>
Mothers against dpp
Adachi-Yamada, T., et al. (1999). p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis. Mol. Cell. Biol. 19(3): 2322-9.
Aldaz, S., Morata, G. and Azpiazu, N. (2005). Patterning function of homothorax/extradenticle in the thorax of Drosophila. Development 132(3): 439-46. 15634705
Allan, D., St. Pierre, S. E., Miguel-Aliaga, I. and Thor, S. (2003). Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Cell 113: 73-86. 12679036
Anderson, J., Salzer, C. L. and Kumar, J. P. (2006). Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. Dev. Biol. 297(2): 536-49. 16780828
Atfi, A., et al. (1997). Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein Kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. J. Biol. Chem. 272(40): 24731-24734.
Aubin, J., Davy, A. and Soriano, P. (2004). In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev. 18: 1482-1494. 15198985
Azpiazu, N. and Morata, G. (2000). Function and regulation of homothorax in the wing imaginal disc of Drosophila. Development 127: 2685-2693.
Bhushan, A., Chen, Y. and Vale, W. (1998). Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos. Dev. Biol. 200(2): 260-268
Candia, A. F., et al. (1997). Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development 124(22): 4467-4480.
Casellas, R. and Brivanlou, A. H. (1998). Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer. Dev. Biol. 198(1): 1-12.
Certel, K., et al. (2000). Restricted patterning of vestigial expression in Drosophila wing imaginal discs requires synergistic activation by both Mad and the Drifter POU domain transcription factor. Development 127: 3173-3183.
Chen, D. and McKearin, D. (2003). Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells. Curr. Biol. 13: 1786-1791. 14561403
Chen, H. B., Shen, J., Ip, Y. T. and Xu, L. (2006). Identification of phosphatases for Smad in the BMP/DPP pathway. Genes Dev. 20: 648-653. 16510868
Chen, X., Rubock, M. J. and Whitman, M. (1996). A transcriptional partner for MAD proteins in TGF-ß signalling. Nature 383: 691-696
Chen, X., et al. (1997). Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389: 85-89.
Chen, Y. G., et al. (1998). Determinants of specificity in TGF-beta signal transduction. Genes Dev. 12(14): 2144-2152.
Chen, Y. G. and Massague, J. (1999). Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors. J. Biol. Chem. 274(6): 3672-7.
Dai, H., et al. (2000). The zinc finger protein Schnurri acts as a Smad partner in mediating the transcriptional response to Decapentaplegic. Dev. Bio. 227: 373-387.
Das, P., et al. (1998). The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling. Development 125: 1519-1528
Datta, P. K., Blake, M. C. and Moses, H. L. (2000). Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1. J. Biol. Chem. 275(51): 40014-9. 11054406
Davis, B. N., Hilyard, A. C., Lagna, G. and Hata, A. (2008). SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454(7200): 56-61. PubMed citation: 18548003
de Caestecker, M. P., et al. (1997). Characterization of functional domains within Smad4/DPC4. J. Biol. Chem. 272 (21): 13690-13696.
Decotto, E. and Ferguson, E. L. (2001). A positive role for Short gastrulation in modulating BMP signaling during dorsoventral patterning in the Drosophila embryo. Development 128: 3831-3841. 11585808
Delaune, E., Lemaire, P. and Kodjabachian, L. (2005). Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition. Development 132(2): 299-310. 15590738
Dennler, S., et al. (1998). Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17(11): 3091-3100.
Dick, A., Risau, W. and Drexler, H. (1998). Expression of Smad1 and Smad2 during embryogenesis suggests a role in organ development. Dev. Dyn. 211(4): 293-305.
Dorfman, R. and Shilo, B.-Z. (2001). Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region. Development 128: 965-972. 11222150
Duan, X., Liang, Y. Y., Feng, X. H. and Lin, X. (2006). Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway. J. Biol. Chem. 281: 36526-36532. Medline abstract: 16931515
Dudu, V., Bittig, T., Entchev, E., Kicheva, A., Julicher, F. and Gonzalez-Gaitan, M. (2006). Postsynaptic mad signaling at the Drosophila neuromuscular junction. Curr. Biol. 16(7): 625-35. 16581507
Faure, S., et al. (2002). Endogenous patterns of BMP signaling during early chick development. Dev. Biol. 244: 44-65. 11900458
Feng, X. H., et al. (1998). The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev. 12(14): 2153-2163.
