Interactive Fly, Drosophila

rutabaga


REFERENCES

Abdel-Majid, R. M., et al. (1998). Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex. Nat. Genet. 19(3): 289-291.

Akalal, D. B., Wilson, C. F., Zong, L., Tanaka, N. K., Ito, K. and Davis, R. L. (2006). Roles for Drosophila mushroom body neurons in olfactory learning and memory. Learn Mem. 13(5): 659-68. Medline abstract: 16980542

Anjard, C., Söderbom, F. and Loomis, W. F. (2001). Requirements for the adenylyl cyclases in the development of Dictyostelium. Development 128: 3649-3654. 11566867

Antoni, F. A., et al. (1998). Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory. J.Neurosci. 18(23): 9650-9661

Bauman, A. L., et al. (2006). Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol. Cell 23(6): 925-31. 16973443

Bellen, H. J., et al. (1987). Two Drosophila learning mutants, dunce and rutabaga, provide evidence of a maternal role for cAMP on embryogenesis. Dev. Biol. 121: 432-44

Berke, B and Wu, C. F. (2002). Regional calcium regulation within cultured Drosophila neurons: Effects of altered cAMP metabolism by the learning mutations dunce and rutabaga. J. Neurosci. 22(11): 4437-4447. 12040051

Bhattacharya, A., Gu, G.G., Singh, S. (1999). Modulation of dihydropyridine-sensitive calcium channels in Drosophila by a cAMP-mediated pathway. J. Neurobiol. 39(4): 491-500.

Brembs, B. and Heisenberg, M (2000). The operant and the classical in conditioned orientation of Drosophila melanogaster at the flight simulator. Learn. Mem. 7: 104-115. 10753977

Cagampang, F. R., et al. (1998). Circadian changes of type II adenylyl cyclase mRNA in the rat suprachiasmatic nuclei. Brain Res. 810(1-2): 279-82.

Cann, M. J. and Levin, L. R. (2000a). Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Dev. Genes Evol. 210: 34-40.

Cann, M. J., Chung, E. and Levin, L. R. (2000b). A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster. Dev. Genes Evol. 210: 200-206

Chakrabarti, S., et al. (1998). Chronic morphine augments G(beta)(gamma)/Gs(alpha) stimulation of adenylyl cyclase: relevance to opioid tolerance. Mol. Pharmacol. 54(4): 655-62.

Chang, D. J., et al. (2000). Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in Aplysia sensory neurons. Proc. Natl. Acad. Sci. 97: 1829-1834.

Chavis, P., et al. (1998). Visualization of cyclic AMP-regulated presynaptic activity at cerebellar granule cells. Neuron 20(4): 773-781.

Cheung, U. S., et al. (1999). Drosophila larval neuromuscular junction's responses to reduction of cAMP in the nervous system. J. Neurobiol. 40(1): 1-13.

Cho, W., Heberlein, U. and Wolf, F. W. (2004). Habituation of an odorant-induced startle response in Drosophila. Genes Brain Behav. 3(3): 127-37. 15140008

Chyb, S., et al. (1999). Modulation of the light response by cAMP in Drosophila photoreceptors. J. Neurosci. 19(20): 8799-8807.

Col, J. al., et al. (2007). Adenylyl cyclase-dependent axonal targeting in the olfactory system. Development 134: 2481-2489. Medline abstract: 17537788

Davis, R. L., et al. (1995). The cyclic AMP system and Drosophila learning. Mol. Cell. Biochem. 149-150: 271-278

Davis, R. L., et al. (1996). Physiology and biochemistry of Drosophila learning mutants. Physiol. Rev. 76: 299-317

Dessauer, C. W. and Gilman, A. G. (1997). The catalytic mechanism of mammalian adenylyl cyclase. Equilibrium binding and kinetic analysis of p-site inhibition. J. Biol. Chem. 272: 27787-27795

Engel, J. E. and Wu, C. F. (1996). Altered habituation of an identified escape circuit in Drosophila memory mutants. J. Neurosci. 16: 3486-3499

Fagnon, D.D. and Tuchek, J.M. (1995). The biochemistry of learning and memory. Molecular and Cellular Biochemistry 149/150: 279-286

Feany, M. B. (1990). Rescue of the learning defect in dunce, a Drosophila learning mutant, by an allele of rutabaga, a second learning mutant. Proc Natl Acad Sci 87: 2795-9

Ferris, J., Ge, H., Liu, L. and Roman, G. (2006). G(o) signaling is required for Drosophila associative learning. Nat. Neurosci. 9(8): 1036-40. 16845387

Gao, M., et al. (1998). Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Proc. Natl. Acad. Sci. 95(3): 1038-1043.

