EGF receptor
Alvarado, D., Rice, A. H. and Duffy, J. B. (2004a). Knockouts of Kekkon1 define sequence elements essential for Drosophila Epidermal growth factor receptor inhibition. Genetics 166: 201-211. 15020418
Alvarado, D., Rice, A. H. and Duffy, J. B. (2004b).
Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1.
Genetics. 2004 May;167(1):187-202. 15166146
Alvarado, D., Klein, D. E. and Lemmon, M. A. (2009). ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature 461(7261): 287-91. PubMed Citation: 19718021
Amin, A., Li, Y. and Finkelstein, R. (1999). Hedgehog activates the EGF receptor pathway during Drosophila head development. Development 126(12): 2623-2630. 10331974
Anton, E. S., et al. (2004). Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat. Neurosci. 7(12): 1319-28. 15543145
Astigarraga, S., et al. (2007). A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling.
EMBO J. 26(3): 668-77. Medline abstract: 17255944
Atit, R., Conlon, R. A. and Niswander, L. (2003). EGF signaling patterns the feather array by promoting the interbud fate. Dev. Cell 4: 231-240. 12586066
Bai, J., Chiu, W., Wang, J., Tzeng, T., Perrimon, N. and Hsu, J. (2001). The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway.
Development. 128(4): 591-601. 11171342
Baonza, A., Casci, T. and Freeman, M. (2001). A primary role for the epidermal growth factor receptor in ommatidial spacing in the Drosophila eye. Curr. Biol. 11: 396-404. 11301250
Barbieri, M. A., et al. (2000). Epidermal growth factor and membrane trafficking: EGF receptor activation of endocytosis requires Rab5a. J. Cell Bio. 151: 539-550. 11062256
Baumann, P. and Skaer, H. (1993). The Drosophila EGF receptor homologue (DER) is
required for Malpighian tubule development. Dev Suppl : 65-75
Bergmann, A., Tugentman, M., Shilo, B.-Z. and Steller, H. (2002). Regulation of cell number by MAPK-dependent control of apoptosis: A mechanism for trophic survival signaling. Dev. Cell 2: 159-170. 11832242
Bersell, K., Arab, S., Haring, B. and Kühn, B. (2009). Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138(2): 257-70. PubMed Citation: 19632177
Bianco, A., et al. (2007). Two distinct modes of guidance signalling during collective migration of border cells. Nature 448: 362-365. PubMed Citation: 17637670
Bourbon, H. M., et al. (2000). A P-insertion screen identifying novel X-linked essential genes in Drosophila. Mech. Dev. 110(1-2): 71-83. PubMed citation: 11744370
Brodu, V., Elstob, P. R. and Gould, A. P. (2004). EGF receptor signaling regulates pulses of cell delamination from the Drosophila ectoderm. Dev. Cell 7: 885-895. 15572130
Brodu, V. and Casanova, J. (2006). The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. Genes Dev. 20(13): 1817-28. 16818611
Brown, K. E., Baonza, A. and Freeman, M. (2006). Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway.
Dev. Biol. 300(2): 710-21. Medline abstract: 16963016
Buff, E., et al. (1998). Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors. Development 125: 2075-2086. 9570772
Burgess, A. W., et al. (2003). An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol. Cell 12: 541-552. PubMed Citation: 14527402
Brachmann, R., et al. (1989). Transmembrane TGF-alpha precursors activate EGF/TGF-alpha
receptors. Cell 56(4): 691-700. 89136015
Brand, A. H. and Perrimon. N. (1994). Raf acts downstream of the EGF receptor to determine
dorsoventral polarity during Drosophila oogenesis. Genes Dev 8: 629-639
Brown, K. E. and Freeman, M. (2003). Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye. Development 130: 5401-5412. 14507785
Buszczak, M., et al. (1999). Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development 126: 4581-4589. 10498692
Cabernard, C. and Affolter, M. (2005). Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev. Cell 9(6): 831-42. 16326394
Campbell, G. (2002). Distalization of the Drosophila leg by graded EGF-receptor activity. Nature 418: 781-785. 12181568
Campbell, G. (2005). Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15. Dev. Biol. 278(2): 607-18. 15680373
Caric, D., et al. (2001). EGFRs mediate chemotactic migration in the developing telencephalon. Development 128: 4203-4216. 11684657
Carmena, A., et al. (1998). Combinatorial signaling codes for the progressive determination of
cell fates in the Drosophila embryonic mesoderm. Genes Dev. 12(24): 3910-3922.
