Syntaxin 1A

Alexiades, M. R. and Cepko, C. L. (1997). Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny. Development 124 (6): 1119-1131.

Aravamudan, B., Fergestad, T., Davis, W. S., Rodesch1, C. J. and Broadie, K. (1999). Drosophila Unc-13 is essential for synaptic transmission. Nature Neurosci. 2: 965-971. 10526334

Barnard, R. J., Morgan. A. and Burgoyne, R. D. (1997). Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. J. Cell Biol. 139(4): 875-883.

Bate, M. and Broadie, K. (1995). Wiring by fly: the neuromuscular system of the Drosophila embryo. Neuron 15 (3): 513-525.

Becher, A., et al. (1999). The synaptophysin-synaptobrevin complex: a hallmark of synaptic vesicle maturation. J. Neurosci. 19(6): 1922-31

Beites, C. L., et al. (1999). The septin CDCrel-1 binds syntaxin and inhibits exocytosis. Nat. Neurosci. 2(5): 434-9. 10321247

Betz, A., et al. (1997). Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. J. Biol. Chem. 272: 2520-2526.

Bittner, M. A., Bennett, M. K. and Holz, R. W. (1996). Evidence that syntaxin 1A is involved in storage in the secretory pathway. J. Biol. Chem. 271 (19): 11214-11221.

Boulianne, G. L. and Trimble, W. S. (1995). Identification of a second homolog of N-ethylmaleimide-sensitive fusion protein that is expressed in the nervous system and secretory tissues of Drosophila. Proc. Natl. Acad. Sci. 92(15): 7095-9.

Broadie, K., et al. (1994). Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission. Proc. Natl. Acad. Sci. 91(22): 10727-31.

Broadie, K. A., et al. (1995). Syntaxin and synaptobrevin function dowstream of vesicle docking in Drosophila. Neuron 15: 663-673

Cerezo, J. R., Jimenez, F. and Moya, F. (1995). Characterization and gene cloning of Drosophila syntaxin 1 (Dsynt1): the fruit fly homologue of rat syntaxin 1. Brain Res. Mol. Brain Res. 29 (2): 245-252.

Chapman, E. R., et al. (1996). A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization. J. Biol. Chem. 271(10): 5844-9.

Cheatham, B., et al. (1996). Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins. Proc. Natl. Acad. Sci. 93: 15169-15173.

Chen, Y. A., Scales, S. J. Scheller, R. H. (2001). Sequential SNARE assembly underlies priming and triggering of exocytosis. Neuron 30: 161-170. 11343652

Chheda, M. G., et al. (2001). Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex. Nature Cell Biology 3: 331-338. 11283605

Chin, A. C., et al. (1993). Differential expression of transcripts from syb, a Drosophila melanogaster gene encoding VAMP (synaptobrevin) that is abundant in non-neuronal cells. Gene 131(2): 175-81.

Conner, S. D. and Wessel, G. M. (1999). Syntaxin is required for cell division. Mol. Biol. Cell 10: 2735-2743.

Coorssen, J. R., et al. (1998). Biochemical and functional studies of cortical vesicle fusion: the SNARE complex and Ca2+ sensitivity. J. Cell Biol. 143(7): 1845-57.

Davis, S., et al. (1996). Brain structure and task-specific increase in expression of the gene encoding syntaxin 1B during learning in the rat: a potential molecular marker for learning-induced synaptic plasticity in neural networks. Eur. J. Neurosci. 8 (10): 2068-2074.

Deitcher, D. L., et al. (1998). Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin. J. Neurosci. 18(6): 2028-39.

DiAntonio, A., Parfitt, K. D. and Schwarz, T. L. (1993a). Synaptic transmission persists in synaptotagmin mutants of Drosophila. Cell 73(7): 1281-90.

DiAntonio, A., et al. (1993b). Identification and characterization of Drosophila genes for synaptic vesicle proteins. J. Neurosci. 13(11): 4924-35.

DiAntonio, A. and Schwarz, T. L. (1994). The effect on synaptic physiology of synaptotagmin mutations in Drosophila. Neuron 12(4): 909-20.

