Sex combs reduced


REFERENCES

Abzhanov, A. and Kaufman, T. C. (1999). Novel regulation of the homeotic gene Scr associated with a crustacean leg-to-maxilliped appendage transformation. Development 126: 1121-1128. 10021332

Alper, S. and Kenyon, C. (2001). REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity. Development 128(10): 1793-804. 11311160

Andrew, D. J., et al. (1994). Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes. EMBO J 13: 1132-44

Andrew, D. J. (1995). The Sex combs reduced gene of Drosophila melanogaster has multiple transcripts. Gene 152: 149-155

Andrew, D. J., et al. (1997). The Drosophila dCREB-A gene is required for dorsal/ventral patterning of the larval cuticle. Development 124: 181-193.

Aubin, J., et al. (1997). Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects. Dev. Biol. 192(2): 432-445.

Aubin, J., et al. (2002a). Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling. Development 129: 4075-4087. 12163410

Aubin, J., et al. (2002b). Cooperation of Hoxa5 and Pax1 genes during formation of the pectoral girdle. Dev. Biol. 244: 96-113. 11900462

Bel, S., et al. (1998). Genetic interactions and dosage effects of Polycomb group genes in mice. Development 125(18): 3543-3551.

Belozerov, V. E., Majumder, P., Shen, P. and Cai, H. N. (2003). A novel boundary element may facilitate independent gene regulation in the Antennapedia complex of Drosophila. EMBO J. 22: 3113-3121. 12805225

Berry, M. and Gehring, W. (2000). Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'. EMBO J. 19: 2946-2957.

Boube, M., et al. (2000). Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev. 14: 2906-2917. 11090137

Breen, T. R. and Harte, P. J. (1993). Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each. Development 117: 119-34. 7900984

Brennecke, J., Stark, A., Russell, R. B. and Cohen, S. M. (2005). Principles of microRNA-target recognition. PLoS Biol. 3(3):e85. 15723116

Brizuela, B. J., et al. (1994). Genetic analysis of the brahma gene of Drosophila melanogaster and polytene chromosome subdivisions 72AB. Genetics 137: 803-813

Brizuela, B. J. and Kennison, J. A. (1997). The Drosophila homeotic gene moira regulates expression of engrailed and HOM genes in imaginal tissues. Mech. Dev. 65(1-2): 209-220.

Calhoun, V. C., Stathopoulos, A. and Levine, M. (2002). Promoter-proximal tethering elements regulate enhancer-promoter specificity in the Drosophila Antennapedia complex. Proc. Natl. Acad. Sci. 99: 9243-9247. 12093913

Calhoun, V. C. and Levine, M. (2003). Long-range enhancer-promoter interactions in the Scr-Antp interval of the Drosophila Antennapedia complex. Proc. Natl. Acad. Sci. 100(17): 9878-83. 12909726

Cerny, A. C., et al. (2005). Breakdown of abdominal patterning in the Tribolium Krüppel mutant jaws. Development 132: 5353-5363. 16280347

Chang, Y.-L., et al. (2001). Essential role of Drosophila Hdac1 in homeotic gene silencing. Proc. Natl. Acad. Sci. Vol. 98: 9730-9735. 11493709

Chen, Y., et al. (1998). A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A. Development 125(9): 1759-1768

Chen, Z. and Han, M. (2001). C. elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification. Curr. Biol. 11: 1874-1879. 11728311

Chíng, Q. L. and Kenyon, C. (1999). egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function. Development 126: 3303-3312.

