Antennapedia

REFERENCES

Adamson, A. L. and Shearn, A. (1996). Molecular genetic analysis of Drosophila ash2, a member of the trithorax group required for imaginal disc pattern formation. Genetics 144(2): 621-33. 8889525

Abbott, M. K. and Kaufman, T. C. (1986). The relationship between the functional complexity and the molecular organization of the Antennapedia locus of Drosophila melanogaster. Genetics 114: 919-42

Aboobaker, A. A. and Blaxter, M. L. (2003). Hox gene loss during dynamic evolution of the nematode cluster. Curr. Biol. 13: 37-40. 12526742

Abzhanov, A. and Kaufman, T. C. (2000). Crustacean (malacostracan) Hox genes and the evolution of the arthropod trunk. Development 127: 2239-2249

Aisemberg, G. O., et al. (1993). Antennapedia-class homebox genes define diverse neuronal sets in the embryonic CNS of the leech. J. Neurobiol 24: 1423-32

Aisemberg, G. O. and Macagno, E. R. (1994). Lox1, an Antennapedia-class homeobox gene, is expressed during leech gangliogenesis in both transient and stable central neurons. Dev Biol 161: 455-65

Appel, B. and Sakonju, S. (1993). Cell-type-specific mechanisms of transcriptional repression by the homeotic gene products UBX and ABD-A in Drosophila embryos. EMBO J 12: 1099-109

Azcoitia, V., Aracil, M., Martinez, A. C. and Torres, M. (2005). The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev. Biol. 280: 307-320. PubMed citation: 15882575

Bermingham, J. R., et al. (1990). Different patterns of transcription from the two Antennapedia promoters during Drosophila embryogenesis. Development 109: 553-66

Bhojwani, J., Shashidhara, L. S. and Sinha, P. (1997). Requirement of teashirt (tsh) function during cell fate specification in developing head structures in Drosophila. Dev. Genes Evol. 207: 137-146

Bilder, D. and Scott, M. P. (1998). Hedgehog and Wingless induce metameric pattern in the Drosophila visceral mesoderm. Dev. Biol. 201(1): 43-56.

Brizuela, B. J. and Kennison, J. A. (1997). The Drosophila homeotic gene moira regulates expression of engrailed and HOM genes in imaginal tissues. Mech. Dev. 65(1-2): 209-220.

Breen, T. R. and Harte, P. J. (1993). Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each. Development 117: 119-34

Burke, T. W. and Kadonaga, J. T. (1996). Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. Genes and Development 10: 711-727. 8598298

Capovilla, M., Kambris, Z. Botas, J. (2001). Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm. Development 128: 1221-1230. 11262224

Carroll, S. B., et al. (1986). The localization and regulation of Antennapedia protein expression in Drosophila embryos. Cell 47: 113-22

Casares, F., Calleja, M. and Sánchez-Herrero, E. (1996). Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes. EMBO J. 15: 3934-42.

Casares, F. and Mann, R. S. (1998). Control of antennal versus leg development in Drosophila. Nature 392(6677): 723-726.

Chíng, Q. L. and Kenyon, C. (1999). egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function. Development 126: 3303-3312.

Cimbora, D. M. and Sakonju, S. (1995). Drosophila midgut morphogenesis requires the function of the segmentation gene odd-paired. Dev Biol 169: 580-595

Clandinin, T. R., et al. (1997). Caenorhabditis elegans HOM-C genes regulate the response of vulval precursor cells to inductive signal. Dev. Biol 182: 150-161

Cordes, R., et al. (2004). Specification of vertebral identity is coupled to Notch signalling and the segmentation clock. Development 131: 1221-1233. 14960495

Cribbs, D. L., et al. (1992). Ectopic expression of the Drosophila homeotic gene proboscipedia under Antennapedia P1 control causes dominant thoracic defects. Genetics 132: 699-711

Ekker, S. C., et al. (1994). The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J 13: 3551-3560

Furukubo-Tokunaga, K. Flister, S. and Gehring, W. J. (1993). Functional specificity of the Antennapedia homeodomain. Proc Natl Acad Sci 90: 6360-4

Emmons, R. B., et al. (2007). Regulation of the Drosophila distal antennal determinant spineless. Dev. Biol. 302: 412-426. Medline abstract: 17084833

Gerasimova, T. I. and Corces, V. G. (1998). Polycomb and trithorax group proteins mediate the function of a chromatin insulator. Cell 92(4): 511-521.

