cAMP-dependent protein kinase 1
Abel, T., et al. (1997). Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88: 615-626. 9054501
Adolfsen, B., Saraswati, S., Yoshihara, M. and Littleton, J. T. (2004). Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment. J. Cell Biol. 166: 249-60. 15263020
Akalal, D. B., Wilson, C. F., Zong, L., Tanaka, N. K., Ito, K. and Davis, R. L. (2006). Roles for Drosophila mushroom body neurons in olfactory learning and memory. Learn Mem 13: 659-668. PubMed Citation: 16980542
Alcedo, J., et al. (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell 86: 221-232. 8706127
Alcedo, J., Zou, Y. and Noll, M. (2000). Posttranscriptional regulation of Smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Molec. Cell 6: 457-465. 10983991
Ali, S., et al. (1998). The A kinase anchoring protein is required for mediating the effect of
protein kinase A on ROMK1 channels. Proc. Natl. Acad. Sci. 95(17): 10274-8.
Ayaz, D., et al. (2008). Axonal injury and regeneration in the adult brain of Drosophila. J. Neurosci. 28(23): 6010-21. PubMed Citation: 18524906
Bagley, E. E., et al. (2004). GABA transporter currents activated by Protein kinase A excite midbrain neurons during opioid withdrawal. Neuron 45: 433-445. 15694329
Baines, R. A. (2003). Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS. J Neurosci 23: 8664-8672. PubMed Citation: 14507965
Balint-Kurti, P., et al. (1998). Non-autonomous regulation of a graded, PKA-mediated
transcriptional activation signal for cell patterning. Development 125(20): 3947-3954.
Baum, B., Li, W. and Perrimon, N. (2000). A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr. Biol. 10: 964-973. 10985383
Bauman, A. L., et al. (2006). Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol. Cell 23(6): 925-31. 16973443
Bartsch, D., et al. (1995). Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell 83: 979-992. PubMed Citation: 8521521
Bhattacharya, A., Lakhman, S.S. and Singh, S. (2004). Modulation of L-type calcium channels in Drosophila via a pituitary adenylyl cyclase-activating polypeptide (PACAP)-mediated pathway. J. Biol. Chem. 279: 37291-37297. Medline abstract: 15201281
Bhave, G., et al. (2002). cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.
Neuron 35: 721-731. 12194871
Bischof, L. J., et al. (1998). Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17. J. Biol. Chem. 273(14): 7941-7948. PubMed Citation: 9525891
Blader, P., et al. (1997). The activity of Neurogenin1 is controlled by local cues in the zebrafish embryo. Development 124(22): 4557-4569. PubMed Citation: 9409673
Brandon, E. P., et al. (1995).
Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. 92: 8851-8855. PubMed Citation: 7568030
Briggs, L. J., et al. (1998). The cAMP-dependent protein kinase site (Ser312) enhances Dorsal nuclear import through facilitating nuclear localization
sequence/importin interaction. J. Biol. Chem. 273(35): 22745-22752. PubMed Citation: 9712906
Burton, K. A., et al. (1997). Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by
cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. 94(20): 11067-11072. PubMed Citation: 9380760
Cai, X., Gu, Z., Zhong, P., Ren, Y. and Yan, Z. (2002). Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons. J. Biol. Chem. 277(39): 36553-62. 12149253
Carrion, A. M., Mellstrom, B. and Naranjo, J. R. (1998). Protein kinase A-dependent derepression of the human Prodynorphin gene via differential binding to an intragenic silencer element. Mol. Cell. Biol. 18(12): 6921-6929. PubMed Citation: 9819380
Casadio, A., et al. (1999). A transient, neuron-wide form of CREB-mediated
long-term facilitation can be stabilized at specific
synapses by local protein synthesis. Cell 99: 221-237. PubMed Citation: 10535740
Cervo, L., Mukherjee, S., Bertaglia, A. and Samanin, R. (1997). Protein kinases A and C are involved in the mechanisms underlying consolidation of cocaine place conditioning. Brain Res. 775(1-2): 30-6. 9439825
