abdominal-A
Abzhanov, A. and Kaufman, T. C. (2000). Crustacean (malacostracan) Hox genes and the evolution of the arthropod
trunk. Development 127: 2239-2249. 10804167
Alexandre, C. and Vincent, J. P. (2003). Requirements for transcriptional repression and activation by Engrailed in Drosophila embryos. Development 130: 729-739. 12506003
Andrew, D. J., et. al. (1994).
Setting limits on homeotic gene function: restraint of Sex
combs reduced activity by teashirt and other homeotic
genes. EMBO J 13: 1132-44
Appel, B. and Sakonju, S. (1993).
Cell-type-specific mechanisms of transcriptional
repression by the homeotic gene products UBX and
abd-A in Drosophila embryos. EMBO J 12: 1099-109.
Averof, M. and Patel, N. H. (1997). Crustacean appendage evolution associated with changes in Hox gene expession. Nature 388: 682-686.
Azpiazu, N. and Morata G. (1998). Functional and regulatory interactions between hox and
extradenticle genes. Genes Dev. 12(2): 261-273.
Bae, E., Calhoun, V. C., Levine, M., Lewis, E. B. and Drewell, R. A. (2002). Characterization of the intergenic RNA profile at abdominal-A and Abdominal-B in the Drosophila bithorax complex. Proc, Natl. Acad. Sci. 99(26): 16847-52. 12481037
Beisel, C., et al. (2007). Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins. Proc. Natl. Acad. Sci. 104(42): 16615-16620. Medline abstract: 17921257
Bel, S., et al. (1998). Genetic interactions and dosage effects of Polycomb group
genes in mice. Development 125(18): 3543-3551.
Bello, B. C., Hirth, F. and Gould, A. C. (2003). A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis. Neuron 37: 209-219. 12546817
Bender, W. and Fitzgerald, D. P. (2002). Transcription activates repressed domains in the Drosophila bithorax complex. Development 129: 4923-4930. 12397101
Bender, W. and Hudson, A. (2000). P element homing to the Drosophila bithorax complex. Development 127: 3981-3992
Bender, W. (2008). MicroRNAs in the Drosophila bithorax complex.
Genes Dev. 22: 14-19. PubMed citation: 18172161
Berger, C., Pallavi, S. K., Prasad, M., Shashidhara, L. S. and Technau, G. M. (2005). A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat. Cell Biol. 7(1): 56-62. Medline abstract: 15580266
Bilder, D., Graba, Y. and Scott, M. (1998). Wnt and TGFbeta signals subdivide the AbdA hox domain during Drosophila mesoderm patterning. Development 125(9): 1781-1790. Medline abstract: 9521915
Bilder, D. and Scott, M. P. (1998b). Hedgehog and Wingless induce metameric pattern in the Drosophila
visceral mesoderm. Dev. Biol. 201(1): 43-56.
Boyle, M. and DiNardo, S. (1995). Specification, migration and assembly of the somatic cells of the Drosophila gonad. Devlopment 121: 1815-25.
Boyle, M., Bonini, N. and DiNardo, S. (1997). Expression and function of clift in the
development of somatic gonadal
precursors within the Drosophila
mesoderm. Development 124: 971-982.
Breen, T. R. and Harte, P. J. (1993). Trithorax regulates multiple homeotic genes in the
bithorax and Antennapedia complexes and exerts
different tissue-specific, parasegment-specific and
promoter-specific effects on each. Development 117: 119-34
Brodu, V., Elstob, P. R. and Gould, A. P. (2002). abdominal A specifies one cell type in Drosophila by regulating one principal target gene. Development 129: 2957-2963. 12050142
Broihier, H. T., et al. (1998). zfh-1 is required for germ cell migration and gonadal mesoderm
development in Drosophila. Development 125(4): 655-666.
Busturia, A. et al. (1989). Genetic structure of the abd-A gene of Drosophila. Development 107: 575-83
Capovilla, M. and Botas, J. (1998).
