roundabout

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Bashaw, G. J., et al. (2000). Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the Roundabout receptor. Cell 101: 703-715.

Bashaw, G. J., Hu, H., Nobes, C. D. and Goodman, C. S. (2001). A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion. J. Cell Bio. 155: 1117-1122. 11756465

Battye, R., et al. (2001). Repellent signaling by Slit requires the leucine-rich repeats. J. Neurosci. 21(12): 4290-4298. 11404414

Bear, J. E., et al. (2000). Negative regulation of fibroblast motility by Ena/VASP proteins. Cell 101: 717-728.

Brose, K., et al. (1999). Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96(6): 795-806.

Campbell, D. S., et al. (2007). Slit1a inhibits retinal ganglion cell arborization and synaptogenesis via Robo2-dependent and -independent pathways. Neuron 55(2): 231-45. PubMed citation: 17640525

Cebria, F. and Newmark, P. A. (2007). Morphogenesis defects are associated with abnormal nervous system regeneration following roboA RNAi in planarians. Development 134: 833-837. Medline abstract: 17251262

Challa, A. K., et al. (2005). Robo3 isoforms have distinct roles during zebrafish development. Mech. Dev. 122: 1073-1086. 16129585

Condron, B. G. (1999). Serotonergic neurons transiently require a midline-derived FGF signal. Neuron 24: 531-540. 10595507

Couch, J. A., Chen, J., Rieff, H.I., Uri, E. M. and Condron, B. G. (2004). robo2 and robo3 interact with eagle to regulate serotonergic neuron differentiation. Development 131(5): 997-1006. 14973268

Crowner, D., Madden, K., Goeke, S. and Giniger, E. (2002). Lola regulates midline crossing of CNS axons in Drosophila. Development 129: 1317-1325. 11880341

Englund, C., et al. (2002). Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea. Development 129: 4941-4951. 12397103

Erskine, L., et al. (2000). Retinal ganglion cell axon guidance in the mouse optic chiasm: Expression and function of robos and slits. J. Neurosci. 20(13): 4975-4982. 10864955

Fan, X., Labrador, J. P., Hing, H. and Bashaw, G. J. (2003). Slit stimulation recruits Dock and Pak to the Roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline. Neuron 40: 113-127. 14527437

Fritz, J. L. and VanBerkum, M. F. A. (2000). Calmodulin and Son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS. Development 127: 1991-2000.

Fritz, J. L. and VanBerkum, M. F. A. (2002). Regulation of rho family GTPases is required to prevent axons from crossing the midline. Dev. Bio. 252: 46-58. 12453459

Furrer, M. P., Kim, S., Wolf, B. and Chiba, A. (2003). Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline. Nat. Neurosci. 6: 223-230. PubMed citation: 12592406

Furrer, M. P., Vasenkova, I., Kamiyama, D., Rosado, Y. and Chiba, A. (2007). Slit and Robo control the development of dendrites in Drosophila CNS. Development 134(21): 3795-804. PubMed citation: 17933790

Georgiou, M, and Tear, G. (2003). The N-terminal and transmembrane domains of Commissureless are necessary for its function and trafficking within neurons. Mech. Dev. 120: 1009-1019. 14550530

Godenschwege, T. A., et al. (2002). Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for Roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity. J. Neurosci. 22(8): 3117-3129. 11943815

Grieshammer, U., et al. (2004). SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev. Cell 6: 709-717. 15130495

Hammond, R., et al. (2005). Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain. Development 132(20): 4483-95. 16162649

Hannula-Jouppi, K., et al. (2005). The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. PLoS. Genet. 1(4): e50. 16254601

Hao, J. C., et al. (2001). C. elegans Slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor. Neuron 32: 25-38. 11604136

Horikawa, K., et al. (2000). Nonphotic entrainment by 5-HT_1A/7 receptor agonists accompanied by reduced Per1 and Per2 mRNA levels in the suprachiasmatic nuclei. J. Neurosci. 20(15): 5867-5873. 10908630

Hu, H., et al. (2005). Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion, Proc. Natl. Acad. Sci. 102: 4613-4618. Medline abstract: 15755809

Hummel, T., Schimmelpfeng, K. and Kl”mbt, C. (1999). Commissure formation in the embryonic CNS of Drosophila. II. Function of the different midline cells. Development 126: 771-779.

Hutson, L. D. and Chien, C.-B. (2002). Pathfinding and error correction by retinal axons: The Role of astray/robo2. Neuron 33: 205-217. 11804569

Jen, J. C., Chan, W. M., Bosley, T. M., Wan, J., Carr, J. R., Rub, U., Shattuck, D., Salamon, G., Kudo, L. C., Ou, J., et al. (2004). Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science 304: 1509-1513. 15105459

Jhaveri, D., Saharan, S., Sen, A. and Rodrigues, V. (2004). Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling. Development 131: 1903-1912. 15056612

Johnson, K. G., et al. (2004). Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent Slit during midline axon guidance. Curr. Biol. 14: 499-504. 15043815

Kang, J.-S., et al. (1997). CDO: An oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. J. Cell Biol. 138: 203-213.

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Keleman, K. and Dickson, B. J. (2001). Short- and long-range repulsion by the Drosophila Unc5 Netrin receptor. Neuron 32: 605-617. 11719202

Keleman, K., et al. (2002). Comm sorts Robo to control axon guidance at the Drosophila midline. Cell 110: 415-427. 12202032

Kidd, T., et al. (1998a). Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell 92(2): 205-215.

Kidd, T., et al. (1998b). Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline. Neuron 20(1): 25-33.

Kidd, T., Bland, K. S. and Goodman, C. S. (1999). Slit is the midline repellent for the robo receptor in Drosophila. Cell 96(6): 785-94.

