E2F


REFERENCES

Aggarwal, B. D. and Calvi, B. R. (2004). Chromatin regulates origin activity in Drosophila follicle cells. Nature 430: 372-376. 15254542

Asano, M, Nevins, J. R. and Wharton, R. P. (1996). Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev. 10: 1422-32

Asano, M. and Wharton, R. P. (1999). E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila. EMBO J. 18(9): 2435-2448. 10228158

Baonza, A. and Freeman, M. (2005). Control of cell proliferation in the Drosophila eye by Notch signaling. Dev. Cell 8(4): 529-39. 15809035

Baudino, T. A., et al. (2003). Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Molec. Cell 11: 905-914. 12718877

Bosco, G., Du, W. and Orr-Weaver, T. L. (2001). DNA replication control through interaction of E2F-RB and the origin recognition complex. Nature Cell Biol. 3: 289-295. 11231579

Boulton, S. J., et al. (2000). A role for ebi in neuronal cell cycle control. EMBO J. 19(20): 5376-86.

Bracken, A. P., et al. (2003). EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 22: 5323-5335. 14532106

Brennan, P., et al. (1999). p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes. Mol. Cell. Biol. 19(7): 4729-38.

Brook, A., Xie, J.-E., Du, W., and Dyson, N. (1996). Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. EMBO J. 15: 3676-83

Buttitta, L. A., Katzaroff, A. J., Perez, C. L., de la Cruz, A. and Edgar B. A. (2007). A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev. Cell 12(4): 631-43. Medline abstract: 17419999

Caldwell, M. C. and Datta, S. (1998). Expression of Cyclin E or DP/E2F rescues the G1 arrest of trol mutant neuroblasts in the Drosophila larval central nervous system. Mech. Dev. 79(1-2): 121-130. 10349625

Callaghan, D. A., et al. (1999), Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity. Dev. Biol. 207(2): 257-70.

Calvi, B. R., Lilly, M. A. and Spradling, A. C. (1998). Cell cycle control of chorion gene amplification. Genes Dev. 12(5): 734-744.

Cam, H., et al. (2003). A common set of gene regulatory networks links metabolism and growth inhibition. Mol. Cell 16(3): 399-411. 15525513

Ceol, C. J. and Horvitz, H. R. (2001). dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Molec. Cell 7: 461-473. 11463372

Chen, C.-R., et al. (2002). E2F4/5 and p107 as smad cofactors linking the TGFß receptor to c-myc repression. Cell 110: 19-32. 12150994

Chen, Z. and Han, M. (2001). C. elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification. Curr. Biol. 11: 1874-1879. 11728311

Cook, J. G., et al. (2002). Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc. Natl. Acad. Sci. 99(3): 1347-52. 11805305

Corbeil, H. B. and Branton, P. E. (1997). Characterization of an E2F-p130 complex formed during growth arrest. Oncogene 15(6): 657-668.

Dagnino, L., et al. (1997). Expression patterns of the E2F family of transcription factors during mouse nervous system development. Mech. Dev. 66(1-2): 13-25.

DeGregori, J., Kowalik, T. and Nevins, J. R. (1995). Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol. Cell Biol. 15: 4215-24

DeGregori, J., et al. (1997). Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. 94(14): 7245-7250.

de la Luna, S., et al. (1999). Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. EMBO J. 18(1): 212-28.

Devgan, V., et al. (2005). p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev. 19: 1485-1495. 15964998

Dick, F. A. and Dyson, N. (2003). pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Molec. Cell 12: 639-649. 14527410

Dimova, D. K., Stevaux, O., Frolov, M. V. and Dyson, N. J. (2003). Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev. 17: 2308-2320. 12975318

Du, W., et al. (1996a). RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10: 1206-1218

Du, W., Xie, J.-E., and Dyson, N. (1996b). Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15: 3684-92

Du, W. (2000). Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development 127: 367-379.

