blistered/Serum response factor

Affolter, M., et al. (1994). The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development. Development 120: 743-753

Alberts, A. S., Geneste, O. and Treisman, R. (1998). Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell 92: 475-487

Angulo, M., Corominas, M. and Serras, F. (2004). Activation and repression activities of ash2 in Drosophila wing imaginal discs. Development 131(20): 4943-53. 15371308

Appel, L.F., Prout, M., Abu-Shumays, R., Hammonds, A., Garbe, J.C., Fristrom, D., and Fristrom, J. (1993). The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis. Proc. Natl. Acad. Sci. 90: 4937-4941. 6289325

Arsenian, S., et al. (1998). Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J. 17(21): 6289-6299.

Baonza, A. and Garcia-Bellido, A. (1999). Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila. Mech. Dev. 80(2): 133-46.

Brentrup, D., Lerch, H.-P., Jackle, H. and Noll, M. (2000). Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signaling. Development 127: 4729-4741.

Browning, C. L., et al. (1998). The developmentally regulated expression of Serum response factor plays a key role in the control of smooth muscle-specific genes. Dev. Biol. 194(1): 18-37.

Caretti, G., Di Padova, M., Micales, B., Lyons, G. E. and Sartorelli, V. (2004). The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 18(21): 2627-38. 15520282

Cen, B., Selvaraj, A., Burgess, R. C., Hitzler, J. K., Ma, Z., Morris, S. W. and Prywes, R. (2003). Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol. Cell. Biol. 23: 6597-6608. 12944485

Chant, J. and Stowers, L. (1995). GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more. Cell 81: 1-4

Chen, G-C., Gajowniczek, P. and Settleman, J. (2004). Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis. Current Biol. 14: 309-313. 14972681

Cook, O., Biehs, B. and Bier, E. (2004). brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila. Development 131: 2113-2124. 15073155

Crozatier, M., Glise B. and Vincent, A. (2002). Connecting Hh, Dpp and EGF signalling in patterning of the Drosophila wing; the pivotal role of collier/knot in the AP organiser. Development 129: 4261-4269. 12183378

Du, K. L., et al. (2004). Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. J. Biol. Chem. 279(17): 17578-86. 14970199

Escalante, R. and Sastre, L. (1998). A serum response factor homolog is required for spore differentiation in Dictyostelium. Development 125(19): 3801-3808

Etkin, A., et al. (2006). A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron 50(1): 127-43. 16600861

Firth, L., et al. (2000). Identification of genomic regions that interact with a viable allele of the Drosophila protein tyrosine phosphatase Corkscrew. Genetics 156: 733-748.

Fristrom, D., et al. (1994). blistered: a gene required for vein/intervein formation in wings of Drosophila. Development 120: 2661-71

Fukushige, T., Brodigan, T. M., Schriefer, L. A., Waterston, R. H. and Krause, M. (2006). Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development. Genes Dev. 20: 3395-3406. Medline abstract: 17142668

Galvagni, F., et al. (1997). Serum Response Factor and protein-mediated DNA bending contribute to transcription of the dystrophin muscle-specific promoter. Mol. Cell. Biol. 17: 1731-43

Geneste, O., Copeland, J.W., and Treisman, R. (2002). LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics. J. Cell Biol. 157: 831-838. 12034774

Gille, H., et al. (1998). Phosphorylation-dependent formation of a quaternary complex at the c-fos SRE. Mol. Cell Biol. 16(3): 1094-1102.

Goodrich, J., et al. (1997). A polycomb-group gene regulates homeotic gene expression in Arabidopsis. Nature 386: 44-51.

Gotwals, P. J. and Fristrom, J. W. (1991). Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in Drosophila. Genetics 127: 747-59

Gomez-Skarmeta, J.-L., et al. (1996). araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes. Cell 85:95-105

Grueneberg, D. A., et al. (1997). A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I. Genes Dev. 11(19): 2482-2493.

