Interactive Fly, Drosophila dorsal
REFERENCES (part 1/2)

Adler, A. S., et al. (2007). Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 21(24): 3244-57. PubMed citation: 18055696

Agalioti, T., Chen, G. and Thanos, D. (2002). Deciphering the transcriptional histone acetylation code for a human gene. Cell 111: 381-392. 12419248

Akimaru, H., Hou, D. X. and Ishii, S. (1997). Drosophila CBP is required for dorsal-dependent twist gene expression. Nat. Genet.17(2): 211-214.

Anest, V., et al. (2003). A nucleosomal function for IkB kinase-alpha in NF-kappaB-dependent gene expression. Nature 423(6940): 659-63. 12789343

Attar, R. M., et al. (1998). Expression of constitutively active IkappaB beta in T cells of transgenic mice: persistent NF-kappaB activity is required for T-cell immune responses. Mol. Cell. Biol. 18(1): 477-487.

Auphan, N., et al. (1995). Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270: 286-290

Avila, A, Silverman, N, Diaz-Meco, M. T. and Moscat, J. (2002). The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway. Mol. Cell Biol. 22(24): 8787-95. 12446795

Ayyar, S., Pistillo, D., Calleja, M., Brookfield, A., Gittins, K., Goldstone, C. and Simpson, P. (2007). NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila. PLoS ONE 2(11): e1178. PubMed citation: 18000549

Baek, S.-H., et al. (2002). Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and ß-amyloid precursor protein. Cell 110: 55-67. 12150997

Bhaskar, V. and Courey, A. J. (2002). The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist. Gene 299(1-2): 173-84. PubMed citation: 12459265

Barboric, M., et al. (2001). NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. Molec. Cell 8: 327-337. 11545735

Bash, J., Zong, W. X. and Gelinas, C. (1997). c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition. Mol. Cell. Biol. 17(11): 6526-6536.

Bash, J., et al. (1999). Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J. 18(10): 2803-2811.

Batsche E., et al. (1998). RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol. Cell. Biol. 18(7): 3647-3658.

Beg, A. A., et al. (1995). Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376: 167-170

Bellavia, D., et al. (2000). Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 19: 3337-3348.

Bergmann, A., et al. (1996). A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila. Mech. Dev. 60: 109-123.

Bhaskar, V., Valentine, S. A. and Courey, A. J. (2000). A functional interaction between Dorsal and components of the Smt3 conjugation machinery. J. Biol. Chem. 275: 4033-4040.

Bhaskar, V., Smith, M. and Courey, A.J. (2002). Conjugation of Smt3 to Dorsal may potentiate the Drosophila immune response, Mol. Cell. Biol. 22: 492-504. 11756545

Bitzer, M., et al. (2000). A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappaB/RelA. Genes Dev. 14: 187-197.

Biemar, F., et al. (2005). Spatial regulation of microRNA gene expression in the Drosophila embryo. Proc. Natl. Acad. Sci. 102(44): 15907-11. 16249329

Biemar, F., et al. (2006). Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array. Proc. Natl. Acad. Sci. 103(34): 12763-8. Medline abstract: 16908844

Brickman, J. M., Adam, M. and Ptashne, M. (1999). Interactions between an HMG-1 protein and members of the Rel family. Proc. Natl. Acad. Sci. 96: 10679-10683.

Briggs, L. J., et al. (1998). The cAMP-dependent protein kinase site (Ser312) enhances Dorsal nuclear import through facilitating nuclear localization sequence/importin interaction. J. Biol. Chem. 273(35): 22745-22752.

Brostjan, C., et al. (1996). Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis. J. Biol. Chem. 271: 19612-19616

Burkly, L., et al. (1995). Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373: 531-536

Bushdid, P. B., et al. (1998). Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature 392(6676): 615-618.