Duronio, R. J. et al. (1995a) The transcription factor E2F is required for S phase during Drosophila oogenesis. Genes & Dev. 9: 1445-55

Duronio, R. J. and O'Farrell, P. H. (1995b). Developmental control of the G1 to S transition in Drosophila: Cyclin E is a limiting downstream target of E2F. Genes & Dev. 9: 1456-68

Duronio, R. J., et al. (1996). E2F-induced S phase requires cyclin E. Genes Dev. 10: 2505-13

Dynlacht, B. D., et al. (1994). DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc. Natl. Acad. Sci. 91: 6359-63

Dynlacht, B. D., et al. (1997). Specific regulation of E2F family members by cyclin-dependent kinases. Mol. Cell. Biol. 17(7): 3867-3875.

Fajas, L., et al. (2002). E2Fs regulate adipocyte differentiation. Dev. Cell 3: 39-49. 12110166

Field, S. J., et al. (1997). E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85: 549-561.

Frolov, M. V., et al. (2001). Functional antagonism between E2F family members. Genes Dev. 15: 2146-2160. 11511545

Garbe, D., Doto, J. B. and Sundaram, M. V. (2004). Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8. Genetics 167(2): 663-72. 15238519

Gaubatz, S., Wood, J. G. and Livingston, D. M. (1998). Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc. Natl. Acad. Sci. 95(16): 9190-9195.

Giangrande, P. H., Zhu, W., Schlisio, S., Sun, X., Mori, S., Gaubatz, S. and Nevins J. R. (2004). A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Genes Dev. 18(23): 2941-51. 15574595

Gill, R. M. and Hamel, P. A. (2000). Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally cifferentiated muscle. J. Cell Biol. 148: 1187-1201.

Hao, X. F., et al. (1995). Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster. J Cell Sci 108: 2945-2954

Hateboer, G., et al. (1996). Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev. 10:2960-2970

Hayes, S., et al. (1998). DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1. Mol. Cell. Biol. 18(1): 240-249.

Heriche, J. K., Ang, D., Bier, E. and O'Farrell, P. H. (2003). Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 4: 9. Medline abstract: 12787468

Hirose, F., Ohshima, N., Shiraki, M., Inoue, Y. H., Taguchi, O., Nishi, Y. Matsukage, A. and Yamaguchi, M. (2001). Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins. Mol. Cell. Biol. 21(21): 7231-42. 11585906

Hochheimer, A., et al. (2002). TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila. Nature 420(6914): 439-45. 12459787

Hofmann, F., et al. (1996). The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev. 10: 2949-2959. 8956996

Hsieh, J. K., et al. (1997). E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11(14): 1840-1852.

Humbert, P. O., et al. (2000a). E2f3 is critical for normal cellular proliferation. Genes Dev. 14: 690-703.

Humbert, P. O., et al. (2000b). E2F4 is essential for normal erythrocyte maturation and neonatal viability. Molec. Cell 6: 281-291. 10983976

Hurford, R. K., et al. (1997). pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes. Dev. 11(11): 1447-1463.

Iakova, P., Awad, S. S., and Timchenko, N. A. (2003). Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Cell 113: 495-506. 12757710

Iavarone, A. and Massague, J. (1999). E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest. Mol. Cell. Biol. 19(1): 916-22.

Irwin, M., et al. (2000). Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 407: 645-648. 11034215

Johnson, D. G., Ohtani, K. and Nevins, J. R. (1994). Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8: 1514-25

Johnson, D. B. (1995). Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity. Oncogene 11: 1585-92

Jordan-Sciutto, K. L., et al. (1997). Reduction in fibronectin expression and alteration in cell morphology are coincident in NIH3T3 cells expressing a mutant E2F1 transcription factor. Exp. Cell Res. 236(2): 527-536

Kato, J-y., et al. (1993). Direct binding of cyclin D to the tetinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7 331-342

Kim, T. H., Goodman, J., Anderson, K. V., Niswander, L. (2007). Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev. Cell 13(1): 87-102. PubMed citation: 17609112

Kitagawa, M., et al. (1995). Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene 10: 229-36

Knudsen, E. S. and Wang, J. Y. (1997). Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol. 17(10): 5771-5783.