Functional dominance among Hox genes: repression dominates activation in
the regulation of dpp. Development 125: 4949-4957
Casares, F. and Sanchez-Herrero, E. (1995). Regulation of the infraabdominal regions of the bithorax complex of Drosophila by gap genes. Development 121: 1855-1866
Casares, F., Calleja, M. and Sánchez-Herrero, E. (1996). functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes. EMBO J. 15: 3934-42.
Casares, F., et al. (1997). The genital disc of Drosophila melanogaster. I. Segmental and compartmental organization. Dev. Genes Evol. 207: 216-228
Castelli-Gair, J., et al. (1994). Dissecting the temporal requirements for homeotic gene
function. Development 120: 1983-1995
Cenci, C. and Gould, A. P. (2005). Drosophila Grainyhead specifies late programmes of neural proliferation by regulating the mitotic activity and Hox-dependent apoptosis of neuroblasts. Development 132(17): 3835-45. 16049114
Charite, J., et al. (1998). Transducing positional information to the Hox genes: critical interaction
of cdx gene products with position-sensitive regulatory elements. Development 125(22): 4349-4358
Chauvet, S., et al. (2000). Distinct Hox protein sequences determine specificity in different tissues. Proc. Natl. Acad. Sci. 97: 4064-4069. Medline abstract: 10737765
Chen, Y., et al. (1998). A genetic screen for modifiers of Drosophila decapentaplegic signaling
identifies mutations in punt, Mothers against dpp and the BMP-7
homologue, 60A. Development 125(9): 1759-1768
Chiang, A., et al. (1995).
Discrete Polycomb-binding sites in each parasegmental
domain of the bithorax complex. Development 121: 1681-1689.
Chiang, C. and Beachy, C. A. (1995a). Expression of a novel Toll-like gene spans the parasegment
boundary and contributes to hedgehog function in the adult
eye of Drosophila. Mech. Dev. 47(3): 225--239.
Chiang, C., Young, K. E. and Beachy, P. A. (1995b). Control of Drosophila tracheal branching by the novel
homeodomain gene unplugged, a regulatory target for
genes of the bithorax complex. Development 121: 3901-3912.
Cimbora, D. M. and Sakonju, S. (1995). Drosophila midgut morphogenesis requires the function of
the segmentation gene odd-paired. Dev Biol 169: 580-595
Cobb, J. and Duboule, D. (2005).
Comparative analysis of genes downstream of the Hoxd cluster in developing digits and
external genitalia. Development 132(13): 3055-67. 1594418
Cumberledge, S., Szabad, J. and Sakonju, S. (1992). Gonad formation and development requires the abd-A domain of the bithorax complex in Drosophila melanogaster. Development 115: 395-402
Duboule, D. (1994). Guidebook to Homeobox Genes. Oxford U. Press, New York. pp. 78-80
Duluc, I., et al. (1997). Changing intestinal connective tissue
interactions alters homeobox gene expression in
epithelial cells. J. Cell Sci. 110: 1317-1324
Di Stefano, L., Ji, J. Y., Moon, N. S., Herr, A. and Dyson, N. (2007).
Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development. Curr. Biol. 17(9): 808-12. Medline abstract: 17462898
Ensini, M., et al. (1998). The control of rostrocaudal pattern in the developing spinal cord: specification of motor neuron subtype identity is initiated by signals from paraxial mesoderm. Development 125: 969-982.
Faucheux, M., et al. (2003). batman interacts with Polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor. Molec. Cell. Bio. 23: 1181-1195. 12556479
Foronda, D., Estrada, B., de Navas, L. and Sanchez-Herrero, E. (2006). Requirement of Abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule. Development 133(1): 117-27. 16319117
Fujimura, Y., et al. (2006). Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133: 2371-2381. Medline abstract: 16687444
Gaunt, S. J., et al. (1999). Evidence that Hoxa expression domains are evolutionarily transposed in
spinal ganglia, and are established by forward spreading in paraxial
mesoderm. Mech. Dev. 82(1-2): 109-118.
Gebelein. B., McKay, D. J. and Mann, R. S. (2004). Direct integration of Hox and segmentation gene inputs during Drosophila development. Nature 431: 653-659. 16556799
Godwin, A. R. and Capecchi, M. R. (1998). Hoxc13 mutant mice lack external hair. Genes Dev. 12(1): 11-20.