Bushdid, P. B., et al. (2001). NF-kappaB mediates fgf signal regulation of msx-1 expression. Dev. Bio. 237: 107-115. 11518509

Cai, H. N., Arnosti, D. N. and Levine, M. (1996). Long-range repression in the Drosophila embryo. Proc. Natl. Acad. Sci. 93: 9309-14

Caldenhoven, E., et al. (1995). Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol 9: 401-412

Cantera, R., Kozlova, T. Barillas-Mury, C. and Kafatos, F. C. (1999). Muscles and innveravtion are affected by loss of Dorsal in the fruit fly, Drosophila melanogaster. Mol. Cell. Neurosci. 13: 131-141. Medline abstract: 10192771

Carter, D. B., et al. (1996). Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science 272: 542-545

Chan, H., Bartos, D. P. and Owen-Schaub, L. B. (1999). Activation-dependent transcriptional regulation of the human fas promoter requires NF-kappaB p50-p65 recruitment. Mol. Cell. Biol. 19(3): 2098-108.

Cheema, Z. F., et al. (1999). Fas/Apo [Apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB. J. Neurosci. 19(5): 1754-70.

Chen, F. E., et al. (1998). Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature 391(6665): 410-413.

Chen, G., Handel, K. and Roth, S. (2000). The maternal NF-kappaB/Dorsal gradient of Tribolium castaneum: dynamics of early dorsoventral patterning in a short-germ beetle. Development 127: 5145-5156.

Chen, L.-f., Mu, Y. and Greene, W. C. (2002). Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J. 21: 6539-6548. 12456660

Cheshire, J. L. and Baldwin, A. S. (1997). Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Mol. Cell. Biol. 17(11): 6746-6754.

Chiu, H., et al. (2005). dUbc9 negatively regulates the Toll-NF-kappaB pathways in larval hematopoiesis and drosomycin activation in Drosophila. Dev. Biol. 288: 60-72. 16248995

Chu, Z. L., et al. (1997). Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc. Natl. Acad. Sci. 94(19): 10057-10062

Clifton, D. R., et al. (1998). NF-kappaB-dependent inhibition of apoptosis is essential for host cell survival during rickettsia rickettsii infection. Proc. Natl. Acad. Sci. 95(8): 4646-4651.

Cogswell, J. P., et al. (1994). NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site. J. Immunol. 153: 712-723

Cowden, J. and Levine, M. (2003). Ventral dominance governs sequential patterns of gene expression across the dorsal-ventral axis of the neuroectoderm in the Drosophila embryo. Dev. Biol. 262: 335-349. 14550796

Cramer, P., et al. (1997). Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 Å resolution. EMBO J. 16(23): 7078-7090

Cramer, P., et al. (1999). Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA. Structure Fold Des. 7(7): 841-52. 10425685

Cremazy, F., Berta, P. and Girard, F. (2000). SoxNeuro, a new Drosophila Sox gene expressed in the developing central nervous system. Mech. Dev. 93: 215-219. 10781960

Creton, R., Kreiling, J. A. and Jaffe, L. F. (2000). Presence and roles of calcium gradients along the dorsal-ventral axis in Drosophila embryos. Dev. Biol. 217: 375-385.

De Caterina, R., et al. (1995). Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J. Clin. Invest. 96: 60-68

Delphin, S. and Stavnezer, J. (1995). Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50. J Exp Med 181: 181-192

Doyle, S. L., Jefferies, C. A. and O'Neill. L. A. (2005). Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide. J. Biol. Chem. 280(25): 23496-501. 15849198

Drier, E. A., Huang, L. H. and Steward, R. (1999a). Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev. 13(5): 556-568.

Drier, E. A., Govind, S. and Steward, R. (1999b). Cactus-independent regulation of Dorsal nuclear import by the ventral signal. Curr. Biol. 10: 23-26.