Fu, W. and Baker, N. E. (2003). Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development. Development 130: 5229-5239. 12954721
Galant, R. and Carroll, S. B. (2002). Evolution of a transcriptional repression domain in an insect Hox protein. Nature 415: 910-913. PubMed citation: 11859369
Gao, S., Steffen, J. and Laughon, A. (2005). DPP-responsive silencers are bound by a trimeric mad-medea complex. J. Biol. Chem. 280(43): 36158-64. 16109720
Gao, S. and Laughon, A. (2006). Decapentaplegic-responsive silencers contain overlapping mad-binding sites. J. Biol. Chem. 281(35): 25781-90. 16829514
Germain, S., et al. (2000). Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes and Dev. 14: 435-451.
George, H. and Terracol, R. (1997). The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors. Genetics. 146(4): 1345-63.
Gilboa, L., and Lehmann, R. (2004). Repression of primordial germ cell differentiation parallels germ line stem cell maintenance. Curr. Biol. 14: 981-986. 15182671
Goold, C. P. and Davis, G. W. (2007). The BMP Ligand Gbb gates the expression of synaptic homeostasis independent of synaptic growth control. Neuron 56: 109-123. Medline abstract: 17920019
Goswami, M., Uzgare, A. R. and Sater, A. K. (2001). Regulation of MAP kinase by the BMP-4/TAK1 pathway in Xenopus ectoderm. Dev. Bio. 236: 259-270. 11476570
Graff, J. M., Bansal, A. and Melton, D. A. (1996). Xenopus Mad proteins transduce distinct subsets of signals for the TGFß superfamily. Cell 85: 479-487
Grienenberger, A., et al. (2003). Tgfß signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development 130: 5445-5455. 14507783
Gruendler, C., Lin, Y., Farley, J. and Wang, T. (2001). Proteasomal degradation of Smad1 induced by bone morphogenetic proteins. J. Biol. Chem. 276: 46533-46543. 11571290
Guss, K. A. et al. (2001). Control of a genetic regulatory network by a selector gene. Science 292: 1164-1167. 11303087
Halfon, M. S., et al. (2000). Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors. Cell 103: 63-74.
Han, Z. S., et al. (1998). A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol. Cell. Biol. 18(6): 3527-39.
Hata, A., et al. (1998). Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor Genes Dev. 12: 186-197
Henderson, K. D., Isaac, D. D. and Andrew, D. J. (1999). Cell fate specification in the Drosophila salivary gland: the integration of homeotic gene function with the DPP signaling cascade. Dev. Biol. 205(1): 10-21.
Hild, M., et al. (1999). The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo. Development 126(10): 2149-2159
Hoodless, P. A., et al. (1996). MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85: 489-500.
Hoodless, P. A., et al. (1999), Dominant-negative Smad2 mutants inhibit Activin/Vg1 signaling and disrupt axis formation in Xenopus. Dev. Biol. 207(2): 364-79.
Howell, M. and Hill, C. S. (1997). XSmad2 directly activates the activin-inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos. EMBO J. 16(24): 7411-7421.
Hu, M. C., Piscione, T. D. and Rosenblum, N. D. (2003). Elevated SMAD1/ß-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice. Development 130: 2753-2766. 12736218
Hu, M. C. and Rosenblum, N. D. (2005). Smad1, ß-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. Development 132: 215-225. 15576399
Hudson, J. B., et al. (1998). The Drosophila Medea gene is required downstream of dppand encodes a functional homolog of human Smad4. Development 125: 1407-1420
Hullinger, T. G., et al. (2001). TGFbeta and BMP-2 activation of the OPN promoter: roles of smad- and hox-binding elements. Exp. Cell Res. 262(1): 69-74. 11120606
Inoue, H., et al. (1998). Interplay of signal mediators of Decapentaplegic (Dpp): Molecular characterization of Mothers against dpp, Medea, and Daughters against dpp. Mol. Biol. Cell 9(8): 2145-2156.