Guillemin, K. et al. (1996). The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal brancing of the tracheal system. Development 122: 1353-62

Hacohen, N., et al. (1998). sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92(2): 253-263.

Halder, G., et al. (1998). The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. Genes Dev. 12(24): 3900-9.

Han, Z., Li, X., Wu, J. and Olson, E. N. (2004). A myocardin-related transcription factor regulates activity of serum response factor in Drosophila. Proc. Natl. Acad. Sci. 101: 12567-12572. 15314239

Hill, C. S., Wynne, J. and Treisman, R. (1995). The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81(7): 1159-1170.

Kim, S., et al. (1997). A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages. Mol. Cell. Biol 17: 2266-78.

Kim, D. W., et al. (1998). TFII-I enhances activation of the c-fos promoter through interactions with upstream elements. Mol. Cell. Biol. 18(6): 3310-3320.

Kuwahara, K., Barrientos, T., Pipes, G. C., Li, S. and Olson, E. N. (2005). Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol. Cell. Biol. 25(8): 3173-81. 15798203

LaJeunesse, D. R., McCartney, B. M. and Fehon, R. G. (2001). A systematic screen for dominant second-site modifiers of Merlin/NF2 phenotypes reveals an interaction with blistered/DSRF and scribbler. Genetics 158: 667-679. 11404331

Landerholm, T. E., et al. (1999). A role for serum response factor in coronary smooth muscle differentiation from proepicardial cells. Development 126(10): 2053-2062.

Liao, J., et al. (1997). Growth hormone regulates ternary complex factors and serum response factor associated with the c-fos serum response element. J. Biol. Chem. 272(41): 25951-25958

Ling, Y., et al.(1997). Molecular characterization of the B-box protein-protein interaction motif of the ETS-domain transcription factor Elk-1. EMBO J 16 (9): 2431-2440.

Mao, J., et al. (1998a). Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13. EMBO J. 17(19): 5638-5646.

Mao, J., et al. (1998b). Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. Proc. Natl. Acad. Sci. 95(22): 12973-6.

Miralles, F., Posern, G., Zaromytidou, A.I. and Treisman, R. (2003). Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113: 329-342. 12732141

Montagne, J., et al. (1996). The Drosophila Serum Response Factor gene is required for the formation of the intervein tissue of the wing and is allelic to blistered. Development 122: 2589-97

Morin, S., et al. (2001). Serum response factor-GATA ternary complex required for nuclear signaling by a G-Protein-coupled receptor. Mol. Cell. Bio. 21: 1036-1044. 11158291

Nussbaumer, U., et al. (2000). Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development. Mech. Dev. 96: 27-36. <

Pic, A., et al. (2000). The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF. EMBO J. 19: 3750-3761.

Poser, S., et al. (2000). SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation. EMBO J. 19: 4955-4966

Posern, B., Miralles, F., Guettler, S. and Treisman, R. (2004). Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL. EMBO J. 23: 3973-3983. 15385960

Price, M. A., Rogers, A. E. and Treisman, R. (1995). Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). EMBO J 14: 2589-2601

Prout, M., et al. (1997). Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster. Genetics 146(1): 275-285.

Reichman-Fried, M. and Shilo, B. Z. (1995). Breathless, a Drosophila FGF receptor homolog, is required for the onset of tracheal cell migration and tracheole formation. Mech Dev 52: 265-273

Roch, F., et al. (1998). Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing. Development 125(10): 1823-1832.

Sahai, E., Alberts, A. S. and Treisman, R. (1998). RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation. Embo J. 17(5): 1350-1361.