Duckett, C. S. and Thompson, C. B. (1997). CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. Genes Dev. 11(21): 2810-2821

Dudley, E., et al. (1999). NF-kappaB regulates Fas/APO-1/CD95- and TCR- mediated apoptosis of T lymphocytes. Eur. J. Immunol. 29(3): 878-86. 99190512

Dubnicoff, T., Valentine, S. A., Chen, G., Shi, T., Lengyel, J. A., Paroush, Z. and Courey, A. J. (1997). Conversion of Dorsal from an activator to a repressor by the global corepressor Groucho. Genes Dev. 11(22): 2952-2957.

Edwards, D. N., Towb, P. and Wasserman, S. A. (1997). An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators. Development 124(19): 3855-3864.

Engström, Y., et al. (1993). kappaB-like motifs regulate the induction of immune genes in Drosophila. J. Mol. Biol. 232: 327-333

Epps, J. L., and Tanda, S. (1998). The Drosophila semushi mutation blocks nuclear import of bicoid during embryogenesis. Curr. Biol. 8: 1277-1280.

Ferrandon D., et al. (1998). A drosomycin-GFP reporter transgene reveals a local immune response in drosophila that is not dependent on the toll pathway. EMBO J. 17(5):1217-1227 98151346

Flores-Saaib, R. D., Jia, S. and Courey, A. J., (2001). Activation and repression by the C-terminal domain of Dorsal. Development 128: 1869-1879. 11311166

Francis, D. A., et al. (1995). Induction of the transcription factors NF-kappa B, AP-1 and NF-AT during B cell stimulation through the CD40 receptor. Int. Immunol. 7: 151-161

Franzoso, G., et al. (1997). Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev. 11(24): 3482-3496

Ganguly, A., Jiang, J. and Ip. Y. T. (2005). Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo. Development 132(15): 3419-29. 15987775

Ganster, R. W., et al. (2001). Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B. Proc. Natl. Acad. Sci. 98(15): 8638-43. 11438703

Gao, Q., Wang, Y. and Finkelstein, R. (1996). orthodenticle regulation during embryonic head development in Drosophila. Mech. Dev. 56: 3-15

Gao, Z., et al. (2005). Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. J. Biol. Chem. 280(22): 21091-8. Medline abstract: 15811852

Georgel, P., et al. (1995). Drosophila immunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter. Nucleic Acids Res 23: 1140-1145

Goldstein, B., Leviten, M. W. and Weisblat, D. A. (2001). Dorsal and Snail homologs in leech development. Dev. Genes Evol. 211: 329-337. 11466529

Gonzalez-Crespo, S. and Levine, M. (1993). Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila. Genes Dev. 7: 1703-13

Gonzalez-Crespo, S. and Levine, M. (1994). Related target enhancers for dorsal and NF-kappa B signaling pathways. Science 264: 255-8

Gordon, M. D., Dionne, M. S., Schneider, D. S. and Nusse, R. (2005). WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature 437(7059): 746-9. 16107793

Goriely, A., et al. (1996). A functional homologue of goosecoid in Drosophila. Development 122: 1641-1650

Govind, S., Brennan, L. and Steward, R. (1993). Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo. Development 117: 135-48

Govind, S., et al. (1996). Regulated nuclear import of the Drosophila rel protein dorsal: structure-function analysis. Mol. Cell. Biol. 16: 1103-1114

Graba, Y., Laurenti, P., Perrin, L., Aragnol, D. and Pradel, J. (1994). The modifier of variegation modulo gene acts downstream of dorsoventral and HOM-C genes and is required for morphogenesis in Drosophila. Dev. Biol. 166: 704-715. 7813788

Grabiner, B. C., et al. (2007). CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-kappaB activation. Genes Dev. 21: 984-996. Medline abstract: 17438001

Graef, I. A., et al. (2001). Evolutionary relationships among Rel domains indicate functional diversification by recombination. Proc. Natl. Acad. Sci. 98: 5740-5745. 11344309

Greten, F. R., et al. (2007). NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130(5): 918-31. Medline abstract: 17803913

Grossniklaus, U., Cadigan, K. M. and Gehring, W. J. (1994). Three maternal coordinate systems cooperate in the patterning of the Drosophila head. Development 120: 3155-3171.

