nanos

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Bhata, K. M. (1999). The posterior determinant Gene nanos Is required for the maintenance of the adult germline stem cells during Drosophila oogenesis. Genetics 151: 1479-1492. PubMed Citation: 10101171

Brechbiel, J. L. and Gavis, E. R. (2008). Spatial regulation of nanos is required for its function in dendrite morphogenesis. Curr. Biol. 18(10): 745-50. PubMed Citation: 18472422

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Chagnovich, D. and Lehmann, R. (2001). Poly(A)-independent regulation of maternal hunchback translation in the Drosophila embryo Proc. Natl. Acad. Sci. 98: 11359-11364. 11562474

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Clark, I. E., Wyckoff, D. and Gavis, E. R. (2000). Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanism. Curr. Biol. 10: 1311-1314. 11069116

Clark, I. E., et al. (2002). A common translational control mechanism functions in axial patterning and neuroendocrine signaling in Drosophila. Development 129: 3325-3334. 12091303

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Crucs, S., Chatterjee, S. and Gavis, E. R. (2000). Overlapping but distinct RNA elements control repression and activation of nanos translation. Molec. Cell 5: 457-467. 10882131

Curtis, D., Apfeld, J. and Lehmann, R. (1995). nanos is an evolutionarily conserved organizer of anterior-posterior polarity. Development 121: 1899-1910. PubMed Citation: 7601003

Curtis, D., et al. (1997). A CCHC metal-binding domain in Nanos is essential for translational regulation. EMBO J. 16: 834-843

Dahanukar, A. and Wharton, R. P. (1996). The Nanos gradient in Drosophila embryos is generated by translational regulation. Genes Dev. 10: 2610-20. PubMed Citation: 9049312

Dahanukar, A., Walker, J. A. and Wharton, R. P. (1999). Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila. Mol. Cell 4: 209-218. PubMed Citation: 10488336

Deshpande, G., et al. (1999). Novel functions of nanos in downregulating mitosis and transcription during the development of the Drosophila germline. Cell 99: 271-281. PubMed Citation: 10555143

Deshpande, G., et al. (2005). Nanos downregulates transcription and modulates CTD phosphorylation in the soma of early Drosophila embryos. Mech. Dev. 122(5): 645-57. 15817222

Ding, D., et al. (1993). Dynamic Hsp83 RNA localization during Drosophila oogenesis and embryogenesis. Mol. Cell Biol. 13: 3773-81. PubMed Citation: 7684502

Edwards, T. A., et al. (2001). Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Cell 105: 281-289. 11336677

Forbes, A. and Lehmann, R. (1998). Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells. Development 125(4): 679-690. PubMed Citation: 9435288

Forrest, K. M., Clark, I. E., Jain, R. A. and Gavis, E. R. (2004). Temporal complexity within a translational control element in the nanos mRNA. Development 131: 5849-5857. 15525666

Forristall, C., et al. (1995). Patterns of localization and cytoskeletal association of two vegetally localized RNAs, Vg1 and Xcat-2. Development 121: 201-208

Gamberi, C., Peterson, D. S., He, L. and Gottlieb, E. (2002). An anterior function for the Drosophila posterior determinant Pumilio. Development 129: 2699-2710. 12015297

Gavis, E. R. and Lehmann, R. (1992). Localization of nanos RNA controls embryonic polarity. Cell 71: 301-313. PubMed Citation: 1423595

Gavis, E. R. and Lehmann, R. (1994). Translational regulation of nanos by RNA localization. Nature 369: 315-8. PubMed Citation: 7514276

Gavis, E. R., Curtis, D. and Lehmann, R. (1996a). Identification of cis-acting sequences that control nanos RNA localization. Dev. Biol. 176: 36-50. PubMed Citation: 8654893

Gavis, E. R., et al. (1996b). A conserved 90 nucleotide element mediates translational repression of nanos RNA. Development 12: 2791-2800. PubMed Citation: 8787753

Gavis, E. R., Chatterjee, S., Ford, N. R. and Wolff, L. J. (2008). Dispensability of nanos mRNA localization for abdominal patterning but not for germ cell development. Mech. Dev. 125(1-2): 81-90. PubMed citation: 18036786

Gerber, A. P., et al. (2006). Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster. Proc. Natl. Acad. Sci. 103: 4487-4492. PubMed Citation: 16537387

Gilboa, L., and Lehmann, R. (2004). Repression of primordial germ cell differentiation parallels germ line stem cell maintenance. Curr. Biol. 14: 981-986. 15182671

Goldstrohm, A. C., Hook, B. A., Seay, D. J. and Wickens, M. (2006). PUF proteins bind Pop2p to regulate messenger RNAs. Nat. Struct. Mol. Biol. 13: 533-539. Medline abstract: 16715093

Hansen, D., et al. (2004). Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation. Development 131: 93-104. 15063172

