hunchback
Abbott, A. L., et al. (2005). The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev. Cell 9: 403-414. 16139228
Abrahante, J. E., et al. (2003). The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Developmental Cell 4: 625-637. 12737799
Berman, B. P., et al. (2002). Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome. Proc. Natl. Acad. Sci. 99: 757-762. 11805330
Brody, T. and Odenwald, W. F. (2000). Programmed transformations in neuroblast
gene expression during Drosophila CNS lineage development. Developmental Biology 226: 34-44. 10993672
Brown, K., et al. (1997). Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91: 845-854. 9413993
Busturia, A. and Bienz, M. (1993). Silencers in Abdominal-B, a homeotic Drosophila gene. EMBO J 12: 1415-25
Casares, F. and Sanchez-Herrero, E. (1995). Regulation of the infraabdominal regions of the bithorax complex of Drosophila by gap genes. Development 121: 1855-1866
Chagnovich, D. and Lehmann, R. (2001). Poly(A)-independent regulation of maternal hunchback translation in the Drosophila embryo
Proc. Natl. Acad. Sci. 98: 11359-11364. 11562474
Chan, C-S., Rastelli, L. and Pirrotta, V. (1994). A Polycomb response element of the Ubx gene that determines an epigenetically inherited state of repression. EMBO J 11: 2553-64
Cho, P. F., et al. (2005). A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell 121(3): 411-23. PubMed citation; Online text
Cho, P. F., et al. (2006). Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos. Curr. Biol. 16(20): 2035-41. PubMed citation: 17055983
Choksi, S. P., et al. (2006). Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev. Cell 11(6): 775-89. Medline abstract: 17141154
Christen, B and Bienz, M. (1994). Imaginal disc silencers from Ultrabithorax: evidence for Polycomb response elements. Mech Dev 48: 255-266
Christopherson, I., et al. (2001). Regulation of L-selectin expression by a dominant negative Ikaros protein. J. Leukoc. Biol. 69(4): 675-83. 11310856
Cleary, M. D. and Doe, C. Q. (2006). Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window. Genes Dev. 20(4): 429-34. 16481472
Clyde, D. E., Corado, M. S., Wu, X., Pare, A., Papatsenko, D. and Small, S. (2003). Self-organizing system of repressor gradients establishes segmental complexity in Drosophila. Nature 426(6968): 849-53. 14685241
Cobb, B. S., et al. (2000). Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. Genes Dev. 14(17): 2146-60. 10970879
Cockerill, K.A., Billin, A.N. and Poole, S.J. (1993). Regulation of expression domains and effects of ectopic expression reveal gap gene-like properties of the linked pdm genes of Drosophila. Mech Dev. 41: 139-153
Cui X. and Doe C. Q. (1995) The role of the cell cycle and cytokinesis in regulating neuroblast sublineage gene expression in the Drosophila CNS. Development 121: 3233-3243. 7588058
Curtis, D., Apfeld, J. and Lehmann, R. (1995). nanos is an evolutionarily conserved organizer of anterior-posterior polarity. Development 121: 1899-1910
Curtis, D., et al. (1997). A CCHC metal-binding domain in Nanos is essential for translational regulation. EMBO J. 16: 834-843
Deshpande, G., Calhoun, G. and Schedl, P. (2004). Overlapping mechanisms function to establish transcriptional quiescence in the embryonic Drosophila germline. Development 131: 1247-1257. 14960492
Edwards, T. A., et al. (2001). Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Cell 105: 281-289. 11336677
Fay, D. S., et al. (1999). A Caenorhabditis elegans homologue of hunchback is required for late stages of development but not early embryonic patterning. Dev. Biol. 205(2): 240-53.
Fu, D. and Ma, J. (2005). Interplay between positive and negative activities that influence the role of Bicoid in transcription.
Nucleic Acids Res. 33(13): 3985-93. 16030350
Fujioka, M., et al. (1999). Analysis of an even-skipped rescue transgene reveals both composite and
discrete neuronal and early blastoderm enhancers, and multi-stripe
positioning by gap gene repressor gradients. Development 126: 2527-2538.