Gross, I., et al. (1996). Drosophila immunity: a comparative analysis of the Rel proteins Dorsal and Dif in the induction of the genes encoding diptericin and cecropin. Nucleic Acids Res. 24: 1238-1245

Grumont, R. J., Strasser, A. and Gerondakis, S. (2003). B cell growth is controlled by Phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-kappaB regulated c-myc transcription. Mol. Cell 10: 1283-1294. 12504005

Gutierrez, H., Hale, V. A., Dolcet, X. and Davies, A. (2005). NF-kappaB signalling regulates the growth of neural processes in the developing PNS and CNS. Development 132(7): 1713-26 . 15743881

Ha, E. M., et al. (2005). An antioxidant system required for host protection against gut infection in Drosophila. Dev. Cell. 8(1): 125-32. 15621536

Häcker, U., et al. (1995). The Drosophila fork head domain protein crocodile is required for the establishment of head structures. EMBO J 14: 5306-5317.

Hader, T., et al. (1999). Receptor tyrosine kinase signaling regulates different modes of Groucho-dependent control of Dorsal. Curr. Biol. 10: 51-54.

Han, Z. S. and Ip, Y. T. (1999). Interaction and specificity of Rel-related proteins in regulating Drosophila immunity gene expression. J. Biol. Chem. 274: 21355-21361.

Harfe, B. D., et al. (1998). Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning. Genes Dev. 12(16): 2623-2635.

Heckscher, E. S., et al. (2007). NF-kappaB, IkappaB, and IRAK control glutamate receptor density at the Drosophila NMJ. Neuron 55: 859-873. Medline abstract: 17880891

Heissmeyer, V., et al. (1999). NF-kappaB p105 is a target of IB kinases and controls signal induction of Bcl-3-p50 complexes. EMBO J. 18(17): 4766-78.

Hirano, F., et al. (1998). Functional interference of Sp1 and NF-kappaB through the same DNA binding site. Mol. Cell. Biol. 18(3): 1266-1274.

Hoeflich, K. P., et al. (2000). Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406(6791): 86-90.

Hoffmann, A., Leung, T.H. and Baltimore, D. (2003). Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J. 22: 5530-5539. 14532125

Hsu, H., et al. (1996a). TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4: 387-396

Hsu. H., Shu, H.B., Pan, M.G. and Goeddel, D.V. (1996b). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84(2): 299-308.

Huang, J. D., et al. (1995). Binding sites for transcription factor NTF-1/Elf-1 contribute to the ventral repression of decapentaplegic. Genes Dev. 9: 3177-3189

Huang, A. M., Rusch, J., and Levine, M. (1997). An anteroposterior Dorsal gradient in the Drosophila embryo. Genes Dev. 11(15): 1963-1973.

Huang, L., Ohsako, S. and Tanda, S. (2005). The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster. Dev. Biol. 280: 407-420. 15882582

Huxford, T., et al. (1998). The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell 95(6): 759-70.

Ip, Y. T., et al. (1992a). The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev. 6: 1728-39

Ip, Y. T., et al. (1992b). dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo. Genes Dev. 6: 1518-30

Ip, Y. T. and Levine, M. (1994). Molecular genetics of Drosophila immunity. Curr. Opin. Genet. Dev. 4: 672-677

Ip, Y. T. (1995). Transcriptional regulation. Converting an activator into a repressor. Curr. Biol. 5: 1-3

Isoda, K. and Nusslein-Volhard, C. (1994). Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus. Proc. Natl. Acad. Sci. 91: 5350-4

Izumi, K. M. and Kieff, E. D. (1997). The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB. Proc. Natl. Acad. Sci. 94(23): 12592-12597.

Jacobs, M. D. and Harrison, S. C. (1998). Structure of an IkappaBalpha/NF-kappaB complex. Cell 95(6): 749-58.

Jazwinska, A., Rushlow, C. and Roth, S. (1999). The role of brinker in mediating the graded response to Dpp in early Drosophila embryos. Development 126(15): 3323-3334.

