Interactive Fly, Drosophila

REFERENCES (part 2/3): Ikeya, M. and Takada, S. (1998). Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome. Development 125(24): 4969-76.
Ikeya, M. and Takada, S. (2001). Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech. Dev. 103: 27-33. 11335109
Ingham, P. W., Taylor, A. M. and Nakano,Y. (1991). Role of the Drosophila ptc gene in positional signalling. Nature 353: 184-7
Ingham, P. W. (1993). Localized hedgehog activity controls spatial limits of wg transcription in the Drosophila embryo. Nature 366: 560-2
Inoue, T., Oz, H. S., Wiland, D., Gharib, S., Deshpande, R., Hill, R. J., Katz, W. S. and Sternberg, P. W. (2004). C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling. Cell 118(6): 795-806. 15369677
Ishikawa, A., et al. (2004). Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling. Mech. Dev. 121(12): 1443-53. 15511637
Itoh, K. and Sokol, S. Y. (1997). Graded amounts of Xenopus dishevelled specify discrete anteroposterior cell fates in prospective ectoderm. Mech. Dev 61: 113-125
Itoh, K., Jacob, J. Y. and Sokol, S. (1998). A role for Xenopus Frizzled 8 in dorsal development. Mech. Dev. 74(1-2): 145-157
Iwaki, D. D., et al. (2001). drumstick, bowl, and lines are required for patterning and cell rearrangement in the Drosophila embryonic hindgut. Dev. Biol. 240(2): 611-26. 11784087
Jagla, K., et al. (1995). Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. Mech. Dev. 53: 345-356.
Jagla, K., et al. (1997a). ladybird, a tandem of homeobox genes that maintain late wingless expression in terminal and dorsal epidermis of the Drosophila embryo. Development 124: 91-100
Jagla, K., et al. (1997b). ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors. Development 124: 3471-3479.
Jagla, T., et al. (1998). ladybird determines cell fate decisions during diversification of Drosophila somatic muscles. Development 125(18): 3699-3708.
Jaiswal, M., Agrawal, N. and Sinha, P. (2006). Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila. Development 133(5): 925-35. 16452097
Jang, C.-C., et al. (2003). Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development. Development 130: 2939-2951. 12756177
Janody, F. Reischl, J. and Dostatni, N. (2000). Persistence of Hunchback in the terminal region of the Drosophila blastoderm embryo impairs anterior development. Development 127: 1573-1582.
Janson, K., Cohen, E. D. and Wilder, E. L. (2001). Expression of DWnt6, DWnt10, and DFz4 during Drosophila development. Mech. Dev. 103: 117-120. 11335117
Jeays-Ward, K., et al. (2003). Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development 130: 3663-3670. 12835383
Jeays-Ward, K., Dandonneau, M. and Swain, A. (2004). Wnt4 is required for proper male as well as female sexual development. Dev. Biol. 276(2): 431-40. 15581876
Jhaveri, D., et al. (2000). Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal. Mech. Dev. 99: 101-111.
Jiang, J. and Struhl, G. (1995). Protein kinase A and Hedgehog signaling in Drosophila limb development. Cell 80 563-572
Jiang, J. and Struhl, G. (1996). Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. Cell 86: 401-409
Jiang, J. and Struhl, G. (1998). Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496.
Jiang, L. I. and Sternberg, P. W. (1998). Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans. Development 125(12): 2337-2347.
Jin, E.-J., et al. (2001). Wnt and BMP signaling govern lineage segregation of melanocytes in the avian embryo. Dev. Biol. 233: 22-37. 11319855
Johnston, L. A. and Schubiger, G. (1996). Ectopic expression of wingless in imaginal discs interferes with decapentaplegic expression and alters cell determination. Development 122, 3519-3529
Johnston, L. A. and Edgar, B. A. (1998). Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature 394(6688): 82-84.
