Medea

Reference names in red indicate recommended papers.

Abdollah, S., et al. (1997). TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem. 272: 27678-27685.

Abe, T., et al. (2005). Notch signaling modulates the nuclear localization of carboxy-terminal-phosphorylated smad2 and controls the competence of ectodermal cells for activin A. Mech. Dev. 122: 671-680. 15817224

Atfi, A., et al. (1997). Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein Kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. J. Biol. Chem. 272(40): 24731-24734.

Baird, S. E. and Ellazar, S. A. (1999). TGFbeta-like signaling and spicule development in Caenorhabditis elegans. Dev. Biol. 212(1): 93-100.

Brummel, T., et al. (1999). The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 13(1): 98-111.

Candia, A. F., et al. (1997). Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development 124(22): 4467-4480.

Chen, D. and McKearin, D. (2003). Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells. Curr. Biol. 13: 1786-1791. 14561403

Chen, W., et al. (2007). Competition between Ski and CBP for binding to Smads in TGF-β signaling. J. Biol. Chem. 282(15): 11365-76. Medline abstract: 17283070

Chen, X., Rubock, M. J. and Whitman, M. (1996). A transcriptional partner for MAD proteins in TGF-ß signalling. Nature 383: 691-696

Chen, X., et al. (1997). Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389: 85-89.

Chen, Y. G., et al. (1998). Determinants of specificity in TGF-beta signal transduction. Genes Dev. 12(14): 2144-2152.

da Graca, L. S., et al. (2004). DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGFß pathway to regulate C. elegans dauer development. Development 131: 435-446. 14681186

Das, P., et al. (1998). The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling. Development 125: 1519-1528.

Das, P., et al. (1999). Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals. Genes to Cells 4: 123-134.

Datta, P. K., Blake, M. C. and Moses, H. L. (2000). Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1. J. Biol. Chem. 275(51): 40014-9. 11054406

de Caestecker, M. P., et al. (1997). Characterization of functional domains within Smad4/DPC4. J. Biol. Chem. 272 (21): 13690-13696.

del Alamo Rodriguez, D., Terriente Felix, J., Diaz-Benjumea, F. J. (2004). The role of the T-box gene optomotor-blind in patterning the Drosophila wing. Dev. Biol. 268(2): 481-92. 15063183

Dong, C., et al. (2000). Microtubule binding to Smads may regulate TGFbeta activity. Molec. Cell 5: 27-34.

Feng, X. H., et al. (1998). The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev. 12(14): 2153-2163.

Feng, X.-H., Lin, X. and Derynck, R. (2000). Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-beta. EMBO J. 19: 5178-5193

Galant, R. and Carroll, S. B. (2002). Evolution of a transcriptional repression domain in an insect Hox protein. Nature 415: 910-913. PubMed citation: 11859369

Gao, S., Steffen, J. and Laughon, A. (2005). DPP-responsive silencers are bound by a trimeric mad-medea complex. J. Biol. Chem. 280(43): 36158-64. 16109720

Gao, S. and Laughon, A. (2006). Decapentaplegic-responsive silencers contain overlapping mad-binding sites. J. Biol. Chem. 281(35): 25781-90. 16829514

Hahn, S. A., et al. (1996). DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353

Hata, A., et al. (1997). Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388(6637): 82-87.

Hata, A., et al. (1998). Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor Genes Dev. 12: 186-197

Henderson, K. D., Isaac, D. D. and Andrew, D. J. (1999). Cell fate specification in the Drosophila salivary gland: the integration of homeotic gene function with the DPP signaling cascade. Dev. Biol. 205(1): 10-21.

Hodge, L. K., et al. (2007). Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron 55(4): 572-86. PubMed citation: 17698011

Howe, J. R., et al. (1998). Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 280(5366): 1086-1088.

Howell, M., et al. (1999). Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes. Dev. Biol. 214(2): 354-69.

Howell, M., Inman, G. J. and Hill, C. S. (2002). A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements. Development 129: 2823-2834. 12050132

Hua, X., et al. (1998). Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev. 12(19): 3084-95.

Hudson, J. B., et al. (1998). The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4. Development 125: 1407-1420. 9502722

Hullinger, T. G., et al. (2001). TGFbeta and BMP-2 activation of the OPN promoter: roles of smad- and hox-binding elements. Exp. Cell Res. 262(1): 69-74. 11120606

Inman, G. J., Nicolas, F. J. and Hill, C. S. (2002). Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-ß receptor activity. Molec. Cell 10: 283-294. 12191474

Inoue, H., et al. (1998). Interplay of signal mediators of Decapentaplegic (Dpp): Molecular characterization of Mothers against dpp, Medea, and Daughters against dpp. Mol. Biol. Cell 9(8): 2145-2156.

