Abdominal-B
Akbari, O. S., et al. (2008). A novel promoter-tethering element regulates enhancer-driven gene expression at the bithorax complex in the Drosophila embryo. Development 135: 123-131. Medline abstract: 18045839
Sipos, L., Mihaly, J., Karch, F., Schedl, P., Gausz, J. and Gyurkovics, H. (1998). Transvection in the Drosophila Abd-B domain: extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the promoter. Genetics 149: 1031-1050. PubMed: 9611211
Ali, N. and Bienz, M. (1991). Functional dissection of Drosophila abdominal-B protein. Mech Dev 35: 55-64
Alper, S. and Kenyon, C. (2001). REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity.
Development 128(10): 1793-804. 11311160
Alper, S. and Kenyon, C. (2002). The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. Development 129: 3335-3348. 12091304
Alvares, L. E., et al. (2003). Intrinsic, Hox-dependent cues determine the fate of skeletal muscle precursors. Dev. Cell 5: 379-390. 12967558
Andrew, D. J., et al. (1994).
Setting limits on homeotic gene function: restraint of Sex
combs reduced activity by teashirt and other homeotic
genes. EMBO J 13: 1132-44
Andrew, D. J., et al. (1997).
The Drosophila dCREB-A gene is required for
dorsal/ventral patterning of the larval cuticle. Development 124: 181-193.
Arenas-Mena, C., Cameron, A. R. and Davidson, E. H. (2000). Spatial expression of Hox cluster genes in the ontogeny of a sea urchin. Development 127: 4631-4643
Auken, K. V., et al. (2000). Caenorhabditis elegans embryonic axial patterning requires two
recently discovered posterior-group Hox genes. Proc. Natl. Acad. Sci. 97: 4499-4503
Averof, M. and Patel, N. H. (1997). Crustacean appendage evolution associated with changes in Hox gene expession. Nature 388: 682-686.
Ayton, P. M. and Cleary, M. L. (2003). Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 17: 2298-2307. 12952893
Bachiller, D., et al. (1994). Conservation of a functional hierarchy between
mammalian and insect Hox/HOM genes.
EMBO J 13: 1930-41
Baird, S. E. and Ellazar, S. A. (1999). TGFbeta-like signaling and spicule development in Caenorhabditis elegans. Dev. Biol. 212(1): 93-100.
Barges, S., et al. (2000). The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain. Development 127: 779-790
Barna, M., et al. (2002). Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev. Cell 3: 499-510. 12408802
Bantignies, F., et al. (2003). Inheritance of Polycomb-dependent chromosomal interactions in Drosophila. Genes Dev. 17: 2406-2420. 14522946
Baum, P. D., et al. (1999). The Caenorhabditis elegans gene ham-2 links hox patterning
to migration of the HSN motor neuron. Genes Dev. 13(4): 472-83.
Bae, E., Calhoun, V. C., Levine, M., Lewis, E. B. and Drewell, R. A. (2002). Characterization of the intergenic RNA profile at abdominal-A and Abdominal-B in the Drosophila bithorax complex. Proc, Natl. Acad. Sci. 99(26): 16847-52. 12481037
Beckers, J., Gérard, M. and Duboule, D. (1996). Transgenic analysis of a potential Hoxd-11 limb regulatory element present in tetrapods and fish. Dev. Biol. 180: 543-553.
Beisel, C., et al. (2007). Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins. Proc. Natl. Acad. Sci. 104(42): 16615-16620. Medline abstract: 17921257
Bel, S., et al. (1998). Genetic interactions and dosage effects of Polycomb group
genes in mice. Development 125(18): 3543-3551.
Bel-Vialar, S., et al. (2000). Altered retinoic acid sensitivity and temporal
expression of Hox genes in Polycomb-M33-deficient
mice. Dev. Biol. 224: 238-249
Bel-Vialar, S., Itasaki, N. and Krumlauf, R. (2002). Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups. Development 129: 5103-5115. 12399303
Benson, G. V., et al. (1996). Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development 122: 2687-96
Berger, C., Pallavi, S. K., Prasad, M., Shashidhara, L. S. and Technau, G. M. (2005). A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat. Cell Biol. 7(1): 56-62. Medline abstract: 15580266
Birve, A., et al. (2001). Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development 128: 3371-3379. 11546753
Blanco, M. J., Misof, B. Y. and Wagner, G. P. (1998). Heterochronic differences of Hoxa-11 expression in Xenopus fore-
and hind limb development: evidence for lower limb identity of the
anuran ankle bones. Dev. Genes Evol. 208(4): 175-87.
Blastyak, A., Mishra, R. K., Karch, F. and Gyurkovics, H. (2006). Efficient and specific targeting of Polycomb group proteins requires cooperative interaction between Grainyhead and Pleiohomeotic. Mol. Cell. Biol. 26(4): 1434-44. 16449654
Boulet, A. M. Lloyd, A. and Sakonju, S. (1991). Molecular definition of the morphogenetic and regulatory functions and the cis-regulatory elements of the
Drosophila Abd-B homeotic gene. Development 111: 393-405
Boulet, A. M. and Capecchi, M. R. (2002). Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton
of the mouse. Dev. Bio. 249: 96-107. 12217321
Boulet, A. M. and Capecchi, M. R. (2004). Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod. Development 131: 299-309. 14668414
Boyle, M. and DiNardo, S. (1995). Specification, migration and assembly of the somatic cells of the Drosophila gonad. Devlopment 121: 1815-25.
