Ecdysone receptor


REFERENCES (part 2/2)

Nagy, L., et al. (1997). Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89 (3): 373-380.

Niederreither, K., et al. (1997). Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. Mech. Dev. 62 (1): 67-78.

No, D., Yao, T. P. and Evans, R. M. (1996). Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. 93 (8): 3346-3351.

Noguti, T., et al., (1995). Insect prothoracicotropic hormone: a new member of the vertebrate growth factor superfamily. FEBS Lett. 376: 251-256. PubMed citation: 7498553

Nomura, T., et al. (1999). Ski is a component of the histone deacetylase complex required for transcriptional repression by mad and thyroid hormone receptor. Genes Dev. 13(4): 412-23.

Ordentlich, P., et al. (1999). Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc. Natl. Acad. Sci. 96(6): 2639-44.

Page-McCaw, A., Serano, J., Sante, J. M. and Rubin, G. M. (2003). Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. Dev. Cell 4: 95-106. 12530966

Park, E. J., et al. (1999). SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. Proc. Natl. Acad. Sci. 96(7): 3519-24.

Park, Y., et al. (2001). even skipped is required to produce a trans-acting signal for larval neuroblast proliferation that can be mimicked by ecdysone. Development 128: 1899-1909. 11311169

Perlmann, T, et al. (1996). Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors. Mol Endocrinol 10 (8): 958-966.

Pierceall, W. E., Li, C., Biran, A., Miura, K., Raikhel, A. S. and Segraves, W. A. (1999). E75 expression in mosquito ovary and fat body suggests reiterative use of ecdysone-regulated hierarchies in development and reproduction. Mol. Cell. Endocrinol. 150: 73-89.

Predki, P. F., et al. (1994). Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain. Mol. Endocrinol. 8(1): 31-9.

Puigserver, P., et al. (1998). A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92(6): 829-39. 9529258

Puzianowska-Kuznicka, M., Damjanovski, S. and Shi, Y. B. (1997). Both thyroid hormone and 9-cis retinoic acid receptors are required to efficiently mediate the effects of thyroid hormone on embryonic development and specific gene regulation in Xenopus laevis. Mol. Cell. Biol. 17(8): 4738-4749.

Qi, J. S., et al. (1997). Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression. Mol. Cell. Biol. 17(12): 7195-7207.

Rastinejad, F., et al. (2000). Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1. EMBO J. 19: 1045-1054.

Remboutsika, E., et al. (1999). The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J. Cell Sci. 112(Pt 11): 1671-1683

Richards G., et al. (1999). The acquisition of competence to respond to ecdysone in Drosophila is transcript specific. Mech. Dev. 82(1-2): 131-139.

Robinow, S., et al. (1993). Programmed cell death in the Drosophila CNS is ecdysone-related and coupled with a specific ecdysone receptor isoform. Development 119: 1251-9

Robinow, S., Draizen, T. A. and Truman, J. W. (1997). Genes that induce apoptosis: transcriptional regulation in identified, doomed neurons of the Drosophila CNS. Dev. Biol. 190(2): 206-213.

Rochette-Egly, C., et al. (1997). Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 90(1): 97-107.

Rusch, A., et al. (1998). Thyroid hormone receptor beta-dependent expression of a potassium conductance in inner hair cells at the onset of hearing. Proc. Natl. Acad. Sci. 95(26): 15758-62.

Rusten, T. E., et al. (2004). Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7: 179-192. 15296715

Rybczynski, R. and Gilbert, L. I. (1995). Prothoracicotropic hormone elicits a rapid, developmentally specific synthesis of beta tubulin in an insect endocrine gland. Dev. Biol. 169: 15-28. PubMed citation: 7750634

Saatcioglu, F., et al. (1997). Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity. Mol. Cell. Biol. 17(8): 4687-4695.

Schubiger, M., et al. (1998). Drosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis. Development 125: 2053-2062. 9570770

Schubiger, M., et al. (2003). Isoform specific control of gene activity in vivo by the Drosophila ecdysone receptor. Mech. Dev. 120: 909-918. 12963111

Schubiger, M., Carre, C., Antoniewski, C. and Truman, J. W. (2005) Ligand-dependent de-repression via EcR/USP acts as a gate to coordinate the differentiation of sensory neurons in the Drosophila wing. Development 132(23): 5239-48. 16267093

Schug, T. T., et al. (2007). Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. Cell 129(4): 723-33. PubMed citation: 17512406

Schulman, I. G., Juguilon, H., and Evans, R. M. (1996). Activation and repression by nuclear hormone receptors: hormone modulates an equilibrium between active and repressive states. Mol. Cell. Biol. 16 (7): 3807-3813.