Gibson, G., Wemple, M. and Helden, S. v. (1999). Potential variance affecting homeotic Ultrabithorax and Antennapedia phenotypes in Drosophila melanogaster. Genetics 151: 1081-1091.

Glicksman, M. S. and Brower, D. L. (1990). Persistent ectopic expression of Drosophila homeotic genes resulting from maternal deficiency of the extra sex combs gene product. Dev Biol 142: 422-31

Gonzalez-Reyes, A., Macias, A. and Morata, G. (1992). Autocatalysis and phenotypic expression of Drosophila homeotic gene Deformed: its dependence on polarity and homeotic gene function. Development 116: 1059-68

Gould, A. P., and White, R. A. H. (1992). Connectin, a target of hemeotic gene control in Drosophila. Development 116: 1163-74

Gutiérrez, L., Zurita, M., Kennison, J. A. and Vázquez, M. (2003). The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein. Development 130: 343-354. 12466201

Herke, S. W. Serio, N. V. and Rogers, B. T. (2005). Functional analyses of tiptop and Antennapedia in the embryonic development of Oncopeltus fasciatus suggests an evolutionary pathway from ground state to insect legs. Development 132: 27-34. 15563520

Heuer, J. G. and Kaufman, T. C. (1992). Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system. Development 115: 35-47

Heuer, J. G., Li, K and Kaufman, T. C. (1995). The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis. Development 121: 3861-3876

Hirth, F., Hartmann, B. and Reichert, H. (1998). Homeotic gene action in embryonic brain development of Drosophila. Development 125: 1579-1589.

Hisa, T. et al. Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J 23: 450-459. PubMed citation: 14713950

Hooper, J. E., et al. (1992). Comparative studies of Drosophila Antennapedia genes. Genetics 132: 453-69

Jaffe, L., Ryoo, H. D. and Mann, R. S. (1997). A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila. Genes Dev 11 (10): 1327-1340.

Johnston, L. A., et al. (1998). The homeobox gene cut interacts genetically with the homeotic genes proboscipedia and Antennapedia. Genetics 149(1): 131-142.

Juan, A. H. and Ruddle, F. H. (2003). Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer. Development 130: 4823-4834. 12917291

Jung, S. H., Evans, C. J., Uemura, C. and Banerjee, U. (2005). The Drosophila lymph gland as a developmental model of hematopoiesis. Development 132: 2521-2533. PubMed citation: 15857916

Kagoshima, H., Cassata, G. and Burglin, T. R. (1999). A Caenorhabditis elegans homeobox gene expressed in the male tail, a link between pattern formation and sexual dimorphism? Dev. Genes Evol. 209(1): 59-62.

Kennison, J. A. and Tamkun, J. W. (1988). Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila. Proc. Natl. Acad. Sci. 85: 8136-8140

Kourakis, M. J., et al. (1997). Conserved anterior boundaries of Hox gene expression in the central nervous system of the leech Helobdella. Dev. Biol. 190(2): 284-300.

Kühnlein, R.P., et al. (1994). spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo. EMBO J 13: 168-179

Kurata, S., et al. (2000). Notch signaling and the determination of appendage identity. Proc. Natl. Acad. Sci. 97: 2117-2122

LaJeunesse, D. and Shearn, A. (1995). Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent, small, and homeotic discs 1 and 2. Mech. Dev. 53: 123-39

Laughon, A., et al. (1986). Structure of transcripts from the homeotic Antennapedia gene of D. melanogaster: two promoters control the major protein-coding region. Mol Cell Biol. 6: 4676-4689