Branford, W. W., et al. (2000). Characterization of Hoxa-10/Hoxa-11
transheterozygotes reveals functional
redundancy and regulatory interactions. Dev. Bio. 224: 373-387
Breen, T. R. and Harte, P. J. (1993). Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each. Development 117: 119-34.
Breiling, A., et al. (2001). General transcription factors bind promoters repressed by Polycomb group proteins. Nature 412: 651-655. 11493924
Brendolan, A., et al. (2005). A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development 132: 3113-3126. 15944191
Broihier, H. T., Kuzin, A., Zhu, Y., Odenwald, W. and Skeath, J. B. (2004). Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis. Development 131: 5233-5242. 15456721
Bromleigh, V. C. and Freedman, L. P. (2000). p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells. Genes Dev. 14: 2581-2586
Brown, J. L., Fritsch, C., Mueller, J. and Kassis, J. A. (2003). The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing. Development 130: 285-294. 12466196
Bruneau, S., et al. (2001). The mouse Hoxd13spdh mutation, a polyalanine expansion similar to human type II synpolydactyly (SPD), disrupts the function but not the expression of other Hoxd genes. Dev. Bio. 237: 345-353. 11543619
Burke, T. W. and Kadonaga, J. T. (1996). Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. Genes and Development 10: 711-727
Busturia, A. and Bienz, M. (1993). Silencers in Abdominal-B, a homeotic Drosophila gene. EMBO J 12: 1415-25.
Busturia, A., Wightman, C. D. and Sakonju, S. (1997). A silencer is required for maintenance of transcriptional
repression throughout Drosophila development. Development 124(21): 4343-4350.
Busturia, A., et al. (2001), The MCP silencer of the Drosophila Abd-B gene requires both Pleiohomeotic and GAGA factor for the maintenance of repression. Development 128: 2163-2173. 11493537
Canudas, S., et al. (2005). dSAP18 and dHDAC1 contribute to the functional regulation of the Drosophila Fab-7 element. Nuc. Acids Res. 33(15): 4857-64. 16135462
Carapuco, M., Novoa, A., Bobola, N. and Mallo, M. (2005). Hox genes specify vertebral types in the presomitic mesoderm. Genes Dev. 19: 2116-2121. 16166377
Carlson, M. R. J., et al. (2001). Expression of Hoxb13 and Hoxc10 in developing
and regenerating axolotl limbs and tails. Dev. Bio. 229: 396-406. 11150241
Caronia, G., et al. (2003). An I47L substitution in the HOXD13 homeodomain causes a novel human limb malformation by producing a selective loss of function. Development 130: 1701-1712. 12620993
Carpenter, E. M., et al. (1997). Targeted disruption of Hoxd-10 affects mouse hindlimb
development. Development 124(22): 4505-4514.
Casanova, J. Sanchez-Herrero, E. and Morata, G. (1986). Identification and characterization of a parasegment specific regulatory element of the Abdominal-B gene of Drosophila. Cell 47: 627-636
Casares, F. and Sanchez-Herrero, E. (1995). Regulation of the infraabdominal regions of the bithorax complex of Drosophila by gap genes. Development 121: 1855-1866. 87051733
Casares, F., et al. (1997). The genital disc of Drosophila melanogaster. I. Segmental and compartmental organization. Dev. Genes Evol. 207: 216-228
Castelli-Gair, J., et al. (1994). Dissecting the temporal requirements for homeotic gene
function. Development 120: 1983-1995
Castelli-Gair, J. (1998). The lines gene of Drosophila is required for specific functions of the
Abdominal-B HOX protein. Development 125: 1269-1274. Medline abstract: 9477325
Cavalli, G. and Paro, R. (1999). Epigenetic inheritance of active chromatin after removal of the main transactivator. Science 286(5441): 955-8
Celniker, S. E., Keelan, D. J. and Lewis, E. B. (1989). The molecular genetics of the bithorax complex of
Drosophila: characterization of the products of the
Abdominal-B domain. Genes Dev 3: 1424-36
Chamberlin, H. M. and Thomas, T. H. (2000). The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect
development and gene expression in Caenorhabditis elegans. Development 127: 713-723
Chen, F. and Capecchi, M. R. (1999). Paralogous mouse hox genes, hoxa9, hoxb9, and hoxd9,
function together to control development of the mammary
gland in response to pregnancy. Proc. Natl. Acad. Sci. 96(2): 541-6. Medline abstract: 9892669
Chen, Y., et al. (2004). Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh. Development 131: 2339-2347. 15102708
Chiang, C. and Beachy, C. A. (1995a). Expression of a novel Toll-like gene spans the parasegment
boundary and contributes to hedgehog function in the adult
eye of Drosophila. Mech. Dev. 47(3): 225--239.
Chiang, C., Young, K. E. and Beachy, P. A. (1995b). Control of Drosophila tracheal branching by the novel
homeodomain gene unplugged, a regulatory target for
genes of the bithorax complex. Development 121: 3901-3912.
Cleard, F., Moshkin, Y., Karch, F. and Maeda, R. K. (2006). Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification. Nat. Genet. 38(8): 931-5. 16823379
Cohn, M. J., et al. (1997). Hox9 genes and vertebrate limb specification. Nature 387 (6628): 97-101.