Clandinin, T. R., et al. (1997). Caenorhabditis elegans HOM-C genes regulate the response of vulval precursor cells to inductive signal. Dev. Biol 182: 150-161

Daubresse, G., Deuring, R., Moore, L., Papoulas, O., Zakrajsek, I., Waldrip, W. R., Scott, M. P., Kennison, J. A. and Tamkun, J. W. (1999). The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity. Development 126: 1175-1187. 10021337

DeCamillis, M. and ffrench-Constant, R. (2003). Proboscipedia represses distal signaling in the embryonic gnathal limb fields of Tribolium castaneum. Dev. Genes Evol. 213(2): 55-64. 12632174

Koh1, K., et al. (2002). Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors -- apparent direct targets of the LIN-39 Hox protein. Development 129: 5171-5180. 12399309

DeCamillis, M. A., et al. (2001). Interactions of the Tribolium Sex combs reduced and proboscipedia orthologs in embryonic labial development. Genetics 159: 1643-1648. 11779803

de Zulueta, P., et al. (1994). Homeotic complex and teashirt genes co-operate to establish trunk segmental identities in Drosophila. Development 120: 2287-2296. 7925029

Eizinger, A. and Sommer, R. J. (1997). The homeotic gene lin-39 and the evolution of nematode epidermal cell fates. Science 278(5337): 452-455.

Elfring, L. K., et al. (1998). Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2. Genetics 148(1): 251-265.

Faucheux, M., et al. (2003). batman interacts with Polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor. Molec. Cell. Bio. 23: 1181-1195. 12556479

Foucher, I., et al. (2002). Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors. Development 129: 4065-4074. 12163409

Gellon, G., et al. (1997). A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development. Development 124(17): 3321-3331.

Gerasimova, T. I. and Corces, V. G. (1998). Polycomb and trithorax group proteins mediate the function of a chromatin insulator. Cell 92(4): 511-521.

Gindhart, J. G. and Kaufman, T. C. (1995a). Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene Sex combs reduced. Genetics 139: 797-814

Gindhart, J. G., Jr., King, A. N. and Kaufman, T. C. (1995b). Characterization of the cis-regulatory region of the Drosophila homeotic gene Sex combs reduced. Genetics 139: 781-795. 7713432

Gleason, J. E., Korswagen, H. C. and Eisenmann, D. M. (2002). Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction. Genes Dev. 16: 1281-1290. 12023306

Gonzalez-Reyes, A., Macias, A. and Morata, G. (1992). Autocatalysis and phenotypic expression of Drosophila homeotic gene Deformed: its dependence on polarity and homeotic gene function. Development 116: 1059-68

Gorman, M. J. and Kaufman, T. C. (1995). Genetic analysis of embryonic cis-acting regulatory elements of the Drosophila homeotic gene Sex combs reduced. Genetics 140: 557-572

Graba, Y., Laurenti, P., Perrin, L., Aragnol, D. and Pradel, J. (1994). The modifier of variegation modulo gene acts downstream of dorsoventral and HOM-C genes and is required for morphogenesis in Drosophila. Dev. Biol. 166: 704-715. 7813788

Grandien, K. and Sommer, R. J. (2001). Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences Genes Dev. 15: 2161-2172. 11511546

Gutiérrez, L., Zurita, M., Kennison, J. A. and Vázquez, M. (2003). The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein. Development 130: 343-354. 12466201

Henderson, K. D., Isaac, D. D. and Andrew, D. J. (1999). Cell fate specification in the Drosophila salivary gland: the integration of homeotic gene function with the DPP signaling cascade. Dev. Biol. 205(1): 10-21.

Henderson, K. D. and Andrew, D. J. (2000). Regulation and function of Scr, exd, and hth in the Drosophila salivary gland. Dev. Biol. 217: 362-374

Heuer, J. G. and Kaufman, T. C. (1992). Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system. Development 115: 35-47

Hirth, F., Hartmann, B. and Reichert, H. (1998). Homeotic gene action in embryonic brain development of Drosophila. Development 125: 1579-1589.

Hughes, C. L. and Kaufman, T. C. (2000). RNAi analysis of Deformed, proboscipedia and Sex combs reduced in the milkweed bug Oncopeltus fasciatus: novel roles for Hox genes in the Hemipteran head. Development 127: 3683-3694. 10934013

Jones, N.A., Kuo, Y.M., Sun, Y.H., Beckendorf, S.K. (1998). The Drosophila pax gene eye gone is required for embryonic salivary duct development. Development 125(21): 4163-4174.