Schwartz, L. M. (1992). Insect muscle as a model for programmed cell death. J. Neurobiol. 23: 1312-26.

Sedkov, Y., et al. (2003). Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. Nature 426(6962): 78-83. 14603321

Serpente, P., Tumpel, S., Ghyselinck, N. B., Niederreither, K., Wiedemann, L. M., Dolle, P., Chambon, P., Krumlauf, R. and Gould, A. P. (2005). Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation. Development 132(3): 503-13. 15634700

Shiotsugu, J., et al. (2004). Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation. Development 131: 2653-2667. 15128657

Sluder, A. E., Lindbloom, T. and Ruvkun, G. (1997). The Caenorhabditis elegans orphan nuclear hormone receptor gene rhr-2 functions in early embryonic development. Dev. Biol. 184: 303-319

Smith, W. A., Varghese, A. H. and Lou, K. J. (1993). Developmental changes in cyclic AMP-dependent protein kinase associated with increased secretory capacity of Manduca sexta prothoracic glands. Mol. Cell. Endocrinol. 90(2): 187-195. PubMed citation: 8495800

Smith, W. A., et al. (1996). Cyclic AMP is a requisite messenger in the action of big PTTH in the prothoracic glands of pupal Manduca sexta. Insect Biochem. Mol. Biol. 26(2): 161-170. PubMed citation: 8882659

Sockanathan, S., Perlmann, T. and Jessell, T. M. (2003). Retinoid receptor signaling in postmitotic motor neurons regulates rostrocaudal positional identity and axonal projection pattern. Neuron 40: 97-111. 14527436

Soller, M., Bownes, M. and Kubli, E. (1999). Control of oocyte maturation in sexually mature Drosophila females. Dev. Biol. 208(2): 337-351.

Song, Q. and Gilbert, L. I. (1994). S6 phosphorylation results from prothoracicotropic hormone stimulation of insect prothoracic glands: a role for S6 kinase. Dev. Genet. 15(4): 332-8. PubMed citation: 7923936

Song, Q. and Gilbert, L. I. (1997). Molecular cloning, developmental expression, and phosphorylation of ribosomal protein S6 in the endocrine gland responsible for insect molting. J. Biol. Chem. 272(7): 4429-4435.

Song, Y., Hui, J. N., Fu, K. K. and Richman, J. M. (2004). Control of retinoic acid synthesis and FGF expression in the nasal pit is required to pattern the craniofacial skeleton. Dev. Biol. 276(2): 313-29. 15581867

Sotiropoulos, A., Gineitis, D., Copeland, J. and Treisman, R. (1999). Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell 98: 159-169. 10428028

Spencer, T. E., et al. (1997). Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389(6647): 194-198.

Stabell, M., Larsson, J., Aalen, R. B. and Lambertsson, A. (2007). Drosophila dSet2 functions in H3-K36 methylation and is required for development. Biochem. Biophys. Res. Commun. 359(3): 784-9. PubMed citation: 17560546

Streichert, L. C., et al. (1997). Steroid hormones act directly to trigger segment-specific programmed cell death of identified motoneurons in vitro. Dev. Biol. 183: 95-107

Subbarayan V, et al. (1997). Limited specificity and large overlap of the functions of the mouse RARgamma1 and RARgamma2 isoforms. Mech. Dev. 66(1-2): 131-142.

Suhr, S. T., et al. (1998). High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor. Proc. Natl. Acad. Sci. 95(14):7999-8004.

Sullivan, A. A. and Thummel, C. S. (2003). Temporal profiles of nuclear receptor gene expression reveal coordinate transcriptional responses during Drosophila development. Mol. Endocrinol. 17(11): 2125-37. 12881508

Sung, C. and Robinow, S. (2000). Characterization of the regulatory elements controlling neuronal expression of the A-isoform of the ecdysone receptor gene of Drosophila melanogaster. Mech. Dev. 237-248.