Copf, T., et al. (2003). Posterior patterning genes and the identification of a unique body region in the brine shrimp Artemia franciscana. Development 130: 5915-5927. 14561635
Crosby, M. A., et al. (1993). The 3' regulatory region of the Abdominal-B gene: genetic analysis supports a model of reiterated and
interchangeable regulatory elements. Genetics 134: 809-24
Moon, H., et al. (2005). CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep. 6(2): 165-70. Medline abstract: 15678159
Daubresse, G., Deuring, R., Moore, L., Papoulas, O., Zakrajsek, I., Waldrip, W. R., Scott, M. P., Kennison, J. A. and Tamkun, J. W. (1999). The Drosophila kismet gene is related to chromatin-remodeling factors and is required for
both segmentation and segment identity. Development 126: 1175-1187.
10021337
DeFalco, T., Le Bras, S. and Van Doren, M. (2004).
Abdominal-B is essential for proper sexually dimorphic development of the Drosophila gonad.
Mech. Dev. 121(11): 1323-33. 15454263
Dejardin, J., Rappaillles, A., Cuvier, O., Grimaud, C., Decoville, M., Locker, D. and Cavalli, G. (2005). Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1. Nature 434: 533-538. 15791260
de la Cruz, C. C., et al. (1999). Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity,
and peripheral nervous system development. Dev. Biol. 216(2): 595-610
de Lorenzi, M., Ali, N., Saari, G. Henry, C. Wilcox, M.E. and Bienz, M. (1988). Evidence that the Abdominal-B r element function is conferred by a trans-regulatory homeoprotein. EMBO J. 7: 3223-3231
de Lorenzi, M. and Bienz, M. (1990a). Expression of Abdominal-B homeoproteins in Drosophila
embryos. Development 108: 323-9
de Lorenzi, M., et al. (1990b). Evidence that the Abdominal-B r element function is conferred by a trans-regulatory homeoprotein. EMBO J 7: 3223-31
de Santa Barbaram, P. and Roberts, D. J. (2002). Tail gut endoderm and gut/genitourinary/tail development: a new tissue-specific role for Hoxa13. Development 129: 551-561. 11830557
Dolle, P., Fraulob, V. and Duboule, D. (1994). Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex. Dev. Suppl. 143-53.
Duluc, I., et al. (1997). Changing intestinal connective tissue
interactions alters homeobox gene expression in
epithelial cells. J. Cell Sci. 110: 1317-1324
Economides, K. D. and Capecchi, M. R. (2003a). Hoxb13 is required for normal differentiation and secretory function of the ventral prostate. Development 130: 2061-2069. 12668621
Economides, K. D. Zeltser, L. and Capecchi, M. R. (2003b). Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae. Dev. Biol. 256: 317-330. 12679105
Ekker, S. C., et al. (1994). The degree of variation in DNA sequence recognition
among four Drosophila homeotic proteins. EMBO J 13: 3551-3560
Estrada, B. and S·nchez-Herrero, E. (2001). The Hox gene Abdominal-B antagonizes appendage development in the genital disc of Drosophila.
Development 128: 331-339. 11152632
Estrada, B., et al. (2002). Genetic and molecular characterization of a novel iab-8 regulatory domain in the Abdominal-B gene of Drosophila
melanogaster. Development 129: 5195-5204. 12399311
Faucheux, M., et al. (2003). batman interacts with Polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor. Molec. Cell. Bio. 23: 1181-1195. 12556479
Ferreira, H. B., et al. (1999). Patterning of Caenorhabditis elegans posterior structures by the
Abdominal-B homolog, egl-5. Dev. Biol. 207(1): 215-228.
Fisher, D. and Méchali, M. (2003). Vertebrate HoxB gene expression requires DNA replication. EMBO J. 22: 3737-3748. 12853488
Foronda, D., Estrada, B., de Navas, L. and Sanchez-Herrero, E. (2006). Requirement of Abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule. Development 133(1): 117-27. 16319117
Formosa, T., Eriksson, P., Wittmeyer, J., Ginn, J., Yu, Y., and Stillman, D.J. (2001). Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN. EMBO J. 20: 3506-3517. 11432837
Forrester, W. C., Kim, C. and Garriga, G. (2004). The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration.
Genetics 168(4): 1951-62. 15371357
Fyodorov, D. V., Blower, M. D., Karpen, G. H. and Kadonaga, J. T. (2004). Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo. Genes Dev. 18(2): 170-83. Medline abstract: 14752009
Gabellini, D., et al. (2003). Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. EMBO J. 22(14): 3715-24. 12853486
Gaunt, S. J., et al. (1999). Evidence that Hoxa expression domains are evolutionarily transposed in
spinal ganglia, and are established by forward spreading in paraxial
mesoderm. Mech. Dev. 82(1-2): 109-118.
Goff, D. J. and Tabin, C. J. (1997). Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Development 124, 627-636
Graba, Y., et al. (1992). Homeotic control in Drosophila; the scabrous gene is an
in vivo target of Ultrabithorax proteins. EMBO J 11: 3375-84.