Kohn, M. J., et al. (2002). Dp1 is required for extra-embryonic development. Development 130: 1295-1305. 12588846

Korenjak, M., et al. (2004). Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell 119(2): 181-93. 15479636

Kuzin, B., et al. (2000). Nitric oxide interacts with the retinoblastoma pathway to control eye development in Drosophila. Curr. Biol 10: 459-462.

Lane, M. E., et al. (2000). A screen for modifiers of Cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2. Genetics 155: 233-244.

Lasorella, A., et al. (2000). Id2 is a retinoblastoma protein target and mediates signaling by Myc oncoproteins. Nature 407: 592-598. 11034201

Le Cam, L., et al. (1999). Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex. EMBO J. 18(7): 1878-1890. 10202151

Legent, K., Dutriaux, A., Delanoue, R. and Silber, J. (2006). Cell cycle genes regulate vestigial and scalloped to ensure normal proliferation in the wing disc of Drosophila melanogaster. Genes Cells 11(8): 907-18. 16866874

Leone, G., et al. (1997). Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387 (6631): 422-426.

Leone G., et al. (1998). E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 12(14): 2120-2130.

Leone, G., et al. (2001). Myc requires distinct E2F activities to induce S phase and apoptosis. Mol. Cell 8: 105-113. 11511364

Lewis, P. W., et al. (2004). Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev. 18: 2929-2940. 15545624

Lissy, N. A., et al. (2000). A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature 407: 642-645. 11034214

Liu, D. X. and Greene, L. A. (2001). Regulation of neuronal survival and death by E2F-dependent gene repression and derepression. Neuron 32: 425-438. 11709154

Liu, D. X., et al. (2005). Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev. 19: 719-732. 15769944

Liu, K., et al. (2004). TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev. 18: 673-686. 15075294

Lu, J., Ruhf, M. L., Perrimon, N. and Leder, P. (2007). A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc. Natl. Acad. Sci. 104(22): 9381-6. Medline abstract: 17517653

Lucibello, F. C., et al. (1997). The differential binding of E2F and CDF repressor complexes contributes to the timing of cell cycle-regulated transcription. Nucleic Acids Res. 25(24): 4921-4925.

Lukas, C., et al. (1999). Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature 401(6755): 815-8.

Martelli, F. and Livingston, D. M. (1999). Regulation of endogenous E2F1 stability by the retinoblastoma family proteins. Proc. Natl. Acad. Sci. 96(6): 2858-63.

Martinez-Balbas, M. A., et al. (2000). Regulation of E2F1 activity by acetylation. EMBO J. 19: 662-671. 10675335

McMahon, S. B., Van, B. H., Dugan, K. A., Copeland, T. D. and Cole, M. D. (1998). The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94: 363-374.

Meraldi, P., et al. (1999). Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat. Cell Biol. 1: 88-93. 10559879

Moon, N. S., et al. (2005). Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell. 9(4):463-75. 16198289

Moon, N. S., Di Stefano, L. and Dyson, N. (2006). A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol. Cell Biol. 26(20): 7601-15. Medline abstract: 16954388

Muller, H., et al. (1997). Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol. Cell. Biol. 17(9): 5508-5520.