Johnston, L. A. and Sanders, A. L. (2003). Wingless promotes cell survival but constrains growth during Drosophila wing development. Nat. Cell Biol. 5: 827-833. 12942089
Jones, W. M. and Bejsovec, A. (2005). RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. Genetics 169(4) :2075-86. 15695356
Joulia, L., Bourbon, H. M. and Cribbs, D. L. (2005). Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts. Dev. Biol. 278(2): 496-510. 15680366
Kadowaki, T., et al. (1996). The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 10: 3116-28
Kanei-Ishii, C., et al. (2004). Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 18: 816-829. 15082531
Kaphingst, K. and Kunes, S. (1994). Pattern formation in the visual centers of the Drosophila brain: wg acts via decapentaplegic to specify the dorsoventral axis. Cell 78: 437-48
Kawakami, Y., et al. (2001). WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Cell 104: 891-900. 11290326
Kawakami, Y., et al. (2006). Wnt/β-catenin signaling regulates vertebrate limb regeneration. Genes Dev. 20: 3232-3237. Medline abstract: 17114576
Kazanskaya, O., et al. (2004). R-Spondin2 is a secreted activator of Wnt/ß-Catenin signaling and is required for Xenopus myogenesis. Dev. Cell 7: 525-534. 15469841
Keeble, T. R., et al. (2006). The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J. Neurosci. 26(21): 5840-8. 16723543
Keisman, E. L. and Baker, B. S. (2001b). The Drosophila sex determination hierarchy modulates wingless and decapentaplegic signaling to deploy dachshund sex-specifically in the genital imaginal disc. Development 128: 1643-1656. 11290302
Keisman, E. L., Christiansen, A. E. and Baker, B. S. (2001b). The sex determination gene doublesex regulates the A/P organizer to direct sex-specific patterns of growth in the Drosophila genital imaginal disc. Dev. Cell 1: 215-225
Kennerdell, J. R. and Carthew, R. W. (1998). Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the Wingless pathway. Cell 95: 1017-1026.
Kengaku, M., et al. (1998). Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280(5367): 1274-1277.
Kenyon, K. L., Ranade, S. S., Curtiss, J. Mlodzik, M. and Pignoni, F. (2003). Coordinating proliferation and tissue specification to promote regional identity in the Drosophila head. Dev. Cell 5: 403-414. 12967560
Kim, B. M., Buchner, G., Miletich, I., Sharpe, P. T., Shivdasani, R. A. (2005). The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev. Cell 8(4): 611-22. 15809042
Kim, C., and Forrester, W. C. (2003). Functional analysis of the domains of the C. elegans Ror receptor tyrosine kinase CAM-1. Dev. Biol. 264: 376-390. PubMed citation: 14651925
Kirkpatrick, C. A., et al. (2004). Spatial regulation of Wingless morphogen distribution and signaling by Dally-like protein. Dev. Cell 7: 513-523. 15469840
Kim, A. S., et al. (2001). Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS. J. Neurosci. 21: RC132: 1-5. 11222670
Kim, S.-H., et al. (2002). Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish. Development 129: 4443-4455. 12223403
Kimura-Yoshida, C., et al. (2005). Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev. Cell 9: 639-650. 16256739
Kirkpatrick, C. A., Dimitroff, B. D., Rawson, J. M. and Selleck, S. B. (2004). Spatial regulation of Wingless morphogen distribution and signaling by Dally-like protein. Dev. Cell 7: 513-523. 15469840
Kispert, A., et al. (1996). Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development 122: 3627-3637. 8951078
Kispert, A., Vainio, S. and McMahon, A. P. (1998). Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development 125(21): 4225-4234.
Klassen, M. P. and Shen, K. (2007). Wnt signaling positions neuromuscular connectivity by inhibiting synapse formation in C. elegans. Cell 130(4): 704-16. PubMed citation: 17719547
Klebes, A., et al. (2005). Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes. Development 132: 3753-3765. 16077094
Klein, T. and Martinez Arias, A. (1999). The Vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila. Development 126: 913-925.
Klein, T. J., Jenny, A., Djiane, A. and Mlodzik, M. (2006). CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. Curr. Biol. 16: 1337-1343. PubMed citation: 16824922
Klingensmith, J., Nusse R., and Perrimon, N. (1994). The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev. 8: 118-30
Kobayashi, M., et al. (2003). Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila. Development 130: 741-751. 12506004
Kofron, M., et al. (2007). Wnt11/β-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin. Development 134: 503-513. Medline abstract: 17202189
Kopp, A., Blackman, R. K. and Duncan, I. (1999). Wingless, Decapentaplegic and EGF Receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila. Development 126: 3495-3507.
Kreuger, J., Perez, L., Giraldez, A. J. and Cohen, S. M. (2004). Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. Dev. Cell 7: 503-512. 15469839
Krylova, O., et al. (2002). WNT-3, Expressed by motoneurons, regulates terminal arborization of Neurotrophin-3-responsive spinal sensory neurons. Neuron 35: 1043-1056. 12354395
Kubo, F., Takeichi, M. and Nakagawa, S. (2003). Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Development 130: 587-598. 12490564
Kubo, F., Takeichi, M. and Nakagawa, S. (2005). Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes. Development 132(12): 2759-70. 15901663
Kubota, K., Goto, S. and Hayashi, S. (2003). The role of Wg signaling in the patterning of embryonic leg primordium in Drosophila. Dev. Biol. 257: 117-126. 12710961
Kudoh, T., Wilson, S. W. and Dawid, I. B. (2002). Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm. Development 129: 4335-4346. 12183385
Kuhl, M., et al. (2000). Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem. 275: 12701-11.