Grewal, S. I. and Rice, J. C. (2004). Regulation of heterochromatin by histone methylation and small RNAs, Curr. Opin. Cell Biol. 16: 230-238. 15145346
Grimaud, C., Bantignies, F., Pal-Bhadra, M., Ghana, P., Bhadra, U. and Cavalli, G. (2006). RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124(5): 957-71. 16530043
Grienenberger. A., et al. (2002). The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression. Curr. Biol. 12(9): 762-6. 12007422
Gutierrez, A., Knoch, L., Witte, H. and Sommer, R. J. (2003). Functional specificity of the nematode Hox gene mab-5. Development 130: 983-993. 12538523
Hagstrom, K., Muller, M. and Schedl, P. (1996). Fab-7 functions as a chromatin domain boundary to ensure proper segmentation specification by the Drosophila bithorax complex. Genes Dev. 10: 3203-15
Hagstrom, K., Muller, M. and Schedl, P. (1997). A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in
the Drosophila bithorax complex. Genetics 146(4): 1365-1380.
Hashimoto, K., et al. (1999). Distinct signaling molecules control Hoxa-11 and Hoxa-13
expression in the muscle precursor and mesenchyme of the
chick limb bud. Development 126(12): 2771-2783. Medline abstract: 10331987
Hendrickson, J. E. and Sakonju, S. (1995). Cis and trans interactions between the iab regulatory
regions and abdominal-A and abdominal-B in Drosophila
melanogaster. Genetics 139: 835-848
Hérault, Y., et al. (1996). Function of the Evx-2 in the morphogenesis of vertebrate limbs. EMBO J. 15: 6727-38.
Hérault, Y., et al. (1997). Ulnaless (Ul), a regulatory mutation inducing both loss-of-function
and gain-of-function of posterior Hoxd genes. Development 124: 3493-3500.
Hèrault, Y., et al. (1998). Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex. Development 125: 1669-1677.
Hérault, Y., et al. (1999). Hox gene expression in limbs: colinearity by opposite regulatory
controls. Dev. Biol. 208(1): 157-65.
Herranz, H. and Morata, G. (2001). The functions of pannier during Drosophila embryogenesis. Development 128: 4837-4846. 11731463
Hirth, F., Hartmann, B. and Reichert, H. (1998). Homeotic gene action in embryonic brain development of Drosophila. Development 125: 1579-1589.
Hogga, I., et al. (2001). Replacement of Fab-7 by the gypsy or scs insulator disrupts long-distance regulatory interactions in the Abd-B gene of the bithorax complex. Molec. Cell 8: 1145-1151. 11741549
Holohan, E. E., et al.. (2007). CTCF genomic binding sites in Drosophila and the Organisation of the Bithorax Complex.
PLoS Genet. 3(7): e112. Medline abstract: 17616980
Hopmann, R., Duncan, D. and Duncan, I. (1995). Transvection in the iab-5,6,7 region of the bithorax
complex of Drosophila: homology independent
interactions in trans. Genetics 139: 815-833
Hostikka, S. L. and Capecchi, M. R. (1998). The mouse Hoxc11 gene: genomic structure and expression pattern. Mech. Dev. 70: 133-145.
Hu, N. and Castelli-Gair, J. (1999). Study of the posterior spiracles of Drosophila as a model to understand the genetic and cellular
mechanisms controlling morphogenesis. Dev. Biol. 214(1): 197-210.
Hughes, C. L. and Kaufman, T. C. (2002). Exploring the myriapod body plan: expression patterns of the ten Hox genes in a centipede. Development 129: 1225-1238. 11874918
Hullinger, T. G., et al. (2001). TGFbeta and BMP-2 activation of the OPN promoter: roles of smad- and hox-binding elements. Exp. Cell Res. 262(1): 69-74. 11120606
Hunter, C. P., et al. (1999). Hox gene expression in a single Caenorhabditis elegans cell is
regulated by a caudal homolog and intercellular signals that inhibit
Wnt signaling. Development 126(4): 805-814. Medline abstract: 9895327
Jeong, S., Rokas, A. and Carroll, S. B. (2006). Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution.
Cell 125(7): 1387-99. 16814723
Jia, S., Noma, K. and Grewal, S. I. (2004). RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. Science 304: 1971-1976. 15218150
Jiang, L. I. and Sternberg, P. W. (1998). Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans. Development 125(12): 2337-2347.
Jones, B. and McGinnis, W. (1993). The regulation of empty spiracles by Abdominal-B
mediates an abdominal segment identity function. Genes Dev 7: 229-40.
Kagoshima, H., Cassata, G. and Burglin, T. R. (1999). A Caenorhabditis elegans homeobox gene expressed in the male tail, a link
between pattern formation and sexual dimorphism? Dev. Genes Evol. 209(1): 59-62.
Kang, S. Y., Kim, S. N., Kim, S. H. and Jeon, S. H. (2006). Temporal and spatial expression of homeotic genes is important for segment-specific neuroblast 6-4 lineage formation in Drosophila. Mol. Cells 21(3): 436-42. Medline abstract: 16819308
Kanzler, B., et al. (1997). CHOXC-8 and CHOXD-13 expression in embryonic chick skin and
cutaneous appendage specification. Dev. Dyn. 210(3): 274-287.
Karch, F., et al. (1994), Mcp and Fab-7: molecular analysis of putative boundaries of
cis-regulatory domains in the bithorax complex of Drosophila
melanogaster.