Muller, H., et al. (2001). E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 15: 267-285. 11159908

Myster, D. L., Bonnette, P. C. and Duronio, R. J. (2000). A role for the DP subunit of the E2F transcription factor in axis determination during Drosophila oogenesis. Development 127: 3249-3261. Medline abstract: 10887081

Narita, M., et al. (2003). Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113: 703-716. 12809602

Nili, E., et al. (2001). Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner Gcl (germ-cell-less). J. Cell Sci. 114: 3297-3307. 11591818

O'Connor, D. J., et al. (1995). Physical and functional interactions between p53 and cell cycle co-operating transcription factors E2F1 and DP1. EMBO J. 14: 6184-92

Ohtani, K. and Nevins, J. R. (1994). Functional properties of a Drosophila homolog of the E2F1 gene. Mol. Cell Biol. 14: 1603-12

Ohtani, K., deGregori, J. and Nevins, J. R. (1995). Regulation of the cyclin E gene by the E2F1 transcription factor. Proc Natl. Acad. Sci. 92: 12146-50

Ohtani, K., et al. (1996). Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol. Cell. Biol. 16: 6977-6984

Oswald, F., et al. (1994). E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions. Oncogene 9: 2029-36

Page, B. D., et al. (2001). The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling. Molec. Cell 7: 451-460

Pan, H., et al. (1998). Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol. Cell 2(3): 283-92.

Phillips, A. C., et al. (1997). Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11(14): 1853-1863.

Pierce, A. M., et al. (1998). Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53. Proc. Natl. Acad. Sci. 95(15): 8858-8863.

Porse, B. T., et al. (2001). E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell 107: 247-258. 11672531

Reddien, P. W., Andersen, E. C., Huang, M. C. and Horvitz, H. R. (2007). DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics 175(4): 1719-33. PubMed citation: 17237514

Rayman, J. B., et al. (2002). E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev. 16: 933-947. 11959842

Rempeli, R. E. (2000). Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Molec. Cell 6: 293-306

Ren, B., et al. (2002). E2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints. Genes Dev. 16: 245-256. 11799067

Royzman, I., Whittaker, A. J. and Orr-Weaver, T. L. (1997). Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes Dev. 11: 1999-2011. Medline abstract: 9271122

Royzman, I., et al. (1999). ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Genes Dev. 13(7): 827-840. Medline abstract: 10197983

Royzman, I., et al. (2002). The E2F cell cycle regulator is required for Drosophila nurse cell DNA replication and apoptosis. Mech. Dev. 119: 225-237. 12464435

Sawado, T., et al. (1998). dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 251(2): 409-15.

Schlisio, S., et al. (2002). Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. EMBO J. 21: 5775-5786. 12411495

Sears, R., Ohtani, K. and Nevins, J. R. (1997). Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol. Cell. Biol. 17(9):5227-5235.

Seum, C., et al. (1996). Position-effect variegation in Drosophila depends on the dose of the gene encoding the E2F transcriptional activator and cell cycle regulator. Development 122: 1949-56

Schulze, A., et al. (1994). Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1. Oncogene 9: 3475-82

Schulze, A., et al. (1995). Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc Natl Acad Sci U S A 92: 11264-11268

Sherr, C. J. (1993). Mammalian G1 cyclins. Cell 73: 1059-1065

Shibutani, S., Swanhart, L. M. and Duronio, R. J. (2007). Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis. Development 134(3): 467-78. Medline abstract: 17185321

Staehling-Hampton, K., et al. (1999). A genetic screen for modifiers of E2F in Drosophila melanogaster. Genetics 153: 275-287.

Stevaux, O., et al. (2002). Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. EMBO J. 21: 4927-4937. 12234932

Stevens, C., Smith, L. and La Thangue, N. B. (2003). Chk2 activates E2F-1 in response to DNA damage. Nat. Cell Biol. 5(5): 401-9. 12717439

Suzuki, A. and Hemmati-Brivanlou, A. (2000). Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis. Molec. Cell 5: 217-229

Tanaka, H., et al. (2002). E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination. Molec. Cell, Vol 9: 1017-1029. 12049738

Tao, Y., et al. (1997). Subunit composition determines E2F DNA-binding site specificity. Mol. Cell. Biol. 17(12): 6994-7007.