Caussanel, V., et al. (1996). Cellular distribution of EGF, TGFalpha and their receptor during
postnatal development and spermatogenesis of the boar testis. Mol. Cell. Endocrinol. 123(1): 61-69.
Cela, C. and Llimargas, M. (2006). Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila. Development 133(16): 3115-25. 16831830
Chen, P., Murphy-Ullrich, J. E., and Wells, A. (1996).
A role for gelsolin in actuating epidermal growth factor
receptor-mediated cell motility.
J. Cell Biol. 134: 689-698. 96326674
Choi, J. H., et al. (2003). Cbl competitively inhibits epidermal growth factor-induced activation of phospholipase C-gamma1.
Mol. Cells 15(2): 245-55. 12803489
Christensen, C., Lauridsen, J. B., Berezin, V., Bock, E. and Kiselyov, V. V. (2006). The neural cell adhesion molecule binds to fibroblast growth factor receptor 2. FEBS Lett. 580: 3386-3390. PubMed Citation: 16709412
Ciapponi, L., et al. (2001). Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes Dev. 15: 1540-1553. 11410534
Clandinin, T. R., DeModena, J. A. and Sternberg, P. W. (1998). Inositol trisphosphate mediates a RAS-independent response to
LET-23 receptor tyrosine kinase activation in C. elegans. Cell 92: 523-533
Clifford, R. and Schupbach, T. (1992). The Torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis. Development 115: 853-872
Clifford, R. and Schupbach, T. (1994). Molecular analysis of the Drosophila EGF receptor
homolog reveals that several genetically defined classes of
alleles cluster in subdomains of the receptor protein. Genetics 137: 531-550
Costa, M., Wilson, E. T. and Wieschaus, E. (1994).
A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation.
Cell 76 (6): 1075-1089.
Crozatier, M., Glise B. and Vincent, A. (2002). Connecting Hh, Dpp and EGF signalling in patterning of the Drosophila wing; the pivotal role of collier/knot in the AP organiser. Development 129: 4261-4269. 12183378
Culí, J., Martín-Blanco, E. and Modolell, J. (2001). The EGF receptor and N signalling pathways act antagonistically in
Drosophila mesothorax bristle patterning. Development 128: 299-308. 11124124
Dardik, A., Smith, R. M. and Schultz, R. M. (1992). Colocalization of transforming growth factor-alpha and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and
preferential localization of the EGFR on the basolateral surface of
the trophectoderm in the mouse blastocyst. Dev. Biol. 154(2): 396-409.
Daub, H., et al. (1996).
Role of transactivation of the EGF receptor in signalling by
G-protein-coupled receptors. Nature 379: 557-560.
Daub, H., et al. (1997). Signal characteristics of G protein-transactivated EGF
receptor. EMBO J. 16(23): 7032-7044
Dekel, I., Russek, N., Jones, T., Mortin, M. A. and Katzav, S. (2000). Identification of the Drosophila melanogaster homologue of the mammalian transducer protein, Vav. FEBS Lett. 472: 99-104. PubMed citation: 10781813
Deng, W. M. and Bownes, M. (1997). Two signalling pathways specify localised expression of the
Broad-Complex in Drosophila eggshell patterning and
morphogenesis. Development 124(22): 4639-4647.
Denning, M. F., et al. (1996). Activation of the epidermal growth factor receptor signal
transduction pathway stimulates tyrosine phosphorylation of
protein kinase C delta. J. Biol. Chem. 271: 5325-5331.