Nucleic Acids Res 22: 3138-3146
Kawakami, Y., et al. (2006). Wnt/β-catenin signaling regulates vertebrate limb regeneration. Genes Dev. 20: 3232-3237. Medline abstract: 17114576
Kmita, M., et al. (2002). Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs. Nature 420: 145-150. 12432383
Knezevic, V., et al. (1997). Hoxd-12 differentially affects preaxial and postaxial chondrogenic
branches in the limb and regulates Sonic hedgehog in a positive
feedback loop. Development 124(22): 4523-4536.
Knosp, W. M., et al. (2004). HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis. Development 131: 4581-4592. 15342482
Kondo, T., et al. (1996). Function of posterior HoxD genes in the morphogenesis of the anal sphincter. Development 122: 2651-59
Kondo, T. and Duboule, D. (1999). Breaking colinearity in the mouse HoxD complex. Cell 97(3): 407-17.
Kopp, A., Duncan, I. and Carroll, S. B. (2000). Genetic control and evolution of sexually dimorphic characters in Drosophila. Nature 408: 553-559. 11117736
Kopp, A., and Duncan, I. (2002). Anteroposterior patterning in adult abdominal
segments of Drosophila. Dev. Bio. 242: 15-30
Korswagen, H. C., et al. (2002). The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 16: 1291-1302. 12023307
Kroon, E., et al. (1998). Hoxa9 transforms primary bone marrow cells through specific
collaboration with Meis1a but not Pbx1b. EMBO J. 17(13): 3714-3725.
Kuhn, D. T., et al. (1995). Analysis of the genes involved in organizing the tail
segments of the Drosophila melanogaster embryo. Mech. Dev. 53: 3-13
Kuziora, M. A. (1993). Abdominal-B protein isoforms exhibit distinct cuticular
transformations and regulatory activities when ectopically
expressed in Drosophila embryos. Mech Dev 42: 125-37
Lamka, M. L., Boulet, A. M. and Sakonju, S. (1992). Ectopic expression of UBX and ABD-B proteins during Drosophila embryogenesis: competition, not a functional
hierarchy, explains phenotypic suppression. Development 116: 841-54.
Lance-Jones, C., et al. (2001). Hoxd10 induction and regionalization in the developing lumbosacral spinal cord. Development 128: 2255-2268
LaRonde-LeBlanc, N. A. and Wolberger, C. (2003). Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev. 17: 2060-2072. 12923056
Laurent, A., et al. (2007). Identification of a new type of PBX1 partner that contains zinc finger motifs and inhibits the binding of HOXA9-PBX1 to DNA. Mech. Dev. 124: 364-376. Medline abstract: 17353115
Lee, N., Maurange, C., Ringrose, L. and Paro, R. (2005). Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature 438(7065): 234-7. 16281037
Liu, J. P., Laufer, E. and Jessell, T. M. (2001). Assigning the positional identity of spinal motor neurons: Rostrocaudal patterning of Hox-c Expression by FGFs, Gdf11, and retinoids. Neuron 32: 997-1012. 11754833
Lin, Q., Wu, D. and Zhou, J. (2003). The promoter targeting sequence facilitates and restricts a distant enhancer to a single promoter in the Drosophila embryo. Development 130: 519-526. 12490558
Lin, Q., Chen, Q., Lin, L. and Zhou, J. (2004). The Promoter Targeting Sequence mediates epigenetically heritable transcription memory. Genes Dev. 18(21): 2639-51. 15520283
Lints, R. and Emmons, S. W. (1999). Patterning of dopaminergic neurotransmitter identity among Caenorhabditis
elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox
gene. Development 126: 5819-5831. Medline abstract: 10572056
Lo, P. C. H., Skeath, J. B., Gajewski, K. Schulz, R. A. and Frasch, M. (2002). Homeotic genes autonomously specify the anteroposterior subdivision of the Drosophila dorsal vessel into aorta and heart. Dev. Bio. 251: 307-319
Logan, M. and Tabin, C. J. (1999). Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity. Science 283(5408): 1736-9.
Luo, L., et al. (2004). The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature 427(6976): 749-53. 14973489
Lupo, R., et al. (2001). Drosophila chromosome condensation proteins
Topoisomerase II and Barren colocalize with Polycomb and
Maintain Fab-7 PRE silencing. Mol. Cell 7: 127-136. 11172718
Ma, L., et al. (1998). Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and
progesterone and repression in mullerian duct by the synthetic estrogen diethylstilbestrol
(DES). Dev. Biol. 197(2): 141-154.
Macias, A., Casanova, J. and Morata, G. (1990). Expression and regulation of the abd-A gene of
Drosophila. Development 110: 1197-207
Mack, J. A., Smith, R. D. and Kuhn, D. T. (1997). Mobile element 297 in the Abd-B gene of Drosophila melanogaster, not Delta 88, is responsible for the tuh-3 mutation. Genetics 147(2): 679-688.
Mahmoudi, T., Zuijderduijn, L. M., Mohd-Sarip, A. and Verrijzer, C. P. (2003). GAGA facilitates binding of Pleiohomeotic to a chromatinized Polycomb response element. Nucleic Acids Res. 31: 4147-4156. 12853632
Marchetti, M., et al. (2003). Differential expression of the Drosophila BX-C in polytene chromosomes in cells of larval fat bodies: a cytological approach to identifying in vivo targets of the homeotic Ubx, Abd-A and Abd-B proteins. Development 130: 3683-3689. 12835385
Martinez, P., et al. (1999). Organization of an echinoderm hox gene cluster.
