numb

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Cheng, X., et al. (2008). Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development 135(20): 3447-58. PubMed Citation: 18799543

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Chien, C. T., et al. (1998). Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo. Mol. Cell. Biol. 18(1): 598-607. PubMed Citation: 9418906

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Eddison, M., Le Roux, I. and Lewis, J. (2000). Notch signaling in the development of the inner ear: Lessons from Drosophila. Proc. Natl. Acad. Sci. 97: 11692-11699

Edenfeld, G., Altenhein, B., Zierau, A., Cleppien, D., Krukkert, K., Technau, G. and Klämbt, C. (2007). Notch and Numb are required for normal migration of peripheral glia in Drosophila. Dev. Biol. 301(1): 27-37. Medline abstract: 17157832

Endo, K., Aoki, T., Yoda, Y., Kimura, K. and Hama, C. (2007). Notch signal organizes the Drosophila olfactory circuitry by diversifying the sensory neuronal lineages. Nat. Neurosci. 10(2): 153-60. Medline abstract: 17220884

Freedman, D. A., Wu, L. & Levine, A. J. (1999). Functions of the MDM2 oncoprotein. Cell Mol. Life Sci. 55: 96-107

Frise, E., et al. (1996). The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc. Natl. Acad. Sci. 93: 11925-32. 8876239

Gho, M. and Schweisguth, F. (1998). Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila. Nature 393(6681): 178-181

Gho, M., Bellaiche, Y. and Schweisguth, F., (1999). Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell. Development 126: 3573-3584

Giniger, E. (1998) A role for Abl in Notch signaling. Neuron 20: 667-681. 9581760

Gomez, M. R. and Bate, M. (1997). Segregation of myogenic lineages in Drosophila requires numb. Development 124(23): 4857-4866

Guo, M., Bier, E., Jan, L.Y. and Jan, Y.N. (1995). tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS. Neuron 14(5): 913-25

Guo, M., Jan, L. Y. and Jan, Y. N. (1996). Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch. Neuron 17: 21-41

Han, Z. and Bodmer, R. (2003). Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development 130: 3039-3051. 12756185

Huang, E. J. et al. (2005). Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19(1): 138-51. 15598981

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Hutterer, A. and Knoblich, J. A. (2005). Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep. 6(9): 836-42. Medline abstract: 16113648

Justice, N., Roegiers, F. Jan, L. Y., and Jan, Y. H. (2003). Lethal giant larvae acts together with Numb in Notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr. Biol. 13: 778-783. 12725738

Juven-Gershon, T., Shifman, O., Unger, T., Elkeles, A., Haupt, Y. & Oren, M. (1998). The Mdm2 oncoprotein interacts with the cell fate regulator Numb. Mol. Cell Biol. 7: 3974-3982

Katanaev, V. L., Ponzielli, R., Semeriva, M. and Tomlinson, A. (2005). Trimeric G protein-dependent Frizzled signaling in Drosophila. Cell 120: 111-122. 15652486

Katanaev, V. L., Tomlinson, A. (2006). Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila. Proc. Natl. Acad. Sci. 103: 6524-6529. 16617104

Knoblich, J. A., Jan, L. Y. and Jan, Y. N. (1995). Asymmetric segregation of Numb and Prospero during cell division. Nature 377: 624-627

Knoblich, J. A., Jan, L. Y. and Jan, Y. N. (1997). The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization. Proc. Natl. Acad. Sci. 94(24): 13005-13010

Kraut, R.,K. et al. (1996b). Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383: 50-55

Kubu, C. J., et al. (2002). Developmental changes in Notch1 and Numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells. Dev. Biol. 244: 199-214. 11900468

Kuo, C. T., et al. (2006). Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127(6): 1253-64. Medline abstract: 17174898

Lear, B. C., Skeath, J. B. and Patel, N. H. (1999). Neural cell fate in rca1 and cycA mutants: the roles of intrinsic and extrinsic factors in asymmetric division in the Drosophila central nervous system. Mech. Dev. 207-219.

