smoothened

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Shyamala, B. V. and Bhat, K. M. (2002). A positive role for Patched-Smoothened signaling in promoting cell proliferation during normal head development in Drosophila. Development 129: 1839-1847. 11934850

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Struhl, G., Barbash, D. A. and Lawrence, P. A. (1997a). Hedgehog organizes the pattern and polarity of epidermal cells in the Drosophila abdomen. Development 124 (11): 2143-2154.

Struhl, G., Barbash, D. A. and Lawrence, P. A. (1997b). Hedgehog acts by distinct gradient and signal relay mechanisms to organize cell type and cell polarity in the Drosophila abdomen. Development 124 (11): 2155-2165.

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Strutt, H., et al. (2001). Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Curr. Biol. Vol 11: 608-613. 11369206

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Taipale, J., Cooper, M. K., Maiti, T., and Beachy, P. A. (2002). Patched acts catalytically to suppress the activity of Smoothened. Nature 418: 892-896. 12192414

Theodosiou, N.A., et al. (1998). slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development. Development 125(17): 3411-3416.

van den Heuvel, M. and Ingham, P. W. (1996). smoothened encodes a receptor-like serpentine protein reuired for hedgehog signalling. Nature 382: 547-551

Varga, Z. M., et al. (2001). Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development 128: 3497-3509. 11566855

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Vrailas, A. D., et al. (2006b). smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye. Development 133(8): 1485-94. 16540506

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Zhang, J., et al. (2001). Downregulation of hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev. Biol. 229: 188-202. 11133163

Zhang, X. M., et al. (2001). Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell 105: 781-792. 11440720

Zhang, Y. and Kalderon, D. (2000). Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling. Development 127: 2165-2176. 10769240

Zhang, Y. and Kalderon, D. (2001). Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature 410: 599-604. 11279500

Zhao, Y., Tong, C. and Jiang, J. (2007). Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 450(7167): 252-8. PubMed citation: 17960137

Zhou, Q., Apionishev, S. and Kalderon, D. (2006). The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. Genetics 173(4): 2049-62. 16783001

Zhu, A. J., Zheng, L., Suyama, K. and Scott, M. P. (2003). Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev. 17: 1240-1252. 12730121

date revised: 10 April 2008

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