Dulubova, I., et al. (1999). A conformational switch in syntaxin during exocytosis: role of munc18. EMBO J. 18: 4372-4382.

Edwardson, J. M., An, S. and Jahn, R. (1997). The secretory granule protein syncollin binds to syntaxin in a Ca2(+)-sensitive manner. Cell 90(2): 325-333.

Fasshauer, D., et al. (1997). A structural change occurs upon binding of syntaxin to SNAP-25. J. Biol. Chem. 272: 4582-4590.

Fasshauer, D., et al. (1998). Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs. Proc. Natl. Acad. Sci. 95(26): 15781-6.

Fergestad, T., Davis, W. S. and Broadie, K. (1999). The Stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal. J. Neurosci. 19(14): 5847-5860.

Fergestad, T. and Broadie, K. (2001). Interaction of Stoned and Synaptotagmin in synaptic vesicle endocytosis. J. Neurosci. 21(4): 1218-1227. 11160392

Fergestad, T., et al. (2001b). Targeted mutations in the Syntaxin H3 domain specifically disrupt SNARE complex function in synaptic transmission. J. Neurosci. 21(23): 9142-9150. 11717347

Fernandez, I., et al. (1998). Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. Cell 94(6): 841-9.

Fernandez, I., et al. (2001). Three-dimensional structure of the Synaptotagmin 1 C₂B-Domain: Synaptotagmin 1 as a phospholipid binding machine. Neuron 32: 1057-1069. 11754837

Fujita, Y., et al. (1998). Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron 20(5): 905-15.

Gaisano, H. Y., et al. (1996). Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells. Mol Biol Cell 7 (12): 2019-2027.

Garcia, E. P., et al. (1994). A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Proc. Natl. Acad. Sci. 91 (6): 2003-2007.

Gibbs, S. M. and Truman, J. W (1998). Nitric oxide and cyclic GMP regulate retinal patterning in the optic lobe of Drosophila. Neuron 20: 83-93.

González-Gaitán, M. 1 and Jäckle, H. (1997). Role of Drosophila a-Adaptin in presynaptic vesicle recycling. Cell, Vol. 88: 767-776. 9118220

Halachmi, N., et al. (1995). Rop and Ras2, members of the Sec1 and Ras families, are localized in the outer membranes of labyrinthine channels and vesicles of Drosophila nephrocyte, the garland cell. Eur. J. Cell Biol. 67 (3): 275-283.

Hata, Y., et al. (1993). Interaction of synaptotagmin with the cytoplasmic domains of neurexins. Neuron 10: 307-15

Hay, J. C., et al. (1997). Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell 89 (1): 149-158.

Hiesinger, P. R., et al. (1999). Neuropil pattern formation and regulation of cell adhesion molecules in Drosophila optic lobe development depend on Synaptobrevin. J. Neurosci. 19(17): 7548-7556.

Hiesinger, P. R., et al. (2005). The v-ATPase V₀ subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell 121(4): 607-20. 15907473

Hirling, H. and Scheller, R. H. (1996). Phosphorylation of synaptic vesicle proteins: modulation of the alpha SNAP interaction with the core complex. Proc. Natl. Acad. Sci. 93 (21): 11945-11949.

Holthuis, J. C. M., et al. (1998). Two syntaxin homologues in the TGN/endosomal system of yeast EMBO J. 17: 113-126.

Huang, F. D., Matthies, H. J., Speese, S. D., Smith, M. A. and Broadie, K. (2004). Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. Nat. Neurosci 7: 1070-1078. 15361878

Huang, F.-D., Woodruff, E., Mohrmann, R. and Broadie, K. (2006). Rolling blackout is required for synaptic vesicle exocytosis. J. Neurosci. 26(9): 2369-2379. 16510714

Ilardi, J. M. et al. (1999). Snapin: a SNARE-associated protein implicated in synaptic transmission. Nature Neurosci. 2(2): 119-124.