Lee, C. Y., et al. (2006). Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev. 20(24): 3464-74. Medline abstract: 17182871

Li, H.-S., et al. (2004). Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40: 1105-1118. 14687546

Li, S.-C., et al. (1997). High-affinity binding of the Drosophila numb phosphotyrosine-binding domain to peptides containing a gly-pro-(p)Tyr motif. Proc. Natl. Acad. Sci. 94(14): 7204-7209

Liebl, E. C., et al. (2003). Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding. Development 130: 3217-3226. 12783792

Lin, H. and Spradling, A. C. (1995). Fusome asymmetry and oocyte determination in Drosophila. Dev. Genet. 1645: 6-12

Lu, B., Rothenberg, M., Jan, L. Y. and Jan, Y. N. (1998). Partner of numb colocalizes with numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors. Cell 95: 225-23

Lu, B., Ackerman, L., Jan, L. Y., Jan, Y. N. (1999). Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division. Molec. Cell 4: 883-891.

Lu, B., et al. (2001). Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409: 522-525. 11206549

Lundell, M. J., et al. (2003). The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila. Development 130: 4109-4121. 12874131

Manning, L. and Doe, C. Q. (1999). Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage. Development 26: 2063-2071

Mayer, B., Emery, G., Berdnik, D., Wirtz-Peitz, F. and Knoblich, J. A. (2005). Quantitative analysis of protein dynamics during asymmetric cell division. Curr. Biol. 15(20): 1847-54. Medline abstract: 16243032

McGill, M. A. and McGlade, C. J. (2003). Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J. Biol. Chem. 278(25): 23196-203. 12682059

Mehta, B. and Bhat, K. M. (2001). Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS. Development 128: 3161-3168. 11688564

Merdes, G., Soba, P., Loewer, A., Bilic, M. V., Beyreuther, K. and Paro, R. (2004). Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J. 23(20): 4082-95. 15385958

Nagel, A. C., Maier, D. and Preiss, A. (2000). Su(H)-independent activity of Hairless during mechano-sensory organ formation in Drosophila. Mech. Dev. 94: 3-12

Nie, J., et al. (2002). LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation EMBO J. 21: 93-102. 11782429

Nishimura, T., et al. (2003). CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol. 5(9): 819-26. 12942088

Nishimura, T. and Kaibuchi, K. (2007). Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev. Cell 13(1): 15-28. Medline abstract: 17609107

O'Connor-Giles, K. M. and Skeath, J. B. (2003). Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila. Dev. Cell 5: 231-243. 12919675

Ohshiro, T., et al. (2000). Role of cortical tumor-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408: 593-596. 21003824

Orgogozo, V., Schweisguth, F. and Bellaïche, Y. (2002). Binary cell death decision regulated by unequal partitioning of Numb at mitosis. Development 129: 4677-4684. 12361960

Park, M., Yaich, L. E. and Bodmer, R. (1998). Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo. Mech. Dev. 75(1-2): 117-26

Peng, C.-Y., et al. (2000). The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408: 596-600. 21003825

Petersen, P. H., et al. (2002). Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 419: 929-934. 12410312

Rasin, M. R., et al. (2007). Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat. Neurosci. 10(7): 819-27. Medline abstract: 17589506

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Rhyu, M. S. and Knoblich, J. (1995). Spindle orientation and asymmetric cell fate. Cell 82: 523-526

Roegiers, F., et al. (2001a). Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage. Nature Cell Bio. 3: 58-67 . 11146627

Roegiers, F., Younger-Shepherd, S., Jan, L. Y. and Jan, Y. N. (2001b). Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila. Proc. Natl. Acad. Sci. 98: 14469-14474. 11734647

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Schuldt, A. J. and Brand, A. H. (1999). Mastermind acts downstream of Notch to specify neuronal cell fates in the Drosophila central nervous system. Dev. Biol. 205(2): 287-295

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Skeath, J. B. and Doe, C. Q. (1998). Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS. Development 125: 1857-1865

Smith, C. A., et al. (2007). aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO J. 26: 468-480. Medline abstract: 17203073

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Wai, P., Truong, B. and Bhat, K. M. (1999). Cell division genes promote asymmetric interaction between Numb and Notch in the Drosophila CNS. Development 126(12): 2759-2770

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Zhong, W., et al. (2000). Mouse numb is an essential gene involved in cortical neurogenesis. Proc. Natl. Acad. Sci. 97: 6844-6849. Medline abstract: 10841580

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date revised: 25 October 2009 

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