Le Roux, I., et al. (1993). Neurotrophic activity of the Antennapedia homeodomain depends on its specific DNA-binding properties. Proc Natl Acad Sci 90: 9120-4

Lin, L. and McGinnis, W. (1992). Mapping functional specificity in the Dfd and Ubx homeo domains. Genes Dev 6: 1071-81

Lewis, E. B., et al. (2003). Evolution of the homeobox complex in the Diptera. Curr. Biol. 13: R587-R588. 12906807

Li, X. and McGinnis, W. (1999). Activity regulation of Hox proteins, a mechanism for altering functional specificity in development and evolution. Proc. Natl. Acad. Sci. 96: 6802-6807.

Liu, J. and Fire, A. (2000). Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm. Development 127: 5179-5190.

Lo, P. C. H., Skeath, J. B., Gajewski, K. Schulz, R. A. and Frasch, M. (2002). Homeotic genes autonomously specify the anteroposterior subdivision of the Drosophila dorsal vessel into aorta and heart. Dev. Bio. 251: 307-319. 12435360

Lu, H.-C., et al. (1997). Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation. Development 124: 1643-1651. 9165113

Lu, Q., et al. (1995). Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol. Cell. Biol. 15 (7): 3786-3795.

Maloof, J. N., et al. (1999). A Wnt signaling pathway controls Hox gene expression and neuroblast migration in C. elegans. Development 126(1): 37-49.

Mandal, L., et al. (2007). A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors. Nature 446: 320-324. PubMed citation: 17361183

Mathies, L.D., Kerridge, S. and Scott, M.P. (1994). Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes. Development 120: 2799-2809

McCormick, A., et al. (1995). Homeotic response elements are tightly linked to tissue-specific elements in a transcriptional enhancer of the teashirt gene. Development 121: 2799-2812

Miller, D. F. B., et al. (2001). Homeotic Complex (Hox) gene regulation and homeosis in the mesoderm of the Drosophila melanogaster embryo: the roles of signal transduction and cell autonomous regulation. Mech. Dev. 102: 17-32. 11287178

Morata, G. and Sanchez-Herrero, E. (1998). Pulling the fly's leg. Nature 392(6677): 657-658

Oh, S. K., Scott. M. P. and Sarnow, P. (1992). Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding. Genes Dev. 6: 1643-53

Orii, H., et al. (1999). The planarian HOM/HOX homeobox genes (Plox) expressed along the anteroposterior axis. Dev. Biol. 210(2): 456-68.

Peltenburg, L. T. and Murre, C. (1997). Specific residues in the Pbx homeodomain differentially modulate the DNA-binding activity of Hox and Engrailed proteins. Development 124 (5): 1089-1098.

Peterson, M. D., et al. (1999). The embryonic expression pattern of labial, posterior homeotic complex genes and the teashirt homologue in an apterygote insect. Dev. Genes Evol. 209: 77-90

Prokop, A ., et al. (1998). Homeotic regulation of segment-specific differences in neuroblast numbers and proliferation in the Drosophila central nervous system. Mech. Dev. 74(1-2): 99-110

Qian, Y. Q., et al. (1992). NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein. Proc Natl Acad Sci 89: 10738-42

Reinitz, J. and Levine, M. (1990). Control of the initiation of homeotic gene expression by the gap genes giant and tailless in Drosophila. Dev Biol 140: 57-72

Reuter, R. and Scott, M. P. (1990). Expression and function of the homoeotic genes Antennapedia and Sex combs reduced in the embryonic midgut of Drosophila. Development 109: 289-303

Riley, G. R., et al. (1991). Positive and negative control of the Antennapedia promoter P2. Dev. Suppl. 1: 177-85

Ross, J. M. and Zarkower, D. (2003). Polycomb group regulation of Hox gene expression in C. elegans. Dev. Cell 4: 891-901. 12791273

Roy, S., Shashidhara, L. S. and VijayRaghavan, K. (1997). Muscles in the Drosophila second thoracic segment are patterned independently of autonomous homeotic gene function. Curr. Biol. 7 (4): 222-227

Saffman, E. E. and Krasnow, M. A. (1994). A differential response element for the homeotics at the Antennapedia P1 promoter of Drosophila. Proc Natl Acad Sci 91: 7420-7424

Salser, S. J. and Kenyon, C. (1992). Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration. Nature 355: 255-8

Sanlioglu, S., et al. (1998). Regulation of a Purkinje cell-specific promoter by homeodomain proteins: repression by engrailed-2 vs. synergistic activation by Hoxa5 and Hoxb7. J. Neurobiol. 36(4): 559-71.