Kunz, M., et al. (2004). Autoregulation of canonical Wnt signaling controls midbrain development. Dev. Biol. 273: 390-401. 15328021
LaBonne, C. and Bronner-Fraser, M. (1998). Neural crest induction in Xenopus: evidence for a two-signal model. Development 125(13): 2403-2414.
Ladher, R. K., et al. (2000). Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev. Biol. 218: 183-198.
Lai, Z. C., Fortini, M. E., Rubin, G. M. (1991). The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins. Mech. Dev. 34: 123-134. 1680377
Landesman, Y. and Sokol, S. Y. (1997). Xwnt-2b is a novel axis-inducing Xenopus Wnt, which is expressed in embryonic brain. Mech. Dev. 63(2): 199-209.
Latinkic, B. V., et al. (2003). Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling. Development 130: 2429-2441. 12702657
Laurent, M. N., et al. (1997). The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer. Development 124(23): 4905-4916.
Laurent, M. N. and Cho, K. W. (1999). Bone morphogenetic protein antagonism of Spemann's organizer is independent of wnt signaling. Dev. Biol. 206(2): 157-62.
Lawrence, P.A., Bodmer, R. and Vincent, J.P. (1995). Segmental patterning of heart precursors in Drosophila. Development 121: 4303-4308
Lawrence, P., Sanson, B. and Vincent, J.-P. (1996). Compartments, wingless and engrailed: patterning and the ventral epidermis of Drosophila embryos. Development 122: 4095-4103
Lawrence, P. A., Casal, J. and Struhl, G. (2002). Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen. Development 129: 2749-2760. 12015301
Lecourtois, M., et al. (2001). Wingless capture by Frizzled and Frizzled2 in Drosophila embryos. Dev. Bio. 235: 467-475. 11437451
Lecuit, T. and Cohen, S. M. (1997). Proximal-distal axis formation in the Drosophila leg. Nature 388(6638): 139-145.
Lee, C. S., et al. (2000). SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127: 109-118.
Lee, H.-H. and Frasch, M. (2000). Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired. Development 127: 5497-5508.
Lee, J. D. and Treisman, J. E. (2001). The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc. Development 128: 1519-1529. 11290291
Lee, N., Maurange, C., Ringrose, L. and Paro, R. (2005). Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature 438(7065): 234-7. 16281037
Lee, S. M. K., et al. (1997). Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development 124: 959-969.
Lee, S. M. K., et al. (2000). A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 127: 457-467.
Lekven, A. C., et al. (2001). Zebrafish wnt8 encodes two Wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Dev. Cell 1: 103-114
Lekven, A. C., Buckles, G. R., Kostakis, N. and Moon, R. T. (2003). wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary. Dev. Bio. 254: 172-187. 12591239
Lessing, D, and Nusse, R. (1998). Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Development 125(8): 1469-1476.
Lewis, J. L., et al. (2004). Reiterated Wnt signaling during zebrafish neural crest development. Development 131(6): 1299-308. 14973296
Leyns, L., et al. (1997). Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell 88 (6): 747-756.
Li, C., et al. (2002). Wnt5a Participates in Distal Lung Morphogenesis. Dev. Bio. 248: 68-81. 12142021
Li, C., et al. (2008). Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol. Biol. 9: 11. PubMed citation: 18215320
Li, J. Y. H., Lao, Z. and Joyner, A. L. (2002). Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer. Neuron 36: 31-43. 12367504
Li, X., Gutjahr, T. and Noll, M. (1993a). Separable regulatory elements mediate the establishment and maintenance of cell states by the Drosophila segment-polarity gene gooseberry. EMBO J 12: 1427-36
Li, X. and Noll, M. (1993b). Role of the gooseberry gene in Drosophila embryos: maintenance of wg expression by a wg--gooseberry autoregulatory loop. EMBO J 12: 4499-509
Lickert, H., et al. (2000). Wnt/beta-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. Development 127: 3805-3813.
Lickert, H., et al. (2005). Dissecting Wnt/ß-catenin signaling during gastrulation using RNA interference in mouse embryos. Development 132: 2599-2609. 15857914
Ligon, K. L., et al. (2003). Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development 130: 2275-2287. 12668639
Lin, H. V., Rogulja, A. and Cadigan, K. M. (2004). Wingless eliminates ommatidia from the edge of the developing eye through activation of apoptosis. Development 131: 2409-2418. 15128670
Lin, R., Hill, R. J. and Priess, J. R. (1998). POP-1 and anterior-posterior fate decisions in C. elegans embryos. Cell 92(2): 229-239.