Taylor-Harding, B., Binne, U. K., Korenjak, M., Brehm, A. and Dyson, N. J. (2004). p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-related genes. Mol. Cell. Biol. 24: 9124-9136. 15456884

Thacker, S. A., Bonnette, P. C. and Duronio, R. J. (2003). The contribution of E2F-regulated transcription to Drosophila PCNA gene function. Curr. Biol. 13: 53-58. 12526745

Timchenko, N. A., Wilde, M., and Darlington, G. J. (1999). C/EBP alpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol. Cell. Biol. 19: 2936-2945. 10082561

Trimarchi, J. M., et al. (1998). E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc. Natl. Acad. Sci. 95(6): 2850-2855.

Trouche, D., et al. (1997). RB and hbrm cooperate to repress the activation functions of E2F1. Proc. Natl. Acad. Sci. 94(21): 11268-11273.

Tsai, K. Y., et al. (1998). Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2(3): 293-304.

Tsai, K. Y., et al. (1999). Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2(3): 293-304.

van Ginkel, P. R., et al. (1997). E2F-mediated growth regulation requires transcription factor cooperation. J. Biol. Chem. 272(29): 18367-18374.

Verona, R., et al. (1997). E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol. Cell. Biol. 17(12): 7268-7282.

Wang, S., et al. (1999). Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. EMBO J. 18(6): 1559-1570.

Wang, S., Zhang, B. and Faller, D. V. (2002). Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J. 21: 3019-3028. 12065415

Wang, Z. M., Yang, H. and Livingston, D. M. (1998). Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts. Proc. Natl. Acad. Sci. 95(26): 15583-6.

Watanabe, G., et al. (1998). Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. Mol. Cell. Biol. 18(6): 3212-3222.

Weng, Li., Zhu, C., Xu, J. and Du, W. (2003). Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J. 22: 3865-3875. 12881421

Wenzel, P. L., et al. (2007). Rb is critical in a mammalian tissue stem cell population. Genes Dev. 21: 85-97. Medline abstract: 17210791

White, J., Stead, E., Faast, R., Conn, S., Cartwright, P. and Dalton, S. (2005). Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol. Biol. Cell 16: 2018-2027. Medline abstract: 15703208

Whitaker, L. L., et al. (1998). Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket. Mol. Cell. Biol. 18(7): 4032-4042.

Whittaker, A. J., Royzman, I. and and Orr-Weaver, T. L. (2000). Drosophila Double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts. Genes Dev. 14: 1765-1776.

Wong, K. K., et al. (1995). v-Abl activates c-myc transcription through the E2F site. Mol. Cell. Biol. 15(12): 6535-6544.

Xin, S., Weng, L., Xu, J. and Du, W. (2002). The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development 129: 1345-1356. 11880344

Xu, M., et al. (1994). Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell Biol. 14: 8420-31

Yamaguchi, M., Hayashi, Y. and Matsukage, A. (1995).Essential role of E2F recognition sites in regulation of the proliferating cell nuclear antigen gene promoter during Drosophila development. J. Biol. Chem. 270: 25159-25165

Yang, R., et al. (1999). Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. 19(3): 2400-7.

Yoshida, K. and Inoue, I. (2004). Regulation of Geminin and Cdt1 expression by E2F transcription factors. Oncogene. 23(21): 3802-12. 14990995

Zerfass-Thome, K., et al. (1997). p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell. Biol. 17: 407-415

Zhang, H. S., Postigo, A. A. and Dean, D. C. (1999). Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition. Cell 97(1): 53-61.

Zheng, N., et al, (1999). Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev. 13(6): 666-74.

Zhu, L., Harlow, E. and Dynlacht, B. D. (1995a). p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9: 1740-52

Zhu, L., et al. (1995b). The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J. 14: 1904-13

Zhu, W., Giangrande, P. H. and Nevins, J. R. (2004) E2Fs link the control of G1/S and G2/M transcription. EMBO J. 23(23): 4615-26. 15510213


E2F: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 10 April 2008

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.