Gavis, E. R. and Lehmann, R. (1994). Translational regulation of nanos by RNA localization. Nature 369: 315-8
Goltsev, Y., et al. (2004). Different combinations of gap repressors for common stripes in Anopheles and Drosophila embryos. Dev. Biol. 275: 435-446. 15501229
Gomez-del Arco, P., Koipally, J. and Georgopoulos, K. (2005). Ikaros SUMOylation:
Switching out of repression. Mol. Cell. Biol. 25: 2688-2697. 15767674
Gregor, T., Tank, D. W., Wieschaus, E. F. and Bialek. W. (2007). Probing the limits to positional information. Cell 130(1): 153-64. Medline abstract: 17632062
Gursky, V. V., Jaeger, J., Kozlov, K. N., Reinitz, J. and Samsonov, A. M. (2004). Pattern formation and nuclear divisions are uncoupled in Drosophila segmentation: Comparison of spatially discrete and continuous models. Physica D 197: 286-302. Full text: Gursky, 2004
Gutjahr, T. Frei, E. and Noll, M. (1993). Complex regulation of early paired expression: initial
activation by gap genes and pattern modulation by pair-rule genes. Development 117: 609-23
Hader, T., et al. (1998). Activation of posterior pair-rule stripe expression in response to maternal caudal and zygotic knirps activities. Mech. Dev. 71(1-2): 177-186.
Hahm, K., et al. (1998). Helios, a T cell-restricted ikaros family member that quantitatively
associates with ikaros at centromeric heterochromatin. Genes Dev. 12(6): 782-796.
Haire, R. N., et al. (2000). Members of the Ikaros gene family are present in early representative vertebrates. J. Immunol. 165(1): 306-12. 10861066
He, Z. B., et al. (2006). Role of hunchback in segment patterning of Locusta migratoria manilensis revealed by parental RNAi.
Dev. Growth Differ. 48(7): 439-45. Medline abstract: 16961591
Hoch, M., Seifert, E. and Jaeckle, H. (1991). Gene expression mediated by cis-acting sequences of the Krüppel gene in response to the Drosophila morphogens Bicoid and Hunchback. EMBO J. 10: 2267-2278
Houchmandzadeh, B., Wieschaus, E. and Leibler, S. (2002). Establishment of developmental precision and proportions in the early Drosophila embryo. Nature 415(6873): 798-802. 11845210
Hu, X., et al. (2001). An intronic Ikaros-binding element mediates retinoic acid suppression of the kappa opioid receptor gene, accompanied by histone deacetylation on the promoters. J. Biol. Chem. 276(7): 4597-603. 11092879
Imokawa, Y. and Yoshizato, K. (1997). Expression of Sonic hedgehog gene in regenerating newt limb blastemas recapitulates that in developing limb buds. Proc. Natl. Acad. Sci. 94(17): 9159-9164.
Isshiki, T., et al. (2001). Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny. Cell 106: 511-521. 11525736
Iwasa, J. H., Suver, D. W. and Savage, R. M. (2000).
The leech hunchback protein is expressed in the epithelium
and CNS but not in the segmental precursor lineages. Dev. Genes Evol. (2000) 210: 277-288
Jack, T. and McGinnis, W. (1990). Establishment of the Deformed expression stripe requires the combinatorial action of coordinate, gap and pair-rule proteins. EMBO J 9: 1187-98
Janody, F. Reischl, J. and Dostatni, N. (2000). Persistence of Hunchback in the terminal region of the Drosophila blastoderm
embryo impairs anterior development. Development 127: 1573-1582.
Jaeger, J., et al. (2004a). Dynamic control of positional information in the early Drosophila embryo. Nature 430: 368-371. 15254541
Jaeger, J., et al. (2004b). Dynamical analysis of regulatory interactions in the gap gene system of Drosophila melanogaster. Genetics 167: 1721-1737. 15342511
Kambadur, R., et al., (1998). Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS. Genes Dev. 12(2): 246-260.
Kanai, M. I., Okabe, M. and Hiromi, Y. (2005). seven-up controls switching of transcription factors that specify temporal identities of Drosophila neuroblasts. Dev Cell. 8(2): 203-13. 15691762
Kehle, J., et al. (1998). dMi-2, a Hunchback-interacting protein that
functions in Polycomb repression. Science 282(5395): 1897-900.