Lindahl, U., Kusche-Gullberg, M. and Kjellen, L. (1998). Regulated diversity of heparan sulfate. J. Biol. Chem. 273: 24979-24982. 9737951
Linker, C., et al. (2003). Intrinsic signals regulate the initial steps of myogenesis in vertebrates. Development 130: 4797-4807. 12917295
Linker, C., et al. (2005). ß-Catenin-dependent Wnt signalling controls the epithelial organisation of somites through the activation of paraxis. Development 132(17): 3895-905. 16100089
Linask, K. K., Knudsen, K. A. and Gui, Y. H. (1997). N-cadherin-catenin interaction: necessary component of cardiac cell compartmentalization during early vertebrate heart development. Dev. Biol. 185(2): 148-164.
Litsiou, A. Hanson, S. and Streit, A. (2005). A balance of FGF, BMP and WNT signalling positions the future placode territory in the head. Development 132: 4051-4062. 16093325
Liu, C., et al. (2003). A role for the mesenchymal T-box gene Brachyury in AER formation during limb development. Development 130: 1327-1337. 12588849
Liu, J. and Farmer, S. R. (2004). Regulating the balance between peroxisome proliferator-activated receptor gamma and ß-catenin signaling during adipogenesis. A glycogen synthase kinase 3ß phosphorylation-defective mutant of ß-catenin inhibits expression of a subset of adipogenic genes. J Biol Chem. 279(43): 45020-7. 15308623
Liu P., et al. (1999). Requirement for Wnt3 in vertebrate axis formation. Nat. Genet. 22(4): 361-5.
Liu, X., Grammont, M. and Irvine, K. D. (2000). Roles for scalloped and vestigial in regulating cell affinity and interactions between the wing blade and the wing hinge. Dev. Bio. 228: 287-303.
Liu, Y., et al. (2005). Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nat. Neurosci. 8(9):1151-9. 16116452
Llimargas, M. (2000). wingless and its signalling pathway have common and separable functions during tracheal development. Development 127: 4407-4417.
Llimargas, M. and Lawrence, P. A. (2001). Seven Wnt homologues in Drosophila: A case study of the developing tracheae. Proc. Natl. Acad. Sci. 98: 14487-14492. 11717401
Lo, P. C. and Frasch, M. (2001). A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila. Mech. Dev. 104: 49-60. 15922573
Lo, P. C. H., Skeath, J. B., Gajewski, K. Schulz, R. A. and Frasch, M. (2002). Homeotic genes autonomously specify the anteroposterior subdivision of the Drosophila dorsal vessel into aorta and heart. Dev. Bio. 251: 307-319. 12435360
Logan, C., et al. (1997). The role of Engrailed in establishing the dorsoventral axis of the chick limb. Development 124 (12): 2317-2324.
Loomis, C. A., et al. (1996). The mouse Engrailed-1 gene and ventral limb patterning. Nature 382: 360-363
Loomis, C., et al. (1998). Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs. Development 125(6): 1137-1148.
Lu, W., Yamamoto, V., Ortega, B. and Baltimore, D. (2004). Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119(1): 97-108. 15454084
Lucas, F. R. and Salinas, P. C. (1998a). WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons. Dev. Biol. 192(1): 31-44.
Lucas, F. R., et al. (1998b). Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. J. Cell Sci. 111(10): 1351-1361
Lüders, F., et al. (2003). slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila. EMBO J. 22: 3635-3644. 12853478
Lundell, M. J. and Hirsh, J. (1992). The zfh-2 gene product is a potential regulator of neuron-specific dopa decarboxylase gene expression in Drosophila. Dev. Biol. 154: 84-94. 1426635
Luo, H., et al. (1999). The Drosophila Jak kinase Hopscotch is required for multiple developmental processes in the eye. Dev. Biol. 213(2): 432-41.