Junge, H. J., et al. (2004). Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity. Cell 118(3): 389-401. 15294163

Katsuyama, Y., et al. (2002). Regulation of Synaptotagmin gene expression during ascidian embryogenesis. Dev. Biol. 244: 293-304. 11944938

Kawasaki, F., Mattiuz, A. M. and Ordway, R. W. (1998). Synaptic physiology and ultrastructure in comatose mutants define an in vivo role for NSF in neurotransmitter release. J. Neurosci. 18(24): 10241-9.

Kawasaki, F. and Ordway, R. W. (1999). The Drosophila NSF Protein, dNSF1, plays a similar role at neuromuscular and some central synapses. J. Neurophysiol. 82(1): 123-130.

Kim, D. K. Catterall W. A. (1997). Ca2+-dependent and -independent interactions of the isoforms of the alpha1A subunit of brain Ca2+ channels with presynaptic SNARE proteins. Proc. Natl. Acad. Sci. 94(26): 14782-14786.

Lao, G., et al. (2000). Syntaphilin: A Syntaxin-1 clamp that controls SNARE assembly. Neuron 25: 191-201

Li, C. and Meinertzhagen, I. A (1997) The effects of 20-hydroxyecdysone on the differentiation in vitro of cells from the eye imaginal disc from Drosophila melanogaster. Invert. Neurosci. 3: 57-6.

Lickteig, K, M., et al. (2001). Regulation of neurotransmitter vesicles by the homeodomain protein UNC-4 and its transcriptional corepressor UNC-37/Groucho in Caenorhabditis elegans cholinergic motor neurons. J. Neurosci. 21(6): 2001-2014. 11245684

Lightfoot, K., et al. (1994). Conserved cis-elements bind a protein complex that regulates Drosophila ras2/rop bidirectional expression. Br. J. Cancer 69 (2): 264-273.

Littleton, J. T., Bellen, H. J. and Perin, M. S. (1993a). Expression of Synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse. Development 118(4): 1077-88.

Littleton, J. T., et al. (1993b). Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release. Cell 74(6): 1125-34.

Littleton, J. T., et al. (1994). Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proc. Natl. Acad. Sci. 91(23): 10888-92.

Littleton, J. T., Upton, L. and Kania, A. (1995). Immunocytochemical analysis of axonal outgrowth in synaptotagmin mutations. J. Neurochem. 65(1): 32-40.

Littleton, J. T., et al. (1998). Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly. Neuron 21(2): 401-13.

Low, S. H., et al. (2003). Syntaxin 2 and Endobrevin are required for the terminal step of cytokinesis in mammalian cells. Dev. Cell 4: 753-759. 12737809

Lukowitz, W., Mayer, U. and Jurgens, G. (1996). Cytokinesis in the arabidopsis embryo involves the syntaxin-related KNOLLE gene product. Cell 84: 61-71.

Mochida, S., et al. (1996). Inhibition of neurotransmission by peptides containing the synaptic protein interaction site of N-type Ca2+ channels. Neuron 17 (4): 781-788.

Muller, J. M. M., et al (1999). An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion. Nat. Cell Biol. 1: 335-340

Nie, Z., et al. (1999). Overexpression of Cysteine-string proteins in Drosophila reveals interactions with Syntaxin. J. Neurosci. 19(23): 10270-10279. 10575024

Niemeyer, B. A. and Schwarz, T. L. (2000). SNAP-24, a Drosophila SNAP-25 homologue on granule membranes, is a putative mediator of secretion and granule-granule fusion in salivary glands. J. Cell Sci. 113: 4055-64. 11058092

Noel, J., et al. (1999). Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron 23: 365-376.

Nonet, M. L., et al. (1998). Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants. J. Neurosci. 18(1): 70-80.

O'Connor, V., et al. (1997). Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion. Proc. Natl. Acad. Sci. 94(22): 12186-12191.

Ordway, R. W., Pallanck, L. and Ganetzky, B. (1994). Neurally expressed Drosophila genes encoding homologs of the NSF and SNAP secretory proteins. Proc. Natl. Acad. Sci. 91(12): 5715-9.