DeWitt, A., et al. (2002). Affinity regulates spatial range of EGF receptor
autocrine ligand binding. Dev. Bio. 250: 305-316. 12376105
Diaz-Benjumea, F. J. and Hafen, E. (1994). The sevenless signalling cassette mediates Drosophila
EGF receptor function during epidermal development. Development 120: 569-78
Di Guglielmo, G. M., et al. (1994). Compartmentalization of SHC, GRB2 and mSOS, and
hyperphosphorylation of Raf-1 by EGF but not insulin in liver
parenchyma. EMBO J. 13: 4269-77.
Dobens, L. L., et al. (1997). The Drosophila bunched gene is a homologue of the
growth factor stimulated mammalian TSC-22 sequence
and is required during oogenesis. Mech. Dev. 65(1-2): 197-208
Dobens, L. L. (2000). Drosophila bunched integrates opposing DPP and EGF signals to set the
operculum boundary. Development 127: 745-754.
Dominguez, M., Wasserman, J. D. and Freeman, M. (1998). Multiple functions of the EGF receptor in Drosophila eye
development. Curr. Biol. 8(19): 1039-48.
Dong, R. and Jacobs, J. R. (1997). Origin and differentiation of supernumerary midline glia in
Drosophila embryos deficient for apoptosis. Dev. Biol. 190(2): 165-177.
Dong, X., et al. (1999). ebi regulates epidermal growth factor receptor signaling pathways in Drosophila. Genes Dev. 13(8): 954-65.
Donlea, J. M., Ramanan, N. and Shaw, P. J. (2009). Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. Science 324(5923): 105-8. PubMed Citation: 19342592
Doroquez, D. B., Orr-Weaver, T. L. and Rebay. I. (2007). Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development.
Mech. Dev. 124(9-10): 792-806. PubMed citation: 17588724
Duchek, P. and Rorth, P. (2001a). Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis. Science 291(5501): 131-3. 11141565
Duchek, P., et al. (2001b). Guidance of cell migration by the Drosophila PDGF/VEGF Receptor. Cell 107: 17-26. 11595182
Dumstrei, K., et al. (1998). EGFR signaling is required for the differentiation and
maintenance of neural progenitors along the dorsal midline of
the Drosophila embryonic head. Development 125(17): 3417-3426.
Dumstrei, K., et al. (2002). Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis. Development 129: 3983-3994. 12163402
Dworkin, I., Palsson, A., Birdsall, K. and Gibson, G. (2003).
Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster. Curr. Biol. 13: 1888-1893. 14588245
Etkin, A., et al. (2006). A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron 50(1): 127-43. PubMed Citation: 16600861
Ebner, R. and Derynck, R. (1991). Epidermal growth factor and transforming growth factor-alpha:
differential intracellular routing and processing of ligand-receptor
complexes. Cell Regul. 2(8): 599-612.
Eisenmann, D. M., et al. (1998). The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. Development 125(18): 3667-3680.
Eresh, S., et al. (1997). A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction. EMBO J. 16: 2014-22.
Escudero, L. M., et al. (2003). Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Development 130: 6305-6316. 14623820
Ferguson, K. M., et al. (2003). EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol. Cell 11: 507-517. 12620237
Firth, L. C. and Baker, N. E. (2005).
Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8(4): 541-51.
15809036
Flames, N., et al. (2004). Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron 44(2): 251-61. 15473965
Foltenyi, K., Greenspan, R. J. and Newport, J. W. (2007). Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nature Neurosci. 10: 1160-1167. Medline abstract: 17694052
Fowler, K. J., et al., (1995). A mutation in the epidermal growth factor receptor in
waved-2 mice has a profound effect on receptor
biochemistry that results in impaired lactation.
Proc. Natl. Acad. Sci. 92: 1465-1469.