Heller, A. and Steinmann-Zwicky, M. (1998). No premature gene expression in germ cells of embryos deriving from nos females. Mech. Dev. 72(1-2): 169-173. PubMed Citation: 9533961

Jain, R. and Gavis, E. R. (2008). The Drosophila hnRNP M homolog, Rumpelstiltskin, regulates nanos mRNA localization, Development 135: 973-982. PubMed Citation: 18234721

Jeske, M., Meyer, S., Temme, C., Freudenreich, D. and Wahle, E. (2006). Rapid ATP-dependent deadenylation of nanos mRNA in a cell-free system from Drosophila embryos. J. Biol. Chem. 281: 25124-25133. Medline abstract: 16793774

Kadyrova, L. Y., Habara, Y., Lee, T. H. and Wharton, R. P. (2007). Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Development 134(8): 1519-27. Medline abstract: 17360772

Kalifa, Y., Huang, T., Rosen, L. N., Chatterjee, S. and Gavis, E. R. (2006). Glorund, a Drosophila hnRNP F/H homolog, is an ovarian repressor of nanos translation. Dev. Cell 10(3): 291-301. 16516833

Kang, D. Pilon, M. Weisblat, D. A. (2002). Maternal and zygotic expression of a nanos-class gene in the leech Helobdella robusta: Primordial germ cells arise from segmental mesoderm. Dev. Biol. 245: 28-41. 11969253

Keyes, L. N. and Spradling, A. C. (1997). The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes. Development 124: 1419-1431. PubMed Citation: 9118812

Kim-Ha, J., Kerr, K. and Macdonald, P. M. (1995). Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential. Cell 81: 403-412. PubMed Citation: 7736592

Kobayashi, S., et al. (1996). Essential role of the posterior morphogen Nanos for germline development in Drosophila. Nature 380 (6576): 708-711. PubMed Citation: 8614464

Köprunner, M., et al. (2001). A zebrafish nanos-related gene is essential for the development of primordial germ cells. Genes Dev. 15: 2877-2885. 11691838

Kraut, R. and Levine, M. (1991). Spatial regulation of the gap gene giant during Drosophila development. Development 111: 601-9. PubMed Citation: 1893877

Kraemer, B., et al. (1999). NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans. Curr. Biol. 9(18): 1009-1018. PubMed Citation: 10508609

Lall, S., Ludwig, M. Z. and Patel, N. H. (2003). Nanos plays a conserved role in axial patterning outside of the Diptera. Curr. Biol. 13: 224-229. 12573218

Lehmann, R. (1988). Phenotypic comparison between maternal and zygotic genes controlling the segmentation pattern of the Drosophila embryo. Development 104 Supplement: 17-27

Lehmann, R. and Nusslein-Volhard, C. (1991). The pole plasm is required for germ cell formation and contains the determinant of posterior polarity, encoded by nanos. Development 112: 679-91. PubMed Citation: 1935684

Lerit, D. A. and Gavis, E. R. (2011). Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. Curr. Biol. 21(6): 439-48. PubMed Citation: 21376599

Lloyd, T. E., et al. (2002). Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108: 261-26. 11832215

MacArthur, H., et al. (1999). Xcat RNA is a translationally sequestered germ plasm component in Xenopus. Mech. Dev. 84 (1-2): 75-88. PubMed Citation: 10473122

Markesich, D. C., et al. (2000). bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery. Development 127: 559-572. 10631177

MacLean, J. N., Zhang, Y., Johnson, B. R. and Harris-Warrick, R. M. (2003). Activity-independent homeostasis in rhythmically active neurons. Neuron 37: 109-120. PubMed Citation: 12526777

Mee, C. J,, Pym, E. C., Moffat, K. G. and Baines, R. A. (2004). Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene. J. Neurosci. 24: 8695-8703. PubMed Citation: 15470135

Mochizuki, K., et al. (2000). Expression and evolutionary conservation of nanos-related genes in Hydra. Dev. Genes Evol. 210: 591-602. 21025766

Morris, J. Z., Hong, A., Lilly, M. A. and Lehmann, R. (2005). twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesis. Development 132(6): 1165-74. Medline abstract: 15703281

Mosquere, L., et al. (1993). An mRNA localized to the vegetal cortex of Xenopus oöcytes encodes a protein with a nanos-like zinc finger. Development 117: 377-386. PubMed Citation: 8223259

Muraro, N. I., et al. (2008). Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons. J. Neurosci. 28(9): 2099-109. PubMed Citation: 18305244

Murata, Y. and Wharton, R. P. (1995). Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos. Cell 80: 747-756. PubMed Citation: 7889568

Nakahata, S., et al. (2001). Biochemical identification of Xenopus Pumilio as a sequence-specific Cyclin B1 mRNA-binding protein that physically interacts with a Nanos homolog, Xcat-2, and a cytoplasmic polyadenylation element-binding protein. J. Biol. Chem. 276: 20945-20953. 11283000