Gu, C., Sorkin, A. and Cooper, D. M. F. (2001). Persistent interactions between the two transmembrane clusters dictate the targeting and functional assembly of adenylyl cyclase. Curr. Bio. 11: 185-190. 11231154

Guillou, J. L., Rose, G. M. and Cooper, D. M. F. (1999). Differential activation of adenylyl cyclases by spatial and procedural learning. J. Neurosci. 19(14): 6183-6190.

Guo, H. F., et al. (1997). Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science 276(5313): 795-8.

Guo, H.-F., et al. (2000). A neurofibromatosis-1-regulated pathway is required for learning in Drosophila. Nature 403: 895-898.

Han, P. L., et al. (1992). Preferential expression of the Drosophila rutabaga gene in mushroom bodies, neural centers for learning in insects. Neuron 9: 619-27

Han, K. A., et al. (1996). DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies. Neuron 16: 1127-1135

Hannan, F., et al. (2006). Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. Human Mol. Genet. 15(7): 1087-1098. 16513807

Hendricks, J. C., et al. (2001). A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat. Neurosci. 4: 1108-1115. 11687816

Hess, K. C., et al. (2005). The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev. Cell 9(2): 249-59. 16054031

Horner, K., et al. (2003). Rodent oocytes express an active adenylyl cyclase required for meiotic arrest. Dev. Biol. 258: 385-396. 12798295

Iiri, T., et al. (1999). A Gsalpha mutant designed to inhibit receptor signaling through Gs. Proc. Natl. Acad. Sci. 96(2): 499-504.

Impey, S., Obrietan, K., Wong, S. T., Poser, S., Yano, S., Wayman, G., Deloulme, J. C., Chan, G., and Storm, D. R. (1998). Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron 21: 869-883.

Kim, M.-J. and Han, J.-K. (1999). The involvement of cAMP signaling pathway in axis specification in Xenopus embryos. Mech. Dev. 89: 55-64.

Kriebel, P. W., Barr, V. A., and Parent, C. A. (2003). Adenylyl cyclase localization regulates streaming during chemotaxis. Cell 112: 549-560. 12600317

Kuromi, H. and Kidokoro, Y. (2000). Tetanic stimulation recruits vesicles from reserve pool via a cAMP-mediated process in Drosophila synapses. Neuron 27: 133-143.

Levin, L. R., et al. (1992). The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase. Cell 68: 479-489

Liu, G., Seiler, H., Wen, A., Zars, T., Ito, K., Wolf, R., Heisenberg, M. and Liu, L. (2006). Distinct memory traces for two visual features in the Drosophila brain. Nature 439(7076): 551-6. 16452971

Liu, L., Wolf, R., Ernst, R. and Heisenberg, M. (1999). Context generalization in Drosophila visual learning requires the mushroom bodies. Nature 400(6746): 753-6.

Makhinson, M., et al. (1999). Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/Calmodulin-dependent Kinase II autophosphorylation. J. Neurosci. 19(7): 2500-2510.

Mao, Z, Roman, G., Zong, L. and Davis, R. L (2004). Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch. Proc. Natl. Acad. Sci. 101: 198-203. Medline abstract: 14684832

Martin, J. R., Ernst, R. and Heisenberg, M. (1998). Mushroom bodies suppress locomotor activity in Drosophila melanogaster. Learn Mem 5(1-2): 179-91.

Meima, M. E. and Schaap, P. (1999). Fingerprinting of adenylyl cyclase activities during Dictyostelium development indicates a dominant role for adenylyl cyclase B in terminal differentiation. Dev. Biol. 212(1): 182-190

Moon, C., et al. (1998). Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J. Neurosci. 18(9): 3195-3205.

Moore, M. S., et al. (1998). Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93: 997-1007.

Nguyen, P. V. and Kandel, E. R. (1996). A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices. J. Neurosci. 16: 3189-3198

Nighorn, Qiu, Y., and Davis, R. L. (1994). Progress in understanding the Drosophila dnc locus. Comp Biochem Physiol Biochem Mol Biol 108: 1-9

Olianas, M. C. and Onali, P. (1999). Mediation by G protein betagamma subunits of the opioid stimulation of adenylyl cyclase activity in rat olfactory bulb. Biochem. Pharmacol. 57(6): 649-52.

Otsuka, H. and Van Haastert, P. J. M. (1998). A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression. Genes Dev. 12: 1738-1748.