Chain, D. G., et al. (1995). Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function
of the ubiquitin system in Aplysia. J. Neurosci. 15(11): 7592-603
Chain, D. G., et al. (1999). Mechanisms for generating the autonomous cAMP-dependent protein
kinase required for long-term facilitation in Aplysia. Neuron 22(1): 147-56
Cheley, S., et al. (1994). Type II regulatory subunits of cAMP-dependent protein kinase and their binding proteins in the nervous system of Aplysia californica. J. Biol. Chem. 269: 2911-20
Chen, E. H. and Baker. B. S. (1997). Compartmental organization of the Drosophila genital imaginal discs. Development 124: 205-218
Chen, C., et al. (1998). Protein kinase A directly regulates the activity and proteolysis of
cubitus interruptus. Proc. Natl. Acad. Sci. 95: 2349-2354
Chen, Y., et al. (1999). Mutants of cubitus interruptus that are independent of PKA regulation are
independent of hedgehog signaling. Development 126: 3607-3616
Chen, Y., Yu, F. H., Surmeier, D. J., Scheuer, T. and Catterall, W. A. (2006). Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C. Neuron 49(3): 409-20. 16446144
Chen, Y., et al. (2010). G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev. 24(18): 2054-2067. PubMed Citation: 20844016
Cheng, X., et al. (1998). Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc. Natl. Acad. Sci. 95(17): 9849-9854
Chheda, M. G., et al. (2001). Phosphorylation of Snapin by PKA
modulates its interaction with the SNARE complex. Nature Cell Biology
3: 331-338. 11283605
Chyb, S., et al. (1999). Modulation of the light response by cAMP in Drosophila
photoreceptors. J. Neurosci. 19(20): 8799-8807
Colledge, M., et al. (2000). Targeting of PKA to Glutamate receptors through a
MAGUK-AKAP complex. Neuron 27: 107-119.
Collier, L. S., Suyama, K., Anderson, J. H., Scott, M. P. (2004). Drosophila Costal1
mutations are alleles of protein kinase A that modulate hedgehog signaling.
Genetics 167(2): 783-96. 15238528
Crocker, A. and Sehgal, A. (2008). Octopamine regulates sleep in Drosophila through protein kinase A-dependent mechanisms. J. Neurosci. 28(38): 9377-85. PubMed Citation: 18799671
Cziko, A.-M. J. et al. (2009). Genetic modifiers of dFMR1 encode RNA granule components in Drosophila. Genetics 182(4): 1051-1060. PubMed Citation: 19487564
Daaka, Y., Luttrell, L. M. and Lefkowitz, R. J. (1997). Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature 389(6655): 88-91
Dai, P., et al. (1999). Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274(12): 8143-52
D'Angiolella, V., et al. (2001). Role for cyclin-dependent kinase 2 in mitosis exit. Curr. Bio. 11: 1221-1226. 11516956
Das, S., et al. (1997). NMDA and D1 receptors regulate the phosphorylation of CREB and the induction of c-fos in striatal neurons in primary culture. Synapse 25(3): 227-233
Davis, R. L., et al. (1995). The cyclic AMP system and Drosophila learning. Mol. and Cell. Biochem. 149/150: 271-278
Davis, G. W., DiAntonio, A., Petersen, S. A. and Goodman, C. S. (1998). Postsynaptic PKA controls quantal size and reveals a retrograde signal that regulates presynaptic transmitter release in Drosophila. Neuron 20: 305-315. PubMed Citation: 9491991
Deshpande, G., et al. (2001). Hedgehog signaling in germ cell migration. Cell 106: 759-769. 11572781
Diviani, D., et al. (2000). Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain. Curr. Biol. 10: 417-420.
Drier, E. A., Huang, L. H. and Steward, R. (1999). Nuclear import of the Drosophila Rel protein Dorsal is
regulated by phosphorylation. Genes Dev. 13(5): 556-568
Dong, J., et al. (1998a). A phosphorylation site in the Ftz homeodomain is required for activity. EMBO J. 17: 2308-2318
Dong, J. M., et al. (1998b). cAMP-induced morphological changes are counteracted by the
activated RhoA small GTPase and the Rho kinase ROKalpha. J. Biol. Chem. 273(35): 22554-22562
Downs, S. M., Hudson, E. R. and Hardie, D. G. (2002). A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes
Dev. Biol. 245: 200-212. 11969266
Dransfield, D. T., et al (1997).
Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. EMBO J. 16: 35-43
Eide, T., et al. (1998). Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Exp. Cell Res. 238(2): 305-316
Epstein, D. J., et al. (1996). Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122(9): 2885-94
Esguerra, M., et al. (1994). Cloned Ca(2+)-dependent K+ channel modulated by a functionally associated protein kinase. Nature 369(6481): 563-5
Fan, C. M., et al. (1995). Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP
signaling pathway. Cell 81: 457-65
Feliciello, A., et al. (1997). A-kinase anchor protein 75 increases the rate and magnitude of
cAMP signaling to the nucleus. Curr. Biol. 7(12): 1011-1014
Fiala, A., Muller, U. and Menzel, R. (1999). Reversible downregulation of protein kinase A during olfactory learning using antisense technique impairs long-term memory formation in the honeybee, Apis mellifera. J Neurosci. 19(22): 10125-34
Firulli, B. A., et al. (2003). PKA, PKC, and the Protein phosphatase 2A influence HAND factor function: A mechanism for tissue-specific transcriptional regulation. Molec. Cell 12: 1225-1237. 14636580
Francis, S. H., and Corbin, J. D. (1994). Structure and function of cyclic nucleotide-dependent protein kinases. Annu. Rev. Physiol. 56: 237-72. PubMed Citation: 8010741
Fraser, I. D. C., et al. (1998). A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events. EMBO J. 17: 2261-2272. PubMed Citation: 9545239
Gao, T., et al. (1997). cAMP-dependent regulation of cardiac L-type Ca2+
channels requires membrane targeting of PKA and
phosphorylation of channel subunits. Neuron 19(1): 185-196. PubMed Citation: 9247274
Gibson, R. M., Ji-Buechler ,Y. and Taylor, S. S. (1997). Interaction of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Electrostatic sites on the type Ialpha regulatory subunit. J. Biol. Chem. 272(26): 16343-16350. PubMed Citation: 9195940
Goldsmith, B. A. and Abrams, T. W. (1992). cAMP modulates multiple K+ currents, increasing spike duration and
excitability in Aplysia sensory neurons. Proc. Natl. Acad. Sci. 89: 11481-5. PubMed Citation: 1333612
Goodwin, S. F., et al. (1997). Defective learning in mutants of the Drosophila gene for a regulatory
subunit of cAMP-dependent protein kinase. J. Neurosci. 17(22): 8817-8827. PubMed Citation: 9348350
Görner, W., et al. (1998). Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev. 12: 586-597. PubMed Citation: 9472026
Goessling, W., et al. (2009). Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 136(6): 1136-47. PubMed Citation: 19303855
Gray, P. C., et al. (1998). Primary structure and function of an A kinase anchoring protein
associated with calcium channels. Neuron 20(5): 1017-1026
Grieco, D., et al. (1996). Requirement for cAMP-PKA pathway activation by M phase-promoting factor in the transition from mitosis to
interphase. Science 271: 1718-1723
Gronholm, M., et al. (2003). Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. J. Biol. Chem. 278(42): 41167-72. 12896975
Guo, H.-F., et al. (2000). A neurofibromatosis-1-regulated pathway is required for learning in Drosophila. Nature 403: 895-898
Feliciello, A., et al. (1997). A-kinase anchor protein 75 increases the rate and magnitude of
cAMP signaling to the nucleus. Curr. Biol. 7(12): 1011-1014
Goodwin, S. F., Del Vecchio, M., Velinzon, K., Hogel, C., Russell, S. R., Tully, T. and Kaiser, K. (1997). Defective learning in mutants of the Drosophila gene for a regulatory subunit of cAMP-dependent protein kinase. J. Neurosci. 17: 8817-8827. 9348350
Hagiwara, M., et al. (1993). Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol. Cell Biol. 13: 4852-9
Han, S. J., Chen, R., Paronetto, M. P. and Conti, M. (2005). Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. Curr. Biol. 15(18): 1670-6. 16169490
Hammerschmidt, M., Bitgood, M. J. and McMahon, A. P. (1996). Protein kinase A is a common negative regulator of Hedgehog signaling
in the vertebrate embryo. Genes Dev. 10: 647-658
Han, J. D., Baker, N. E. and Rubin, C. S. (1997) Molecular characterization of a novel A kinase anchor protein from Drosophila melanogaster. J. Biol. Chem. 272(42): 26611-26619
Harvie, P. D., Filippova, M. and Bryant, P. J. (1998). Genes expressed in the ring gland, the major endocrine organ of
Drosophila melanogaster. Genetics 149(1): 217-231
Haug, L. S., et al. (1999). Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic nucleotide-dependent kinases in vitro and in rat cerebellar slices in situ. J. Biol. Chem. 274(11): 7467-73. 10066812
Hebb, D. O. (1949). The Organization of Behavior. Wiley, New York
Hegde, A. N., Goldberg, A. L. and Schwartz, J. H. (1993). Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity. Proc. Natl. Acad. Sci. 90(16): 7436-40
Hegde, A. N., et al. (1997). Ubiquitin C-terminal hydrolase is an
immediate-early gene essential for
long-term facilitation in Aplysia. Cell 89: 115-126
Hendricks, J. C., et al. (2001). A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat. Neurosci. 4: 1108-1115. 11687816
Hensch, T. K., et al. (1998). Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice. J. Neurosci. 18(6): 2108-2117
Hoffman, D. A. and Johnston, D. (1998). Downregulation of transient K+ channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC. J. Neurosci. 18(10): 3521-3528
Homayouni, R., Byrne, J. H. and Eskin, A. (1995). Dynamics of protein phosphorylation in sensory neurons of Aplysia. J. Neurosci. 15: 429-38
Howe, A. K. and Juliano, R. L. (2000). Regulation of anchorage-dependent signal transduction by Protein kinase A and p21-activated kinase.
