mutations in the Drosophila gene bullwinkle cause the formation of abnormal eggshell structures and bicaudal embryos. Development 121: 3023-3033

Rivera-Pomar, R., et al. (1995). Activation of posterior gap gene expression in the Drosophila blastoderm. Nature 376: 253-256

Saget, O., et al. (1998). Needs and targets for the multi sex combs gene product in Drosophila melanogaster. Genetics 149(4): 1823-1838.

Salles, F. J., et al. (1994). Coordinate initiation of Drosophila development by regulated polyadenylation of maternal messenger RNAs. Science 266: 1996-1999

Schaner, C. E., et al. (2003). A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies. Dev. Cell 5: 747-757. 14602075

Semotok, J. L., et al. (2005). Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo. Curr. Biol. 15(4): 284-94. Medline abstract: 15723788

Smibert, C. A., et al. (1996). Smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo. Genes Dev. 10: 2600-2609

Smibert, C. A., et al. (1999). Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro. RNA 5(12): 1535-47. Medline abstract: 10606265

Smith, J. L., Wilson, J. E. and Macdonald, P. M. (1992). Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos. Cell 70: 849-59

Sonoda, J. and Wharton, R. P. (1999). Recruitment of Nanos to hunchback mRNA by Pumilio. Genes Dev. 13: 2704-2712.

Sonoda, J. and Wharton, R. P. (2001). Drosophila Brain tumor is a translational repressor. Genes Dev. 15(6): 762-73. 11274060

Subramaniam, K. and Seydoux, G. (1999). nos-1and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans. Development 126: 4861-4871.

Suzanne, M., et al. (1999). The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development. Genes Dev. 13: 1464-1474.

Suzuki, A., Tsuda, M. and Saga, Y. (2007). Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development. Development 134(1): 77-83. 17138666

Temme, C., Zaessinger, S., Meyer, S., Simonelig, M. and Wahle, E. (2004). A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila. EMBO J. 23(14): 2862-71. Medline abstract: 15215893

Verrotti, A. C. and Wharton, R. P. (2000). Nanos interacts with Cup in the female germline of Drosophila. Development 127: 5225-5232.

Wang, C. and Lehmann, R. (1991). nanos is the localized posterior determinant of Drosophila. Cell 66: 637-647

Wang, C., Dickinson, L. K. and Lehmann, R. (1994). Genetics of nanos localization in Drosophila. Dev. Dyn. 199: 103-15

Wawersik, M. and Van Doren, M. (2005). nanos is required for formation of the spectrosome, a germ cell-specific organelle. Dev. Dyn. 234: 22-27. Medline abstract: 16028275

Wharton, R. P. and Struhl, G. (1989). Structure of the Drosophila BicaudalD protein and its role in localizing the the posterior determinant nanos. Cell 59: 881-92

Wharton, R. P. and Struhl, G. (1991). RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos. Cell 67: 955-67

Wreden, C., et al. (1997). Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA. Development 124(15): 3015-3023.

Ye, B., et al. (2004). nanos and pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr. Biol. 14: 314-321. 14972682

Zaessinger, S., Busseau, I. and Simonelig, M. (2006). Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4. Development 133(22): 4573-83. Medline abstract: 17050620

Zhang, B., et al. (1997). A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature 390: 477-484.

date revised: 2 June 2007

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