Francavilla, C., Loeffler, S., Piccini, D., Kren, A., Christofori, G. and Cavallaro, U. (2007). Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor. J. Cell Sci. 120: 4388-4394. PubMed Citation: 18042627
Freeman, M. (1994). The spitz gene is required for photoreceptor determination in the
Drosophila eye where it interacts with the EGF receptor. Mech Dev 48: 25-33
Freeman, M. (1996). Reiterative use of the EGF Receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87: 651-660
Freeman, M. and Bienz, M. (2001). EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye. EMBO Reports 2: 157-162. 11258709
Gabay, L., et al. (1996). EGF receptor signaling induces pointed P1 and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Development 122: 3355-3362
Gabay, L., Seger, R. and Shilo, B. Z. (1997). MAP kinase in situ activation atlas during Drosophila
embryogenesis. Development 124: 3535-3541.
Gaengel, K. and Mlodzik, M. (2003). Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6. Development 130: 5413-5423. 14507782
Galisteo, M. L., et al. (1995). Tyrosine phosphorylation of the c-cbl proto-oncogene protein
product and association with epidermal growth factor (EGF)
receptor upon EGF stimulation. J. Biol. Chem. 270: 20242-20245.
Gallio, M., et al. (2004). Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. Development 131: 3605-3614. 15229181
Garcia-Alonso, L., Romani, S. and Jimenez, F. (2000). The EGF and FGF receptors mediate Neuroglian function to control growth cone decisions during sensory axon
guidance in Drosophila. Neuron 28: 741-752
Garoia, F., Grifoni, D., Trotta, V., Guerra, D., Pezzoli, M. C. and Cavicchi, S. (2005).
The tumor suppressor gene fat modulates the EGFR-mediated proliferation
control in the imaginal tissues of Drosophila melanogaster.
Mech. Dev. 122(2): 175-87. 15652705
Garrett, T. P. J., et al. (2002). Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Cell 110: 763-773. 12297049
Gaul, U., Mardon, G. and Rubin, G.M. (1992). A putative Ras GTPase activating protein acts as a negative regulator of signaling by the sevenless receptor tyrosine kinase. Cell 68: 1007-1019
Ghashghaei, H. T., et al. (2006). The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone.
Proc. Natl. Acad. Sci. [Epub ahead of print]. 16446434
Ghiglione, C., et al. (1999). The transmembrane molecule kekkon 1 acts in a feedback loop to
negatively regulate the activity of the Drosophila EGF receptor
during oogenesis. Cell 96(6): 847-56. 99200395
Ghiglione, C., et al. (2003). Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1. Development 130: 4483-4493. 12900463
Gilboa, L. and Lehmann, R. (2006). Soma-germline interactions coordinate homeostasis and growth in the Drosophila gonad. Nature 443: 97-100. Medline abstract: 16936717
Gohla, A., Harhammer, R., and Schultz, G. (1998). The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor
receptor to Rho. J. Biol. Chem. 273(8): 4653-4659.
Goishi, K., et al. (2003). Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects. Mech. Dev. 120: 811-822. 12915231
Goldman, B., Mach, A. and Wurzel, J. (1996). Epidermal growth factor promotes a cardiomyoblastic phenotype in
human fetal cardiac myocytes. Exp. Cell Res. 228(2): 237-245.
Golembo, M., et al. (1996). Argos transcription is induced by the Drosophila EGF
receptor pathway to form an inhibitory feedback loop. Development 122: 223-230
Gonzalez-Reyes, A., Elliott, H. and St Johnston, D. (1995).
Polarization of both major body axes in Drosophila by
gurken-torpedo signalling. Nature 375: 654-658
Gonzalez-Reyes, A. and Johnston, D. S. (1998). Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesis. Development 125(15): 2837-2846.
Goode, S., Wright, D. and Mahowald, A. P. (1992). The neurogenic locus brainiac cooperates with the
Drosophila EGF receptor to establish the ovarian follicle
and to determine its dorsal-ventral polarity. Development 116: 177-92
Goto, S., and Hayashi, S. (1997). Specification of the embryonic limb primordium by graded activity of Decapentaplegic. Development 124: 125-132
Gotoh, N. et al. (1992). A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor. Biochem. Biophys. Res. Commun. 186: 768-774. PubMed Citation: 1323290
Gotoh, N., et al. (1994).
Epidermal growth factor-receptor mutant lacking the
autophosphorylation sites induces phosphorylation of Shc protein
and Shc-Grb2/ASH association and retains mitogenic activity.
