Serrate

Alexandre, C., Lecourtois, M. and Vincent, J.-P. (1999). Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals. Development 126: 5689-5698

Bachmann, A. and Knust, E. (1998a). Dissection of cis-regulatory elements of the Drosophila gene Serrate. Dev. Genes Evol. 208(6): 346-51.

Bachmann, A. and Knust, E. (1998b). Positive and negative control of Serrate expression during early development of the Drosophila wing. Mech. Dev. 76(1-2): 67-78.

Bash, J., et al. (1999). Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J. 18(10): 2803-2811.

Bishop, S. A., et al. (1999). Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch. Development 126: 2993-3003.

Buckles, G. R., et al. (2001). four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg. Development 128: 3533-3542. 11566858

Chen, C. W. J., et al. (1997). Asymmetric expression of Notch/Delta/Serrate is associated with the anterior-posterior axis of feather buds. Dev. Biol. 188(1): 181-187.

Chen, J., Moloney, D. J. and Stanley, P. (2001). PMC Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1. Proc. Natl. Acad. Sci. 98(24): 13716-21. 11707585

Chern, J. J., and and Choi, K. W. (2002). Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. Development 129: 4005-4013. 12163404

Cho, K.-O., et al. (2000). Novel signaling from the peripodial membrane Is essential for eye disc patterning in Drosophila. Cell 103: 331-342.

Daudet, N., Ariza-McNaughton, L. and Lewis, J. (2007). Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development 134: 2369-2378. Medline abstract: 17537801

de Celis, J.F., Barrio, R., del Arco, A. and Garcia-Bellido, A. (1993). Genetic and molecular characteriation of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila. Proc. Natl. Acad. Sci. 90: 4037-41

de Celis, J.F. and Garcia-Bellido, A. (1994). Modifications of the Notch function by Abruptex mutations in Drosophila melanogaster. Genetics 136: 183-94

de Celis, J. F. and Bray. S. (1997). Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development 124(17): 3241-3251.

de Celis, J. F., et al. (1998). Notch signalling mediates segmentation of the Drosophila leg. Development 125: 4617-4626

de Celis, J. F. and Bray, S. J. (2000). The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe. Development 127: 1291-1302.

Diaz-Benjumea, F.J. and Cohen, S.M. (1995). Serrate signals through Notch to establish a wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development 121: 4215-4225

Doherty, D., et al (1996). Delta is a ventral dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes & Dev. 10: 421-434

Duvic, B., et al. (2002). Notch signaling controls lineage specification during Drosophila larval hematopoiesis. Curr. Biol. 12: 1923-1927. 12445385

Eddison, M., Le Roux, I. and Lewis, J. (2000). Notch signaling in the development of the inner ear: Lessons from Drosophila. Proc. Natl. Acad. Sci. 97: 11692-11699.

Fitzgerald, K. and Greenwald, I. (1995). Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. Development 121: 4275-4282

Fleming, R. J., Scottgale, T.N., Diederich, R.J. and Artavanis-Tsakonas, S. (1990).The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev. 4: 2188-2201

Fleming, R. J., Gu, Y., and Hukriede, N. A. (1997). Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124(15): 2973-2981.

Fuwa, T. J., et al. (2006). The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. Mol. Genet. Genomics 275(3):251-63. 16395579

Gallet, A. and Therond, P. P. (2005). Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment. Dev. Biol. 277(1): 51-62. 15572139

Gibson, M. C. and Schubiger, G. (2000). Peripodial cells regulate proliferation and patterning of Drosophila imaginal discs. Cell 103: 343-350.

Glittenberg, M., Pitsouli, C., Garvey, C., Delidakis, C. and Bray, S. (2006). Role of conserved intracellular motifs in Ser signalling, cis-inhibition and endocytosis. EMBO J. 25: 4697-4706. PubMed citation: 17006545

Gu, Y., Hukriede, N.A. and Fleming, R.J. (1995). Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development 121: 855-865

Haberman, A. S., Isaac, D. D. and Andrew, D. J. (2003). Specification of cell fates within the salivary gland primordium. Dev. Biol. 258: 443-453. 12798300

Heilig, J. S., Freeman, M., Laverty, T., Lee, K. J., Campos, A. R., Rubin, G. M. and Steller, H. (1991). Isolation and characterization of the disconnected gene of Drosophila melanogaster. EMBO J. 10: 809-815.

Hukriede, N. A. and Fleming, R. J. (1997a). Beaded of Goldschmidt, an antimorphic allele of Serrate, encodes a protein lacking transmembrane and intracellular domains. Genetics 145: 359-374.

Hukriede, N. A., Gu, Y. and Fleming, R. J. (1997b). A dominant-negative form of Serrate acts as a general antagonist of Notch activation. Development 124(17): 3427-3437.

Ikeuchi, T. and Sisodia, S. S. (2003). The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent 'gamma-secretase' cleavage. J. Biol. Chem. 278(10): 7751-4. 12551931

Jack, J. and DeLotto, Y. (1992). Effect of wing scalloping mutations on cut expression and sense organ differentiation in the Drosophila wing margin. Genetics 131: 353-63

Jiang, R., et al. (1998). Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 12(7): 1046-1057.

Jönsson, F. and Knust, E. (1996). Distinct functions of the Drosophila genes Serrate and Delta revealed by ectopic expression during wing development. Dev. Genes Evol. 206: 91-101

Kim, J., Irvine, K.D. and Carroll, S.B. (1995). Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell 82: 795-802

Kiyota, T., et al. (2001). X-Serrate-1 is involved in primary neurogenesis in Xenopus laevis in a complementary manner with X-Delta-1. Dev. Genes Evol. 211: 367-376. 11685570

Kiyota, T. and Kinoshita, T. (2004). The intracellular domain of X-Serrate-1 is cleaved and suppresses primary neurogenesis in Xenopus laevis. Mech Dev. 121(6): 573-85. 15172688

Klein, T., Brennan, K. and Arias, A. M. (1997). An intrinsic dominant negative activity of Serrate that is modulated during wing development in Drosophila. Dev. Biol. 189(1): 123-134

Klein, T. and Arias, A. M. (1998). Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development. Development 125(15): 2951-2962.