Pineda, V. V., et al. (2004). Removal of Gialpha1 constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation. Neuron 41: 153-163. 14715142

Quinn, W.G., Harris, W.A. and Benzer, S. (1974). Conditioned behavior in Drosophila melanogaster. Proc Natl Acad Sci 71: 708-712

Scholich, K., et al. (1999). Facilitation of signal onset and termination by Adenylyl cyclase. Science 283(5406): 1328-1331

Shima, F., et al. (1997). Effect of association with Adenylyl cyclase-associated protein on the interaction of yeast Adenylyl cyclase with Ras protein. Mol. Cell. Biol. 17: 1057-64

Sindreu, C. B., Scheiner, Z. S. and Storm, D. R. (2007). Ca2+-stimulated adenylyl cyclases regulate ERK-dependent activation of MSK1 during fear conditioning. Neuron 53(1): 79-89. Medline abstract: 17196532

Skoulakis, E. M., Kalderon, D. and Davis, R. L. (1993). Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory. Neuron 11: 197-208

Söderbom, F., et al. (1999). An adenylyl cyclase that functions during late development of Dictyostelium. Development 126: 5463-5471

Storm, D. R., et al. (1998). Impaired cerebellar long-term potentiation in type I adenylyl cyclase mutant mice. Neuron 20: 1199-1210.

Suzuki, N., et al. (1990). Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins. Proc. Natl. Acad. Sci. 87(22): 8711-5.

Venkatesh, K., et al. (2001). Interactions between the inositol 1,4,5-trisphosphate and cyclic AMP signaling pathways regulate larval molting in Drosophila. Genetics 158: 309-318. 11333238

Villacres, E. C., et al. (1995). Developmentally expressed Ca(2+)-sensitive adenylyl cyclase activity is disrupted in the brains of type I adenylyl cyclase mutant mice. J. Biol. Chem. 270: 14352-14357.

Wang, B., Shaulsky, G. and Kuspa, A. (1999). Multiple developmental roles for CRAC, a cytosolic regulator of adenylyl cyclase. Dev. Biol. 208(1): 1-13.

Wayman, G. A., et al. (1994). Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo. J. Biol. Chem. 269: 25400-5.

Wei, F., et al. (2002). Genetic elimination of behavioral sensitization in mice lacking Calmodulin-stimulated adenylyl cyclases. Neuron 36: 713-726. 12441059

Wei, J., et al. (1998). Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: a mechanism for attenuation of olfactory signals. Neuron 21(3): 495-504.

Wenzel-Seifert. K., et al. (1998). Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity. Biochem J. 334 ( Pt 3): 519-24.

Wong, S. T., et al. (1999). Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron 23: 787-798.

Xia, X. G., et al. (1991). Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain: expression in areas associated with learning and memory. Neuron 6: 431-43

Yan, L., et al. (2007). Type 5 Adenylyl cyclase disruption increases longevity and protects against stress. Cell 130: 247-258. Medline abstract: 17662940

Yovell, Y., et al. (1992). A quantitative study of the Ca2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and rat. J. Neurochem. 59: 1736-44.

Zars, T., Wolf, R., Davis, R., Heisenberg, M. (2000a). Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram. Learn Mem. 7(1): 18-31.

Zars, T., Fischer, M., Schulz, R. and Heisenberg, M. (2000b). Localization of short-term memory in Drosophila . Science 288: 672-5.

Zhang, G., et al. (1997) Structure of the adenylyl cyclase catalytic core. Nature 6: 903-908. 9069282

Zhao, M.-L., and Wu, C.-F. (1997). Alterations in frequency coding and activity dependence of excitability in cultured neurons of Drosophila memory mutants. J. Neurosci. 15: 2187-2199.

Zhong, Y. and Wu, C. F. (1991). Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade. Science 251: 198-201

Zhong, Y., Budnik, V. and Wu, C. F. (1992). Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade. J Neurosci 12: 644-51

Zhong, Y. and Wu, C. F. (1993). Differential modulation of potassium currents by cAMP and its long-term and short-term effects: dunce and rutabaga mutants of Drosophila. J Neurogenet 9: 15-27

Zhong, Y. (1995a). Mediation of PACAP-like neuropeptide transmission by coactivation of Ras/Raf and cAMP signal transduction pathways in Drosophila. Nature 375(6532): 588-92.

Zhong, Y. and Pena, L. A. (1995b). A novel synaptic transmission mediated by a PACAP-like neuropeptide in Drosophila. Neuron 14(3): 527-36.

Zhong, Y. and Wu, C.-F. (2004). Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila. J. Neurosci. 24(6): 1439-1445. 14960616


rutabaga: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 20 October 2007

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