Proc. Natl. Acad. Sci. 91: 167-171.
Gotoh, N., et al. (1995). The SH2 domain of Shc seppresses EGF-induced mitogenesis in a dominant negative manner.
Oncogene 11: 2525-2533.
Haglund, K., et al. (2005). Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep. 6(7): 635-41. 15962011
Hajnal, A., Whitfield, C. W. and Kim, S. K. (1997). Inhibition of Caenorhabditis elegans vulval induction by gap-1 and
by let-23 receptor tyrosine kinase. Genes Dev. 11(20): 2715-2728.
Hannan, F., et al. (2006). Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. Human Mol. Genet. 15(7): 1087-1098. 16513807
Held, L. I., Jr. (2002). Bristles induce bracts via the EGFR pathway on Drosophila legs. Mech. Dev. 117: 225-234. 12204262
Hime, G. R., et al. (1997). D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF
receptor in vivo, despite lacking C-terminal adaptor binding sites. Oncogene 14(22): 2709-19.
Hopper, N. A. (2006). The adaptor protein soc-1/Gab1 modifies growth factor receptor output in C. elegans. Genetics 173(1): 163-75. 16547100
Hornstein, I., Mortin, M. A. and Katzav, S. (2003). DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways. Oncogene 22: 6774-6784. PubMed citation: 14555990
Hsu, T., et al. (1996). The transcription factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis. Genes Dev. 10: 1411-21
Huang, F. and Sorkin, A. (2005). Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis.
Mol. Biol. Cell 16(3): 1268-81. 15635092
Huang, Z., Shilo, B.-Z. and Kunes, S. (1998). A retinal axon fascicle uses Spitz, an EGF Receptor ligand, to construct a synaptic cartridge in the brain of
Drosophila. Cell. 693-703.
Inbal, A., Volk, T. and Salzberg, A. (2004). Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors. Dev. Cell 7: 241-250. 15296720
Irie M., et al. (1999). Isolation and characterization of mammalian homologues of Caenorhabditis
elegans lin-7: localization at cell-cell junctions. Oncogene 18(18): 2811-7.
Islam, R., Wei, S. Y., Chiu, W. H., Hortsch, M. and Hsu, J. C. (2003). Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway.
Development. 130(10): 2051-9. 12668620
Jazwinska, A., Ribeiro, C. and Affolter, M. (2003). Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Nat. Cell Biol. 5: 895-901. 12973360
Jekely, G., Sung, H. H., Luque, C. M. and Rorth, P. (2005).
Regulators of endocytosis maintain localized receptor tyrosine
kinase signaling in guided migration. Dev. Cell 9(2): 197-207. 16054027
Jhaveri, D., et al. (2000). Sense organ identity in the Drosophila antenna is specified by the
expression of the proneural gene atonal. Mech. Dev. 99: 101-111.
Jiang, H. and Edgar, B. A. (2009). EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 136(3): 483-93. PubMed Citation: 19141677
Jones, P. L., Crack, J. and Rabinovitch, M. (1997). Regulation of Tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alphavbeta3 Integrin to promote
epidermal growth factor receptor phosphorylation and growth. J. Cell Biol. 139: 279-293
Jura, N., et al. (2009). Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell 137(7): 1293-307. PubMed Citation: 19563760
Kaech, S. M., Whitfield, C. W. and Kim, S. K. (1998). The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane
localization of the C. elegans EGF receptor LET-23 in vulval epithelial
cells. Cell 94(6): 761-71.
Kashiwagi, M., Kuroki, T. and Huh, N. H. (1997). Specific inhibition of hair follicle formation by epidermal growth factor in an
organ culture of developing mouse skin. Dev. Biol. 189(1): 22-32
Kashimata, M. and Gresik, E. W. (1997). Epidermal growth factor system is a physiological regulator of
development of the mouse fetal submandibular gland and regulates
expression of the alpha6-integrin subunit. Dev. Dyn. 208(2): 149-161.
Kashimata, M., et al. (2000). The ERK-1/2 signaling pathway is involved in the
stimulation of branching morphogenesis of fetal
mouse submandibular glands by EGF.