Sutherland, J. D., et al. (1995). Drosophila hormone receptor 38: a second partner for Drosophila USP suggests an unexpected role for nuclear receptors of the nerve growth factor-induced protein B type. Proc. Natl. Acad. Sci. 92: 7966-7970

Swevers, L., et al. (1996). Bombyx EcR (BmEcR) and Bombyx USP (BmCF1) combine to form a functional ecdysone receptor. Insect Biochem Mol Biol 26 (3): 217-221.

Takeshita, A., et al. (1997). TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J. Biol. Chem. 272: 27629-27634

Talbot, W. S., Swyryd, E. A. and Hogness, D. S. (1993). Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell 73: 1323-37

Taneja, R., et al. (1997). Phosphorylation of activation functions AF-1 and AF-2 of RARalpha and RARgamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment. EMBO J. 16(21): 6452-6465

Tenbaum, S. P., et al. (2003). Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain. Dev. Bio. 254: 149-160. 12606288

Terashima, J., Takaki, K., Sakurai, S. and Bownes, M. (2005). Nutritional status affects 20-hydroxyecdysone concentration and progression of oogenesis in Drosophila melanogaster. J. Endocrinol. 187(1): 69-79. 16214942

Thomas, H.E., Stunnenberg, H.G. and Stewart, A.F. (1993). Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle. Nature 362: 471-475

Thummel, C. S. (1995). From embryogenesis to metamorphosis: the regulation and function of Drosophila nuclear receptor superfamily members. Cell 83: 871-877

Torchia, J., et al. (1997). The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387(6634): 677-684.

Tourmente, S., et al. (1993). Enhancer and silencer elements within the first intron mediate the transcriptional regulation of the beta 3 tubulin gene by 20-hydroxyecdysone in Drosophila Kc cells. Insect Biochem. Mol. Biol. 23: 137-43

Tran, H. T., et al. (2001). Requirement of co-factors for the ligand-mediated activity of the insect ecdysteroid receptor in yeast. J. Mol. Endocrinol. 27(2): 191-209. 11564603

Treuter, E., et al. (1999). Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes. J. Biol. Chem. 274: 6667-6677.

Truman, J. W., et al. (1994). Ecdysone receptor expression in the CNS correlates with stage-specific responses to ecdysteroids during Drosophila and Manduca development. Development 120: 219-34

Truman, J. W. (1996). Steroid receptors and nervous system metamorphosis in insects. Dev. Neurosci. 18 (1-2): 87-101.

Tsai, C.-C., et al. (1999). SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression Is critical for development. Mol. Cell 4: 175-186

Ulisse, S., Iwamura, S. and Tata, J. R. (1997). Differential responses to ligands of overexpressed thyroid hormone and retinoid X receptors in a Xenopus cell line and in vivo. Mol. Cell. Endocrinol. 126 (1): 17-24.

Urnov, F. D., et al. (2000). Targeting of N-CoR and histone deacetylase 3 by the oncoprotein v-erbA yields a chromatin infrastructure-dependent transcriptional repression pathway. EMBO J. 19(15): 4074-90.

van der Wees, J., et al. (1998). Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain. Development 125(3): 545-556.

Varghese, J. and Cohen, S. M. (2007). microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila. Genes Dev. 21(18): 2277-82. Medline abstract: 17761811

Vermaak, D., et al. (1999). Functional analysis of the SIN3-histone deacetylase RPD3-RbAp48-histone H4 connection in the Xenopus oocyte. Mol. Cell Biol. 19(9): 5847-60.

Vermot, J., et al. (2005). Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons. Development 132(7): 1611-21 . 15753214

Vogtli, M., et al. (1998). High level transactivation by the ecdysone receptor complex at the core recognition motif. Nucleic Acids Res. 26(10): 2407-2414.

Walkley, C. R., et al. (2007). A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell 129(6): 1097-110. PubMed citation: 17574023

Waller, A. (1850). Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of primitive fibres. Philos. Trans. R. Soc. London Ser. B 140: 423-429

Ward, R. E., et al. (2003). GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis. Dev. Biol. 256: 389-402. 12679111

Watson, R. D., et al. (1996). Involvement of microtubules in prothoracicotropic hormone-stimulated ecdysteroidogenesis by insect (Manduca sexta) prothoracic glands. J. Exp. Zool. 276(1): 63-69. PubMed citation: 8828185

Westin, S., et al. (1998). Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators. Nature 395(6698): 199-202.