Kennerdell, J. R. Yamaguchi, S. and Carthew, R. W. (2002). RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev. 16: 1884-1889. 12154120
Kerszberg, M. and Changeux, J. P. (1994). A model for reading morphogenetic gradients:
autocatalysis and competition at the gene level. Proc Natl Acad Sci 91: 5823-7
Kim, J., et al. (1999). Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10(3): 345-55.
Klug, A., and Schwabe, J. R. (1995). Zinc fingers. FASEB J. 9: 597-604
Koipally, J., et al. (1999). Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. 18(11): 3090-100.
Koipally, J. and Georgopoulos, K. (2000). Ikaros interactions with CtBP reveal a repression mechanism that is independent
of histone deacetylase activity. J. Biol. Chem. 275(26): 19594-602.
Kosman, D. and Small, S. (1997). Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps. Development 124: 1343-1354
Kraemer, B., et al. (1999). NANOS-3 and FBF proteins physically interact to control the
sperm-oocyte switch in Caenorhabditis elegans. Curr. Biol. 9(18): 1009-1018.
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., and Tuschl, T. (2001). Identification of novel genes coding for small expressed RNAs. Science 294: 853-858. 11679670
Lall, S., Ludwig, M. Z. and Patel, N. H. (2003). Nanos plays a conserved role in axial patterning outside of the Diptera. Curr. Biol. 13: 224-229. 12573218
Langeland, J. A., et al. (1994). Positioning adjacent pair-rule stripes in the posterior Drosophila embryo. Development 120: 2945-2955
Lauderdale, J. D., et al. (1998). Regulation of netrin-1a expression by hedgehog proteins. Mol. Cell. Neurosci. 11: 194-205.
Lebrecht, D., et al (2005). Bicoid cooperative DNA binding is critical for
embryonic patterning in Drosophila. Proc. Natl. Acad. Sci. 102(37): 13176-81. 16150708
Lin, S.-Y., et al. (2003). The C. elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microrna target. Dev. Cell 4: 639-650. 12737800
Liu, P. Z. and Kaufman, T. C. (2004). hunchback is required for suppression of abdominal identity, and for proper germband growth and segmentation in the intermediate germband insect Oncopeltus fasciatus. Development 131: 1515-1527. 14998925
Mahmoudi, T., Zuijderduijn, L. M., Mohd-Sarip, A. and Verrijzer, C. P. (2003). GAGA facilitates binding of Pleiohomeotic to a chromatinized Polycomb response element. Nucleic Acids Res. 31(14): 4147-56. 12853632
Margolis, J. S. (1994). A small region surrounding the distal promoter of the
hunchback gene directs maternal expression. Dev Biol 163: 381-8
Margolis, J. S., et al. (1995). Posterior stripe expression of hunchback is driven from
two promoters by a common enhancer element. Development 121: 3067-3077
McCarty, A. S., et al. (2003). Selective dimerization of a C2H2 zinc finger subfamily. Mol. Cell 11: 459-470. 12620233
McKeon, J. , et al. (1994). Mutations in some Polycomb group genes of Drosophila
interfere with regulation of segmentation genes. Mol Gen Genet 244: 474-483
Mettler, U., Voglerc G. and Urban, J. (2006). Timing of identity: spatiotemporal regulation of hunchback in neuroblast lineages of Drosophila by Seven-up and Prospero. Development 133(3): 429-37. 16396905
Mito, T., et al. (2005). Non-canonical functions of hunchback in segment patterning of the intermediate germ cricket Gryllus bimaculatus. Development 132(9): 2069-79.15788457
Morgan, B., et al. (1997). Aiolos, a lymphoid restricted transcription factor that interacts with
Ikaros to regulate lymphocyte differentiation. EMBO J. 16(8): 2004-2013.
Murata, Y. and Wharton, R. P. (1995). Binding of pumilio to maternal hunchback mRNA is
required for posterior patterning in Drosophila embryos. Cell 80: 747-756
Niessing, D., et al. (2000). Homeodomain position 54 specifies transcriptional versus
translational control by Bicoid. Molec. Cell 5: 395-401.
O'Neill, D. W., et al. (2000). An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol. Cell. Biol. 20(20): 7572-82. 11003653
Patel, N. H., et al. (2001). Grasshopper hunchback expression reveals conserved and novel aspects of axis formation and segmentation. Development 128: 3459-3472. 11566852
Pelegri, F. and Lehmann, R. (1994) A role of Polycomb group genes in the regulation of Gap gene
expression in Drosophila.. Genetics 136:1341-1353.