Lyu, J. and Joo, C.-K. (2004). Wnt signaling enhances FGF2-triggered lens fiber cell differentiation. Development 131: 1813-1824. 15084465
Ma, C. and Moses, K. (1995). Wingless and ptc are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye. Development 121: 2279-2289
Ma, L. and Wang, H. Y. (2007). Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway. J. Biol. Chem. 282(39): 28980-90. PubMed citation: 17684012
Majumdar, A., et al. (2003). Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 130: 3175-3185. 12783789
Mandal, L., Banerjee, U. and Hartenstein, V. (2004). Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm. Nat. Genet. 36: 1019-1023. 15286786
Mao, B., et al. (2002). Kremen proteins are Dickkopf receptors that regulate Wnt/ß-catenin signalling. Nature 417: 664-667. 12050670
Marois, E., Mahmoud, A. and Eaton, S. (2006). The endocytic pathway and formation of the Wingless morphogen gradient. Development 133(2): 307-17. 16354714
Marlow, F., et al. (2004). No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish. Development 131: 203-216
Marlow, G., et al. (2002). Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr. Biol. 12: 876-884. 12062050
Mathew, D., Ataman, B., Chen, J., Zhang, Y., Cumberledge, S. and Budnik, V. (2005). Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 310(5752): 1344-7. 16311339
Matsui, T., et al. (2005). Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev. 19(1): 164-75. 15630025
Mazaleyrat, S. L., et al. (2003). Down-regulation of Notch target gene expression by Suppressor of deltex. Dev. Bio. 255: 363-372. 12648496
Megason, S. G. and McMahon, A. P. (2002). A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129: 2087-2098. 11959819
Magie, C. R. and Parkhurst, S. M. (2005). Rho1 regulates signaling events required for proper Drosophila embryonic development. Dev. Biol. 278(1): 144-54. 15649467
Majumdar, A., Nagaraj, R. and Banerjee, U. (1997). strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin in Drosophila. Genes Dev. 11: 1341-1353
Makita, R., et al. (1998). Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and no tail activity. Mech. Dev. 71(1-2): 165-176.
Maloof, J. N., et al. (1999). A Wnt signaling pathway controls Hox gene expression and neuroblast migration in C. elegans. Development 126(1): 37-49.
Mann, R. S. and Abu-Shaar, M. (1996). Nuclear import of the homeodomain protein Extradenticle in response to Wg and Dpp signalling. Nature 383(6601): 630-633.
Manoukian, A. S., et al. (1995). The porcupine gene is required for wingless autoregulation in Drosophila. Development 112: 4037-44
Mansouri, A. and Gruss, P. (1998). Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord. Mech. Dev. 78(1-2): 171-178.
Marcelle, C., Stark, M. R. and Bronner-Fraser, M. (1997). Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite. Development 124(20): 3955-3963.
Martin, B. S. and Bate, M. (2001). Hindgut visceral mesoderm requires an ectodermal template for normal development in Drosophila. Development 128: 233-242. 11124118
Marvin, M. J., et al. (2001). Inhibition of Wnt activity induces heart formation from posterior mesoderm. Genes Dev. 15: 316-327. 11159912
Mathies, L.D., Kerridge, S. and Scott, M.P. (1994). Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes. Development 120: 2799-2809

Matsunaga, E., Katahira, T. and Nakamura, H. (2002). Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development. Development 129: 5269-5277. 12399317
Maurel-Zaffran, C. and Treisman, J. E. (2000). pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila. Development 127: 1007-1016.
Maves, L. and Schubiger, G. (1998). A molecular basis for transdetermination in Drosophila imaginal discs: interactions between wingless and decapentaplegic signaling. Development 125(1): 115-124. 9389669
Mayr, T., et al. (1997). Fritz: a secreted frizzled-related protein that inhibits Wnt activity. Mech. Dev. 63 (1): 109-125.
McBride, H. J., Fatke, B. and Fraser, S. E. (2002). Wnt signaling components in the chicken intestinal tract. Dev. Biol. 256(1): 18-33. 12654289
McCartney, B. M., et al. (1999). Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J. Cell Biol. 146(6): 1303-18.
McClure, K. D. and Schubiger, G. (2008). A screen for genes that function in leg disc regeneration in Drosophila melanogaster. Mech. Dev. 125(1-2): 67-80. PubMed citation
McDonald, J. A. and Doe, C. Q. (1997). Establishing neuroblast-specific gene expression in the Drosophila CNS: huckebein is activated by Wingless and Hedgehog and repressed by Engrailed and Gooseberry. Development 124: 1079-1087
McGrew, L. L., Hoppler, S. and Moon, R. T. (1997). Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus. Mech. Dev. 69(1-2): 105-114
McLin, V. A., Rankin, S. A. and Zorn, A. M. (2007). Repression of Wnt/β-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development 134: 2207-2217. Medline abstract: 17507400
Merabet, S., et al. (2002). A green fluorescent protein reporter genetic screen that identifies modifiers of Hox gene function in the Drosophila embryo. Genetics 162: 189-202. 12242233
Merabet, S., Hombria, J. C., Hu, N., Pradel, J. and Graba, Y. (2005). Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis. Development 132(13): 3093-3102. 15930099
Mercurio, S., et al. (2004). Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex. Development 131: 2137-2147. 15105373
Mericskay, M., Kitajewski, J. and Sassoon, D. (2004). Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus. Development 131: 2061-2072. 15073149
Merzdorf, C. S. and Sive, H. L. (2006). The zic1 gene is an activator of Wnt signaling. Int. J. Dev. Biol. 50(7): 611-7. Medline abstract: 16892174
Micchelli, C. A., Rulifson, E. J. and Blair, S. S. (1997). The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124 (8): 1485-1495.