Ito, Y., et al. (2001). Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-ß-mediated epidermal homeostasis. Dev. Bio. 236: 181-194. 11456453

Janknecht, R., Wells, N. J. and Hunter, T. (1998). TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 12(14): 2114-2119.

Ji, Y.-J., et al. (2004). RNT-1, the C. elegans homologue of mammalian RUNX transcription factors, regulates body size and male tail development. Dev. Biol. 274: 402-412. 15385167

Johnson, A. N., Bergman, C. M., Kreitman, M. and Newfeld, S. J. (2003). Embryonic enhancers in the dpp disk region regulate a second round of Dpp signaling from the dorsal ectoderm to the mesoderm that represses Zfh-1 expression in a subset of pericardial cells. Dev. Biol. 262: 137-151. 14512024

Kawabata, M., et al. (1998). Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J. 17(14): 4056-4065.

Kim, R. H., et al. (2000). A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-ß signal transduction. Genes Dev. 14: 1605-1616.

Kirilly, D., Spana, E. P., Perrimon, N., Padgett, R. W. and Xie, T. (2005). BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.Dev. Cell 9(5): 651-62. 16256740

Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C.A., and Ghosh, S. 1999. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Dev. 13: 2059-2071. 10465784

Kretzschmar, M., et al. (1997). The TGF-ß family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11: 984-995

Kurisaki, K., et al. (2003). Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation. Mol. Cell. Biol. 23(13): 4494-510. 12808092

Labbe, E., et al. (1998). Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell (1): 109-20.

Lagna, G., et al. (1996). Partnership between DPC4 and SMAD proteins in TGF-ß signaling pathways. Nature 383: 832-836

LeSueur, J. A. and Graff, J. M. (1999). Spemann organizer activity of Smad10. Development 126(1): 137-146.

LeSueur, J. A., et al. (2002). Smad10 is required for formation of the frog nervous system. Dev. Cell 2: 771-783. 12062089

Li, W., et al. (2003). Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice. Development 130: 6143-6153. 14597578

Lien, C. L., et al. (2002). Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site. Dev. Biol. 244: 257-266. 11944935

Liberati, N. T., et al. (1999). Smads bind directly to the jun family of AP-1 transcription factors. Proc. Natl. Acad. Sci. 96(9): 4844-9.

Liberatore, C. M., et al. (2002). Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region. Dev. Biol. 244: 243-256. 11944934

Liu, F., Pouponnot, C. and Massague, J. (1997). Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11(23): 3157-3167.

Luo, K., et al. (1999). The Ski oncoprotein interacts with the Smad proteins to repress TGF signaling. Genes Dev. 17: 2196-2206.

Marquez, R. M., et al. (2001). Transgenic analysis of the Smad family of TGF-ß signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157: 1639-1648. 11290719

McCabe, B. D., et al. (2004). Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41(6): 891-905. 15046722

Müller, B., et al. (2003). Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell 113: 221-233. 12705870

Muzzopappa, M. and Wappner, P. (2005). Multiple roles of the F-box protein Slimb in Drosophila egg chamber development. Development 132: 2561-2571. 15857915

Nakao, A, et al. (1997). TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16(17): 5353-5362

Nguyen, H. T. and Xu, X. (1998). Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules. Dev. Biol. 204(2): 550-66.

Nishimura, R., et al. (1998). Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J. Biol. Chem. 273(4): 1872-9.

Patterson, G. I., et al. (1997). The DAF-3 smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 11(20): 2679-2690.

Pyrowolakis, G., et al. (2004). A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev. Cell 7: 229-240. 15296719

Raftery, L. A., Twombly, V., Wharton, K., and Gelbart, W. M. (1995). Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139: 241-254.

Raftery, L.A. and Sutherland, D. J. (1999). TGF-beta family signal transduction in Drosophila development: from Mad to Smads. Dev. Biol. 210(2): 251-68.

Rawson, J. M., Lee, M., Kennedy, E. L. and Selleck, S. B. (2003). Drosophila neuromuscular synapse assembly and function require the TGF-beta type I receptor saxophone and the transcription factor Mad. J. Neurobiol. 55: 134-150. 12672013

Reddien, P. W., Bermange, A. L., Kicza, A. M. and S·nchez Alvarado, A. (2007). BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development 134(22): 4043-51. Medline abstract: 17942485

Savage, C., et al. (1996). Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components. Proc. Natl. Acad. Sci. 93: 790-794

Sekelsky, J. J., et al. (1995). Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139: 1347-1358

Shen, J. and Dahmann, C. (2005). The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev. Biol. 279(1): 31-43. 15708556

Shi, Y., et al. (1997). A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388(6637): 87-93.