White, K. P., et al. (1997). Coordination of Drosophila metamorphosis by two ecdysone-induced nuclear receptors. Science 276: 114-117.

White, K., et al. (1999). Microarray analysis of Drosophila development during metamorphosis. Science 286: 2179-2184.

Williams, D. W. and Truman, J. W. (2005). Cellular mechanisms of dendrite pruning in Drosophila: insights from in vivo time-lapse of remodeling dendritic arborizing sensory neurons. Development 132: 3631-3642. 16033801

Witten, J. L. and Truman, J. W. (1996). Developmental plasticity of neuropeptide expression in motoneurons of the moth, Manduca sexta: steroid hormone regulation. J. Neurobiol. 29 (1): 99-114.

Wu, Z., et al. (1999). Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98(1): 115-24. 10412986

Voegel, J. J., et al. (1998). The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways EMBO J. 17: 507-519.

Wendling, O., et al. (2001). Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning. Development 128: 2031-2038

Wong, C.-W. and Privalsky, M. L. (1998). Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors. Mol. Cell. Biol. 18(10): 5724-5733.

Wong, J. and Shi, Y. B. (1995a). Coordinated regulation of and transcriptional activation by Xenopus thyroid hormone and retinoid X receptors. J. Biol. Chem. 270 (31): 18479-18483.

Wong, J., Shi, Y. B. and Wolffe, A. P. (1995b). A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor. Genes Dev. 9 (21): 2696-2711.

Wong, J., Shi, Y. B. and Wolffe, A. P. (1997a). Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activation. EMBO J. 16(11): 3158-3171.

Wong, J., et al. (1997b). Structural and functional features of a specific nucleosome containing a recognition element for the thyroid hormone receptor. EMBO J. 16(23): 7130-7145

Wong, J., et al. (1998). Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase. EMBO J. 17(2): 520-34.

Woodard, C. T., Baehrecke, E. H. and Thummel, C. S. (1994). A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone. Cell 79 607-615

Wu, Q., et al. (1997). Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids. Mol. Cell. Biol. 17(11): 6598-6608.

Xiao, J. H., et al. (1999). Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors. EMBO J. 18(6): 1539-1548

Yao, T. P., et al. (1992). Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. Cell 71: 63-72

Yao, T. P., et al. (1993). Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. Nature 366: 476-9

Yoshida I., et al. (1998). A novel member of the bombyxin gene family: structure and expression of bombyxin G1 gene, an insulin-related peptide gene of the silkmoth bombyx mori. Dev. Genes Evol. 208(7): 407-10.

Yuan, C. X., et al. (1998). The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. 95(14): 7939-7944.

Zelhof, A. C., et al. (1995). Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. Proc. Natl. Acad. Sci 92: 10477-81

Zhang, L. X., et al. (1995). Evidence for the involvement of retinoic acid receptor RAR alpha-dependent signaling pathway in the induction of tissue transglutaminase and apoptosis by retinoids. J. Biol. Chem. 270 (11): 6022-6029.

Zhang, J., Zamir, I. and Lazar, M. A. (1997). Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression. Mol. Cell. Biol. 17(12): 6887-6897.

Zheng, X., et al. (2003). TGF-ß signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain. Cell 112: 303-315. 12581521

Zhou, B., et al. (1998). Regulation of the transcription factor E75 by 20-hydroxyecdysone and juvenile hormone in the epidermis of the tobacco hornworm, Manduca sexta, during larval molting and metamorphosis. Dev. Biol. 193(2): 127-138

Zhou, D., et al. (2000). PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1). Mol. Endocrinol. 14(7): 986-98. 10894149

Zhou, D. and Chen, S. (2001). PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif. Nucleic Acids Res. 29(19): 3939-48. 11574675

back to Ecdysone receptor References part 1/2


Ecdysone receptor: Biological Overview | Evolutionary homologs | Bombyx and Manduca prothoracicotropic hormone | Regulation | Targets of Activity | Protein interactions | Developmental Biology | Effects of Mutation

date revised: 10 April 2008

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