Developmental Biology 220: 183-196
Kashiwagi, M., Kuroki, T. and Huh, N. (1997). Specific inhibition of hair follicle formation by epidermal growth
factor in an organ culture of developing mouse skin. Dev. Biol. 189(1): 22-32.
Katz, W. S., et al. (1996).
A point mutation in the extracellular domain activates LET-23,
the Caenorhabditis elegans epidermal growth factor receptor homolog.
Mol. Cell. Biol. 16: 529-537.
Katzen, A. L., Kornberg, T. and Bishop, J. M. (1991). Expression during Drosophila development of DER, a
gene related to erbB-1 and neu: correlations with mutant
phenotypes. Dev Biol 145: 287-301
Kelley, R. L. (1993). Initial organization of the Drosophila dorsoventral axis
depends on an RNA-binding protein encoded by the squid
gene. Genes Dev 7: 948-60
Kerber, B., Fellert, S. and Hoch, M., (1998). Seven-up, the Drosophila homolog of the COUP-TF orphan
receptors, controls cell proliferation in the insect kidney. Genes Dev. 12(12): 1781-1786.
Kim, H. J., Taylor, L. J. and Bar-Sagi, D. (2007). Spatial regulation of EGFR signaling by Sprouty2. Curr. Biol. 17: 455-461. Medline abstract: 17320394
Kim, S. H. and Crews, S. T. (1993). Influence of Drosophila ventral epidermal development by
the CNS midline cells and spitz class genes. Development 118: 893-901
Kim, S.K., and Horvitz, H.R. (1990). The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates. Genes Dev. 4: 357-371.
Kiselyov, V. V., Skladchikova, G., Hinsby, A. M., Jensen, P. H., Kulahin, N., Soroka, V., Pedersen, N., Tsetlin, V., Poulsen, F. M., Berezin, V. et al. (2003). Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure 11: 691-701. PubMed Citation: 15326546
Knöll, B., et al. (2006). Serum response factor controls neuronal circuit assembly in the hippocampus. Nat. Neurosci. 9(2): 195-204. PubMed Citation: 16415869
Kockel, L., et al. (1997). Jun in Drosophila development:
redundant and nonredundant functions
and regulation by two MAPK signal
transduction pathways. Genes Dev. 11:1748-1758
Kojima, T., Tsuji, T. and Saigo, K. (2005). A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. Dev. Biol. 279(2): 434-45. 15733670
Kopp, A., Blackman, R. K. and Duncan, I. (1999). Wingless, Decapentaplegic and EGF Receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila. Development 126: 3495-3507.
Kuang, B., Wu, S. C., Shin, Y., Luo L. and Kolodziej, P. (2000). split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo. Development 127: 1517-1529. PubMed Citation: 10704397
Kubota, K., et al. (2000). EGF receptor attenuates Dpp signaling and helps to distinguish the wing and leg cell fates in Drosophila. Development 127: 3769-3776.
Kumar, J. P., et al. (1998). Dissecting the roles of the Drosophila EGF receptor in eye
development and MAP kinase activation. Development 125(19): 3875-3885
Kumar, J. P. and Moses, K. (2001). EGF receptor and Notch signaling act upstream of Eyeless/Pax6 to control eye specification. Cell 104: 687-697. 11257223
Kuo, Y. M., et al. (1996). Salivary duct determination in Drosophila: roles of the EGF receptor signaling pathway and the transcription factors Fork head and Trachealess. Development 122: 1909-17
Kurada, P. and White, K. (1998). Ras promotes cell survival in Drosophila by downregulating hid
expression. Cell 95(3): 319-29.
Lai, K. M.., et al. (1995). A Drosophila shc gene product is implicated in signaling
by the DER receptor tyrosine kinase. Mol Cell Biol 15: 4810-4818
Larkin, M. K., et al. (1999).