Jiang, J. and Levine, M. (1993). Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen. Cell 72: 741-52

Jimenez, G., et al. (2000). Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Genes Dev. 14(2): 224-31.

Jones, P. L., Ping, D. and Boss, J. M. (1997). Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB. Mol. Cell. Biol. 17(12): 6970-6981.

Kanegae, Y., et al. (1998). Role of Rel/NF-kappaB transcription factors during the outgrowth of the vertebrate limb. Nature 392(6676): 611-614.

Kannabiran, C., Zeng, X. and Vales, L. D. (1997). The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression. Mol. Cell. Biol. 17(1): 1-9.

Kao, K. R. and Lockwood, A. (1996). Negative regulation of dorsal patterning in early embryos by overexpression of XrelA, a Xenopus homolog of NF-kappaB. Mech. Dev. 58: 129-139

Kassel, O., et al. (2004). A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters. Genes Dev. 18: 2518-2528. 15489293

Kim, T., Yoon, Y., Cho, H., Lee, W-B., Kim, J., Song, Y-H., Kim, S.N., Yoon, J.H., Kim-Ha, J. and Kim, Y-J. (2005). Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP-1 and the NF-kappaB signaling modules. Nat. Immunol. 6: 211-218. 15640802

Kirov, N., et al. (1993). Conversion of a silencer into an enhancer: evidence for a co-repressor in dorsal-mediated repression in Drosophila. EMBO J. 12: 3193-9

Kirov, N., et al. (1994) The Drosophila dorsal morphogen represses the tolloid gene by interacting with a silencer element. Mol. Cell. Biol. 14: 713-22

Kirov, N. C., Lieberman, P. M. and Rushlow, C. (1996). The transcriptional corepressor DSP1 inhibits activated transcription by disrupting TFIIA-TBP complex formation. EMBO J. 15: 7079-7087

Klement, J. F., et al. (1996). IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice. Mol. Cell. Biol. 16: 2341-2349

Kontgen, F., et al. (1995). Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9: 1965-1977

Klug, C. A., et al. (1994). The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes. Genes Dev. 8: 678-687.

Kralova, J., et al. (1996). Synergistic stimulation of avian IkappaBalpha transcription by rel and fos/jun factors. Oncogene 12: 2595-2604

Kubota, K., Keith, F. J. and Gay, N. J. (1993). Relocalization of Drosophila dorsal protein can be induced by a rise in cytoplasmic calcium concentration and the expression of constitutively active but not wild-type Toll receptors. Biochem. J. 296 ( Pt 2): 497-503

Kubota, K. and Gay, N. J. (1995a). Calcium destabilises Drosophila cactus protein and dephosphorylates the dorsal transcription factor. Biochem. Biophys. Res. Commun. 214: 1191-1196

Kubota, K. and Gay, N. J. (1995b). The dorsal protein enhances the biosynthesis and stability of the Drosophila I kappa B homologue cactus. Nucleic Acids Res. 23: 3111-3118

Kunsch, C., et al. (1994). Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6. J. Immunol. 153: 153-64

Lake, B. B., Ford, R. and Kao, K. R. (2001). Xrel3 is required for head development in Xenopus laevis. Development 128: 263-273

Lamb, J. A., et al. (2003). JunD mediates survival signaling by the JNK signal transduction pathway. Molec. Cell 11: 1479-1489. 12820962

Latimer M., et al. (1998). The N-terminal domain of IkappaB alpha masks the nuclear localization signal(s) of p50 and c-Rel homodimers. Mol. Cell. Biol. 18(5): 2640-2649.

Lee, H. H., et al. (1999). NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc. Natl. Acad. Sci. 96(16): 9136-41.

Lehming, N. (1994). An HMG-like protein that can switch a transcriptional activator to a repressor. Nature 371: 175-179

Lehming, N., et al. (1995). Interactions of a Rel protein with its inhibitor. Proc. Natl. Acad. Sci. 92: 10242-10246

Lehming, N., et al. (1998). Chromatin components as part of a putative transcriptional repressing complex. Proc. Natl. Acad. Sci. 95(13): 7322-7326.