Jullien, D., Crozatier, M. and Kas, E. (1997). cDNA sequence and expression pattern of the Drosophila melanogaster PAPS synthetase gene: a new salivary gland marker. Mech. Dev. 68(1-2): 179-186.

Jun, S., Wallen, R.V., Goriely, A., Kalionis, B., Desplan, C. (1998). Lune/eye gone, a pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition. Proc. Natl. Acad. Sci. 95(23): 13720-13725.

Kehle, J., et al. (1998). dMi-2, a Hunchback-interacting protein that functions in Polycomb repression. Science 282(5395): 1897-900.

Kim, S. Y., Paylor, S.W., Magnuson, T. and Schumacher, A. (2006). Juxtaposed Polycomb complexes co-regulate vertebral identity. Development 133(24): 4957-68. Medline abstract: 17107999

Kokubo, H., et al. (1997). Involvement of the Bombyx Scr gene in development of the embryonic silk gland. Dev. Biol. 186(1): 46-57.

Kourakis, M. J., et al. (1997). Conserved anterior boundaries of Hox gene expression in the central nervous system of the leech Helobdella. Dev. Biol. 190(2): 284-300.

LaJeunesse, D. and Shearn, A. (1995). Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent, small, and homeotic discs 1 and 2. Mech. Dev. 53: 123-39

LeMotte, P. K., et al. (1989). The homeotic gene Sex combs reduced of Drosophila: gene structure and embryonic expression. EMBO J 8: 219-27

Liu, J. and Fire, A. (2000). Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm. Development 127: 5179-5190.

Lu, Q., et al. (1995). Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol. Cell. Biol. 15 (7): 3786-3795.

Mahaffey, J. W., Diederich, R. J. and Kaufman, T. C. (1989). Novel patterns of homeotic protein accumulation in the head of the Drosophila embryo. Development 105: 167-74

Maloof, J. N. and Kenyon, C. (1998). The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling. Development 125(2): 181-190. 9486792

Martinez-Arias, A., et al. (1987). The spatial and temporal deployment of Dfd and Scr transcripts throughout development of Drosophila. Development 100: 673-83

Mihaly, J., Misra, R. K. and Karch, F. (1998). A conserved sequence motif in Polycomb-response elements. Mol. Cell 1: 1065-1066

Miller, D. F. B., et al. (2001a). Cross-regulation of Hox genes in the Drosophila melanogaster embryo. Mech. Dev. 102: 3-16. 11287177

Miller, D. F. B., et al. (2001b). Homeotic Complex (Hox) gene regulation and homeosis in the mesoderm of the Drosophila melanogaster embryo: the roles of signal transduction and cell autonomous regulation. Mech. Dev. 102: 17-32. 11287178

Mishra, K., et al. (2003). Trl-GAGA directly interacts with lola like and both are part of the repressive complex of Polycomb group of genes. Mech. Dev. 120: 681-689. 12834867

Nowling, T., et al. (1999). Hoxa5 gene regulation: A gradient of binding activity to a brachial spinal cord element. Dev. Biol. 208(1): 134-46.

Oosterveen, T., et al. (2003). Retinoids regulate the anterior expression boundaries of 5' Hoxb genes in posterior hindbrain. EMBO J. 22(2): 262-9. 12514132

Orii, H., et al. (1999). The planarian HOM/HOX homeobox genes (Plox) expressed along the anteroposterior axis. Dev. Biol. 210(2): 456-68.

Panzer, S., Weigel, D. and Beckendorf, S. K. (1992). Organogenesis in Drosophila melanogaster: embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes. Development 114: 49-57

Pattatucci, A. M., Otteson, D. C. and Kaufman. T. C. (1991a). A functional and structural analysis of the Sex combs reduced locus of Drosophila melanogaster. Genetics 129: 423-41

Pattatucci, A. M. and Kaufman, T. C. (1991b). The homeotic gene Sex combs reduced of Drosophila melanogaster is differentially regulated in the embryonic and imaginal stages of development. Genetics 129: 443-61

Pederson, J. D., Kiehart, D. P. and Mahaffey, J. W. (1996). The role of HOM-C genes in segmental transformations: Reexamination of the Drosophila Sex combs reduced embryonic phenotype. Dev. Biol. 180: 131-142

Percival-Smith, A., et al. (1997). Genetic characterization of the role of the two HOX proteins, Proboscipedia and Sex Combs Reduced, in determination of adult antennal, tarsal, maxillary palp and proboscis identities in Drosophila melanogaster. Development 124(24): 5049-5062.