Role of Notch pathway in terminal follicle cell differentiation
during Drosophila oogenesis. Dev. Genes Evol. 209: 301-311
Layalle, S., et al. (2004). Control of bract formation in Drosophila: poxn, kek1, and the EGF-R pathway. Genesis 39: 246-255. Medline abstract: 15286997
Lazarovici, P., et al. (1997). Down-regulation of Epidermal Growth Factor Receptors by Nerve
Growth Factor in PC12 Cells Is p140(trk)-, Ras-, and Src-dependent. J Biol Chem 272 (17): 11026-11034
Levkowitz, G., et al. (1999). Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of
growth factor signaling by c-Cbl/Sli-1. Mol. Cell 4(6): 1029-40.
Lemmon, M. A., et al. (1997). Two EGF molecules contribute additively to stabilization of the
EGFR dimer. EMBO J. 16: 281-294
Lesokhin, A. M., et al. (1999). Several levels of EGF receptor signaling during photoreceptor
specification in wild-type, Ellipse, and null mutant Drosophila. Dev. Biol. 205(1): 129-44.
Lill, N. L., et al. (2000). The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of
the epidermal growth factor receptor. J. Biol. Chem. 275(1): 367-77.
Lillien, L. (1995). Changes in retinal fate induced by overexpression of EGF receptor. Nature 377: 158-162.
Lillien, L. and Wancio, D. (1998). Changes in epidermal growth factor receptor expression and competence to generate
glia regulate timing and choice of differentiation in the retina. Mol. Cell. Neurosci. 10: 296-308
Lillien, L. and Raphael, H. (2000). BMP and FGF regulate the development of EGF-responsive neural progenitor cells. Development 127: 4993-5005
Lim, J. and Choi, K.-W. (2004). Induction and autoregulation of the anti-proneural gene Bar during retinal neurogenesis in Drosophila. Development 131: 5573-5580. 15496446
Lim, Y. M., et al. (1997). Dominant mutations of Drosophila MAP kinase kinase and their
activities in Drosophila and yeast MAP kinase cascades
Genetics 146 (1): 263-273.
Liu, B. and Neufeld, A. H. (2004). Activation of epidermal growth factor receptors directs astrocytes to organize in a network surrounding axons in the developing rat optic nerve. Dev. Biol. 273: 297-307. 15328014
Lloyd, T. E., et al. (2002). Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108: 261-269. 11832215
Lu, Q., et al. (2003). TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. Proc. Natl. Acad. Sci. 100(13): 7626-31. 12802020
Lu, X., et al. (1994). Genetic and molecular analyses of mutations involved in
Drosophila raf signal transduction. EMBO J 13: 2592-9
Luetteke, N. C., et al. (1994). The mouse waved-2 phenotype results from a point
mutation in the EGF receptor tyrosine kinase.
Genes Dev 8: 399-413.
Luetteke, N. C., et al. (1999). Targeted inactivation of the EGF and amphiregulin genes
reveals distinct roles for EGF receptor ligands in mouse
mammary gland development. Development 126(12): 2739-2750
Luschnig, S., Krauss, J., Bohmann, K., Desjeux, I. and Nüsslein-Volhard, C. (2000). The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases. Mol. Cell 5(2): 231-41. PubMed Citation: 10882065
Lyulcheva, E., Taylor, E., Michael, M., Vehlow, A., Tan, S., Fletcher, A., Krause, M. and Bennett, D. (2008). Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation.
Dev. Cell 15(5): 680-90. PubMed Citation: 19000833
Maitra, S., Kulikauskas, R. M., Gavilan, H. and Fehon, R. G. (2006). The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr. Biol. 16(7): 702-9. 16581517
Malliri, A., et al. (1998). The transcription factor AP-1 Is required for EGF-induced activation of Rho-like
GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. J. Cell Biol. 143(4): 1087-1099
Mao, Y. and Freeman, M. (2009). Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling. Development 136(3): 473-81. PubMed Citation: 19141676
Martin-Blanco, E., et al. (1999). A temporal switch in DER signaling controls the specification and
differentiation of veins and interveins in the Drosophila wing. Development 126: 5739-5747
Mayer, U. and Nusslein-Volhard, C. (1988). A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes Dev. 2: 1496-1511. 3209069
McNeill, H., Craig, G. M. and Bateman, J. M. (2008). Regulation of neurogenesis and epidermal growth factor receptor signaling by the Insulin receptor/Target of rapamycin pathway in Drosophila. Genetics 179: 843-853. PubMed Citation: 18505882
Meisner, H., et al. (1997). Interactions of Drosophila Cbl with Epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol. Cell. Biol 2217-25
Merabet, S., Hombria, J. C., Hu, N., Pradel, J. and Graba, Y. (2005).