Klein, T., et al. (2003). The tumor suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development. Dev. Bio. 255: 313-333. 12648493

Klueg, K. M. and Muskavitch, M. A. T. (1999). Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila. J. of Cell Sci. 112: 3289-3297.

Kuo, Y. M., et al. (1996). Salivary duct determination in Drosophila: roles of the EGF receptor signaling pathway and the transcription factors Fork head and Trachealess. Development 122: 1909-17

Kuure, S., et al. (2005). Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching. Mech. Dev. 122(6): 765-80. 15905075

Laufer, E., et al. (1997). Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation. Nature 386: 366-373

LaVoie, M. J. and Selkoe, D. J. (2003). The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J. Biol. Chem. 278(36): 34427-37. 12826675

Lawrence, N., et al. (2000). Structural requirements for Notch signaling with Delta and Serrate during the development and patterning of the wing disc of Drosophila. Development 127: 3185-3195.

Lawrence, P. A. and Struhl, G. (1996). Morphogens, compartments and pattern: Lessons from Drosophila. Cell 85: 951-961

Le Borgne, R., Remaud, S., Hamel, S. and Schweisguth, F. (2005). Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol. 3(4): e96. 15760269

Lei, L., Xu, A., Panin, V. M. and Irvine, K. D. (2003). An O-fucose site in the ligand binding domain inhibits Notch activation. Development 130: 6411-6421. Medline abstract: 14627724

Luo, B., et al. (1997). Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol. Cell. Biol. 17(10): 6057-6067.

Micchelli, C. A., Rulifson, E. J. and Blair, S. S. (1997). The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124 (8): 1485-1495.

Milan, M., Diaz-Benjumea, F. J. and Cohen, S. M. (1998). Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function. Genes Dev. 12(18): 2912-2920.

Milan, M. and Cohen, S. M. (2000). Temporal regulation of Apterous activity during development of the Drosophila wing. Development 127: 3069-3078.

Myat, A., et al. (1996). A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis. Dev. Biol. 174: 233-247

Okajima, T., K. D. (2002). Regulation of Notch signaling by O-linked fucose. Cell 111: 893-904. 12526814

Okajima, T., Xu, A. and Irvine, K. D. (2003). Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. J. Biol. Chem. 12909620

Panin, V. M., et al. (1997). Fringe modulates Notch-ligand interactions. Nature 387(6636): 908-912.

Panin, V. M., Shao, L., Lei, L., Moloney, D. J., Irvine, K. D. and Haltiwanger, R. S. (2002). Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. J. Biol. Chem. 277: 29945-29952. 12036964

Papayannopoulos, V., et al. (1998). Dorsal-ventral signaling in the Drosophila eye. Science 281(5385): 2031-4.

Pitsouli, C. and Delidakis, C. (2005). The interplay between DSL proteins and ubiquitin ligases in Notch signaling. Development 132(18): 4041-50. 16093323

Rauskolb, C. and Irvine, K. D. (1999). Notch-mediated segmentation and growth control of the Drosophila leg. Dev. Biol. 210(2): 339-50.

Rauskolb, C. (2001). The establishment of segmentation in the Drosophila leg. Development 128: 4511-4521. 11714676

Rodriguez-Esteban, C., et al. (1997). Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb. Nature 386: 360-366

Rones, M. S., et al. (2000). Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis. Development 127: 3865-3876.

Sasamura, T., et al. (2003). neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development 130: 4785-4795. 12917292

Singh, A. and Choi, K.-W. (2003). Initial state of the Drosophila eye before dorsoventral specification is equivalent to ventral. Development 130: 6351-6360. 14623824

Sidow, A., et al. (1997). Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature 389(6652): 722-725.

Singh, A., et al. (2004). Dorso-ventral asymmetric functions of teashirt in Drosophila eye development depend on spatial cues provided by early DV patterning genes. Mech. Dev. 121: 365-370. 15110046

Sivasankaran, R., et al. (2000). The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family. Mech. Dev. 427-431.

Speicher, S.A., Thomas, U., Hinz, U. and Knust, E. (1994). The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation. Development 120: 535-44

Sun, X. and Artavanis-Tsakonas, S. (1997). Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development 124(17): 3439-3448.

Tax, F. E., Yeargers, J.J. and Thomas, J.H. (1994). Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature 368: 150-154

Thomas, U., Speicher, S.A. and Knust, E. (1991).The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs. Development 111: 749-61

Thomas, U., et al. (1995). Phenotypic and molecular characterization of SerD, a dominant allele of the Drosophila gene Serrate. Genetics 139: 203-213

Valsecchi, V., et al. (1997). JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial--mesenchymal interactions. Mech. Dev. 69(1-2): 203-207

Wiellette, E. L. and McGinnis, W. (1999). Hox genes differentially regulate Serrate to generate segment-specific structures. Development 126(9): 1985-1995.

Yan, S.-J., et al. (2004). Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development 131: 285-298. 14701680

Zeng, C., et al. (1998). Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage. Genes Dev.12: 1086-1091.

Zine, A., Van De Water, T. R. and de Ribaupierre, F. (2000). Notch signaling regulates the pattern of auditory hair cell differentiation in mammals Development 127: 3373-3383.

date revised: 15 October 2007 

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