Leitges, M., et al. (2001). Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Molec. Cell 8: 771-780. 11684013

Lemaitre, B., et al. (1995). Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. EMBO J. 14: 536-545

Lemaitre, B., et al. (1996). The Dorsoventral regulatory gene cassette saätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-983

Leung, T. H., Hoffmann, A. and Baltimore, D. (2004). One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell 118(4): 453-64. 15315758

Levkau, B., et al. (1999). Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappaB loop. Nat. Cell Biol. 1: 227-233.

Lezoualc'h, F., et al. (1998). High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells. J. Neurosci. 18(9): 3224-3232.

Li, J. M., et al. (1998). Transforming growth factor beta stimulates the human immunodeficiency virus 1 enhancer and requires NF-kappaB activity. Mol. Cell. Biol. 18(1): 110-121.

Li, Q., et al. (2000). Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev. 14: 1729-1733.

Liaw, G. J. and Lengyel, J. A. (1993). Control of tailless expression by bicoid, dorsal and synergistically interacting terminal system regulatory elements. Mech. Dev. 40: 47-61

Lin, L., DeMartino, G. N. and Greene, W. C. (1998). Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome. Cell 92(6): 819-828.

Lin, L. I., DeMartino, G. N. and Greene, W. C. (2000). Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production. EMBO J. 19: 4712-4722.

Liu, Z., et al. (1996). Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87: 565-576

Liu, L., et al. (1998). DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties. Mol. Cell. Biol. 18(7): 4221-4234.

Luecke, H. F. and Yamamoto, K. R. (2005). The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev. 19(9): 1116-27. 15879558

Maggert, K., Levine M., and Frasch, M. (1995). The somatic-visceral subdivision of the embryonic mesoderm is initiated by dorsal gradient thresholds in Drosophila. Development 121: 2107-2116

Maggirwar, S. B., et al. (1998). Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons. J. Neurosci. 18(24): 10356-65. 99071305

Manfruelli, P., et al. (1999). A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J. 18: 3380-3391.

Markstein, M., et al. (2002). Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo Proc. Natl. Acad. Sci. 99: 763-768. 11752406

Markstein, M., et al. (2004). A regulatory code for neurogenic gene expression in the Drosophila embryo. Development 131: 2387-2394. 15128669

Marshall, H. E. and Stamler, J. S. (2001). Inhibition of NF-kappa B by S-nitrosylation. Biochemistry 40(6): 1688-93. 11327828

Matthews, J. R., et al. (1996). Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res. 24: 2236-2242

Meléndez, A., Li, W. and Kalderon, D. (1995). Activity, expression and function of a second Drosophila protein kinase A catalytic subunit gene. Genetics 141: 1507-20

McKinsey, T. A., et al. (1996). Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB. Mol. Cell. Biol. 16: 2083-2090

Medzhitov, R., Preston-Hurlburt, P. and Janeway, C. A. (1997). A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388(6640): 394-397.

Mettouchi, A., et al. (1997). The c-Jun-indued transformation process involves complex regulation of Tenascin-C expression. Mol. Cell. Biol. 17: 3202-3209.

Misra, S., et al. (1998). Positive and negative regulation of Easter, a member of the serine protease family that controls dorsal-ventral patterning in the Drosophila embryo Development 125: 1261-1267.

Morisato, D. (2001). Spätzle regulates the shape of the Dorsal gradient in the Drosophila embryo. Development 128: 2309-2319

Muraoka, R. S., et al. (2000). Mesenchymal expression of Nuclear Factor-kappaB inhibits epithelial growth and branching in the embryonic chick lung. Dev. Biol. 225: 322-338. 10985853

Continued: Dorsal References part 2/2


dorsal: Biological Overview |Evolutionary Homologs | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.