Miller C, Sassoon DA., et al. (1998). Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract. Development 125(16): 3201-3211.
Miller, D. F. B., et al. (2001). Homeotic Complex (Hox) gene regulation and homeosis in the mesoderm of the Drosophila melanogaster embryo: the roles of signal transduction and cell autonomous regulation. Mech. Dev. 102: 17-32. 11287178
Millar, S. E., et al. (1999). WNT signaling in the control of hair growth and structure. Dev. Biol. 207(1): 133-149.
Miletich, I., and Limbourg-Bouchon, B. (2000). Drosophila null slimb clones transiently deregulate Hedgehog-independent transcription of wingless in all limb discs, and induce decapentaplegic transcription linked to imaginal disc regeneration. Mech. Dev. 93: 15-26.
Miskolczi-McCallum, C. M., Scavetta, R. J., Svendsen, P. C., Soanes, K. H. and Brook, W. J. (2005). The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development. Dev. Biol. 2005 278(2): 459-72. 15680363
Mito, T., et al. (2002). Involvement of hedgehog, wingless, and dpp in the initiation of proximodistal axis formation during the regeneration of insect legs, a verification of the modified boundary model. Mech. Dev. 114: 27-35. 12175487
Miyawaki, K., et al. (2004). Involvement of Wingless/Armadillo signaling in the posterior sequential segmentation in the cricket, Gryllus bimaculatus (Orthoptera), as revealed by RNAi analysis. Mech. Dev. 121: 119-130. 15037314
Moeller, C., et al. (2003). Carboxypeptidase Z (CPZ) modulates Wnt signaling and regulates the development of skeletal elements in the chicken. Development 130: 5103-5111. 12944424
Mohler, J., Mahaffey, J.W., Deutsch, E., and Vani, K. (1995a). Control of Drosophila head segment identity by the bZIP homeotic gene cnc. Development 121: 237-247

Mohler, J. (1995b). Spatial regulation of segment polarity gene expression in the anterior terminal region of the Drosophila blastoderm embryo. Mech Dev 50: 151-161
Mohler, J. (1995). Spatial regulation of segment polarity gene expression in the anterior terminal region of the Drosophila blastoderm embryo. Mech Dev 50: 151-161
Molenaar, M., et al. (1996). XTcf-3 transcription factor mediates ß-catenin-induced axis formation in Xenopus embryos. Cell 86: 391-399
Moline, M. M., Southern, S. and Bejsovec, A. (1999). Directionality of Wingless protein transport influences epidermal patterning in the Drosophila embryo. Development 126: 4375-4384.
Moline, M. M., Dierick, H. A., Southern, C. and Bejsovec, A. (2000). Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic Wingless signal transduction. Curr. Biol. 10: 1127-1130. 10996794
Momoi, A., et al. (2003). Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8. Mech. Dev. 120: 477-489. 12676325
Monsoro-Burq, A. H., Wang, E. and Harland, R. (2004). Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. Dev. Cell 8: 167-178. 15691759
Moon, R. T., Brown, J. D. and Torres, M. (1997). WNTs modulate cell fate and behavior during vertebrate development. Trends Genet. 13: 157-163
Monkley, S. J., (1996). Targeted disruption of the Wnt2 gene results in placentation defects. Development 122, 3343-3353
Morgan, R., et al. (1999). A conserved 30 base pair element in the Wnt-5a promoter is sufficient both to drive its' early embryonic expression and to mediate its' repression by otx2. Mec. Dev. 85(1-2): 97-102.
Morel, V. and Arias, A. M. (2004). Armadillo/ß-catenin-dependent Wnt signalling is required for the polarisation of epidermal cells during dorsal closure in Drosophila. Development 131: 3273-3283. 15226252
Morimura, S., et al., (1996). decapentaplegic overexpression affects Drosophila wing and leg imaginal disc development and wingless expression. Dev. Biol 177 136-51
Morkel, M., et al. (2003). �-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development 130: 6283-6294. 14623818
Motzny, C. K. and Holmgren, R. (1995). The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech Dev 52: 137-150
Mukhopadhyay, M., et al. (2001). Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Developmental Cell 1: 423-434
Mullen, J. R. and DiNardo, S. (1995). Establishing parasegments in Drosophila embryos: roles of odd-skipped and naked genes. Dev. Biol. 169: 295-308
Mullor, J. L., et al. (2001). Wnt signals are targets and mediators of Gli function. Curr. Biol. 11: 769-773. 11378387
Muroyama, Y., et al. (2002). Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 16: 548-553. 11877374
Myers, D. C., Sepich, D. S. and Solnica-Krezel, L. (2002). Bmp activity gradient regulates convergent extension during zebrafish gastrulation. Dev. Biol. 243: 81-98. 11846479
Nakagawa, S., et al. (2003). Identification of the laminar-inducing factor: Wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro. Dev. Bio. 260: 414-425. 12921742
Nakagoshi, H., et al. (1998). A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells. Genes Dev. 12: 2724-2734.