Gould, A. P., and White, R. A. H. (1992). Connectin, a target of hemeotic gene control in Drosophila. Development 116: 1163-74
Graba, Y., et al. (1992). Homeotic control in Drosophila; the scabrous gene is an
in vivo target of Ultrabithorax proteins. EMBO J 11: 3375-84
Greig, S. and Akam, M. (1993). Homeotic genes autonomously specify one aspect of
pattern in the Drosophila mesoderm. Nature 362: 630-2
Grienenberger, A., et al. (2003). Tgfß signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development 130: 5445-5455. 14507783
Hendrickson, J. E. and Sakonju, S. (1995). Cis and trans interactions between the iab regulatory
regions and abdominal-A and Abdominal-B in Drosophila
melanogaster. Genetics 139: 835-848
Heuer, J. G., Li, K and Kaufman, T. C. (1995). The Drosophila homeotic target gene centrosomin (cnn)
encodes a novel centrosomal protein with leucine zippers
and maps to a genomic region required for midgut
morphogenesis. Development 121: 3861-3876.
Hirth, F., Hartmann, B. and Reichert, H. (1998). Homeotic gene action in embryonic brain development of Drosophila. Development 125: 1579-1589.
Hittinger, C. T., Stern, D. L. and Carroll, S. B. (2005). Pleiotropic functions of a conserved insect-specific Hox peptide motif. Development 132(23): 5261-70. 16267091
Hogga, I. and Karch, F. (2002). Transcription through the iab-7 cis-regulatory domain of the bithorax complex interferes with maintenance of Polycomb-mediated silencing. Development 129: 4915-4922. 12397100
Isaacs, H. V., Pownall, M. E. and Slack, J. M. (1998). Regulation of Hox gene expression and posterior development by the
Xenopus caudal homologue Xcad3. EMBO J. 17(12): 3413-3427.
Jijakli, H. and Ghysen, A. (1992). Segmental determination in Drosophila central nervous
system: analysis of the abdominal-A region of the bithorax
complex. Int J Dev Biol 36: 93-9
Johnson, F. B., Parker, E. and Krasnow, M. A. (1995). Extradenticle protein is a selective cofactor for the
Drosophila homeotics: role of the homeodomain and
YPWM amino acid motif in the interaction. Proc Natl Acad Sci 92: 739-743
Kang, S. Y., Kim, S. N., Kim, S. H. and Jeon, S. H. (2006). Temporal and spatial expression of homeotic genes is important for segment-specific neuroblast 6-4 lineage formation in Drosophila. Mol. Cells 21(3): 436-42. Medline abstract: 16819308
Kanzler, B., et al. (1997). CHOXC-8 and CHOXD-13 expression in embryonic chick skin and
cutaneous appendage specification. Dev. Dyn. 210(3): 274-287.
Karch, F., Bender W. and Weiffenbach, B. (1990).
abd-A expression in Drosophila embryos. Genes Dev 4: 1573-87. 1979297
Kehle, J., et al. (1998). dMi-2, a Hunchback-interacting protein that
functions in Polycomb repression. Science 282(5395): 1897-900.
Kopp, A., and Duncan, I. (2002). Anteroposterior patterning in adult abdominal
segments of Drosophila. Dev. Bio. 242: 15-30
Kurant, E., et al. (1998). dorsotonals/ homothorax, the Drosophila homologue of meis1, interacts with
extradenticle in patterning of the embryonic PNS. Development 125, 1037-1048.
Lewis, D. L., DeCamillis, M. and Bennett, R. L. (2000). Distinct roles of the homeotic genes Ubx and abd-A in beetle embryonic abdominal appendage development. Proc. Natl. Acad. Sci. 97: 4504-4509.