Proc. Natl. Acad. Sci. 96(4): 1469-74. Medline abstract: 9990047
McCall, K., O'Connor, M. B. and Bender, W. (1994). Enhancer traps in the Drosophila bithorax complex mark
parasegmental domains. Genetics 138: 387-399
Medina-Martinez, O., Bradley, A. and Ramirez-Solis, R. (2000). A large targeted deletion of Hoxb1-Hoxb9
produces a series of single-segment anterior
homeotic transformations. Dev. Biol. 222: 71-83
Merabet, S., et al. (2002). A green fluorescent protein reporter genetic screen that identifies modifiers of Hox gene function in the Drosophila embryo. Genetics 162: 189-202. 12242233
Merabet, S., Hombria, J. C., Hu, N., Pradel, J. and Graba, Y. (2005).
Hox-controlled reorganisation of intrasegmental patterning cues underlies
Drosophila posterior spiracle organogenesis.
Development 132(13): 3093-3102. 15930099
Meyer, C. A., et al. (2002). Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression. Development 129: 319-328. 11807025
Michelson, A. M. (1994). Muscle pattern diversification in Drosophila is
determined by the autonomous function of homeotic genes
in the embryonic mesoderm. Development 120: 755-768
Miguel-Aliaga, I. and Thor, S. (2004). Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity. Development 131(24): 6093-105. 15537690
Mihaly, J., Mishra, R. K. and Karch, F. (1998). A conserved sequence motif in Polycomb-response element. Mol. Cell 1: 1065-1066. 9651590
Miller C, Sassoon DA., et al. (1998). Wnt-7a maintains appropriate uterine patterning during the
development of the mouse female reproductive tract. Development 125(16): 3201-3211.
Milne, T. A., et al. (2002). MLL targets SET domain methyltransferase activity to hox gene promoters. Mol. Cell 10: 1107-1117. 12453418
Mishra, K., et al. (2003). Trl-GAGA directly interacts with lola like and both are part of the repressive complex of Polycomb group of genes. Mech. Dev. 120: 681-689. 12834867
Misulovin, Z., et al. (2008). Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome.
Chromosoma 117(1): 89-102. Medline abstract: 17965872
Mito, Y., Henikoff, J. G. and Henikoff, S. (2007). Histone replacement marks the boundaries of cis-regulatory domains. Science 315(5817): 1408-1411. Medline abstract: 17347439
Mohan, M., et al. (2007). The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. EMBO J. 26(19): 4203-14. Medline abstract: 17805343
Mohd-Sarip, A., Venturini, F., Chalkley, G.E. and Verrijzer, C.P. (2002).
Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression.
Mol. Cell Biol. 22: 7473-7483. 12370294
Mohd-Sarip, A., et al. (2005). Synergistic recognition of an epigenetic
DNA element by Pleiohomeotic and a Polycomb core complex. Genes Dev. 19: 1755-1760. 16077005
Monge, I., Kondoa, T. and Duboule D. (2003). An enhancer-titration effect induces digit-specific regulatory alleles of the hoxd cluster. Dev. Biol. 256: 212-220. 12679098
Morgan, E. A., et al. (2003). Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development 130: 3095-3109. 12783783
Moshkin, Y. M., et al. (2001). The Bithorax Complex of Drosophila melanogaster: Underreplication and morphology in polytene chromosomes. Proc. Natl. Acad. Sci. 98: 570-574. 11136231
Muller, M., et al. (1999). The Mcp element from the Drosophila melanogaster Bithorax Complex
mediates long-distance regulatory interactions. Genetics 153: 1333-1356. Medline abstract: 10545463
Muragaki, Y., Mundlos, S., Upton, J. and Olsen, B. R. (1996). Altered growth and branching patterns in synpolydactyly
caused by mutations in HOXD13. Science 272: 548-551.
Nakamura, T., et al. (2002). ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol. Cell 10: 1119-1128. 12453419
Noma, K., et al. (2004). RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing, Nat. Genet. 36: 1174-1180. 15475954
Ohtsuki, S., Levine, M. and Cai, H. N. (1998). Different core promoters possess distinct regulatory activities in the Drosophila embryo. Genes Dev. 12: 547-556.
Omelchenko, N. and Lance-Jones, C. (2003). Programming neural Hoxd10: in vivo evidence that early node-associated signals predominate over paraxial mesoderm signals at posterior spinal levels. Dev. Biol. 261: 99-115. 12941623
Orlando, V. and Paro, R. (1993). Mapping Polycomb-repressed domains in the bithorax
complex using in vivo formaldehyde cross-linked chromatin. Cell 75: 1187-98
Orphanides, G., Wu, W.H., Lane, W.S., Hampsey, M., and Reinberg, D. (1999). The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. Nature 400: 284-288. 10421373
Pal-Bhadra, M., Bhadra, U. and Birchler, J. A. (1997). Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent, Cell 90: 479-490. 9267028
Pal-Bhadra, M., Bhadra, U. and Birchler, J. A. (1999). Cosuppression of nonhomologous transgenes in Drosophila involves mutually related endogenous sequences, Cell 99: 35-46. 10520992
Pal-Bhadra, M., Bhadra, U. and Birchler, J. A. (2002). RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila' Mol. Cell 9: 315-327. 11864605
Pal-Bhadra, M., et al. (2004). Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery, Science 303: 669-672. 14752161
Papenbrock, T., et al. (1998). Murine Hoxc-9 gene contains a structurally and functionally conserved
enhancer. Dev. Dyn. 212(4): 540-7.