Perdomo, J., et al. (2000). Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. J. Biol. Chem. 275(49): 38347-54. 10978333
Perkins, T. J., Jaeger, J., Reinitz, J. and Glass, L. (2006). Reverse engineering the gap gene network of Drosophila melanogaster. PLoS Comput. Biol. 2(5): e51. 16710449
Poux, S., Kostic, C. and Pirrotta, V. (1996). Hunchback-independent silencing of late Ubx enhancers by a polycomb group response element. EMBO J. 15: 4713-22
Pultz, M. A., Pitt, J. N. and Alto, N. M. (1999). Extensive zygotic control of the anteroposterior axis in the wasp
Nasonia vitripennis. Development 126(4): 701-710.
Riley, G. R., et al. (1991). Positive and negative control of the Antennapedia promoter P2. Dev Suppl 1: 177-85
Rivera-Pomar, R., et al. (1995a). Activation of posterior gap gene expression in the Drosophila blastoderm. Nature 376: 253-256
Rivera-Pomar, R. and Jäckle, H. (1996b). From gradients to stripes in Drosophila embryogenesis: Filling in the gaps. Trends Genet 12: 478-483. 8973159
Rohr, K. B., Tautz, D. and Sander, K. (1999). Segmentation gene expression in the mothmidge Clogmia albipunctata
(Diptera, psychodidae) and other primitive dipterans. Dev. Genes Evol. 209(3): 145-54.
Rusch, D. B. and Kaufman, T. C. (2000). Regulation of proboscipedia in Drosophila by homeotic selector
genes. Genetics 156: 183-194.
Sabbattini, P., et al. (2001). Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J. 20(11): 2812-22. 11387214
Saget, O., et al. (1998). Needs and targets for the multi sex combs gene product in
Drosophila melanogaster. Genetics 149(4): 1823-1838.
Sanchez, L. and Thieffry, D. (2001). A logical analysis of the gap gene system. J. Theor. Biol. 211: 115-141. 11419955
Sanchez-Herrero, E. (1991). Control of the expression of the bithorax complex genes abdominal-A and Abdominal-B by cis-regulatory regions in Drosophila embryos. Development 111: 437-49
Sauer, F. and Jackle, H. (1995). Heterodimeric Drosophila gap gene protein complexes acting as transcriptional repressors. EMBO J 14: 4773-4780
Sauer, F., Hansen, S. K. and Tjian, R. (1996). Multiple TAFIIs directing synergistic activation of
transcription. Science 270: 1783-1788 Savage, R. M. and Shankland, M. (1996). Identification and characterization of a hunchback orthologue, Lzf2. and its expression during leech embryogenesis. Dev. Biol. 175: 205-217
Schaeffer, V., et al. (1999). Bicoid functions without its TATA-binding protein-associated factor interaction
domains. Proc. Natl. Acad. Sci. 96(8): 4461-6.
Schröder, R. (2003). The genes orthodenticle and
hunchback substitute for bicoid in the beetle Tribolium. Nature 422: 422(6932):621-5. 12687002
Shimell, M. J., et al. (2000). Functional analysis of repressor binding sites
in the iab-2 regulatory region of the abdominal-A
homeotic gene. Dev. Biol. 218: 38-52.
Schulz, C. and Tautz, D. (1994). Autonomous concentration-dependent activation and
repression of Krüppel by hunchback in the Drosophila embryo. Development 120: 3043-3049
Schulz, C. and Tautz, D. (1995). Zygotic caudal regulation by hunchback and its role in
abdominal segment formation of the Drosophila embryo. Development 121: 1023-1028
Simpson-Brose, M., Treisman, J. and Desplan, C. (1994). Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila. Cell 78: 855-865
Small, S., Blair, A. and Levine, M. (1992). Regulation of even-skipped stripe 2 in the Drosophila
embryo. EMBO J 11: 4047-57
Small, S., Blair, A. and Levine, M. (1996). Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo. Dev. Biol. 175: 314-324
Sonoda, J. and Wharton, R. P. (1999). Recruitment of Nanos to hunchback mRNA by Pumilio. Genes Dev. 13: 2704-2712.