Inoue, T. and Thomas, J. H. (2000). Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation. Dev. Biol. 217: 192-204.
Ishitani, T., (1999). The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature 399: 798-802. Medline abstract: 10391247
Ishitani, T., Kishida, S., Hyodo-Miura, J., Ueno, N., Yasuda, J., Waterman, M., Shibuya, H., Moon, R. T., Ninomiya-Tsuji, J. and Matsumoto, K. (2003a). The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol. Cell. Biol. 23: 131-139. Medline abstract: 12482967
Ishitani, T., Ninomiya-Tsuji, J. and Matsumoto, K. (2003b). Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol. Cell. Biol. 23: 1379-1389. Medline abstract: 12556497
Itoh, F., et al. (2001). Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. EMBO J. 20: 4132-4142. 11483516
Jin, W., et al. (2006). Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins. Dev. Cell 10(4): 461-71. 16580992
Karaulanov, E., Knochel, W. and Niehrs, C. (2004). Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. EMBO J. 23: 844-856. 14963489
Kavsak, P., et al. (2000). Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the Tgf-beta receptor for degradation. Mol. Cell 6: 1365-1375. 11163210
Kanei-Ishii, C., et al. (2004). Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 18: 816-829. Medline abstract: 15082531
Kida, Y., et al. (2004). Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis. Development 131: 4179-4187. 15280207
Kim, J., et al. (1997). Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388: 304-8
Kirkpatrick, H., Johnson, K. and Laughon, A. (2001). Repression of Dpp targets by binding of Brinker to Mad sites. J. Biol. Chem. 276: 18216-18222. 11262410
Knockaert, M., Sapkota, G., Alarcon, C., Massague, J. and Brivanlou, A. H. (2006). Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. Proc. Natl. Acad. Sci. 103: 11940-11945. Medline abstract: 16882717
Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C.A., and Ghosh, S. 1999. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Dev. 13: 2059-2071. 10465784
Kramer, C., et al. (2002). Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling. Dev. Bio. 250: 263-279. 12376102
Kretzschmar, M., et al. (1997). The TGF-ß family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11: 984-995
Kretzschmar, M., et al. (1999). A mechanism of repression of TGFbeta/Smad signaling by oncogenic Ras. Genes Dev. 13(7): 804-816.
Kubota, K., et al. (2000). EGF receptor attenuates Dpp signaling and helps to distinguish the wing and leg cell fates in Drosophila. Development 127: 3769-3776.
Kusanagi, K., et al. (2000). Characterization of a bone morphogenetic protein-responsive Smad-binding element. Mol. Biol. Cell 11: 555-565.
Kwon, C., et al. (2004). Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc. Development 131: 2681-2692. 15128656
Labbe, E., Letamendia, A. and Attisano, L. (2000). Association of smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Proc. Natl. Acad. Sci. 97(15): 8358-63.
Lagna, G., et al. (1996). Partnership between DPC4 and SMAD proteins in TGF-ß signaling pathways. Nature 383: 832-836
Lechleider, R. J., et al. (2001). Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion. Dev. Biol. 240(1): 157-67. 11784053
Lecuit, T., et al. (1996). Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381: 387-393
Lee, H. H. and Frasch, M. (2005). Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction. Development 132: 1429-1442. 15750188
Lee, K.-H., Evans, S., Ruan, T. Y. and Lassar, A. B. (2004). SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer. Development 131: 4709-4723. 15329343
LeSueur, J. A. and Graff, J. M. (1999). Spemann organizer activity of Smad10. Development 126(1): 137-146.
Letizia, A., Barrio, R. and Campuzano, S. (2007). Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterning. Development 134(7): 1337-46. Medline abstract: 17329358
Liberatore, C. M., et al. (2002). Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region. Dev. Biol. 244: 243-256. 11944934
Lien, C. L., et al. (2002). Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site. Dev. Biol. 244: 257-266. 11944935
Lilja, T., et al. (2003). The CBP coactivator functions both upstream and downstream of Dpp/Screw signaling in the early Drosophila embryo. Dev. Biol. 262: 294-302. 14550792
Liu, B., et al. (1999). FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals. Mol. Cell. Biol. 19(1): 424-30.