Nat. Cell Biol. 2: 593-600. 10980699
Hu, S. C., Chrivia, J. and Ghosh, A. (1999). Regulation of CBP-mediated transcription by neuronal calcium signaling. Neuron 22(4): 799-808
Huang, A. M. and Rubin, G. M. (2000). A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Genetics 156(3): 1219-30. 11063696
Huang, G., et al. (2007). Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop. Genes Dev. 21(24): 3283-95. PubMed citation: 18079175
Huang, L. J., et al. (1997). D-AKAP2, a novel protein kinase A anchoring protein with a
putative RGS domain. Proc. Natl. Acad. Sci. 94(21): 11184-11189
Huang, Y.-Y., et al. (1995), A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning.
Cell 83: 1211-1222
Huang, Y. Y. and Kandel, E. R. (1998). Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala. Neuron 21(1): 169-178
Huang, Z. and Kunes, S. (1998). Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly. Development 125: 3753-3764
Ice, R. J., Wildonger, J., Mann, R. S. and Hiebert, S. W. (2005). Comment on 'Nervy links protein kinase A to plexin-mediated semaphorin repulsion'.
Science 309(5734): 558. PubMed citation: 16040690
Imai, T., Suzuki, M. and Sakano, H. (2006). Odorant receptor-derived cAMP signals direct axonal targeting. Science 314(5799): 657-61. Medline abstract: 16990513
Impey, S., et al. (1996). Induction of CRE-mediated gene expression by stimuli that generate
long-lasting LTP in area CA1 of the hippocampus. Neuron 16: 973-982
Impey, S., et al. (1998). Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent
transcription and ERK nuclear translocation. Neuron 21(4): 869-83
Islam, M. S., et al. (1998). In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation. Proc. Natl. Acad. Sci. 95(11): 6145-6150
Jackson, S. M. and Blochlinger, K. (1997). cut interacts with Notch and protein kinase A to regulate egg
chamber formation and to maintain germline cyst integrity during
Drosophila oogenesis. Development 124: 3663-3672
Jackson, S. M. and Berg, C. A. (2002). An A-kinase anchoring protein is required for Protein kinase A regulatory subunit localization and morphology of actin structures during oogenesis in Drosophila. Development 129: 4423-4433. 12223401
Jia, J., et al. (2002). Shaggy/GSK3 antagonizes Hedgehog signaling by regulating Cubitus interruptus. Nature 416: 548-551. 11912487
Jiang, J. and Struhl, G. (1995). Protein kinase A and Hedgehog signaling in Drosophila limb development. Cell 80 563-572
Johnson, L. R., et al. (1997). Assembly of AKAP82, a protein kinase A anchor protein, into the fibrous sheath of mouse sperm. Dev. Biol. 192(2): 340-350
Joiner, W. J., Crocker, A., White, B. H. and Sehgal, A. (2006). Sleep in Drosophila is regulated by adult mushroom bodies. Nature 441(7094): 757-60. Medline abstract: 16760980
Joore, J., et al. (1998). Protein kinase A is involved in the induction of early mesodermal marker genes by activin. Mech. Dev. 79(1-2): 5-16
Kaang, B. K., Kandel, E. R. and Grant, S. G. (1993). Activation of cAMP-responsive genes by stimuli that produce
long-term facilitation in Aplysia sensory neurons. Neuron 10: 427-35
Kalderon, D. and Rubin, G. M. (1988). Isolation and characterization of Drosophila cAMP-dependent protein kinase gene. Genes Dev. 2: 1539-56
Kameyama, K., et al. (1998). Involvement of a postsynaptic protein kinase A substrate in the
expression of homosynaptic long-term depression. Neuron 21(5): 1163-75
Kiger, J. A., et al. (1999). Transgenic inhibitors identify two roles for Protein Kinase A in
Drosophila development. Genetics 152(1): 281-290
Kiger, J. A. and O'Shea, C. (2001a). Genetic evidence for a protein kinase A/Cubitus interruptus complex that facilitates processing of Cubitus interruptus in Drosophila. Genetics 158: 1157-1166. 11454764
Kiger, J. A., Natzle, J. E. and Green, M. M. (2001b). Hemocytes are essential for wing maturation in Drosophila melanogaster. Proc. Natl. Acad. Sci. 98(18): 10190-5. 11504926
Kikuchi, A. and Williams, L. T. (1996).
Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase. J. Biol. Chem. 271(1): 588-94
Kilman, V. L., Zhang, L., Meissner, R. A., Burg, E. and Allada, R. (2009). Perturbing dynamin reveals potent effects on the Drosophila circadian clock. PLoS One 4(4): e5235. PubMed Citation: 19384421
Kilstrup-Nielsen, C., Alessio, M. and Zappavigna, V. (2003). PBX1 nuclear export is regulated independently of PBX-MEINOX interaction by PKA phosphorylation of the PBC-B domain. EMBO J. 22: 89-99. 12505987
Kim, C., Cheng, C. Y., Saldanha, S. A. and Taylor, S. S. (2007). PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell 130(6): 1032-43. PubMed citation; Online text
Kimura, K.-i., Kodama, A., Hayasaka, Y. and Ohta, T. (2004). Activation of the cAMP/PKA signaling pathway is required for post-ecdysial cell death in wing epidermal cells of Drosophila melanogaster. Development 131: 1597-1606. 14998927
Kotani, S., et al. (1998). PKA and MPF-activated polo-like kinase regulate anaphase-promoting
complex activity and mitosis progression. Mol. Cell 1(3): 371-80
Krashes, M. J., Keene, A. C., Leung, B., Armstrong, J. D. and Waddell, S. (2007). Sequential use of mushroom body neuron subsets during drosophila odor memory processing. Neuron 53: 103-115. PubMed Citation: 17196534
Krushel, L. A., et al. (1998). Neural cell adhesion molecule (N-CAM) domains and intracellular
signaling pathways involved in the inhibition of
astrocyte proliferation. Proc. Natl. Acad. Sci. 95: 2592-2596
Lane-Ladd, S. B., et al. (1997). CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a
role in opiate dependence. J. Neurosci. 17(20): 7890-7901
Lane, M. E. and Kalderon, D. (1993). Genetic investigation of cAMP-dependent protein kinase function in Drosophila development. Genes Dev. 7: 1229-1243
Lane, M. E. and Kalderon, D. (1994). RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal
transduction to direct normal microtubule organization. Genes Dev. 8: 2986-2995
Lane, M. E. and Kalderon, D. (1995). Localization and functions of protein kinase A during Drosophila oogenesis. Mech. Dev. 49: 191-200
Lee, H.-K., et al. (2000). Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic
plasticity. Nature 405: 955-959
Lee, H., Rezai-Zadeh, N. and Seto, E. (2004). Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.