Osten, P., et al. (1998). The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. Neuron 21(1): 99-110.

Pallanck, L., et al. (1995). Distinct roles for N-ethylmaleimide-sensitive fusion protein (NSF) suggested by the identification of a second Drosophila NSF homolog. J. Biol. Chem. 270(32): 18742-4.

Patel, S. K., et al. (1998). Organelle membrane fusion: a novel function for the syntaxin homolog Ufe1p in ER membrane fusion. Cell 92(5): 611-620.

Perin, M. S., et al. (1991). Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans. J. Biol. Chem. 266(1): 615-22.

Peters, C. and Mayer, A. (1998). Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion. Nature 396(6711): 575-80.

Phillips, A. M., et al. (2000). The products of the Drosophila stoned locus interact with synaptic vesicles via Synaptotagmin. J. Neurosci. 20(22): 8254-8261. 11069931

Prekeris, R., et al. (1998). Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. J. Cell Biol. 143(4): 957-71.

Quetglas, S., et al. (2002). Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis. EMBO J. 21: 3970-3979. 12145198

Rabouille, C., et al. (1998). Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. Cell 92(5): 603-610.

Reist, N. E., et al. (1998). Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila. J. Neurosci. 18(19): 7662-73.

Riento, K., et al. (1998). Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. J. Cell Sci. 111( Pt 17): 2681-2688.

Risinger, C., et al. (1997). Complex gene organization of synaptic protein SNAP-25 in Drosophila melanogaster. Gene 194(2): 169-77. 9272858

Robinson, I. M., Ranjan, R. and Schwarz, T. L. (2002). Synaptotagmins I and IV promote transmitter release independently of Ca²⁺ binding in the C₂A domain. Nature 418: 336-340. 12110845

Rosenmund, C., et al. (2002). Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron 33: 411-424. 11832228

Ruden, D. M., et al. (2000). Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Dev. Biol. 218: 314-325.

Ruiz-Montasell, B., et al. (1996). Differential distribution of syntaxin isoforms 1A and 1B in the rat central nervous system. Eur. J. Neurosci. 8: 2544-2552

Saitoe, M., et al. (2001). Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release. Science 293: 514-7. 11463917

Salem, N., et al. (1998). A v-SNARE participates in synaptic vesicle formation mediated by the AP3 adaptor complex. Nature Neurosci. 1(7): 551-556.

Sampo, B., Kaech, S., Kunz, S. and Banker, G. (2003). Two distinct mechanisms target membrane proteins to the axonal surface. Neuron 37: 611-624. 12597859

Scales, S. J., et al. (2000). SNAREs contribute to the specificity of membrane fusion. Neuron. 26: 457-464.

Schiavo, G., et al. (1997). Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses. Proc. Natl. Acad. Sci. 94: 997-1001.

Schulz, J. R., Wessel, G. M. and Vacquier, V. D. (1997). The exocytosis regulatory proteins syntaxin and VAMP are shed from sea urchin sperm during the acrosome reaction. Dev. Biol. 191(1): 80-87.

Schulze, K. L., Littleton, J. T., Salzberg, A., Halachmi, N., Stern, M., Lev, Z. and Bellen, H. J. (1994). Rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo. Neuron 13: 1099-1108.

Schulze, K. L., et al. (1995). Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell 80 (2): 311-320.

Schulze, K. L. and Bellen, H. J. (1996). Drosophila syntaxin is required for cell viability and may function in membrane formation and stabilization. Genetics 144 (4): 1713-1724.

Shao, X., et al. (1997). Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch. Neuron 18 (1): 133-142.

Shiff, G. and Morel, N. (1997). Rapid anterograde axonal transport of the syntaxin-SNAP 25-VAMP complex. J. Neurochem. 68 (4): 1663-1667.

Shuang, R., et al. (1998). Regulation of Munc-18/Syntaxin 1A interaction by Cyclin-dependent Kinase 5 in nerve endings. J. Biol. Chem. 273(9): 4957-4966.