Liu, F., Pouponnot, C. and Massague, J. (1997). Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11(23): 3157-3167.
Liu, X., et al. (1997). Transforming growth factor beta-induced phosphorylation of smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl. Acad. Sci. 94(20): 10669-10674.
Lo, R. S., et al. (1998). The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors. EMBO J. 17: 996-1005.
Lo, R. S., Wotton, D. and Massague, J. (2001). Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J. 20: 128-136
Macías-Silva, M., et al. (1996). MADR2 is a substrate of the TGFß receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87: 1215-24
Macias-Silva, M., et al. (1998). Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J. Biol. Chem. 273(40): 25628-36.
Marqués, G., et al. (2002). The Drosophila BMP type II receptor Wishful thinking regulates neuromuscular synapse morphology and function. Neuron 33: 529-543. 11856528
Marquez, R. M., et al. (2001). Transgenic analysis of the Smad family of TGF-ß signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157: 1639-1648. 11290719
Massagué, J. (1996). TGFß signaling: Receptors, transducers and Mad proteins. Cell 85: 947-950
McCabe, B. D., et al. (2003). The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. Neuron 39: 241-254. 12873382
Meersseman, G., et al. (1997). The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation. Mech Dev 61 (1-2): 127-140.
Melhuish, T. A. and Wotton, D. (2000). The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J. Biol. Chem. 275(50): 39762-6. 10995736
Messenger, N. J., et al. (2005). Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. Dev. Cell 8(4): 599-610. 15809041
Monsoro-Burq, A.-H. and Le Douarin, N. (2000). Left-right asymmetry in BMP4 signalling pathway during chick gastrulation. Mech. Dev. 97: 105-108.
Moustakas, A. and Kardassis, D. (1998). Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc. Natl. Acad. Sci. 95(12): 6733-6738.
Müller, B., et al. (2003). Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell 113: 221-233. 12705870
Nakashima, K., et al. (1999). Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284(5413): 479-482
Nakayama, T., et al. (1998a). Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning. Development 125(5): 857-867.
Nakayama, T., et al. (1998b). Smad6 functions as an intracellular antagonist of some TGF-beta family members during Xenopus embryogenesis. Genes Cells 3(6): 387-94.
Nelles, L., et al. (2003). Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1. Genomics 82(4): 460-9. 13679026
Newfeld, S. J., et al. (1996). Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-ß responsive cells. Development 122: 2099-2108
Newfeld, S. J., et al. (1997). Mothers against dpp participates in a DPP/TGF-beta responsive serine-threonine kinase signal transduction cascade. Development 124(16): 3167-3176.
Nguyen, H. T. and Xu, X. (1998). Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules. Dev. Biol. 204(2): 550-66.
Nitta, K. R., Tanegashima, K., Takahashi, S. and Asashima, M. (2004). XSIP1 is essential for early neural gene expression and neural differentiation by suppression of BMP signaling. Dev. Biol. 275(1): 258-67. 15464588
Ogasawara, T., Kawaguchi, H., Jinno, S., Hoshi, K., Itaka, K., Takato, T., Nakamura, K. and Okayama, H. (2004). Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. Mol. Cell Biol. 24(15): 6560-8. 15254224
Osada, S.-I., et al. (2000). Activin/Nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1. Development 127: 2503-2514. 10804190
Osada, S.-I. Ohmori, S.-y. and Taira, M. (2003). XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos. Development 130: 1783-1794. 12642484
Patterson, G. I., et al. (1997). The DAF-3 smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 11(20): 2679-2690.