Mol. Cell. Biol. 24(2): 765-73. 14701748
Lepage, T., et al. (1995). Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373: 711-715
Lester, L. B., Langeberg, L. K., Scott, J. D. (1997). Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proc. Natl. Acad. Sci. 94(26): 14942-14947
Levine, J. D., et al. (1994). Altered circadian pacemaker functions and cyclic AMP rhythms in the Drosophila learning mutant dunce. Neuron 13: 967-74
Leyssen, M. and Hassan, B. A. (2007). A fruitfly's guide to keeping the brain wired. EMBO Rep. 8: 46-50. PubMed Citation: 17203102
Li, W., et al. (1995). Function of protein kinase A in Hedgehog signal transduction and Drosophila imaginal disc development. Cell 80: 553-562
Li, W., Tully, T. and Kalderon, D. (1996). Effects of a conditional Drosophila PKA mutant on olfactory learning and memory. Learn Mem. 2(6): 320-33
Li, Z., Rossi, E., Hoheisel, J., Kalderon, D. and Rubin, C. (1999). Generation of a novel A kinase anchoring protein and a myristoyalted
alanine-rich C kinase substrate-linked analog from a single gene. J. Biol. Chem. 274: 27191-27200. 10480936
Liao, X., et al. (1999). Activation of protein kinase A contributes to the expression but not the induction of long-term hyperexcitability caused by axotomy of Aplysia sensory neurons. J. Neurosci. 19(4): 1247-56
Liou, H. H., Zhou, S. S. and Huang, C. L. (1999). Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. Proc. Natl. Acad. Sci. 96(10):5820-5
Lu, Y., et al. (2007). The AKAP Yu is required for olfactory long-term memory formation in Drosophila. Proc. Natl. Acad. Sci. USA 104(34): 13792-13797. PubMed Citation: 17690248
Majercak, J., Kalderon, D. and Edery, I. (1997). Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function. Mol. Cell. Biol. 17(10): 5915-5922
Mansuy, I. M., et al. (1998). Restricted and
regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92: 39-49
Marks, S. A. and Kalderon, D. (2011). Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation. Development 138(12): 2533-42. PubMed Citation: 21610030
Martin, D. E., Soulard, A. and Hall, M. N. (2004). TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119: 969-979. 15620355
Martin, S. G. and St Johnston, D. (2003). A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421(6921): 379-84. 12540903
Marx, S. O., et al. (2000). PKA phosphorylation dissociates FKBP12.6 from the
calcium release Channel (ryanodine receptor): defective
regulation in failing hearts. Cell 101: 365-376
Masai, I., et al. (2005). The hedgehog-PKA pathway regulates two distinct steps of the differentiation of retinal ganglion cells: the cell-cycle exit of retinoblasts and their neuronal maturation.
Development 132(7): 1539-53. 15728672
McGuire, S. E., Le, P. T. and Davis, R. L. (2001). The role of Drosophila mushroom body signaling in olfactory memory. Science 293: 1330-1333. PubMed Citation: 11397912
Meima, M. E. and Schaap, P. (1999). Fingerprinting of adenylyl cyclase activities during Dictyostelium development indicates a
dominant role for adenylyl cyclase B in terminal differentiation. Dev. Biol. 212(1): 182-190
Meléndez, A., Li, W. and Kalderon, D. (1995). Activity, expression and function of a second Drosophila protein kinase A catalytic subunit gene. Genetics 141: 1507-20
Methot, N. and Basler, K. (1999). Hedgehog controls limb development by
regulation the activities of distinct transcription activator and repressor
forms of Cubitus interruptus. Cell 96: 819-831
Miller, M. J., et al. (1998). Differential effects of protein kinase A on Ras effector pathways. Mol. Cell. Biol. 18(7): 3718-3726
Moita, M. A., Lamprecht, R., Nader, K. and LeDoux, J. E. (2002) A-kinase anchoring proteins in amygdala are involved in auditory fear memory. Nat. Neurosci. 5: 837-838. PubMed Citation: 12172550
Mohanty, S., et al. (2001). Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium. Genes Dev. 15: 1435-1448. 11390363
Monnier, D. and Loeffler, J. P. (1998). Pituitary adenylate cyclase-activating polypeptide stimulates proenkephalin gene transcription through AP1- and
CREB-dependent mechanisms. DNA Cell Biol. 17(2): 151-159
Moon, C., et al. (1998). Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in
olfactory receptor neurons. J. Neurosci. 18(9): 3195-3205
Moore, M. S., et al. (1998). Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway.
Cell 93: 997-1007
Muller, U. (1997). Neuronal cAMP-dependent protein kinase type II is concentrated in mushroom bodies of
Drosophila melanogaster and the honeybee Apis mellifera. J. Neurobiol. 33(1): 33-44.
Muller, U. and Carew, T. J. (1998). Serotonin induces temporally and mechanistically distinct phases of persistent PKA activity in Aplysia sensory neurons. Neuron 21(6): 1423-34
Müller, U. (2000). Prolonged activation of cAMP-dependent protein kinase
during conditioning induces long-term memory in
honeybees. Neuron 27: 159-168.
Muniz, M., et al. (1997). Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-golgi network. Proc. Natl. Acad. Sci. 94(26): 14461-14466
Continued: cAMP-dependent protein kinase 1 - References part 2/2
cAMP-dependent protein kinase 1:
Biological Overview
| Evolutionary Homologs
| Regulation
| Protein Interactions
| Developmental Biology
| Effects of Mutation
Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.
The Interactive Fly resides on the
Society for Developmental Biology's Web server.