Shioda, T., et al. (1998). Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator. Proc. Natl. Acad. Sci. 95(17): 9785-90.

Sirard, C., et al., (1998). The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12(1): 107-119.

Song, X., et al. (2004). Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development 131(6): 1353-64. 14973291

Sotillos, S. and de Celis, J. F. (2006). Regulation of decapentaplegic expression during Drosophila wing veins pupal development. Mech. Dev. 123(3): 241-51. 16423512

Souchelnytskyi, S., et al. (1997). Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J. Biol. Chem. 272: 28107-28115

Sutherland, D. J., et al. (2003). Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo. Development 130: 5705-5716. 14534137

Suzuki, A., et al. (1997). Smad5 induces ventral fates in Xenopus embryo. Dev. Biol. 184 (2): 402-405.

Takaesu, N. T., et al. (2002). Combinatorial signaling by an unconventional Wg pathway and the Dpp pathway requires Nejire (CBP/p300) to regulate dpp expression in posterior tracheal branches. Dev. Biol. 247: 225-236. 12086463

Takaesu, N. T., Herbig, E., Zhitomersky, D., O'Connor, M. B. and Newfeld, S. J. (2005). DNA-binding domain mutations in SMAD genes yield dominant-negative proteins or a neomorphic protein that can activate WG target genes in Drosophila. Development 132(21): 4883-94. 16192307

Takaesu, N. T., et al. (2006). dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2. Genetics 174(3): 1299-313. Medline abstract: 16951053

Takaku, K., et al. (1998). Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92(5): 645-656.

Takeda, M., et al. (2004). Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. Mol. Biol. Cell 15(3): 963-72. Medline abstract: 14699069

Thatcher, J. D., Haun, C. and Okkema, P. G. (1999). The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development 126(1): 97-107.

Topper, J. N., et al. (1998). CREB binding protein is a required coactivator for smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. 95(16): 9506-9511.

Tropepe, V., et al. (2001). Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 30: 65-78. 11343645

Vindevoghel, L., et al. (1998). SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta. Proc. Natl. Acad. Sci. 95(25): 14769-74.

Walsh, C. M. and Carroll, S. B. (2007). Collaboration between Smads and a Hox protein in target gene repression. Development 134(20): 3585-92. PubMed citation: 17855427

Wang, J. Mohler, W. A. and Savage-Dunn, C. (2005). C-terminal mutants of C. elegans Smads reveal tissue-specific requirements for protein activation by TGF-ß signaling. Development 132: 3505-3513. 16000380

Wharton, S. J., Basu, S. P. and Ashe, H. L. (2004). Smad affinity can direct distinct readouts of the embryonic extracellular Dpp gradient in Drosophila. Curr. Biol. 14: 1550-1558. 15341741

Watanabe, M. and Whitman, M. (1999). FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo. Development 126: 5621-5634.

Wisotzkey, R. G., et al. (1998). Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125: 1433-1445. 9502724

Wong, C., et al. (1999). Smad3-smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. Mol. Cell. Biol. 19(3): 1821-30.

Wu, J., et al. (2002). Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGFβ signaling. Cell 111: 357-367. Medline abstract: 12419246

Wu, K.. et al. (2003). DACH1 inhibits TGF-beta signaling through binding Smad4. J. Biol. Chem. 278: 51673-51684. 14525983

Wu, R.-Y., et al. (1997). Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17: 2521-28.

Xiao, C., et al. (2003). Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 17: 2933-2949. 14633973

Xu, X., et al. (1998). Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 12(15): 2354-2370.

Yang, X., et al. (1998). The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc. Natl. Acad. Sci. 95(7): 3667-3672.

Yingling, J. M., et al. (1997). Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. Mol. Cell. Biol. 17(12): 7019-7028.

Zhang, Y., (1996). Receptor-associated MAD homologues synergize as effectors of the TGF-ß response. Nature 383: 168-172

Zhang, Y., Feng, X. H. and Derynck, R. (1998). Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394: 909-913.

Yoshida, S., et al. (2005). DPP signaling controls development of the lamina glia required for retinal axon targeting in the visual system of Drosophila. Development 132(20): 4587-98. 16176948

date revised: 15 April 2008 

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