Phippen, T. M., et al. (2000). Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression. J. Biol. Chem. 275(48): 37628-37. 10973955
Podos, S. D., Hanson, K. K., Wang, Y.-C. and Ferguson, E. L. (2001). The Smurf1 ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis. Dev. Cell 1: 567-578. 11703946
Postigo, A. A. (2003a). Opposing functions of ZEB proteins in the regulation of the TGFß/BMP signaling pathway. EMBO J. 22: 2443-2452. 12743038
Postigo, A. A., Depp, J. L., Taylor, J. T. and Kroll, K. L. (2003b). Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 22: 2453-2462. 12743039
Prall, O. W. J. et al. (2007). An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128: 947-959. Medline abstract: 17350578
Pyrowolakis, G., Hartmann, B., Muller, B., Basler, K. and Affolter, M. (2004). A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev. Cell 7: 229-240. PubMed citation: 15296719
Qin, B. Y., et al. (2001). Structural basis of Smad1 activation by receptor kinase phosphorylation. Mol. Cell 8: 1303-1312. 11779505
Raftery, L. A., et al. (1995). Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139: 241-254
Raftery, L.A. and Sutherland, D. J. (1999). TGF-beta family signal transduction in Drosophila development: from Mad to Smads. Dev. Biol. 210(2): 251-68.
Rawson, J. M., Lee, M., Kennedy, E. L. and Selleck, S. B. (2003). Drosophila neuromuscular synapse assembly and function require the TGF-beta type I receptor saxophone and the transcription factor Mad. J. Neurobiol. 55: 134-150. 12672013
Rios, I., et al. (2004). Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling. Development 131: 3159-3168. 15197161
Rushlow, C., et al. (2001). Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs. Genes Dev. 15: 340-351. 11159914
Saller, E. and Bienz, M. (2001). Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription. EMBO Reports 2: 298-305. 11306550
Savage, C., et al. (1996). Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components. Proc. Natl. Acad. Sci. 93: 790-794
Schmierer, B. and Hill, C. S. (2005). Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads. Mol. Cell. Biol. 25: 9845-9858. Medline abstract: 16260601
Sekelsky, J. J., et al. (1995). Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139: 1347-1358
Seoane, J., et al. (2004). Integration of Smad and Forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117: 211-223. 15084259
Sheng, G., dos Reis, M. and Stern, C. D. (2003). Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. Cell 115(5): 603-13. 14651851
Shi, Y., et al. (1997). A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388(6637): 87-93.
Shivdasani, A. A. and Ingham, P. W. (2003). Regulation of stem cell maintenance and transit amplifying cell proliferation by TGF-ß signaling in Drosophila spermatogenesis. Curr. Biol. 13: 2065-2072. 14653996
Smit, L., Baas, A., Kuipers, J., Korswagen, H., van de Wetering, M. and Clevers, H. (2004). Wnt activates the Tak1/Nemo-like kinase pathway. J. Biol. Chem. 279: 17232-17240. Medline abstract: 14960582
Song, X., et al. (2004). Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development 131(6): 1353-64. 14973291
Sotillos, S. and de Celis, J. F. (2006). Regulation of decapentaplegic expression during Drosophila wing veins pupal development. Mech. Dev. 123(3): 241-51. 16423512
Sutherland, D. J., et al. (2003). Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo. Development 130: 5705-5716. 14534137
Suzuki, A., et al. (1997). Smad5 induces ventral fates in Xenopus embryo. Dev. Biol. 184 (2): 402-405.
Szuts, D. and Bienz, M. (2000). LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator. Proc. Natl. Acad. Sci. 97: 5351-5356.
Takaesu, N. T., et al. (2002). Combinatorial signaling by an unconventional Wg pathway and the Dpp pathway requires Nejire (CBP/p300) to regulate dpp expression in posterior tracheal branches. Dev. Biol. 247: 225-236. 12086463
Takaesu, N. T., et al. (2006). dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2. Genetics 174(3): 1299-313. Medline abstract: 16951053
Tang, S. J., et al. (1998). The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development 125(10): 1877-1887.
Tanimoto, H., Itoh, S., ten Dijke, P. and Tabata, T. (2000). Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Mol. Cell 5: 59-71. 10678169
Torres-Vazquez, J., et al. (2001). The transcription factor Schnurri plays a dual role in mediating Dpp signaling during embryogenesis. Development 128: 1657-1670. 11290303
Tremblay, K. D., Dunn, N. R. and Robertson, E. J. (2001). Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development 128: 3609-3621. 11566864
Tsuneizumi, K., et al. (1997). Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature 389(6651): 627-631.