Kim, Y.-S., et al. (2002). Constitutively active myosin light chain kinase alters axon guidance decisions in Drosophila embryos. Dev. Bio. 249: 367-381. 12221012

Kinrade, E. F. V., et al. (2001). Roundabout signalling, cell contact and trophic support confine longitudinal glia and axons in the Drosophila CNS. Development 128: 207-216. 11124116

Lee, H., et al. (2004). The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. Neuron 42: 913-926. 15207236

Lee, S., et al. (2007). The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion. Development 134(9): 1767-77. Medline abstract: 17409115

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Li, H. S., et al. (1999). Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 96(6): 807-18.

Long, H., et al. (2004). Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron 42: 213-223. 15091338

Lundström, A., et al. (2004). Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev. 18: 2161-2171. 15342493

Marillat, V., et al. (2004). The Slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons. Neuron 43: 69-79. 15233918

Mehta, B. and Bhat, K. M. (2001). Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS. Development 128: 3161-3168. 11688564

Merritt, D. J. and Whitington, P. M. (1995). Central projections of sensory neurons in the Drosophila embryo correlate with sensory modality, soma position, and proneural gene function. J. Neurosci. 15: 1755-1767. 7891133

Miyasaka, N., Sato, Y., Yeo, S. Y., Hutson, L. D., Chien, C. B., Okamoto, H. and Yoshihara, Y. (2005). Robo2 is required for establishment of a precise glomerular map in the zebrafish olfactory system. Development 132(6): 1283-93. 15716341

Mörcka, C., Axäng, C. and Pilon, M. (2003). A genetic analysis of axon guidance in the C. elegans pharynx. Dev. Biol. 260: 158-175. 12885562

Murray, M. J. and Whitington, P. M. (1999). Effects of roundabout on growth cone dynamics, filopodial length, and growth cone morphology at the midline and throughout the neuropile. J. Neurosci. 19(18): 7901-7912.

Myat, A., et al. (2002). Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor. Neuron 35: 447-459. 12165468

Nguyen Ba-Charvet, K. T., et al. (1999). Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. Neuron 22(3): 463-73.

Nusslein-Volhard, C., Wieschaus, E. and Kluding, H. (1984). Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193: 267-282

Qian, L., Liu, J. and Bodmer, R. (2005). Slit and Robo control cardiac cell polarity and morphogenesis. Curr. Biol. 15(24): 2271-8. 16360689

Rajagopalan, S., et al. (2000). Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS. Cell 103: 1033-1045

Ratnaparkhi, A., Banerjee, S. and Hasan, G. (2002). Altered levels of Gq activity modulate axonal pathfinding in Drosophila. J. Neurosci. 22(11): 4499-4508. 12040057

Sabatier, C., et al. (2004). The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell 117(2): 157-69. 15084255

Santiago-Martínez, E., Soplop, N. H. and Kramer, S. G. (2006). Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration. Proc. Natl. Acad. Sci. 103: 12441-12446. Medline abstract: 16888037

Schimmelpfeng, K., Gögel, S. and Klämbt, C. (2001). The function of leak and kuzbanian during growth cone and cell migration. Mech. Dev. 106: 25-36. 11472832

Schrader, S. and Merritt, D. J. (2000). Central projections of Drosophila sensory neurons in the transition from embryo to larva. J. Comp. Neurol. 425: 34-44. 10940940

Seeger, M., et al. (1993). Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10(3): 409-426.

Simpson, J. H., et al. (2000a). Short-range and long-range guidance by Slit and its Robo receptors: Robo and Robo2 play distinct roles in midline guidance. Neuron 28: 753-766. 11163264

Simpson, J. H., et al. (2000b). Short-range and long-range guidance by Slit and its Robo receptors: A combinatorial code of Robo receptors controls lateral position. Cell 103: 1019-1032

Steigemann, P., Molitor, A., Fellert, S., Jackle, H. and Vorbruggen, G. (2004). Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling. Curr. Biol. 14(3): 225-30. 14761655

Sun, Q., et al. (2000). Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo. Development 127: 801-812.

Tayler, T. D., Robichaux, M. B. and Garrity, P. A. (2004). Compartmentalization of visual centers in the Drosophila brain requires Slit and Robo proteins. Development 131(23): 5935-45. 15525663

Wang, K. H., et al. (1999). Biochemical purification of a mammalian Slit protein as a positive regulator of sensory axon elongation and branching. Cell 96(6): 771-84.

Whitford, K. L. et al. (2002). Regulation of cortical dendrite development by slit-robo interactions. Neuron 33: 47-61. 11779479

Wills, Z., et al. (2002). A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron 36: 611-622. 12441051

Wolf, B. D. and Chiba, A. (2000). Axon pathfinding proceeds normally despite disrupted growth cone decisions at CNS midline. Development 127: 2001-2009.

Wong, K., et al. (2001). Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 107: 209-221. 11672528

Xian, J., et al. (2001). Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Proc. Natl. Acad. Sci. 98: 15062-15066. 11734623

Yang, L. and Bashaw, G. J. (2006). Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline. Neuron 52(4): 595-607. Medline abstract: 17114045

Yuan, W., et al. (1999). The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev. Biol. 212(2): 290-306.

Zallen, J. A., Yi, B. A. and Bargmann, C. I. (1998). The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans. Cell 92(2): 217-227.

Zallen, J. A., Kirch, S. A. and Bargmann, and C. I. (1999). Genes required for axon pathfinding and extension in the C. elegans nerve ring. Development 126: 3679-3692.

Zlatic, M., Landgraf, M. and Bate, M. (2003). Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system. Neuron 37: 41-51. 12526771

date revised: 10 April 2008

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