Samakovlis, C., et al. (1996). Development of the Drosophila tracheal system occurs by series of morphologically distinct but genetically coupled branching events. Development 122: 1395-07

Schnorr, J. D., et al. (2001). Ras1 interacts with multiple new signaling and cytoskeletal loci in Drosophila eggshell patterning and morphogenesis. Genetics 159: 609-622. 11606538

Schratt, G., Philippar, U., Berger, J., Schwarz, H., Heidenreich, O. and Nordheim, A. (2002). Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J. Cell Biol. 156: 737-750. 11839767

Sealy, L., Malone, D. and Pawlak, M. (1997). Regulation of the cfos Serum Response Element by C/EBP beta. Mol. Cell. Biol. 17: 1744-55

Selvaraj, A. and Prywes, R. (2003). Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. J. Biol. Chem. 278: 41977-41987. 14565952

Simon, K. J., Grueneberg, D. A. and Gilman, M. (1997). Protein and DNA contact surfaces that mediate the selective action of the Phox1 homeodomain at the c-fos serum response element. Mol. Cell. Biol. 17(11): 6653-6662.

Small, E. M., Warkman, A. S., Wang, D. Z., Sutherland, L. B., Olson, E. N. and Krieg, P. A. (2005). Myocardin is sufficient and necessary for cardiac gene expression in Xenopus. Development 132(5): 987-97. 15673566

Somogyi, K and Rørth, P. (2004). Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration. Dev. Cell 7: 85-93. 15239956

Sotiropoulos, A., Gineitis, D., Copeland, J. and Treisman, R. (1999). Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell 98: 159-169. 10428028

Strahl, T., Gille, H. and Shaw, P. E. (1996). Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase subgroups. Proc. Natl. Acad. Sci. 93(21): 11563-11568.

Sturtevant, M. A., Roark, M. and Bier, E. (1993). The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev. 7: 961-73

Sutherland, D., Samakovlis, C. and Krasnow, M. A. (1996). branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and pattern of branching. Cell 87: 1891-1101

Treisman, R. (1995). Journey to the surface of the cell: Fos regulation and the SRE. EMBO J. 14: 4905-13

Vervoort, M., Crozatier, M., Valle, D. and Vincent, A. (1999). The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. Curr. Biol. 9(12): 632-9.

Vogel, A. M. and Gerster, T. (1999). A zebrafish homolog of the serum response factor gene is highly expressed in differentiating embryonic myocytes. Mech. Dev. 81(1-2): 217-21.

Walsh, E. P. and Brown, N. H. (1998). A screen to identify Drosophila genes required for integrin-mediated adhesion. Genetics 150: 791-805.

Wang, D. Z., Li, S., Hockemeyer, D., Sutherland, L., Wang, Z., Schratt, G., Richardson, J. A., Nordheim, A. and Olson, E. N. (2002). Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc. Natl. Acad. Sci. 99: 14855-14860. 12397177

Wang, D., Chang, P. S., Wang, Z., Sutherland, L., Richardson, J. A., Small, E., Krieg, P. A. and Olson, E. N. (2001). Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 105: 851-862. 11439182

Watanabe, T., Hongo, I., Kidokoro, Y. and Okamoto, H. (2005). Functional role of a novel ternary complex comprising SRF and CREB in expression of Krox-20 in early embryos of Xenopus laevis. Dev. Biol. 277(2): 508-21. 15617690

Weatherbee, S. D., et al. (1998). Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere. Genes Dev. 12(10): 1474-1482.

Weatherbee, S. D., et al. (1999). Ultrabithorax function in butterfly wings and the evolution of insect wing patterns. Curr. Biol. 9(3): 109-15.

West, A. G., Shore, P. and Sharrocks, A. D. (1997). DNA binding by MADS-box transcription factors: a molecular mechanism fo differential DNA bending. Mol. Cell. Biol. 17: 2876-87.

Yun, C.-H., et al. (2007). Negative regulation of Activin/Nodal signaling by SRF during Xenopus gastrulation. Development 134: 769-777. Medline abstract: 17259304

Zhao, Y., Samal, E. and Srivastava, D. (2005). Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 436: 214-220. 15951802

date revised: 25 August 2007

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