Lewis, E.B. (1978). A gene complex controlling segmentation in Drosophila. Nature 276: 565-70
Lo, P. C. H., Skeath, J. B., Gajewski, K. Schulz, R. A. and Frasch, M. (2002). Homeotic genes autonomously specify the anteroposterior subdivision of the Drosophila dorsal vessel into aorta and heart. Dev. Bio. 251: 307-319. 12435360
Lovato, T. L., et al. (2002). The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel. Development 129: 5019-5027. 12397110
Macias, A., Casanova, J. and Morata, G. (1990). Expression and regulation of the abd-A gene of
Drosophila. Development 110: 1197-207
Macias, A., Pelaz, S. and Morata, G. (1994). Genetic factors controlling the expression of the
abdominal-A gene of Drosophila within its domain. Mech. Dev. 46: 15-25.
McCall, K., O'Connor, M. B. and Bender, W. (1994). Enhancer traps in the Drosophila bithorax complex mark
parasegmental domains. Genetics 138: 387-399
Manak, J. R. Mathies, L. D. and Scott, M. P. (1994). Regulation of a decapentaplegic midgut enhancer by
homeotic proteins. Development 120: 3605-3619.
Marchetti, M., et al. (2003). Differential expression of the Drosophila BX-C in polytene chromosomes in cells of larval fat bodies: a cytological approach to identifying in vivo targets of the homeotic Ubx, Abd-A and Abd-B proteins. Development 130: 3683-3689. 12835385
Mathies, L.D., Kerridge, S. and Scott, M.P. (1994). Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes. Development 120: 2799-2809. Merabet, S., et al. (2002). A green fluorescent protein reporter genetic screen that identifies modifiers of Hox gene function in the Drosophila embryo. Genetics 162: 189-202. 12242233
Merabet. S., et al. (2003). The hexapeptide and linker regions of the AbdA hox protein regulate its activating and repressive functions. Dev. Cell 4: 761-768. 12737810
Michelson, A. M. (1994). Muscle pattern diversification in Drosophila is
determined by the autonomous function of homeotic genes
in the embryonic mesoderm. Development 120: 755-768
Mihaly, J., et al. (1997). In situ dissection of the Fab-7 region of the
bithorax complex into a chromatin domain
boundary and a Polycomb-response element. Development 124: 1809-1820.
Mihaly, J., Misra, R. K. and Karch, F. (1998). A conserved sequence motif in Polycomb-response elements. Mol. Cell 1: 1065-1066
Mishra, K., et al. (2003). Trl-GAGA directly interacts with lola like and both are part of the repressive complex of Polycomb group of genes. Mech. Dev. 120: 681-689. 12834867
Mito, Y., Henikoff, J. G. and Henikoff, S. (2007). Histone replacement marks the boundaries of cis-regulatory domains. Science 315(5817): 1408-1411. Medline abstract: 17347439
Monier, B., Astier, M., Semeriva, M. and Perrin, L. (2005). Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart.
Development 132(23): 5283-93. 16284119
Moore, L., et al. (1998).
Gonadal mesoderm and fat body initially follow a common
developmental path in Drosophila. Development 125(5): 837-844
Morey, C., et al. (2007). Nuclear reorganisation and chromatin decondensation are conserved, but distinct, mechanisms linked to Hox gene activation. Development 134: 909-919. Medline abstract: 17251268
Mukai, M., Kashikawa, M. and Kobayashi, S. (1999). Induction of indora expression in pole cells by the mesoderm is required for
female germ-line development in Drosophila melanogaster.
Development 126: 1023-1029. Medline abstract: 9927602
Neuteboom, S. T. and Murre, C. (1997). Pbx raises the DNA binding specificity but not the
selectivity of Antennapedia Hox proteins. Mol. Cell. Biol. 17(8): 4696-4706.