Nakagoshi, H., et al. (2002). Refinement of wingless expression by a Wingless-and Notch-responsive homeodomain protein, Defective proventriculus. Dev. Bio. 249: 44-56. 12217317
Nakamura, K., et al. (2005). Wnt signaling drives WRM-1/ß-catenin asymmetries in early C. elegans embryos. Genes Dev. 19: 1749-1754. 16077004
Nambu, P. A. and Nambu, J. R. (1996). The Drosophila fish-hook gene encodes a HMG domain protein essential for segmentation and CNS development. Development 122: 3467-75
Nasevicius, A., et al. (1998). Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation. Development 125(21): 4283-4292.
Nasiadka, A. and Krause, H. M. (1999). Kinetic analysis of segmentation gene interactions in Drosophila embryos. Development 126: 1515-1526.
Nasonkin, I., Alikasifoglu, A., Ambrose, C., Cahill, P., Cheng, M., Sarniak, A., Egan, M. and Thomas, P. (1999). A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system. J. Biol. Chem. 274: 29420-24925. 10506204
Neumann, C. J. and Cohen, S. M. (1996a). Distinct mitogenic and cell fate specification functions of wingless in different regions of the wing. Development 122: 1781-89
Neumann, C. J. and Cohen, S. M. (1996b). A heirarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing. Development 122, 3477-3485
Neumann, C. J. and Cohen, S. M. (1997). Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development 124: 871-880
Neumann, C. J. and Cohen, S. M. (1998). Boundary formation in Drosophila wing: Notch activity attenuated by the POU protein Nubbin. Science 281(5375): 409-413
Newfeld, S. J. and Takaesu, N. T. (2002). An analysis using the hobo genetic system reveals that combinatorial signaling by the Dpp and Wg pathways regulates dpp expression in leading edge cells of the dorsal ectoderm in Drosophila melanogaster. Genetics 161: 685-692. 12072465
Ng, M., et al. (1996). Specification of the wing by localized expression of wingless protein. Nature 381: 316-318
Niwa, N., et al. (2000). Correlation of diversity of leg morphology in Gryllus bimaculatus (cricket) with divergence in dpp expression pattern during leg development. Development 127: 4373-4381.
Noordermeer, J., et al. (1994). dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature 367: 80-3
Nulsen, C. and Nagy, L. N. (1999). The role of wingless in the development of multibranched crustacean limbs. Dev. Genes Evol. 209: 340-348.
Ohkawara, B., et al. (2003). Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 130: 2129-2138. 12668627
Ohuchi. H., et al. (1997). A chick wingless mutation causes abnormality in maintenance of Fgf8 expression in the wing apical ridge, resulting in loss of the dorsoventral boundary. Mech. Dev. 62 (1): 3-13.
O'Keefe, L., et al. (1997). Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis. Development 124(23): 4837-45.
Olivera-Martinez, I., et al. (2001). Dorsal dermis development depends on a signal from the dorsal neural tube, which can be substituted by Wnt-1. Mech. Dev. 100: 233-244. 11165480
Ossipova, O., Dhawan, S., Sokol, S. and Green, J. B. (2005). Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. Dev. Cell 8(6): 829-41. 15935773
Osumi, N., et al. (1997). Pax-6 is involved in the specification of hindbrain motor neuron subtype. Development 124(15): 2961-2972.
Overton, P. M., Chia, W. and Buescher, M (2007). The Drosophila HMG-domain proteins SoxNeuro and Dichaete direct trichome formation via the activation of shavenbaby and the restriction of Wingless pathway activity. Development 134(15): 2807-13 . PubMed citation; Online text
Packard, M., et al. (2002). The Drosophila Wnt, Wingless, provides an essential signal for pre- and postsynaptic differentiation. Cell 111: 319-330. 12419243
Panakova, D., Sprong, H., Marois, E., Thiele, C. and Eaton, S. (2005). Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 435: 58-65. PubMed citation: 15875013
Pandur, P., et al. (2002). Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature 418: 636-641. 12167861
Pankratz, M. J. and Hoch, M. (1995). Control of epithelial morphogenesis by cell signaling and integrin molecules in the Drosophila foregut. Development 121: 1885-1898
Park, J.-S.. Valerius, M. T. and McMahon, A. P. (2007). Wnt/β-catenin signaling regulates nephron induction during mouse kidney development. Development 134: 2533-2539. Medline abstract: 17537789
Park, M., et al. (1996). The Wingless signaling pathway is directly involved in Drosophila heart development. Dev. Biol 177: 104-116.