Scanga, S., Manoukian, A. and Larsen, E. (1995). Time- and concentration-dependent response of the Drosophila antenna imaginal disc to Antennapedia. Dev Biol 169: 673-682

Shiga, Y., et al. (2002). Evolving role of Antennapedia protein in arthropod limb patterning. Development 129: 3555-3561. 12117806

Southworth J. W. and Kennison, J. A. (2002). Transvection and silencing of the Scr homeotic gene of Drosophila melanogaster. Genetics 161: 733-746. 12072469

Stratford, T. H., Kostakopoulou, K. and Maden, M. (1997). Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb. Development 124(21): 4225-4234.

Stroeber, W.L., Jorgensen, E.M. and Garber, M.L. (1986). Multiple transcripts from the Antennapedia gene of D. menalogaster. Mol Cell Biol. 6: 4667-4675

Struhl, G. (1981). A homeotic mutation transforming leg to eye antenna in Drosophila. Nature 292: 635-639

Strutt, H., Cavalli, G. and Paro, R. (1997). Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression. EMBO J. 16:3621-3632.

Talbert, P. B. and Garber, R. L. (1994). The Drosophila homeotic mutation Nasobemia (AntpNs) and its revertants: an analysis of mutational reversion. Genetics 138: 709-720

Tiret, L., et al. (1998). Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice. Development 125(2): 279-291. 9486801

Vazquez, M., Moore, L. and Kennison, J. A. (1999). The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the Brahma chromatin-remodeling factor to regulate transcription. Development 126: 733-742.

Walldorf, U., Binner, P. and Fleig, R. (2000). Hox genes in the honey bee Apis mellifera Dev. Genes Evol. 210: 483-492. 11180797

Wharton, K. A., et al. (1999). Genetic analysis of the bone morphogenetic protein-related gene, gbb, identifies multiple requirements during Drosophila development. Genetics 152: 629-640.

Wiellette, E. L. and McGinnis, W. (1999a). Hox genes differentially regulate Serrate to generate segment-specific structures. Development 126(9): 1985-1995.

Wiellette, E. L., et al. (1999b). spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk. Development 126: 5373-5385. 10556062

Wu, X., et al. (2001). Thoracic patterning by the Drosophila gap gene hunchback. Dev. Bio. 237: 79-92. 11518507

Ye, X., et al. (1997). Ultrabithorax and Antennapedia 5' untranslated regions promote developmentally regulated internal translation initiation. Mol. Cell. Biol. 17: 1714-1721

Yao, L. C., et al. (1999). A common mechanism for antenna-to-leg transformation in Drosophila: suppression of homothorax transcription by four HOM-C genes. Dev. Biol. 211(2): 268-76.

Zhang, H., et al. (2003). Global regulation of Hox gene expression in C. elegans by a SAM domain protein. Dev. Cell 4: 903-915. 12791274

Zeng, W., et al. (1993). Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity. Development 118: 339-52

Zink, B., et al. (1991). Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster. EMBO J 10: 153-62

Zhu, A. and Kuziora, M. A. (1996). Homeodomain interaction with the ß subunit of the general transcription factor TFIIE. J. Biol. Chem. 269: 20993-96

Zorin, I. D., Gerasimovaa, T. I. and Corcesa, V. G. (1999). The lawc gene is a new member of the trithorax-Group that affects the function of the gypsy insulator of Drosophila. Genetics 152: 1045-1055.

date revised: 30 May 2008

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.