Oosterveen, T., et al. (2003). Retinoids regulate the anterior expression boundaries of 5' Hoxb genes in posterior hindbrain. EMBO J. 22(2): 262-9. 12514132
Parrish, J. Z., et al. (2007). Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev. 21: 956-972. Medline abstract: 17437999
Patterson, L. T., Pembaur, M. and Potter, S. S. (2001). Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. Development 128: 2153-2161. 11493536
Peterson, M. D., et al. (1999). The embryonic expression pattern of labial,
posterior homeotic complex genes and the teashirt homologue
in an apterygote insect. Dev. Genes Evol. 209: 77-90
Ponzielli, R., et al. (2002). Heart tube patterning in Drosophila requires integration of axial and segmental information provided by the Bithorax Complex genes and hedgehog signaling. Development 129: 4509-4521. 12223408
Popperl, H., Bienz, M., Studer, M., Chan, S.-K., Aparicio, S., Brenner, S., Mann, R.S., and Krumlauf, R. (1995). Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. Cell 81: 1031-1042. 7600572
Pownall, M. E., et al. (1996). eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis
in Xenopus. Development 122: 3881-3892
Prokop, A. and Technau, G. M. (1994). Early tagma-specific commitment of Drosophila CNS progenitor NB1-1. Development 120: 2567-78
Prokop, A ., et al. (1998). Homeotic regulation of segment-specific differences in
neuroblast numbers and proliferation in the Drosophila
central nervous system. Mech. Dev. 74(1-2): 99-110
Regulski, M. et. al. (1985). Homeo Box genes of the Antennapedia and Bithorax complexes of Drosophila. Cell 43: 71-80
Rudolph, T., et al. (2007). Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3.
Mol. Cell 26(1): 103-15. Medline abstract: 17434130
Saffman, E. E. and Krasnow, M. A. (1994). A differential response element for the homeotics at the
Antennapedia P1 promoter of Drosophila. Proc Natl Acad Sci 91: 7420-7424
Sanchez-Herrero, E. (1991). Control of the expression of the bithorax complex genes
abdominal-A and Abdominal-B by cis-regulatory regions
in Drosophila embryos. Development 111: 437-49
Sanchez-Herrero, E., et al. (1994). Developmental consequences of unrestricted expression of
the abd-A gene of Drosophila.
Mech Dev 46: 153-167
Shimell, M. J., et al. (2000). Functional analysis of repressor binding sites
in the iab-2 regulatory region of the abdominal-A
homeotic gene. Dev. Biol. 218: 38-52.
Shimizu, T., Bae, Y.-K. and Hibi, M. (2006). Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Development 133: 4709-4719. Medline abstract: 17079270
Shippy, T. D., Brown, S. J. and Denell, R. E. (1998). Molecular characterization of the Tribolium abdominal-A ortholog
and implications for the products of the Drosophila gene. Dev. Genes Evol. 207(7): 446-52.
Stark, A., Bushati, N., Jan, C. H., Kheradpour, P., Hodges, E., Brennecke, J., Bartel, D. P., Cohen, S. M. and Kellis, M. (2008). A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. Genes Dev. 22(1): 8-13. PubMed citation: 18172160
Strutt, H., Cavalli, G. and Paro, R. (1997). Co-localization of Polycomb protein and GAGA factor on
regulatory elements responsible for the maintenance of homeotic
gene expression. EMBO J. 16:3621-3632.
Szuts, D., Freeman, M. and Bienz, M. (1997). Antagonism between EGFR and Wingless signalling in
the larval cuticle of Drosophila. Development 124(16): 3209-3219.
Vachon, G. (1992). Homeotic genes of the bithroax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell 71: 437-450.
van den Akker, E., et al. (1999). Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes. Mech. Dev. 89: 103-114
van Den Akker, E., et al. (2001). Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. Development. 128(10): 1911-21. 11311170
van Dijk, M. A. and Murre, C. (1994). Extradenticle raises the DNA binding specificity of
homeotic selector gene products.
Cell 78: 617-624.
Vermot, J., et al. (2005). Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons. Development 132(7): 1611-21 . 15753214
Wiellette, E. L. and McGinnis, W. (1999). Hox genes differentially regulate Serrate to generate segment-specific
structures. Development 126(9): 1985-1995. Medline abstract: 10101132
White, R. A. H., et al. (2000). The design and analysis of a homeotic response element. Mech. Dev. 91: 217-226
Zheng, Z., et al. (1999). Homeotic gene expression in the wild-type and a homeotic mutant of the moth Manduca sexta. Dev. Genes Evol. 209: 460-472.
abdominal-A:
Biological Overview
| Evolutionary Homologs
| Transcriptional Regulation
| Targets of activity
| Protein Interactions
| Developmental Biology
| Effects of Mutation
date revised: 25 October 2007
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