Sonoda, J. and Wharton, R. P. (2001). Drosophila Brain tumor is a translational repressor. Genes Dev. 15(6): 762-73. 11274060
Stauber, M., Taubert, H. and Schmidt-Ott, U. (2000). Function of bicoid and hunchback homologs in the basal cyclorrhaphan
fly Megaselia (Phoridae). Proc. Natl. Acad. Sci. 97: 10844-10849.
Struhl, G. (1989). The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell 57: 1259-73
Struhl, G., Johnston, P. and Lawrence, P. A. (1992). Control of Drosophila body pattern by the hunchback morphogen gradient. Cell 69: 237-249
Sun, L., Liu, A. and Georgopoulos, K. (1996). Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J. 15(19): 5358-5369.
Tautz, D., et al. (1987). Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes. Nature 327: 383-389
Tautz, D. (1988). Regulation of the Drosophila segmentation gene hunch back by two maternal morphogenetic centers. Nature 332: 281-4
Treisman, H. and Desplan, C. (1989). The products of the Drosophila gap genes hunchback and
Kruppel bind to the hunchback promoters. Nature 341: 335-7
Trinh, L. A., et al. (2001). Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes Dev. 15(14): 1817-32. 11459831
Urbach, R. and Technau, G. M. (2003). Molecular markers for identified neuroblasts in the developing brain of Drosophila. Development 130: 3621-3637. 12835380
Weigmann K. and Lehner C. F. (1995) Cell fate specification by even-skipped expression in the Drosophila nervous system is coupled to cell cycle progression. Development 121: 3713-3721. 8582283
Werbrock, A. H., et al. (2001). A polychaete hunchback ortholog. Dev. Bio. 235: 476-488. 11437452
Wharton, R. P. and Struhl, G. (1991). RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos. Cell 67: 955-67
Wharton, R. P., et al. (1998). The Pumilio RNA-binding domain is also a translational regulator. Mol. Cell 1(6): 863-72.
Wimmer, E. A., et al., (1995). Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead. Mech. Dev. 53: 235-245
Wimmer, E. A., et al. (2000). bicoid-independent formation of thoracic segments in
Drosophila. Science 287: 2476-2479.
Wolf, C. and Schuh, R. (2000). Single mesodermal cells guide outgrowth of ectodermal tubular structures in Drosophila. Genes Dev. 14: 2140-2145. 10970878
Wolff, C., et al. (1998). Regulation of the Tribolium homologues of caudal and
hunchback in Drosophila: evidence for maternal gradient systems in a short germ embryo. Development 125(18): 3645-3654.
Wreden, C., et al. (1997). Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA. Development 124(15): 3015-3023.
Wu, X., Vakani, R. and Small, S. (1998). Two distinct mechanisms for differential positioning of gene expression borders involving the Drosophila gap protein giant. Development 125: 3765-3774.
Wu, X., et al. (2001). Thoracic patterning by the Drosophila gap gene hunchback. Dev. Bio. 237: 79-92. 11518507
Zamore, P. D., Williamson, J. R. and Lehmann, R. (1997). The Pumilio protein binds RNA through a conserved domain that
defines a new class of RNA-binding proteins. RNA 3(12): 1421-33.
Zamore, P. D., et al. (1999). The PUMILIO-RNA interaction: a single RNA-binding domain
monomer recognizes a bipartite target sequence. Biochemistry 38(2): 596-604.
Zhang, B., et al. (1997). A conserved RNA-binding protein that regulates sexual fates in
the C. elegans hermaphrodite germ line. Nature 390: 477-484.
Zhang, C. C. and Bienz, M. (1992). Segmental determination in Drosophila conferred by
hunchback (hb), a repressor of the homeotic gene Ultrabithorax (Ubx). Proc. Natl. Acad. Sci. 89: 7511-5
Zuo, P., et al. (1991). Activation and repression of transcription by the gap
proteins hunchback and Kruppel in cultured Drosophila cells. Genes Dev 5: 254-64
hunchback:
Biological Overview
| Evolutionary Homologs
| Regulation
| Targets of activity
| Protein Interactions
| Post-transcriptional Regulation
| Developmental Biology
| Effects of Mutation
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