Percival-Smith, A. and Hayden, D. J. (1998). Analysis in Drosophila melanogaster of the interaction between Sex combs reduced and Extradenticle activity in the determination of tarsus and arista identity. Genetics 150(1): 189-198.

Prince, V. E., Price, A. L. and Ho, R. K. (1998). Hox gene expression reveals regionalization along the anteroposterior axis of the zebrafish notochord. Dev. Genes Evol. 208(9): 517-522.

Qi, D., Jin, H., Lilja, T. and Mannervik, M. (2006). Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin. Genetics 174(1): 241-51. Medline abstract: 16816423

Reuter, R. and Scott, M. P. (1990). Expression and function of the homoeotic genes Antennapedia and Sex combs reduced in the embryonic midgut of Drosophila. Development 109: 289-303

Robertson, L. K., et al. (2004). An interactive network of zinc-finger proteins contributes to regionalization of the Drosophila embryo and establishes the domains of HOM-C protein function. Development 131: 2781-2789. 15142974

Rogers, B. T., Peterson, M. D. and Kaufman, T. C. (1997). Evolution of the insect body plan as revealed by the Sex combs reduced expression pattern. Development 124: 149-157. 9006076

Rusch, D. B. and Kaufman, T. C. (2000). Regulation of proboscipedia in Drosophila by homeotic selector genes. Genetics 156: 183-194.

Sanlioglu, S., et al. (1998). Regulation of a Purkinje cell-specific promoter by homeodomain proteins: repression by engrailed-2 vs. synergistic activation by Hoxa5 and Hoxb7. J. Neurobiol. 36(4): 559-71.

Searcy, R. D. and Yutzey, K. E. (1998). Analysis of Hox gene expression during early avian heart development. Dev. Dyn. 213(1): 82-91.

Shippy, T. D., et al. (2006). The Tribolium castaneum ortholog of Sex combs reduced controls dorsal ridge development. Genetics 174(1): 297-307. 16849608

Shroff, S., Joshi, M. and Orenic, T. V. (2007). Differential Delta expression underlies the diversity of sensory organ patterns among the legs of the Drosophila adult. Mech. Dev. 124: 43-58. Medline abstract: 17107776

Southworth J. W. and Kennison, J. A. (2002). Transvection and silencing of the Scr homeotic gene of Drosophila melanogaster. Genetics 161: 733-746. 12072469

Srinivasan, S., et al. (2005). The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II. Development 132: 1623-1635. 15728673

Tayyab, I., Hallahan, H. M. and Percival-Smith, A. (2004). Analysis of Drosophila proboscipedia mutant alleles. Genome 47(3): 600-9. 15190377

Telford, M. J. and Thomas, R. H. (1998). Expression of homeobox genes shows chelicerate arthropods retain their deutocerebral segment. Proc. Natl. Acad. Sci. 95(18): 10671-5.

Walldorf, U., Binner, P. and Fleig, R. (2000). Hox genes in the honey bee Apis mellifera Dev. Genes Evol. 210: 483-492

Zeng, W., et al (1993). Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity. Development 118: 339-52

Zhao, J. J., Lazzarini, R. A. and Pick, L. (1993). The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene. Genes Dev 7: 343-54

Zhou, B., Bagri, A. and Beckendorf, S. K. (2001). Salivary gland determination in drosophila: a salivary-specific, fork head enhancer integrates spatial pattern and allows fork head autoregulation. Dev. Bio. 237: 54-67. 11518505


Sex combs reduced: Biological Overview | Evolutionary Homologs | Regulation | Targets of Activity, Homeotic Effects, Post-Transcriptional Regulation and Protein Interactions | Developmental Biology | Effects of Mutation

date revised: 20 August 2007 

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