Somma, M. P., et al. (2002). Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells. Mol. Biol. Cell 13: 2448-2460. 12134082

Söllner, et al. (1993). SNAP receptors implicated in vesicle targeting and fusion. Nature 362: 318-324

Stimson, D. T., et al. (1998). A product of the Drosophila stoned locus regulates neurotransmitter release. J. Neurosci. 18(23): 9638-9649.

Stanley, E. F. and Mirotznik, R. R. (1997). Cleavage of syntaxin prevents G-protein regulation of presynaptic calcium channels. Nature 385: 340-343.

Stewart, B. A., et al. (2001). SNARE-dependent signaling at the Drosophila wing margin. Dev. Bio. 234: 13-23. 11356016

Sudhof, T. C., et al. (1989). A synaptic vesicle membrane protein is conserved from mammals to Drosophila. Neuron 2(5): 1475-81.

Sugita, S., et al. (2001). Synaptotagmin VII as a plasma membrane Ca2+ sensor in exocytosis. Neuron 30: 459-473. 11395007

Sugita, S., et al. (2002). Synaptotagmins form a hierarchy of exocytotic Ca2+ sensors with distinct Ca2+ affinities. EMBO J. 21: 270-280. 11823420

Sutton, R. B., et al. (1998). Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature 395: 347-53. 9759724

Sweeney, S. T., et al. (1995). Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects. Neuron 14(2): 341-51.

Takei, N., et al. (1997). Brain-derived neurotrophic factor increases the stimulation-evoked release of glutamate and the levels of exocytosis-associated proteins in cultured cortical neurons from embryonic rats. J. Neurochem. 68 (1): 370-375.

Tolar, L. A. and Pallanck, L. (1998). NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking. J. Neurosci. 18(24): 10250-6.

Ubach, J., et al. (1998). Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain? EMBO J. 17(14): 3921-3930.

Valdez, A. C., et al. (1999). Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. J. Cell Sci. 112 ( Pt 6): 845-54.

van Swinderen, B., et al. (1999). A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans. Proc. Natl. Acad. Sci. 96(5): 2479-2484.

Veeranna, G. P. and Pant, H. C. (1997). Expression of p67 (Munc-18), Cdk5, P-NFH and syntaxin during development of the rat cerebellum. Dev. Neurosci. 19 (2): 172-183.

Vilinsky, I., et al. (2002). A Drosophila SNAP-25 null mutant reveals context-dependent redundancy with SNAP-24 in neurotransmission. Genetics 162: 259-271. 12242238

Wada, Y. et al. (1997). Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae. J. Cell Sci. 110: 1299-1306

Weber, T., et al. (1998). SNAREpins: Minimal machinery for membrane fusion. Cell 92: 759-772.

Weimbs, T., et al. (1997). A conserved domain is present in different families of vesicular fusion proteins: a new superfamily Proc. Natl. Acad. Sci. 94: 3046-3051.

Wiser, O., Bennett, M. K. and Atlas, D. (1996). Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels. EMBO J. 15 (16): 4100-4110.

Wu, M. N., et al. (1998). ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner EMBO J. 17: 127-139.

Wu, M. N., et al. (1999). Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo. Neuron 23: 593-605.

Yoshihara, M., et al. (1999). Selective effects of neuronal-synaptobrevin mutations on transmitter release evoked by sustained versus transient Ca2+ increases and by cAMP. J. Neurosci. 19(7): 2432-41.

Yoshihara, M., Suzuki, K. and Kidokoro, Y. (2000). Two independent pathways mediated by cAMP and protein kinase A enhance spontaneous transmitter release at Drosophila neuromuscular junctions. J. Neurosci. 20(22): 8315-22. 11069938

Zhang, X., et al. (2002). Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis. Neuron 34: 599-611. 12062043

Zhong, P., et al. (1997). An alpha-helical minimal binding domain within the H3 domain of syntaxin is required for SNAP-25 binding Biochemistry 36 (14): 4317-4326.

date revised: 25 November 2005

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.