Pacquelet, A., Zanin, E., Ashiono, C. and Gotta, M. (2007). PAR-6 levels are regulated by NOS-3 in a CUL-2 dependent manner in Caenorhabditis elegans. Dev. Biol. 319(2): 267-72. PubMed Citation: 18502413

Pelegri, F. and Lehmann, R. (1994) A role of Polycomb group genes in the regulation of Gap gene expression in Drosophila. Genetics 136: 1341-1353. PubMed Citation: 8013911

Pilon, M. and Weisblat, D. A. (1997). A nanos homolog in leech. Development 124: 1771-1780. PubMed Citation: 9165124

Rabinowitz, J. S., et al. (2008). Nanos is required in somatic blast cell lineages in the posterior of a mollusk embryo. Curr. Biol. 18: 331-336. PubMed Citation: 18308570

Rittenhouse, K. R. and Berg, C. A. (1995). Mutations in the Drosophila gene bullwinkle cause the formation of abnormal eggshell structures and bicaudal embryos. Development 121: 3023-3033. PubMed Citation: 7555728

Rivera-Pomar, R., et al. (1995). Activation of posterior gap gene expression in the Drosophila blastoderm. Nature 376: 253-256. PubMed Citation: 7617036

Rouget, C., et al. (2010). Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature 467(7319): 1128-32. PubMed Citation: 20953170

Saget, O., et al. (1998). Needs and targets for the multi sex combs gene product in Drosophila melanogaster. Genetics 149(4): 1823-1838. PubMed Citation: 9691040

Salles, F. J., et al. (1994). Coordinate initiation of Drosophila development by regulated polyadenylation of maternal messenger RNAs. Science 266: 1996-1999. PubMed Citation: 7801127

Schaner, C. E., et al. (2003). A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies. Dev. Cell 5: 747-757. 14602075

Semotok, J. L., et al. (2005). Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo. Curr. Biol. 15(4): 284-94. Medline abstract: 15723788

Smibert, C. A., et al. (1996). Smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo. Genes Dev. 10: 2600-2609. PubMed Citation: 8895661

Smibert, C. A., et al. (1999). Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro. RNA 5(12): 1535-47. Medline abstract: 10606265

Smith, J. L., Wilson, J. E. and Macdonald, P. M. (1992). Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos. Cell 70: 849-59. PubMed Citation: 1516136

Sonoda, J. and Wharton, R. P. (1999). Recruitment of Nanos to hunchback mRNA by Pumilio. Genes Dev. 13: 2704-2712. PubMed Citation: 10541556

Sonoda, J. and Wharton, R. P. (2001). Drosophila Brain tumor is a translational repressor. Genes Dev. 15(6): 762-73. 11274060

Subramaniam, K. and Seydoux, G. (1999). nos-1and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans. Development 126: 4861-4871. PubMed Citation: 10518502

Suzanne, M., et al. (1999). The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development. Genes Dev. 13: 1464-1474. PubMed Citation: 10364162

Suzuki, A., Tsuda, M. and Saga, Y. (2007). Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development. Development 134(1): 77-83. 17138666

Temme, C., Zaessinger, S., Meyer, S., Simonelig, M. and Wahle, E. (2004). A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila. EMBO J. 23(14): 2862-71. Medline abstract: 15215893

Verrotti, A. C. and Wharton, R. P. (2000). Nanos interacts with Cup in the female germline of Drosophila. Development 127: 5225-5232. PubMed Citation: 11060247

Wang, C. and Lehmann, R. (1991). nanos is the localized posterior determinant of Drosophila. Cell 66: 637-647. PubMed Citation: 1908748

Wang, C., Dickinson, L. K. and Lehmann, R. (1994). Genetics of nanos localization in Drosophila. Dev. Dyn. 199: 103-15. PubMed Citation: 7515724

Wawersik, M. and Van Doren, M. (2005). nanos is required for formation of the spectrosome, a germ cell-specific organelle. Dev. Dyn. 234: 22-27. Medline abstract: 16028275

Wharton, R. P. and Struhl, G. (1989). Structure of the Drosophila BicaudalD protein and its role in localizing the the posterior determinant nanos. Cell 59: 881-92. PubMed Citation: 2590944

Wharton, R. P. and Struhl, G. (1991). RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos. Cell 67: 955-67. PubMed Citation: 1720354

Wreden, C., et al. (1997). Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA. Development 124(15): 3015-3023. PubMed Citation: 9247343

Ye, B., et al. (2004). nanos and pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr. Biol. 14: 314-321. 14972682

Zaessinger, S., Busseau, I. and Simonelig, M. (2006). Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4. Development 133(22): 4573-83. Medline abstract: 17050620

Zhang, B., et al. (1997). A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature 390: 477-484. PubMed Citation: 9393998

date revised: 15 June 2011

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