Papenbrock, T., Visconti, R. P. and Awgulewitsch, A. (2000). Loss of fibula in mice overexpressing Hoxc11. Mech. Dev. 92: 113-123
Parrish, J. Z., et al. (2007). Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev. 21: 956-972. Medline abstract: 17437999
Peichel, C. L., Prabhakaran, B. and Vogt, T. F. (1997). The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning. Development 124: 3481-3492.
Peterson, M. D., et al. (1999). The embryonic expression pattern of labial,
posterior homeotic complex genes and the teashirt homologue
in an apterygote insect. Dev. Genes Evol. 209: 77-90
Phelan, M. L. and Featherstone, M. S. (1997). Distinct HOX N-terminal arm residues are responsible for specificity
of DNA recognition by HOX monomers and HOX.PBX
heterodimers. J. Biol. Chem. 272 (13): 8635-8643.
Post, L. C., et al. (2000). Severe limb defects in hypodactyly mice result
from the expression of a novel, mutant HOXA13 protein. Dev. Biol. 217: 290-300
Reinitz, J. and Levine, M. (1990). Control of the initiation of homeotic gene expression by
the gap genes giant and tailless in Drosophila. Dev. Biol. 140: 57-72.
Ringrose, L., Rehmsmeier, M., Dura, J. M. and Paro, R. (2003). Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. Dev. Cell 5: 759-771. 14602076
Rinn, J. L., et al. (2007). Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129(7): 1311-23. Medline abstract: 17604720
Ross, J. M. and Zarkower, D. (2003). Polycomb group regulation of Hox gene expression in C. elegans. Dev. Cell 4: 891-901. 12791273
S·nchez, L., et al. (1997). The genital disc of Drosophila melanogaster II. Role of the genes hedgehog, decapentaplegic and wingless. Dev. Genes Evol. 207: 229-241
Sanchez-Herrero, E. (1991). Control of the expression of the bithorax complex genes
abdominal-A and Abdominal-B by cis-regulatory regions in Drosophila embryos. Development 111: 437-49
Sato, K., et al. (2007). Specification of cell fate along the proximal-distal axis in the developing chick limb bud. Development 134: 1397-1406. Medline abstract: 17329359
Schweinsberg, S E. and Schedl, P. (2004a). Developmental modulation of Fab-7 boundary function. Development 131: 4743-4749. 15329342
Schweinsberg, S., Hagstrom, K., Gohl, D., Schedl, P., Kumar, R. P.,
Mishra, R. and Karch, F. (2004b). The enhancer-blocking activity of the
Fab-7 boundary from the Drosophila bithorax complex requires GAGA-factor-binding sites. Genetics 168(3): 1371-84. 15579691
Shen, W. F., et al. (1997). AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol. Cell. Biol. 17(11): 6448-6458.
Shimizu, T., Bae, Y.-K. and Hibi, M. (2006). Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Development 133: 4709-4719. Medline abstract: 17079270
Shimojima, T., et al. (2003). Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev. 17: 1605-1616. 12815073
Shiotsugu, J., et al. (2004). Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation. Development 131: 2653-2667. 15128657
Shubin, N., Tabin, C. and Carroll, S. (1997). Fossils, genes and the evolution of animal limbs. Nature 388:639-648.
Sipos, L., et al. (1998). Transvection in the Drosophila Abd-B domain. Extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the
promoter. Genetics 149(2): 1031-1050.
Small, K. M. and Potter, S. S. (1993). Homeotic transformations and limb defects in Hox A11 mutant mice. Genes Dev 7: 2318-28
Sordino, P., Duboule, D. and Kondo, T. (1996). Zebrafish Hoxa and Evx-2 genes: cloning, developmental expression and implications for the functional evolution of posterior Hox genes. Mech. Dev. 59(2): 165-175.
Spitz, F., Gonzalez, F. and Duboule, D. (2003). A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell 113: 405-417. 12732147
Srinivasan, S., et al. (2005). The
Drosophila trithorax group protein Kismet facilitates an early step
in transcriptional elongation by RNA Polymerase II. Development 132:
1623-1635. 15728673
Stadler, H. S., Higgins, K. M. and Capecchi, M. R. (2001). Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development 128: 4177-4188. 11684655
Strutt, H., Cavalli, G. and Paro, R. (1997a). Co-localization of Polycomb protein and GAGA factor on
regulatory elements responsible for the maintenance of homeotic
gene expression. EMBO J. 16:3621-3632.
Strutt, H. and Paro, R. (1997b). The polycomb group protein complex of Drosophila melanogaster
has different compositions at different target genes. Mol. Cell. Biol. 17(12): 6773-6783.