Udagawa, Y., et al. (2000). Schnurri interacts with Mad in a Dpp-dependent manner. Genes Cells 5(5): 359-69. 10886364
Ulloa, L., Doody, J. and Massague, J. (1999). Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 397(6721): 710-3.
van Grunsven, L. A., et al. (2003). Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin. J. Biol. Chem. 278(28): 26135-45. 12714599
Verschueren, K., et al. (1999). SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J. Biol. Chem. 274(29): 20489-98. 10400677
von Both, I., et al. (2004). Foxh1 is essential for development of the anterior heart field. Dev. Cell 7: 331-345. 15363409
Walsh, C. M. and Carroll, S. B. (2007). Collaboration between Smads and a Hox protein in target gene repression. Development 134(20): 3585-92. PubMed citation: 17855427
Waltzer, L. and Bienz, M. (1999). A function of CBP as a transcriptional co-activator during Dpp signalling. EMBO J. 18(6): 1630-1641. 10075933
Wan, M., et al. (2001). Transcriptional mechanisms of BMP-induced osteoprotegrin gene expression. J. Biol. Chem. 276: -/-. 11139569
Wharton, S. J., Basu, S. P. and Ashe, H. L. (2004). Smad affinity can direct distinct readouts of the embryonic extracellular Dpp gradient in Drosophila. Curr. Biol. 14: 1550-1558. 15341741
Weisberg, E., et al. (1998). A mouse homologue of FAST-1 transduces TGFbeta superfamily signals and is expressed during early embryogenesis. Mech. Dev. 79(1-2): 17-27
Wiersdorff, V., et al. (1996). Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development 122: 2153-62
Wilson, P. A., et al. (1997). Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development 124(16): 3177-3184.
Wisotzkey, R. G., et al. (1998). Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125: 1433-1445
Wotton, D., et al. (1999). A Smad transcriptional corepressor. Cell 97(1): 29-39.
Wu, G., et al. (2000). Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science 287: 92-97.
Wu, J. W., et al. (2002). Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-ß signaling. Cell 111: 357-367. 12419246
Xiao, C., et al. (2003). Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 17: 2933-2949. 14633973
Xie, T. and Spradling, A. C. (1998). decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94(2): 251-260.
Xu, M., Kirov, N. and Rushlow, C. (2005). Peak levels of BMP in the Drosophila embryo control target genes by a feed-forward mechanism. Development 132: 1637-1647. 15728670
Yamamoto, N., et al. (1997). Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts. Biochem. Biophys. Res. Commun. 238(2): 574-80.
Yanagisawa, J., et al. (1999). Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. Science 283(5406): 1317-21.
Yingling, J. M., et al. (1997). Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. Mol. Cell. Biol. 17(12): 7019-7028.
Yoshida, Y., et al. (2000). Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103: 1085-1097
Yu, X., et al. (1998). Transcriptional repression due to high levels of Wingless signalling. EMBO J. 17: 7021-7032. 9835654
Zhang, Y., (1996). Receptor-associated MAD homologues synergize as effectors of the TGF-ß response. Nature 383: 168-172
Zhang, Y., Feng, X. H. and Derynck, R. (1998). Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394: 909-913.
Zhao, G.-Q. and Hogan, B. L. M. (1997). Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. Mech. Dev. 61: 63-73.
Zeng, Y. A., et al. (2007). Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation. Development 134: 2061-2071. Medline abstract: 17507407
Zhu, C. H. and Xie, T. (2003). Clonal expansion of ovarian germline stem cells during niche formation in Drosophila. Development 130: 2579-2588. 12736203
Zhu, H., et al. (1999). A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400(6745): 687-93.
Zuzarte-Luísa, V., et al. (2004). A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Dev. Bio. 272: 39-52. 15242789
date revised: 15 August 2008
Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.
The Interactive Fly resides on the
Society for Developmental Biology's Web server.