Papayannopoulos, V., et al. (1998). Dorsal-ventral signaling in the Drosophila eye. Science 281(5385): 2031-4.
Parr, B. A. and McMahon, A. P. (1998). Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature 395(6703): 707-10.
Parr, B. A., et al. (2001). Wnt7b regulates placental development in mice. Dev. Bio. 237: 324-332. 11543617
Pazdera, T. M., Janardhan, P. and Minden J. S. (1998). Patterned epidermal cell death in wild-type and segment polarity mutant Drosophila embryos. Development 125(17): 3427-3436.
Penzo-Mendez, A., et al. (2003). Activation of Gßgamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. Dev. Biol. 257: 302-314. 12729560
Perantoni, A. O., et al. (2005). Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development 132(17): 3859-71. 16049111
Pereira, P. S., Pinho, S., Johnson, K., Couso, J. P. and Casares, F. (2006). A 3' cis-regulatory region controls wingless expression in the Drosophila eye and leg primordia. Dev. Dyn. 235: 225-234. Medline abstract: 16261625
Pérez-Garijo, A., MartÍn, F. A. and Morata, G. (2004). Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila. Development 131: 5591-5598. 15496444
Perez-Garijo, A., Martin, F. A., Struhl, G. and Morata, G. (2005). Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila. Proc. Natl. Acad. Sci. 102(49): 17664-9. 16314564
Person, A. D., et al. (2005). Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development. Dev. Biol. 278(1): 35-48. 15649459
Pfeiffer, S., et al. (2000). The progeny of wingless-expressing cells deliver the signal at a distance in Drosophila embryos. Curr. Biol. 10: 321-324.
Pfeiffer, S., et al. (2002). Producing cells retain and recycle Wingless in Drosophila embryos. Curr. Biol. 12: 957-962. 12062063
Phillips, R. G., Warner, N. L. and Whittle, J. R. (1999). Wingless signaling leads to an asymmetric response to Decapentaplegic-dependent signaling during sense organ patterning on the notum of Drosophila melanogaster. Dev. Biol. 207(1): 150-162.
Piccolo S., et al. (1999). The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397(6721): 707-10.
Pichaud, F. and Casares, F. (2000). homothorax and iroquois-C genes are required for the establishment of territories within the developing eye disc. Mech. Dev. 96: 15-25.
Piddini, E., et al. (2005). Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs. Development 132: 5479-5489. 16291792
Piepenburg, O., Vorbruggen, G., Jackle, H. (2000). Drosophila segment borders result from unilateral repression of hedgehog activity by wingless signaling. Mol. Cell 6(1): 203-9. 10949042
Pierce, S. B. and Kimelman, D. (1995). Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3. Development 121: 755-765
Pinson, K. I., Brennan, J., Monkley, S., Avery, B. and Skarnes, W. C. (2000). An LDL-receptor-related protein mediates Wnt signaling in mice. Nature 407: 535-538.
Pinto, D., et al. (2003). Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17: 1709-1713. 12865297
Polesskaya, A., Seale, P. and Rudnicki, M. A. (2003). Wnt signaling induces the myogenic specification of resident CD45⁺ adult stem cells during muscle regeneration. Cell 113: 841-852. 12837243
Popperl, H., et al. (1997). Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm. Development 124(15): 2997-3005.
Porter, J. A., et al. (1996). Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell 86: 21-34
Poux, S., Kostic, C. and Pirrotta, V. (1996). Hunchback-independent silencing of late Ubx enhancers by a polycomb group response element. EMBO J. 15: 4713-22
Prasad, M., Bajpai, R. and Shashidhara, L. S. (2003). Regulation of Wingless and Vestigial expression in wing and haltere discs of Drosophila. Development 130: 1537-1547. 12620980
Price, M. H., et al. (2006). Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle. J. Cell Sci. 119: 403-415. 16418222
Prinos, P., et al. (2001). Multiple pathways governing Cdx1 expression during murine development. Dev. Bio. 239: 257-269
Prpic, N. M. (2004). Homologs of wingless and decapentaplegic display a complex and dynamic expression profile during appendage development in the millipede Glomeris marginata (Myriapoda: Diplopoda). Front. Zool. 1(1): 6. 12194820
Prud'homme, B., et al. (2003). Arthropod-like expression patterns of engrailed and wingless in the annelid Platynereis dumerilii suggest a role in segment formation. Curr. Biol. 13: 1876-1881. 14588243
Continued: Wingless references: Part 3/3 | back to Part 1/3

The Interactive Fly resides on the
Society for Developmental Biology's Web server.