Teng, Y., Girard, L., Ferreira, H. B., Sternberg, P. W. and Emmons, S. W. (2004). Dissection of cis-regulatory elements in the C. elegans Hox gene egl-5 promoter. Dev. Biol. 276(2): 476-92. 15581880
Thummel, R., et al. (2004). Differences in expression pattern and
function between zebrafish hoxc13 orthologs: recruitment of Hoxc13b into
an early embryonic role. Dev. Biol. 274: 318-333. 15385162
Taylor, H. S. (1998). A regulatory element of the empty spiracles homeobox gene is composed of three distinct conserved regions that bind regulatory proteins. Molec. Reprod. Dev. 49: 246-253. 9491376
Toker, A. S., et al. (2003). The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3. Development 130: 3831-3840. 12835398
Torok, M. A., et al. (1998). Expression of HoxD genes in developing and regenerating axolotl limbs. Dev. Biol. 200(2): 225-233
van der Knaap, J.A., Kumar, B. R. P., Moshkin, Y. M., Langenberg, K., Krijgsveld, J., Heck, A. J. R., Karch, F. and Verrijzer, C. P. (2005). GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. Mol. Cell 17: 695-707. 15749019
Vargesson, N., et al. (1997). Cell fate in the chick limb bud and relationship
to gene expression. Development 124: 1909-1918.
Vazquez, J., Muller, M., Pirrotta, V., Sedat, J. W. (2006). The Mcp element mediates stable long-range chromosome-chromosome interactions in Drosophila. Mol. Biol. Cell. 17(5): 2158-65. 16495335
Verdel, A. et al. (2004). RNAi-mediated targeting of heterochromatin by the RITS complex, Science 303: 672-676. 14704433
Vigano, M. A., et al., (1998). Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context. Mol. Cell. Biol. 18(11): 6201-12.
Wahba, G. M., Hostikka, S. L. and Carpenter, E. M. (2001). The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton. Dev. Bio. 231: 87-102. 11180954
Wan, M., et al. (2001). Transcriptional mechanisms of BMP-induced osteoprotegrin gene expression. J. Biol. Chem. 276: -/-. 11139569
Wang, G. G., Pasillas, M. P. and Kamps, M. P. (2006). Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes.
Mol. Cell. Biol. 26(10): 3902-16. Medline abstract: 16648484
Wang, H. B., Wang, L. J., Erdjument-Bromage, H., Vidal, M., Tempst, P., Jones, R. S. and Zhang, Y. (2004). Role of histone H2A ubiquitination in polycomb silencing. Nature 431: 873-878. 15386022
Warot, X., et al. (1997). Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13
mutations on morphogenesis of the terminal parts of the digestive
and urogenital tracts. Development 124(23): 4781-4791.
Wellik, D. M., Hawkes, P. J. and Capecchi, M. R. (2002). Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev. 16: 1423-1432. 12050119
Williams, T. M., Williams, M. E. and Innis, J. W. (2005). Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. Dev. Biol. 277(2): 457-71. 15617687
Yamamoto, M., et al. (1998). Coordinated expression of Hoxa-11 and Hoxa-13 during limb muscle
patterning. Development 125(7): 1325-1335.
Yodera, J. H. and Carroll, S. B. (2006). The evolution of abdominal reduction and the recent origin of distinct Abdominal-B transcript classes in Diptera. Evol. Dev. 8: 241-51. 16686635
Zakany, J., et al. (1997). Deletion of a HoxD enhancer induces transcriptional heterochrony leading to
transposition of the sacrum. EMBO J. 16(14): 4393-4402.
Zavortink, M. and Sakonju, S. (1989). The morphogenetic and regulatory functions of the
Drosophila Abdominal-B gene are encoded in overlapping
RNAs transcribed from separate promoters. Genes Dev 3: 1969-81
Zhang, H. and Emmons, S. W. (2001). The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression. Development 128: 767-777. 11171401
Zhang, H., et al. (2003). Global regulation of Hox gene expression in C. elegans by a SAM domain protein. Dev. Cell 4: 903-915. 12791274
Zhao, Y. and Potter, S. S. (2001). Functional specificity of the Hoxa13 homeobox. Development 128: 3197-3207. 11688568
Zhao, Y. and Potter, S. S. (2002). Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes. Dev. Biol. 244: 21-36. 11900456
Zhou, J., et al. (1996). The Fab-7 element of the bithorax complex attenuate enhancer-promoter interactions in the Drosophila embryo. Genes Dev. 10: 3195-3201
Zhou, J., et al. (1999a). Characterization of the transvection mediating region of the Abdominal-B
locus in Drosophila. Development 126: 3057-3065. Medline abstract: 10375498
Zhou, J. and Levine, M. (1999b). A novel cis-regulatory element, the PTS, mediates an
anti-insulator activity in the Drosophila embryo. Cell 99: 567-575
Zhu, A. and Kuziora, M. A. (1996). Homeodomain interaction with the ß subunit of the general transcription factor TFIIE. J. Biol. Chem. 20993-96
Zuniga, A, and Zeller, R. (1999). Gli3 (Xt) and formin (ld) participate in the positioning of the
polarising region and control of posterior limb-bud identity. Development 126(1): 13-21. Medline abstract: 9834182
Abdominal-B:
Biological Overview
| Evolutionary Homologs
| Promoter Structure
| Transcriptional Regulation
| Targets of activity
| Protein Interactions
| Developmental Biology
| Effects of Mutation
date revised: 15 February 2008
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