Hox-controlled reorganisation of intrasegmental patterning cues underlies
Drosophila posterior spiracle organogenesis.
Development 132(13): 3093-3102. 15930099
Miettinen, P. J., et al (1997). Impaired lung branching morphogenesis in the absence of functional
EGF receptor. Dev. Biol. 186(2): 224-236.
Miettinen, P. J., et al. (2000). Impaired migration and delayed differentiation of pancreatic islet cells in mice
lacking EGF-receptors. Development 127: 2617-2627.
Miller, D. T. and Cagan, R. L. (1998). Local induction of patterning and programmed cell death in the developing Drosophila retina. Development 125: 2327-2335
Moghal, N. and Sternberg. P. W. (2003). A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans. Development 130: 57-69. 12441291
Mohler, J., et al. (2000). Activation of knot(kn) specifies the 3-4 intervein region in the Drosophila wing. Development 127: 55-63.
Monserrate, J. P., Brachmann, C. B. (2006). Identification of the death zone: a spatially restricted region for programmed cell death that sculpts the fly eye.
Cell Death Differ. [Epub ahead of print] 16710366
Montgomery, R. B., et al. (1995). Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase
activities by a mutant epidermal growth factor receptor. J. Biol. Chem. 270: 30562-30566
Moon, N. S., Di Stefano, L. and Dyson, N. (2006). A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol. Cell Biol. 26(20): 7601-15. Medline abstract: 16954388
Morey, M., et al. (2001). Modulation of the Ras/MAPK signaling pathway by the redox function of selenoproteins in Drosophila melanogaster. Dev. Bio. 238: 145-156
Moriai, T., et al. (1994). A variant epidermal growth factor receptor exhibits altered type
alpha transforming growth factor binding and transmembrane
signaling. Proc. Natl. Acad. Sci. 91: 10217-10221.
Moriki, T., Maruyama, H. and Maruyama, I. N. (2001). Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain. J. Mol. Biol. 311: 1011-1026. 11531336
Morimoto, A. M., et al. (1996). Pointed, an ETS domain transcription factor,
negatively regulates the EGF receptor pathway
in Drosophila oogenesis. Development 122: 3745-3754
Moro L., et al. (1998). Integrins induce activation of EGF receptor: role in MAP kinase
induction and adhesion-dependent cell survival. EMBO J. 17(22): 6622-32.
Morrison, P., Saltiel, A. R. and Rosner, M. R. (1996). Role of mitogen-activated protein kinase kinase in regulation of
the epidermal growth factor receptor by protein kinase C.
J. Biol. Chem. 271: 12891-12896. 996278681:
Moscatello, D. K., et al. (1996). Transformational and altered signal transduction by a naturally
occurring mutant EGF receptor.
Oncogene 13: 85-96.
Mosesson, Y., et al. (2009). Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Dev Cell. 16(5): 687-98. PubMed Citation: 19460345
Murali, R., et al. (1996). Structural analysis of p185c-neu and epidermal growth factor
receptor tyrosine kinases: oligomerization of kinase domains. Proc. Natl. Acad. Sci. 93: 6252-6257
Murillas, R., et al. (1995). Expression of a dominant negative mutant of epidermal growth
factor receptor in the epidermis of transgenic mice elicits striking
alterations in hair follicle development and skin structure.
EMBO J 14: 5216-5223.
Continued: References part 2/2
EGF receptor
:
Biological Overview
| Evolutionary Homologs
| Regulation
| Protein Interactions
| Developmental Biology
| Effects of Mutation
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